自主神经再平衡与缺血性室性心律失常
|
摘要
交感神经活性过度激活所致的自主神经系统失衡与缺血性室性心律失常的发生密切相关。神经刺激或消融可促进自主神经再平衡,从而有效地预防缺血性室性心律失常的发生。现就自主神经再平衡策略与缺血性室性心律失常的研究进展做一综述。
The imbalance of autonomic nervous system caused by sympathetic hyperactivity is closely related to the occurrence of ventricular arrhythmias(VAs) induced by myocardial ischemia. Nerve stimulation or ablation can promote nerual-rebalance and effectively prevent the occurrence of VAs induced by myocardial ischemia. This paper reviews the research progress of nerual-rebalance strategy and VAs induced by myocardial ischemia.
The imbalance of autonomic nervous system caused by sympathetic hyperactivity is closely related to the occurrence of ventricular arrhythmias(VAs) induced by myocardial ischemia. Nerve stimulation or ablation can promote nerual-rebalance and effectively prevent the occurrence of VAs induced by myocardial ischemia. This paper reviews the research progress of nerual-rebalance strategy and VAs induced by myocardial ischemia.
引文
[1]赵艳茹,韦国千,金恩泽,等.心肌梗死后交感神经重构及其治疗进展[J].心血管病学进展,2016,37(5):533-536.
[2] Jardine DL,Charles CJ,Frampton CM,et al.Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model[J].Am J Physiol Heart Circ Physiol,2007,293(1):H433-439.
[3] Zhou S,Jung BC,Tan AY,et al.Spontaneous stellate ganglion nerve activity and ventricular arrhythmia in a canine model of sudden death[J]. Heart Rhythm,2008,5(1):131-139.
[4] Galvan A,Stauffer WR,Acker L,et al.Nonhuman primate optogenetics:recent advances and future directions[J].J Neurosci,2017,37(45):10894-10903.
[5] Arrenberg AB,Stainier DY,Baier H,et al.Optogenetic control of cardiac function[J].Science,2010,330(6006):971-974.
[6] Bruegmann T,Boyle PM,Vogt CC,et al. Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations[J].J Clin Invest,2016,126(10):3894-3904.
[7] Wengrowski AM,Wang X,Tapa S,et al.Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function[J].Cardiovasc Res,2014,105(2):143-150.
[8] Yu L,Zhou L,Cao G,et al.Optogenetic modulation of cardiac sympathetic nerve activity to prevent ventricular arrhythmias[J].J Am Coll Cardiol,2017,70(22):2778-2790.
[9] Yu L,Scherlag BJ,Dormer K,et al.Autonomic denervation with magnetic nanoparticles[J].Circulation,2010,122(25):2653-2659.
[10] Yu L,Scherlag BS,Dormer K,et al.Targeted ganglionated plexi denervation using magnetic nanoparticles carrying calcium chloride payload[J]. JACC Clin Electrophysiol,2018,4(10):1347-1358.
[11] Hou Y,Zhou Q,Po SS. Neuromodulation for cardiac arrhythmia[J]. Heart Rhythm,2016,13(2):584-592.
[12] Vaseghi M,Salavatian S,Rajendran PS,et al.Parasympathetic dysfunction and antiarrhythmic effect of vagal nerve stimulation following myocardial infarction[J]. JCI Insight,2017,2(16):e86715.
[13] Yamaguchi N,Yamakawa K,Rajendran PS,et al.Anti-arrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction[J].Heart Rhythm,2018,15(8):1214-1222.
[14] Chen M,Zhou X,Yu L,et al.Low-level vagus nerve stimulation attenuates myocardial ischemic reperfusion injury by anti-oxidative stress and anti-apoptosis reactions in Canines[J].J Cardiovasc Electrophysiol,2016,27(2):224-231.
[15] Frangos E,Ellrich J,Komisaruk BR.Non-invasive access to the vagus nerve central projections via electrical stimulation of the external ear:f MRI evidence in humans[J].Brain Stimul,2014,8(3):624-636.
[16] Wang Z,Yu L,Huang B,et al.Low-level transcutaneous electrical stimulation of the auricular branch of vagus nerve ameliorates left ventricular remodeling and dysfunction by downregulation of matrix metalloproteinase 9 and transforming growth factorβ1[J].J Cardiovasc Pharmacol,2015,65(4):342-348.
[17] Wang Z,Yu L,Wang S,et al.Chronic intermittent low-level transcutaneous electrical stimulation of auricular branch of vagus nerve improves left ventricular remodeling in conscious dogs with healed myocardial infarction[J]. Circ Heart Fail,2014,7(6):1014-1021.
