急性冠脉综合征患者NLR、MPV与Gensini评分的相关性分析
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摘要
目的:探讨急性冠脉综合征(Acute Coronary Syndrome,ACS)患者的中性粒细胞/淋巴细胞(Neutrophils/lymphocyte,NLR)、平均血小板体积(Mean platelet volume,MPV)与Gensini评分的相关性。方法:将156例ACS患者依据冠状动脉造影结果分为单支病变组、双支病变组及三支病变组,比较各组间NLR、MPV、Gensini评分及一般临床资料,并分析不同指标之间的相关性。结果:与双支病变组、单支病变组相比较,三支病变组吸烟、糖尿病、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、尿酸(uric acid,UA)、NLR、MPV、Gensini评分均显著升高(P<0.05);与单支病变组相比较,双支病变组吸烟、糖尿病、LDL-C、HDL-C、UA、NLR、MPV、Gensini评分均显著升高(P<0.05);三组间年龄、性别、高血压、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、肌酐(creatinine,Cr)比较差异均无统计学意义(P>0.05)。Pearson相关性分析表明:NLR、MPV与Gensini评分均呈正相关(r=0.482、0.702, P<0.05)。结论:ACS患者MPV和NLR与冠状动脉病变程度呈显著正相关,可有效评估冠状动脉狭窄程度。
Objective: To investigate the correlation of neutrophils/lymphocyte(NLR), mean platelet volume(MPV) with gensini score in Acute coronary syndrome(ACS). Methods: 156 cases of ACS patients were divided into three groups according to the results of coronary angiography: single lesion group, double branch lesions, tripathic group. The NLR, MPV, Gensini score and general clinical data were compared between different groups and the correlation of different index were analyzed. Results: Compared with the single vessel lesion group and double branch lesion group, the percentage of patients with smoking and diabetes, the serum LDL-C、HDL-C,UA, NLR, MPV and Gensini score were significantly increased in the three branches of lesion group(P<0.05); Compared with single vessel lesion group, the above index were significantly increased in he double branch lesion group(P<0.05). There was no significant difference in the age, gender, percentage of patients with hypertension, TC, TG and Cr between the three groups(P>0.05). The Pearson correlation analysis showed that NLR and MPV were positively correlated with Gensini score(r=0.482, 0.702, P<0.05). Conclusions: The MPV and NLR were significantly positive correlated with the degree of coronary artery disease in patients with ACS, and they can effectively assess the degree of coronary artery stenosis.
Objective: To investigate the correlation of neutrophils/lymphocyte(NLR), mean platelet volume(MPV) with gensini score in Acute coronary syndrome(ACS). Methods: 156 cases of ACS patients were divided into three groups according to the results of coronary angiography: single lesion group, double branch lesions, tripathic group. The NLR, MPV, Gensini score and general clinical data were compared between different groups and the correlation of different index were analyzed. Results: Compared with the single vessel lesion group and double branch lesion group, the percentage of patients with smoking and diabetes, the serum LDL-C、HDL-C,UA, NLR, MPV and Gensini score were significantly increased in the three branches of lesion group(P<0.05); Compared with single vessel lesion group, the above index were significantly increased in he double branch lesion group(P<0.05). There was no significant difference in the age, gender, percentage of patients with hypertension, TC, TG and Cr between the three groups(P>0.05). The Pearson correlation analysis showed that NLR and MPV were positively correlated with Gensini score(r=0.482, 0.702, P<0.05). Conclusions: The MPV and NLR were significantly positive correlated with the degree of coronary artery disease in patients with ACS, and they can effectively assess the degree of coronary artery stenosis.
