实时与瞬时弹性成像在肝纤维化评价中的应用
|
摘要
目的探讨超声实时组织弹性成像(RTE)与瞬时弹性成像(FS)在慢性乙肝患者肝纤维化程度评价中的应用价值。方法选取210例慢性乙肝患者作为观察组,另选取120例健康志愿者作为对照组。对两组研究对象实施超声RTE与FS检查,观察组最终通过穿刺活检确定肝纤维化程度。对比两组研究对象的肝纤维化指数、肝脏硬度值,分析RTE、FS检查指标与肝纤维化程度的关系。结果对照组与观察组各亚组的应变均值(MEAN)、标准偏差(SD)、复杂度(COMP)、偏度(SKEW)、蓝色领域百分比(AREA)值比较,差异均有统计学意义(P<0.05)。观察组中,F0期患者的MEAN、SD、COMP、SKEW、AREA值与对照组比较,差异无统计学意义(P>0.05)。随着肝纤维化分期的升高,MEAN呈现出下降趋势(F0期>F1期>F2期>F3期>F4期),SD、COMP、SKEW、AREA水平均呈现出升高趋势(F0期 Objective To investigate the value of real-time tissue ultrasound elastography(RTE) and FibroScan(FS) in the evaluation of liver fibrosis in patients with chronic hepatitis B. Methods A total of 210 patients with chronic hepatitis B were studied to develop the liver fibrosis index 120 healthy volunteers were served as a control group. Liver elasticity was measured with ultrasound RTE and FS examination the stage of liver fibrosis was determined by percutaneous liver biopsy. The liver fibrosis index and liver hardness values of the two groups were compared, and the relationship between RTE and FS examination indexes and liver fibrosis degree were analyzed.Results The different of MEAN, SD, COMP, SKEW and AREA value of the control group and the observation group were significant(P<0.05). In the observation group, the MEAN, SD, COMP, SKEW, and AREA values of the F0 patients were not significantly different from those of the control group(P>0.05). MEAN shows a downward trend(F0 phase>F1 phase>F2 phase>F3 phase>F4 phase).The SD, COMP, SKEW and AREA levels showed an increasing trend with the increase of liver fibrosis stage(F0 phase
引文
[1] 李颖,黄岩花,陈方红.超声弹性成像联合血清标志物评估慢性乙肝肝纤维化的价值研究[J].中国现代医生,2018,56(1):123-6.
[2] 李晶晶,代倩,马双双,等.瞬时弹性成像联合血清HBsAg水平对慢性HBV感染者肝纤维化的无创诊断价值[J].安徽医科大学学报,2017,52(4):537-41.
[3] 刘丹,朱清静,万十千.瞬时弹性成像技术检测肝脾硬度值对乙肝肝硬化患者食管静脉曲张破裂出血的预测价值[J].中国医学装备,2017,14(4):80-3.
[4] 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015更新版)[J].中华传染病杂志,2015,33(11):641-62.
[5] 石俊英,张斯佳,史景璐,等.经量化扩散加权成像与超声剪切波弹性成像对乙型肝炎相关性肝纤维化比较分析[J].中国临床医学影像杂志,2017,28(6):447-9.
[6] Xu S H,Li Q,Hu Y P,et al.Development of a model based on biochemical,real-time tissue elastography and ultrasound data for the staging of liver fibrosis and cirrhosis in patients with chronic hepatitis B[J].Mol Med Rep,2016,14(4):3609-19.
[7] Xu L,Lu W,Li P,et al.A comparison of hepatic steatosis index,controlled attenuation parameter and ultrasound as noninvasive diagnostic tools for steatosis in chronic hepatitis B[J].Dig Liver Dis,2017,49(8):910-7.
[8] 李昶玥,郑颖,张嫄,等.实时二维剪切波弹性成像技术无创评价肝纤维化程度及其与病理分期的相关性研究[J].临床超声医学杂志,2018,20(8):518-21.
[9] 刘芳,魏琳,王珊珊,等.瞬时弹性成像技术联合血清学指标对慢性乙型肝炎肝纤维化的诊断价值研究[J].中国全科医学,2016,19(25):3039-44.
[2] 李晶晶,代倩,马双双,等.瞬时弹性成像联合血清HBsAg水平对慢性HBV感染者肝纤维化的无创诊断价值[J].安徽医科大学学报,2017,52(4):537-41.
[3] 刘丹,朱清静,万十千.瞬时弹性成像技术检测肝脾硬度值对乙肝肝硬化患者食管静脉曲张破裂出血的预测价值[J].中国医学装备,2017,14(4):80-3.
[4] 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015更新版)[J].中华传染病杂志,2015,33(11):641-62.
[5] 石俊英,张斯佳,史景璐,等.经量化扩散加权成像与超声剪切波弹性成像对乙型肝炎相关性肝纤维化比较分析[J].中国临床医学影像杂志,2017,28(6):447-9.
[6] Xu S H,Li Q,Hu Y P,et al.Development of a model based on biochemical,real-time tissue elastography and ultrasound data for the staging of liver fibrosis and cirrhosis in patients with chronic hepatitis B[J].Mol Med Rep,2016,14(4):3609-19.
[7] Xu L,Lu W,Li P,et al.A comparison of hepatic steatosis index,controlled attenuation parameter and ultrasound as noninvasive diagnostic tools for steatosis in chronic hepatitis B[J].Dig Liver Dis,2017,49(8):910-7.
[8] 李昶玥,郑颖,张嫄,等.实时二维剪切波弹性成像技术无创评价肝纤维化程度及其与病理分期的相关性研究[J].临床超声医学杂志,2018,20(8):518-21.
[9] 刘芳,魏琳,王珊珊,等.瞬时弹性成像技术联合血清学指标对慢性乙型肝炎肝纤维化的诊断价值研究[J].中国全科医学,2016,19(25):3039-44.