[18] Yu L,Wang S,Zhou X,et al.Chronic intermittent low-level stimulation of tragus reduces cardiac autonomic remodeling and ventricular arrhythmia inducibility in a post-infarction canine model[J]. JACC Clin Electrophysiol,2016,2(3):330-339.
[19] Yu L,Huang B,Po SS,et al.Low-level tragus stimulation for the treatment of ischemia and reperfusion injury in patients with ST-segment elevation myocardial infarction:a proof-of-concept study[J].JACC Cardiovasc Interv,2017,10(15):1511-1520.
[20] Odenstedt J,Linderoth B,Bergfeldt L,et al. Spinal cord stimulation effects on myocardial ischemia,infarct size,ventricular arrhythmia,and noninvasive electrophysiology in a porcine ischemia-reperfusion model[J].Heart Rhythm,2011,8(6):892-898.
[21] Lopshire JC,Zhou X,Dusa C,et al.Spinal cord stimulation improves ventricular function and reduces ventricular arrhythmias in a canine postinfarction heart failure model[J].Circulation,2009,120(4):286-294.
[22] Wang S,Zhou X,Huang B,et al.Spinal cord stimulation protects against ventricular arrhythmias by suppressing left stellate ganglion neural activity in an acute myocardial infarction canine model[J].Heart Rhythm,2015,12(7):1628-1635.
[23] Bakris GL,Nadim MK,Haller H,et al.Baroreflex activation therapy provides durable benefit in patients with resistant hypertension:results of long-term followup in the Rheos Pivotal Trial[J].J Am Soc Hypertens,2012,6(2):152-158.
[24] Gronda E,Seravalle G,Brambilla G,et al.Chronic baroreflex activation effects on sympathetic nerve traffic,baroreflex function,and cardiac haemodynamics in heart failure:a proof-of-concept study[J].Eur J Heart Fail,2015,16(9):977-983.
[25] Liao K,Yang K,Huang B,et al. Carotid baroreceptor stimulation prevents arrhythmias induced by acute myocardial infarction through autonomic modulation[J].J Cardiovasc Pharmacol,2014,64(5):431-437.
[26] Liao K,Yu L,Yang K,et al.Low-level carotid baroreceptor stimulation suppresses ventricular arrhythmias during acute ischemia[J].PLoS One,2014,9(10):e109313.
[27] Sheng X,Chen M,Huang B,et al.Cardioprotective effects of low-level carotid baroreceptor stimulation against myocardial ischemia-reperfusion injury in canine model[J].J Interv Card Electrophysiol,2016,45(2):131-140.
[28] He B,Lu Z,He W,et al.The effects of atrial ganglionated plexi stimulation on ventricular electrophysiology in a normal canine heart[J].J Interv Card Electrophysiol,2013,37(1):1-8.
[29] He B,Lu Z,He W,et al.Effects of low-intensity atrial ganglionated plexi stimulation on ventricular electrophysiology and arrhythmogenesis[J]. Auton Neurosci,2013,174(1-2):54-60.
[30] Downar J,Blumberger DM,Daskalakis ZJ.Repetitive transcranial magnetic stimulation:an emerging treatment for medication-resistant depression[J]. CMAJ,2016,188(16):1175-1177.
[31] Wang S,Zhou X,Huang B,et al. Noninvasive low-frequency electromagnetic stimulation of the left stellate ganglion reduces myocardial infarction-induced ventricular arrhythmia[J].Sci Rep,2016,6:30783.
[32] Huang B,Yu L,Scherlag BJ,et al.Left renal nerves stimulation facilitates ischemia-induced ventricular arrhythmia by increasing nerve activity of left stellate ganglion[J].J Cardiovasc Electrophysiol,2015,25(11):1249-1256.
[33] Huang B,Yu L,He B,et al.Renal sympathetic denervation modulates ventricular electrophysiology and has a protective effect on ischaemia-induced ventricular arrhythmia[J].Exp Physiol,2014,99(11):1467-1477.
[34] Dominik L,Klaus W,Christian U,et al.Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs[J]. Heart Rhythm,2013,10(10):1525-1530.
[35] Jackson N,Gizurarson S,Azam MA,et al.Effects of renal artery denervation on ventricular arrhythmias in a postinfarct model[J].Circ Cardiovasc Interv,2017,10(3):e004172.
[36] Remo BF,Preminger M,Bradfield J,et al.Safety and efficacy of renal denervation as a novel treatment of ventricular tachycardia storm in patients with cardiomyopathy[J]. Heart Rhythm,2014,11(4):541-546.
[37] Hoffmann BA,Steven D,Willems S,et al.Renal sympathetic denervation as an adjunct to catheter ablation for the treatment of ventricular electrical storm in the setting of acute myocardial infarction[J]. J Cardiovasc Electrophysiol,2013,24(10):1175-1178.
