痤疮病人发病相关影响因素的调查分析
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摘要
目的调查分析影响痤疮发病的相关因素,为痤疮的预防和治疗提供理论依据。方法分别对来我院门诊就诊的323例痤疮病人及259例无痤疮的健康人进行饮食、生活习惯、生理特征等的问卷调查,采用单因素分析和多因素Logistic回归分析筛选痤疮发病相关影响因素。结果进食纯牛奶(95%CI=1.005～1.246,P<0.05)、甜食(95%CI=1.008～1.285,P<0.05)、辛辣食品(95%CI=1.228～1.576,P<0.05)频率高以及有痤疮遗传家族史(95%CI=2.738～5.524,P<0.05)、压力大(95%CI=1.164～1.457,P<0.05)是痤疮发生的危险因素,睡眠充足(95%CI=0.547～0.938,P<0.05)是痤疮发生的保护因素。具有痤疮家族史者上述因素的影响更明显,且排便障碍(95%CI=1.424～1.758,P<0.05)、出汗(95%CI=1.219～1.687,P<0.05)、化妆(95%CI=1.423～1.989,P<0.05)是痤疮发病额外的危险因素。结论痤疮的发生与多种因素有关,健康合理的饮食及生活习惯是防止痤疮发生发展的重要措施,特别是对有痤疮家族史者需更加注意。
Objective To survey the influencing factors related to the incidence of acne and to provide a theoretical basis for the prevention and treatment of acne. Methods A questionnaire on diet,lifestyle,and physiological characteristics was administered to 323 patients with acne and 259 healthy subjects without acne who attended the Outpatient Department of our hospital;univariate and multivariate logistic regression analyses were used to screen out the influencing factors related to the incidence of acne. Results Frequent ingestion of pure milk,sweet food,and spicy food,family history of acne,and excessive stress were risk factors for acne(95%confidence interval(CI)=1.005-1.246,1.008-1.285,1.228-1.576,2.738-5.524,and 1.164-1.457,respectively,all P<0.05);sufficient sleep was a protective factor for acne(95% CI=0.547-0.938,P<0.05).Patients with a family history of acne were more susceptible to the above factors.In addition,constipation,sweating,and applying cosmetics were extra risk factors for acne(95% CI=1.424-1.758,1.219-1.687,and 1.423-1.989,respectively,all P<0.05). Conclusion The incidence of acne is related to a variety of external factors.Developing a healthy eating habit and lifestyle is an important way to prevent the development and progression of acne,especially for those with a family history of acne.
Objective To survey the influencing factors related to the incidence of acne and to provide a theoretical basis for the prevention and treatment of acne. Methods A questionnaire on diet,lifestyle,and physiological characteristics was administered to 323 patients with acne and 259 healthy subjects without acne who attended the Outpatient Department of our hospital;univariate and multivariate logistic regression analyses were used to screen out the influencing factors related to the incidence of acne. Results Frequent ingestion of pure milk,sweet food,and spicy food,family history of acne,and excessive stress were risk factors for acne(95%confidence interval(CI)=1.005-1.246,1.008-1.285,1.228-1.576,2.738-5.524,and 1.164-1.457,respectively,all P<0.05);sufficient sleep was a protective factor for acne(95% CI=0.547-0.938,P<0.05).Patients with a family history of acne were more susceptible to the above factors.In addition,constipation,sweating,and applying cosmetics were extra risk factors for acne(95% CI=1.424-1.758,1.219-1.687,and 1.423-1.989,respectively,all P<0.05). Conclusion The incidence of acne is related to a variety of external factors.Developing a healthy eating habit and lifestyle is an important way to prevent the development and progression of acne,especially for those with a family history of acne.
引文
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[17]BURRIS J,SHIKANY J M,RIETKERK W,et al.A low glycemic index and glycemic load diet decreases insulin-like growth factor-1among adults with moderate and severe acne:a short-duration,2-week randomized controlled trial[J].Journal of the Academy of Nutrition and Dietetics,2018,118(10):1874-1885.
[18]TAN J K,GOLD L F,ALEXIS A F.Current concepts in acne pathogenesis:pathways to inflammation[J].Seminars in Cutaneous Medicine and Surgery,2018,37(3):S60-S62.
