Nrf2与心脏衰老的相关研究进展
摘要
<正>心血管疾病是导致全球人口致残率及致死率增加的首要病因之一。尽管目前及时的药物及手术治疗挽救了大批患者生命,但是心血管疾病的总体死亡人数仍处于持续上升趋势,其中一个重要原因就在于人口老龄化的增加。衰老不仅影响心脏收缩及舒张功能,而且增加心脏对损伤的易感性。因此,如何延缓心脏衰老成为当前研究的热点。核因子相关因子-2(Nrf2)属于碱性亮氨酸拉链家族成员,被认为是调控氧化应激最为关键的转录因子。大量的研究
引文
[1] Stee nman M, Lan de G. Cardiac aging and heart disease in humans[J]. Biophys Rev, 2017, 9(2):131-137.
[2] Smith SC, Zhang X, Zhang X, et al. GDF11 does not rescue aging-related pathological hypertrophy[J]. Circ Res, 2015, 117(11):926-932.
[3] Huang CL, Goncalves A, Shah AM, et al. Age-and sex-related Influences on left ventricular mechanics in elderly individuals free of prevalent heart failure:the ARIC study(atherosclerosis risk in communities)[J]. Circ Cardiovasc Imaging, 2017, 10(1):e004510.
[4] Kwak HB, Lee Y, Kim JH, et al. MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart[J].J Gerontol A Biol Sci Med Sci, 2015, 70(5):533-544.
[5] Li Q, Xiang Y, Chen Y, et al. Ginsenoside Rg1 protects cardiomyocytes against hypoxia/reoxygenation injury via activation of Nrf2/HO-1 signaling and inhibition of JNK[J]. Cell Physiol Biochem, 2017, 44(1):21-37.
[6] Hajra S, Patra AR, Basu A, et al. Prevention of doxorubicin(DOX)-induced genotoxicity and cardiotoxicity:Effect of plant derived small molecule indole-3-carbinol(I3C)on oxidative stress and inflammation[J]. Biomed Pharmacother, 2018, 101:228-243.
[7] Martin B, Gabris-Weber BA, Reddy R, et al. Relaxin reverses inflammatory and immune signals in aged hearts[J]. PLo S One,2018, 13(1):e0190935.
[8] Ramos GC, Van Den Berg A, Nunes-Silva V, et al. Myocardial aging as a T-cell-mediated phenomenon[J]. Proc Natl Acad Sci U SA, 2017, 114(12):e2420-e2429.
[9] Holloway PM, Gillespie S, Becker F, et al. Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways[J].Vascul Pharmacol, 2016, 85:29-38.
[10] Sharma A, Rizky L, Stefanovic N, et al. The nuclear factor(erythroid-derived 2)-like 2(Nrf2)activator dh404 protects against diabetes-induced endothelial dysfunction[J]. Cardiovasc Diabetol, 2017, 16(1):33.
[11] Shirakabe A, Ikeda Y, Sciarretta S, et al. Aging and autophagy in the heart[J]. Circ Res, 2016, 118(10):1563-1576.
[12] Kumar RR, Narasimhan M, Shanmugam G, et al. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress[J]. J Transl Med, 2016, 14:86.
[13] Wang W, Li S, Wang H, et al. Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins[J]. J Mol Cell Cardiol,2014, 72:305-315.
[14] Storm J, Chen QM. Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction[J]. Toxicol Appl Pharmacol, 2017, 327:52-58.
[15] Bubb KJ, Kok C, Tang O, et al. The NRF2 activator DH404attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling[J]. Free Radic Biol Med,2017, 108:585-594.
[16] Li Y, Zhang H. Soybean isoflavones ameliorate ischemic cardiomyopathy by activating Nrf2-mediated antioxidant responses[J]. Food Funct, 2017, 8(8):2935-2944.
[17] Zhao C, Zhang Y, Liu H, et al. Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation[J]. Biochem Biophys Res Commun, 2017, 490(2):552-559.
[18] Zhang B, Shen Q, Chen Y, et al. Myricitrin alleviates oxidative stress-induced inflammation and apoptosis and protects mice against diabetic cardiomyopathy[J]. Sci Rep, 2017, 7:44239.