[38] Yu L,Huang B,Zhou X,et al.Renal sympathetic stimulation and ablation affect ventricular arrhythmia by modulating autonomic activity in a cesium-induced long QT canine model[J].Heart Rhythm,2017,14(6):912-919.
[39] Schwartz PJ.Cardiac sympathetic denervation to prevent life-threatening arrhythmias[J]. Nat Rev Cardiol,2014,11(6):346-353.
[40] Amer M,Burrows WM,Dickfeld TM.Unilateral sympathetic ganglion denervation in the management of sustained ventricular tachycardia[J]. Heart Rhythm Case Rep,2017,3(10):467-469.
[2] Jardine DL,Charles CJ,Frampton CM,et al.Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model[J].Am J Physiol Heart Circ Physiol,2007,293(1):H433-439.
[3] Zhou S,Jung BC,Tan AY,et al.Spontaneous stellate ganglion nerve activity and ventricular arrhythmia in a canine model of sudden death[J]. Heart Rhythm,2008,5(1):131-139.
[4] Galvan A,Stauffer WR,Acker L,et al.Nonhuman primate optogenetics:recent advances and future directions[J].J Neurosci,2017,37(45):10894-10903.
[5] Arrenberg AB,Stainier DY,Baier H,et al.Optogenetic control of cardiac function[J].Science,2010,330(6006):971-974.
[6] Bruegmann T,Boyle PM,Vogt CC,et al. Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations[J].J Clin Invest,2016,126(10):3894-3904.
[7] Wengrowski AM,Wang X,Tapa S,et al.Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function[J].Cardiovasc Res,2014,105(2):143-150.
[8] Yu L,Zhou L,Cao G,et al.Optogenetic modulation of cardiac sympathetic nerve activity to prevent ventricular arrhythmias[J].J Am Coll Cardiol,2017,70(22):2778-2790.
[9] Yu L,Scherlag BJ,Dormer K,et al.Autonomic denervation with magnetic nanoparticles[J].Circulation,2010,122(25):2653-2659.
[10] Yu L,Scherlag BS,Dormer K,et al.Targeted ganglionated plexi denervation using magnetic nanoparticles carrying calcium chloride payload[J]. JACC Clin Electrophysiol,2018,4(10):1347-1358.
[11] Hou Y,Zhou Q,Po SS. Neuromodulation for cardiac arrhythmia[J]. Heart Rhythm,2016,13(2):584-592.
[12] Vaseghi M,Salavatian S,Rajendran PS,et al.Parasympathetic dysfunction and antiarrhythmic effect of vagal nerve stimulation following myocardial infarction[J]. JCI Insight,2017,2(16):e86715.
[13] Yamaguchi N,Yamakawa K,Rajendran PS,et al.Anti-arrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction[J].Heart Rhythm,2018,15(8):1214-1222.
[14] Chen M,Zhou X,Yu L,et al.Low-level vagus nerve stimulation attenuates myocardial ischemic reperfusion injury by anti-oxidative stress and anti-apoptosis reactions in Canines[J].J Cardiovasc Electrophysiol,2016,27(2):224-231.
[15] Frangos E,Ellrich J,Komisaruk BR.Non-invasive access to the vagus nerve central projections via electrical stimulation of the external ear:f MRI evidence in humans[J].Brain Stimul,2014,8(3):624-636.
[16] Wang Z,Yu L,Huang B,et al.Low-level transcutaneous electrical stimulation of the auricular branch of vagus nerve ameliorates left ventricular remodeling and dysfunction by downregulation of matrix metalloproteinase 9 and transforming growth factorβ1[J].J Cardiovasc Pharmacol,2015,65(4):342-348.
[17] Wang Z,Yu L,Wang S,et al.Chronic intermittent low-level transcutaneous electrical stimulation of auricular branch of vagus nerve improves left ventricular remodeling in conscious dogs with healed myocardial infarction[J]. Circ Heart Fail,2014,7(6):1014-1021.
[18] Yu L,Wang S,Zhou X,et al.Chronic intermittent low-level stimulation of tragus reduces cardiac autonomic remodeling and ventricular arrhythmia inducibility in a post-infarction canine model[J]. JACC Clin Electrophysiol,2016,2(3):330-339.
[19] Yu L,Huang B,Po SS,et al.Low-level tragus stimulation for the treatment of ischemia and reperfusion injury in patients with ST-segment elevation myocardial infarction:a proof-of-concept study[J].JACC Cardiovasc Interv,2017,10(15):1511-1520.
[20] Odenstedt J,Linderoth B,Bergfeldt L,et al. Spinal cord stimulation effects on myocardial ischemia,infarct size,ventricular arrhythmia,and noninvasive electrophysiology in a porcine ischemia-reperfusion model[J].Heart Rhythm,2011,8(6):892-898.