引文
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[13]Paquissi F C.The role of inflammation in cardiovascular diseases:the predictive value of neutrophil-lymphocyte ratio as a marker in peripheral arterial disease[J].Ther Clin Risk Manag,2016,12(15):851-860
[14]Ciekg,Aiikgoz SK,Bozbay M,et al.Neutrophillymphocyteratio and platelet-lymphocyte ratio combination canpredict prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronaryintervention[J].Angiology,2015,66(5):441-447
[15]Pan W,Zhao D,Zhang C,et al.Application of neutrophil/lymphocyte ratio in predicting coronary blood flow and mortalityin patients with ST-elevation myocardial infarction undergoingpercutaneous coronary intervention[J].J Cardiol,2015,66(1):9-14
[16]Verdoia M,Barbieri L,Di GG,et al.Neutrophil to lymphocyte ratio and the extent of coronary artery disease:Results from a large cohort study[J].Angiology,2016,67(1):75-82
[17]张光宇,陈明,余志敏,等.中性粒细胞与淋巴细胞比值与冠状动脉狭窄程度的关系[J].心脏杂志,2014,05(26):575-578
[18]刘洋,周叶,吕侣,等.稳定型冠心病患者外周血中性粒细胞/淋巴细胞计数比值与冠脉斑块易损性的相关性分析[J].解放军医学院学报,2017,08(38):711-715
[19]解飞,吴娟.平均血小板体积与冠心病的相关性[J].中国老年学杂志,2015,17(44):4833-4834
[20]De Luca G,Santagostino M,Secco GG.Mean platelet volume and the extent of coronary artery disease:results from a large prospective study[J].Atherosclerosis,2009,3(12):1992-2011
[2]崔寒英.冠心病患者血清超敏C-反应蛋白、胱抑素C水平变化的意义分析[J].河北医药,2016,12(38):1771-1775
[3]刘子铭,赵菲菲,李凯勇,等.中性粒细胞与淋巴细胞比值和冠心病关系的探讨[J].武汉大学学报(医学版),2018,01(39):114-119
[4]Rechciński T,Jasińska A,Fory J,et al.Prognostic value of platelet indicesafter acute myocardial infarction treated with primary percutaneous coronary intervention[J].Cardiol J,2013,20(5):491-498
[5]汪洋,李彩荣,王宁夫.平均血小板容积和Gensini积分对急性ST段抬高型心肌梗死患者PCI术后预后的影响[J].临床和实验医学杂志,2018,06(17):602-604
[6]龙崇荣,唐能华,苟代玉.中性粒-淋巴细胞比值评估老年心肌梗死患者预后的价值[J].心血管康复医学杂志,2016,04(11):378-381
[7]谢灵芝,郑青,陈宁琳.2型糖尿病并发冠心病患者中性粒细胞/淋巴细胞比值的变化及意义[J].江苏医药,2018,02(44):185-188
[8]Kounis NG,soufras GD,Tsigkas G,et al.White blood cell counts,leukocyte ratios,and eosinophils as inflammatory markers in patients with coronary artery disease[J].Clin Appl Thromb Hemost,2015,21(2):139-143
[9]杨宇宏,张志珺.外周血中性粒细胞/淋巴细胞值与脑血管病相关性研究进展[J].东南大学学报(医学版),2017,02(36):301-305
[10]刘涛,李浪.血小板调控CD4+T淋巴细胞与动脉粥样硬化关系的研究进展[J].广东医学,2014,21(35):3421-3424
[11]Blum A,Sclarovsky S,Rehavia E,et al.Levels of Tlymphocyte subpopulationsinterleukin-1 betaand soluble interleukin-2 receptor in acute myocardial infarction[J].Am Heart J,1994,127(5):1226-1230
[12]赵燕,张毅刚,王海波,等.STEMI患者入院后急性期内NLR数值与院内MACE发生率的相关性[J].岭南心血管病杂志,2017,02(23):133-137
[13]Paquissi F C.The role of inflammation in cardiovascular diseases:the predictive value of neutrophil-lymphocyte ratio as a marker in peripheral arterial disease[J].Ther Clin Risk Manag,2016,12(15):851-860
[14]Ciekg,Aiikgoz SK,Bozbay M,et al.Neutrophillymphocyteratio and platelet-lymphocyte ratio combination canpredict prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronaryintervention[J].Angiology,2015,66(5):441-447
[15]Pan W,Zhao D,Zhang C,et al.Application of neutrophil/lymphocyte ratio in predicting coronary blood flow and mortalityin patients with ST-elevation myocardial infarction undergoingpercutaneous coronary intervention[J].J Cardiol,2015,66(1):9-14
[16]Verdoia M,Barbieri L,Di GG,et al.Neutrophil to lymphocyte ratio and the extent of coronary artery disease:Results from a large cohort study[J].Angiology,2016,67(1):75-82
[17]张光宇,陈明,余志敏,等.中性粒细胞与淋巴细胞比值与冠状动脉狭窄程度的关系[J].心脏杂志,2014,05(26):575-578
[18]刘洋,周叶,吕侣,等.稳定型冠心病患者外周血中性粒细胞/淋巴细胞计数比值与冠脉斑块易损性的相关性分析[J].解放军医学院学报,2017,08(38):711-715
[19]解飞,吴娟.平均血小板体积与冠心病的相关性[J].中国老年学杂志,2015,17(44):4833-4834
[20]De Luca G,Santagostino M,Secco GG.Mean platelet volume and the extent of coronary artery disease:results from a large prospective study[J].Atherosclerosis,2009,3(12):1992-2011