[19] Gao L, Zimmerman MC, Biswal S, et al. Selective Nrf2 gene deletion in the rostral ventrolateral medulla evokes hypertension and sympathoexcitation in mice[J]. Hypertension, 2017, 69(6):1198-1206.
[20] Bai J, Yu XJ, Liu KL, et al. Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats[J]. Toxicol Appl Pharmacol, 2017, 333:100-109.
[2] Smith SC, Zhang X, Zhang X, et al. GDF11 does not rescue aging-related pathological hypertrophy[J]. Circ Res, 2015, 117(11):926-932.
[3] Huang CL, Goncalves A, Shah AM, et al. Age-and sex-related Influences on left ventricular mechanics in elderly individuals free of prevalent heart failure:the ARIC study(atherosclerosis risk in communities)[J]. Circ Cardiovasc Imaging, 2017, 10(1):e004510.
[4] Kwak HB, Lee Y, Kim JH, et al. MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart[J].J Gerontol A Biol Sci Med Sci, 2015, 70(5):533-544.
[5] Li Q, Xiang Y, Chen Y, et al. Ginsenoside Rg1 protects cardiomyocytes against hypoxia/reoxygenation injury via activation of Nrf2/HO-1 signaling and inhibition of JNK[J]. Cell Physiol Biochem, 2017, 44(1):21-37.
[6] Hajra S, Patra AR, Basu A, et al. Prevention of doxorubicin(DOX)-induced genotoxicity and cardiotoxicity:Effect of plant derived small molecule indole-3-carbinol(I3C)on oxidative stress and inflammation[J]. Biomed Pharmacother, 2018, 101:228-243.
[7] Martin B, Gabris-Weber BA, Reddy R, et al. Relaxin reverses inflammatory and immune signals in aged hearts[J]. PLo S One,2018, 13(1):e0190935.
[8] Ramos GC, Van Den Berg A, Nunes-Silva V, et al. Myocardial aging as a T-cell-mediated phenomenon[J]. Proc Natl Acad Sci U SA, 2017, 114(12):e2420-e2429.
[9] Holloway PM, Gillespie S, Becker F, et al. Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways[J].Vascul Pharmacol, 2016, 85:29-38.
[10] Sharma A, Rizky L, Stefanovic N, et al. The nuclear factor(erythroid-derived 2)-like 2(Nrf2)activator dh404 protects against diabetes-induced endothelial dysfunction[J]. Cardiovasc Diabetol, 2017, 16(1):33.
[11] Shirakabe A, Ikeda Y, Sciarretta S, et al. Aging and autophagy in the heart[J]. Circ Res, 2016, 118(10):1563-1576.
[12] Kumar RR, Narasimhan M, Shanmugam G, et al. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress[J]. J Transl Med, 2016, 14:86.
[13] Wang W, Li S, Wang H, et al. Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins[J]. J Mol Cell Cardiol,2014, 72:305-315.
[14] Storm J, Chen QM. Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction[J]. Toxicol Appl Pharmacol, 2017, 327:52-58.
[15] Bubb KJ, Kok C, Tang O, et al. The NRF2 activator DH404attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling[J]. Free Radic Biol Med,2017, 108:585-594.
[16] Li Y, Zhang H. Soybean isoflavones ameliorate ischemic cardiomyopathy by activating Nrf2-mediated antioxidant responses[J]. Food Funct, 2017, 8(8):2935-2944.
[17] Zhao C, Zhang Y, Liu H, et al. Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation[J]. Biochem Biophys Res Commun, 2017, 490(2):552-559.
[18] Zhang B, Shen Q, Chen Y, et al. Myricitrin alleviates oxidative stress-induced inflammation and apoptosis and protects mice against diabetic cardiomyopathy[J]. Sci Rep, 2017, 7:44239.
[19] Gao L, Zimmerman MC, Biswal S, et al. Selective Nrf2 gene deletion in the rostral ventrolateral medulla evokes hypertension and sympathoexcitation in mice[J]. Hypertension, 2017, 69(6):1198-1206.
[20] Bai J, Yu XJ, Liu KL, et al. Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats[J]. Toxicol Appl Pharmacol, 2017, 333:100-109.