[21] Lopshire JC,Zhou X,Dusa C,et al.Spinal cord stimulation improves ventricular function and reduces ventricular arrhythmias in a canine postinfarction heart failure model[J].Circulation,2009,120(4):286-294.
[22] Wang S,Zhou X,Huang B,et al.Spinal cord stimulation protects against ventricular arrhythmias by suppressing left stellate ganglion neural activity in an acute myocardial infarction canine model[J].Heart Rhythm,2015,12(7):1628-1635.
[23] Bakris GL,Nadim MK,Haller H,et al.Baroreflex activation therapy provides durable benefit in patients with resistant hypertension:results of long-term followup in the Rheos Pivotal Trial[J].J Am Soc Hypertens,2012,6(2):152-158.
[24] Gronda E,Seravalle G,Brambilla G,et al.Chronic baroreflex activation effects on sympathetic nerve traffic,baroreflex function,and cardiac haemodynamics in heart failure:a proof-of-concept study[J].Eur J Heart Fail,2015,16(9):977-983.
[25] Liao K,Yang K,Huang B,et al. Carotid baroreceptor stimulation prevents arrhythmias induced by acute myocardial infarction through autonomic modulation[J].J Cardiovasc Pharmacol,2014,64(5):431-437.
[26] Liao K,Yu L,Yang K,et al.Low-level carotid baroreceptor stimulation suppresses ventricular arrhythmias during acute ischemia[J].PLoS One,2014,9(10):e109313.
[27] Sheng X,Chen M,Huang B,et al.Cardioprotective effects of low-level carotid baroreceptor stimulation against myocardial ischemia-reperfusion injury in canine model[J].J Interv Card Electrophysiol,2016,45(2):131-140.
[28] He B,Lu Z,He W,et al.The effects of atrial ganglionated plexi stimulation on ventricular electrophysiology in a normal canine heart[J].J Interv Card Electrophysiol,2013,37(1):1-8.
[29] He B,Lu Z,He W,et al.Effects of low-intensity atrial ganglionated plexi stimulation on ventricular electrophysiology and arrhythmogenesis[J]. Auton Neurosci,2013,174(1-2):54-60.
[30] Downar J,Blumberger DM,Daskalakis ZJ.Repetitive transcranial magnetic stimulation:an emerging treatment for medication-resistant depression[J]. CMAJ,2016,188(16):1175-1177.
[31] Wang S,Zhou X,Huang B,et al. Noninvasive low-frequency electromagnetic stimulation of the left stellate ganglion reduces myocardial infarction-induced ventricular arrhythmia[J].Sci Rep,2016,6:30783.
[32] Huang B,Yu L,Scherlag BJ,et al.Left renal nerves stimulation facilitates ischemia-induced ventricular arrhythmia by increasing nerve activity of left stellate ganglion[J].J Cardiovasc Electrophysiol,2015,25(11):1249-1256.
[33] Huang B,Yu L,He B,et al.Renal sympathetic denervation modulates ventricular electrophysiology and has a protective effect on ischaemia-induced ventricular arrhythmia[J].Exp Physiol,2014,99(11):1467-1477.
[34] Dominik L,Klaus W,Christian U,et al.Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs[J]. Heart Rhythm,2013,10(10):1525-1530.
[35] Jackson N,Gizurarson S,Azam MA,et al.Effects of renal artery denervation on ventricular arrhythmias in a postinfarct model[J].Circ Cardiovasc Interv,2017,10(3):e004172.
[36] Remo BF,Preminger M,Bradfield J,et al.Safety and efficacy of renal denervation as a novel treatment of ventricular tachycardia storm in patients with cardiomyopathy[J]. Heart Rhythm,2014,11(4):541-546.
[37] Hoffmann BA,Steven D,Willems S,et al.Renal sympathetic denervation as an adjunct to catheter ablation for the treatment of ventricular electrical storm in the setting of acute myocardial infarction[J]. J Cardiovasc Electrophysiol,2013,24(10):1175-1178.
[38] Yu L,Huang B,Zhou X,et al.Renal sympathetic stimulation and ablation affect ventricular arrhythmia by modulating autonomic activity in a cesium-induced long QT canine model[J].Heart Rhythm,2017,14(6):912-919.
[39] Schwartz PJ.Cardiac sympathetic denervation to prevent life-threatening arrhythmias[J]. Nat Rev Cardiol,2014,11(6):346-353.
[40] Amer M,Burrows WM,Dickfeld TM.Unilateral sympathetic ganglion denervation in the management of sustained ventricular tachycardia[J]. Heart Rhythm Case Rep,2017,3(10):467-469.