MicroRNA-137甲基化改变在肿瘤中作用的研究进展
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摘要
MicroRNA-137(miR-137)异常表达与多种肿瘤的发生发展密切相关,miR-137启动子区域甲基化改变是使其异常表达的重要机制之一。其甲基化改变的程度在多种肿瘤中明显增高,但发生甲基化改变的频率在不同肿瘤中明显不同,也在不同肿瘤中与不同的临床病理特征相关,此外,发生甲基化改变的肿瘤患者预后更差。miR-137启动子区域甲基化改变可促进肿瘤发生发展,并具有在早期能被检测、高特异性等特点,表明有作为肿瘤标记物的潜能,且逆转其甲基化改变亦可为肿瘤治疗提供新的策略及突破口。
The aberrant expression of MicroRNA-137(miR-137) is correlated with different tumors closely, miR-137 promoter methylation considered as one of the most important mechanisms through which miR-137 expression can be regulated. The degree of promoter methylation of miR-137 was significantly increased in tumors, but the frequencies varied. In addition, it correlated with different clinical and pathological characteristics in tumors. Furthermore, miR-137 promoter methylation indicated poor prognosis. miR-137 promoter methylation promoted the initiation and progression of tumors, it was of potential to be a biomarker and reversed the methylation status of miR-137 represented a novel strategy of cancer treatment.
The aberrant expression of MicroRNA-137(miR-137) is correlated with different tumors closely, miR-137 promoter methylation considered as one of the most important mechanisms through which miR-137 expression can be regulated. The degree of promoter methylation of miR-137 was significantly increased in tumors, but the frequencies varied. In addition, it correlated with different clinical and pathological characteristics in tumors. Furthermore, miR-137 promoter methylation indicated poor prognosis. miR-137 promoter methylation promoted the initiation and progression of tumors, it was of potential to be a biomarker and reversed the methylation status of miR-137 represented a novel strategy of cancer treatment.
引文
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[3]Lin RT,Liu JQ,Lu HY,et al.Micro RNA-155 plays a critical role in the initiation of food allergen-related inflammation in the intestine[J].Oncotarget,2017,8(40):67497-67505.DOI:10.18632/oncotarget.18723.
[4]Bartoszewski R,Serocki M,Janaszak-Jasiecka A,et al.miR-200b downregulates Kruppel Like Factor 2(KLF2)during acute hypoxia in human endothelial cells[J].Eur J Cell Biol,2017,96(8):758-766.DOI:10.1016/j.ejcb.2017.10.001.
[5]Xia YF,Pei GH,Wang N,et al.miR-3156-3p is downregulated in HPV-positive cervical cancer and performs as a tumor-suppressive miRNA[J].Virol J,2017,14(1):20.DOI:10.1186/s12985-017-0695-7.
[6]He Z,Yu L,Luo S,et al.miR-296 inhibits the metastasis and epithelial-mesenchymal transition of colorectal cancer by targeting S100A4[J].BMC Cancer,2017,17(1):140.DOI:10.1186/s12885-017-3121-z.
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[36]Wiklund ED,Gao S,Hulf T,et al.MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma[J].PLoS One,2011,6(11):e27840.DOI:10.1371/journal.pone.0027840.
[37]党军,边永钎,孙建勇,等.OLP和OSCC中p16和miR-137基因甲基化的初步研究[J].临床口腔医学杂志,2012,28(6):345-349.DOI:10.3969/j.issn.1003-1634.2012.06.009.
[38]张玮.抑癌基因miR137在子宫内膜癌中高度甲基化及其机制的研究[D].济南:济南大学,2016.
[39]Daniunaite K,Dubikaityte M,Gibas P,et al.Clinical significance of miRNA host gene promoter methylation in prostate cancer[J].Hum Mol Genet,2017,26(13):2451-2461.DOI:10.1093/hmg/ddx138.