[19]KIM H,MOON S Y,SOHN M Y,et al.Insulin-like growth factor-1increases the expression of inflammatory biomarkers and sebum production in cultured sebocytes[J].Annals of Dermatology,2017,29(1):20-25.
[20]ABO E N,ALENEZI N G,ALSHAMARI N G,et al.Epidemiology of acne vulgaris in adolescent male students in Arar,Kingdom of Saudi Arabia[J].J Egypt Public Health Assoc,2016,91(3):144-149.
[21]WEI B,PANG Y,ZHU H,et al.The epidemiology of adolescent acne in North East China[J].J Eur Acad Dermatol Venereol,2010,24(8):953-957.
[22]赵惠娟,闫慧敏,郭独一,等.饮食与生活习惯对痤疮发病的影响[J].中国麻风皮肤病杂志,2016,32(10):588-591.
[23]MALEKI A,KHALID N.Exploring the relationship between stress and acne:a medical student’s perspective[J].Clinical Cosmetic and Investigational Dermatology,2018,11(2):173-174.
[24]ZARI S,ALRAHMANI D.The association between stress and acne among female medical students in Jeddah,Saudi Arabia[J].Clinical Cosmetic and Investigational Dermatology,2017,10(5):503-506.
[25]JOVIC A,MARINOVIC B,KOSLOVIC K,et al.The impact of pyschological stress on acne[J].Acta Dermatovenerologica Croatica,2017,25(2):133-141.
[26]BILGIC O,BILGIC A,ALTINYAZAR H C.Relationship between sleep quality and facial sebum levels in women with acne vulgaris[J].Indian Journal of Dermatology Venereology&Leprology,2016,82(3):313-314.
[27]PAERNA E,ALUOJA A,KINGO K.Quality of Life and emotional state in chronic skin disease[J].Acta DermatoVenereologica,2015,95(3):312-316.
[28]CAPITANIO B,SINAGRA J L,OTTAVIANI M,et al.Acne and smoking[J].Dermato-endocrinology,2009,1(3):129-135.
[29]PURI P,NANDAR S K,KATHURIA S,et al.Effects of air pollution on the skin:a review[J].Indian Journal of Dermatology Venereology&Leprology,2017,83(4):415-423.
[30]CLAUDEL J P,AUFFRET N,LECCIA M T,et al.Acne and nutrition:hypotheses,myths and facts[J].Journal of the European Academy of Dermatology and Venereology,2018,32(10):1631-1637.
[31]EL-ALAWL Z,ABDEL-IATIF NEMR N,ABDUL-RAZZAKK,et al.Factors believed by Jordanian ache patients to affect their acne condition[J].Eastern Mediterranean Health Journal,2006,12(6):840-846.
[2]宋凡君,张邵婕,肖斌,等.痤疮与皮肤屏障[J].实用皮肤病学杂志,2018,11(2):97-100.
[3]张莉,胡志帮.痤疮炎症的发生机制研究进展[J].山东医药,2018,58(34):110-112.
[4]ALANAZI M S,HAMMAD S M.Psychological impact of acne vulgaris among female secondary school students in Arar city,Saudi Arabia,in 2018[J].Electron Physician,2018,10(8):7224-7229.
[5]POCHYNOK T,CHERNYSHOV I P,ASAYEVICH N,et al.Quality of life of school and university students with acne[J].Acta Dermatovenerologica Croat,2018,26(2):139-145.
[6]徐海丰,张瑜,李中文,等.秦皇岛市120例重度痤疮学生的心理及睡眠质量状况临床调查分析[J].中国美容医学,2017,26(8):100-102.
[7]KHANNA R,SHIFRIN N,NEKTALOVA T.Diet and dermatology:Google search results for acne,psoriasis,and eczema[J].Cutis,2018,102(1):44,46,48.
[8]KATTA R,KRAMER M J.Skin and diet:an update on the role of dietary change as a treatment strategy for skin disease[J].Skin Therapy Letter,2018,23(1):1-5.
[9]李圣杰,张友灿,郑高美,等.泰安市某高校大学生痤疮患病情况及多种影响因素Logistic分析[J].中国皮肤性病学杂志,2012,26(7):625-627.
[10]ADEBAMOWO C A,SPIEGELMAN D,DANBY F W,et al.High school dietary dairy intake and teenage acne[J].Journal of the American Academy of Dermatology,2005,52(2):207-214.
[11]文莉,文晓懿,许成蓉.青春期后痤疮发病影响因素分析[J].华中科技大学学报(医学版),2011,40(4):441-444.
[12]ISMAIL N H,MANAF Z A,AZIZAN N Z.High glycemic load diet,milk and ice cream consumption are related to acne vulgaris in Malaysian young adults:a case control study[J].BMC Dermatology,2012,12(13):1-8.
[13]杨擎宇,汪樊,冯爱平.寻常性痤疮严重度的影响因素分析[J].中国皮肤性病学杂志,2009,23(7):425-428.
[14]CERMAN A A,AKTAS E,ALTUNAY I K,et al.Dietary glycemic factors,insulin resistance,and adiponectin levels in acne vulgaris[J].Journal of the American Academy of Dermatology,2016,75(1):155-162.
[15]鞠强.饮食与痤疮[J].上海医药,2016,37(9):7-9,70.
[16]SUPPIAH T,SUNDRAM T,TAN E,et al.Acne vulgaris and its association with dietary intake:a Malaysian perspective[J].Asia Pacific Journal of Clinical Nutrition,2018,27(5):1141-1145.
[17]BURRIS J,SHIKANY J M,RIETKERK W,et al.A low glycemic index and glycemic load diet decreases insulin-like growth factor-1among adults with moderate and severe acne:a short-duration,2-week randomized controlled trial[J].Journal of the Academy of Nutrition and Dietetics,2018,118(10):1874-1885.
[18]TAN J K,GOLD L F,ALEXIS A F.Current concepts in acne pathogenesis:pathways to inflammation[J].Seminars in Cutaneous Medicine and Surgery,2018,37(3):S60-S62.
[19]KIM H,MOON S Y,SOHN M Y,et al.Insulin-like growth factor-1increases the expression of inflammatory biomarkers and sebum production in cultured sebocytes[J].Annals of Dermatology,2017,29(1):20-25.
[20]ABO E N,ALENEZI N G,ALSHAMARI N G,et al.Epidemiology of acne vulgaris in adolescent male students in Arar,Kingdom of Saudi Arabia[J].J Egypt Public Health Assoc,2016,91(3):144-149.
[21]WEI B,PANG Y,ZHU H,et al.The epidemiology of adolescent acne in North East China[J].J Eur Acad Dermatol Venereol,2010,24(8):953-957.
[22]赵惠娟,闫慧敏,郭独一,等.饮食与生活习惯对痤疮发病的影响[J].中国麻风皮肤病杂志,2016,32(10):588-591.
[23]MALEKI A,KHALID N.Exploring the relationship between stress and acne:a medical student’s perspective[J].Clinical Cosmetic and Investigational Dermatology,2018,11(2):173-174.
[24]ZARI S,ALRAHMANI D.The association between stress and acne among female medical students in Jeddah,Saudi Arabia[J].Clinical Cosmetic and Investigational Dermatology,2017,10(5):503-506.
[25]JOVIC A,MARINOVIC B,KOSLOVIC K,et al.The impact of pyschological stress on acne[J].Acta Dermatovenerologica Croatica,2017,25(2):133-141.
[26]BILGIC O,BILGIC A,ALTINYAZAR H C.Relationship between sleep quality and facial sebum levels in women with acne vulgaris[J].Indian Journal of Dermatology Venereology&Leprology,2016,82(3):313-314.
[27]PAERNA E,ALUOJA A,KINGO K.Quality of Life and emotional state in chronic skin disease[J].Acta DermatoVenereologica,2015,95(3):312-316.
[28]CAPITANIO B,SINAGRA J L,OTTAVIANI M,et al.Acne and smoking[J].Dermato-endocrinology,2009,1(3):129-135.
[29]PURI P,NANDAR S K,KATHURIA S,et al.Effects of air pollution on the skin:a review[J].Indian Journal of Dermatology Venereology&Leprology,2017,83(4):415-423.
[30]CLAUDEL J P,AUFFRET N,LECCIA M T,et al.Acne and nutrition:hypotheses,myths and facts[J].Journal of the European Academy of Dermatology and Venereology,2018,32(10):1631-1637.
[31]EL-ALAWL Z,ABDEL-IATIF NEMR N,ABDUL-RAZZAKK,et al.Factors believed by Jordanian ache patients to affect their acne condition[J].Eastern Mediterranean Health Journal,2006,12(6):840-846.