2013～2015年济南市大气污染物SO_2和NO_2对居民心血管疾病应急呼叫事件影响的急性效应
|
摘要
目的定量分析济南市大气污染物SO_2和NO_2对居民心血管疾病应急呼叫事件的急性影响。方法描述性分析2013～2015年济南市逐日气象、空气污染物和居民心血管疾病应急呼叫事件资料。采用基于Quasi-Poisson回归的广义相加模型分别进行SO_2、NO_2与逐日居民心血管疾病应急呼叫事件的单污染物模型、滞后效应(lag1～lag7)和累积滞后效应(lag01～lag07)分析。计算污染物浓度每升高10μg/m~3,居民心血管疾病应急呼叫事件风险增加的超额危险度及95%置信区间(95%CI)。结果 2013～2015年济南市逐日SO_2、NO_2浓度水平及居民心血管疾病应急呼叫事件数的均值分别为73μg/m~3、55μg/m~3及17人。SO_2、NO_2浓度每升高10μg/m~3,当日(lag0)居民心血管疾病应急呼叫事件风险可分别增加0. 41%(95%CI:0. 10%～0. 72%)和0. 99%(95%CI:0.27%～1. 71%),同时存在显著的累积滞后效应。结论济南市大气污染物SO_2、NO_2均对居民心血管疾病应急呼叫事件风险存在急性效应。
Objectives To evaluate the acute effects of air pollutants( SO_2 and NO_2) on the emergency callings( EC)for cardiovascular disease in Jinan City,China. Methods Daily meteorological,air pollutants and EC data between2013 and 2015 were collected for a descriptive analysis. A generalized additive model based on Quasi-Poisson regression was used to estimate the acute effects of each pollutant and EC. The lag pattern of lag days( lag1-lag7) and moving average effect( lag01-lag07) were explored. The excess risk of EC and 95% confidence interval( 95% CI) was calculated with an increase of 10 μg/m~3 in concentrations of SO_2 and NO_2,separately. Results The average of daily SO_2 and NO_2 concentrations and EC number were 73 μg/m~3,55 μg/m~3 and 17 callings per day,respectively. Per 10 μg/m~3 increase in concentrations of SO_2 and NO_2,at lag0,the EC could rise 0. 41%( 95% CI: 0. 10%-0. 72%) and 0. 99%( 95% CI: 0. 27%-1. 71%),respectively. Conclusion An obvious association is found in the acute effects of SO_2 and NO_2 to the emergency callings for cardiovascular disease in Jinan City,China.
Objectives To evaluate the acute effects of air pollutants( SO_2 and NO_2) on the emergency callings( EC)for cardiovascular disease in Jinan City,China. Methods Daily meteorological,air pollutants and EC data between2013 and 2015 were collected for a descriptive analysis. A generalized additive model based on Quasi-Poisson regression was used to estimate the acute effects of each pollutant and EC. The lag pattern of lag days( lag1-lag7) and moving average effect( lag01-lag07) were explored. The excess risk of EC and 95% confidence interval( 95% CI) was calculated with an increase of 10 μg/m~3 in concentrations of SO_2 and NO_2,separately. Results The average of daily SO_2 and NO_2 concentrations and EC number were 73 μg/m~3,55 μg/m~3 and 17 callings per day,respectively. Per 10 μg/m~3 increase in concentrations of SO_2 and NO_2,at lag0,the EC could rise 0. 41%( 95% CI: 0. 10%-0. 72%) and 0. 99%( 95% CI: 0. 27%-1. 71%),respectively. Conclusion An obvious association is found in the acute effects of SO_2 and NO_2 to the emergency callings for cardiovascular disease in Jinan City,China.
引文
[1] World Health Organization. Ambient air pollution:a global assessment of exposure and burden of disease[R]. Geneva:WHO,2016.
[2]Shang Y,Sun Z,Cao J,et al. Systematic review of Chinese studies of short-term exposure to air pollution and daily mortality[J]. Environ Int,2013,54:100-111.doi:10. 1016/j. envint. 2013. 01. 010.
[3] Beelen R,Raaschou-Nielsen O,Stafoggia M,et al.Effects of long-term exposure to air pollution on naturalcause mortality:an analysis of 22 European cohorts w ithin the multicentre ESCAPE project[J]. Lancet,2014,383(9919):785-795.
[4]Lai HK,Tsang H,Wong CM. Meta-analysis of adverse health effects due to air pollution in Chinese populations[J]. BMC Public Health,2013,13:360. doi:10.1186/1471-2458-13-360.
[5] Weichenthal S,Hoppin JA,Reeves F. Obesity and the cardiovascular health effects of fine particulate air pollution[J]. Obesity(Silver Spring),2014,22(7):1580-1589.
[6]崔亮亮,李新伟,张扬,等. 2013年1月山东省济南市灰霾期间急性呼吸系统危重症状的研究分析[J].疾病监测,2014,29(11):852-856.CUI Liangliang,LI Xinw ei,ZHANG Yang,et al. Impact of dust haze on acute and severe respiratory symptoms in Jinan,Shandong,January 2013[J]. Disease Surveillance,2014,29(11):852-856.
[7]崔亮亮,周敬文,张军,等.灰霾期间常见一般和危重症状的急性效应分析[J].环境与健康杂志,2014,31(7):600-603.CUI Liangliang,ZHOU Jingw en,ZHANG Jun,et al.Analysis of acute symptoms in common and critically ill patients during haze event[J]. Journal of Environment and Health,2014,31(7):600-603.
[8]崔亮亮,李新伟,耿兴义,等. 2013年济南市大气PM2. 5污染及雾霾事件对儿童门诊量影响的时间序列分析[J].环境与健康杂志,2015,32(6):489-493.CUI Liangliang,LI Xinw ei,Geng Xingyi,et al. Effectsof PM2. 5and haze event on hospital visiting of children in Ji'nan,2013:a time series analysis[J]. Journal of Environment and Health,2015,32(6):489-493.
[9]Cui LL,Zhang J,Zhang J,et al. Acute respiratory and cardiovascular health effects of an air pollution event,January 2013,Jinan,China[J]. Public Health,2016,131:99-102. doi:10. 1016/j. puhe. 2015. 11. 003.
[10]Liu P,Wang X,Fan J,et al. Effects of air pollution on hospital emergency room visits for respiratory diseases:urban-suburban differences in eastern China[J]. Int J Environ Res Public Health,2016,13(3):231-240.
[11]Verbeke T. Generalized Additive Models:an Introduction w ith R by S. N. Wood[J]. Journal of the Royal Statistical Society:Series A(Statistics in Society),2007,170:262. doi:10. 1111/j. 1467-985X. 2006.00455_15. x.
[12] Hurvich,CM,Simonoff,JS,Tsai C. Smoothing parameter selection in nonparametric regression using an improved Akaike information criterion[J]. Journal of the Royal Statistical Society:Series B(Statistical M ethodology), 1998, 60:271-293. doi:10. 1111/1467-9868. 00125.
[13] Zhang Y,Wang SG,Ma YX,et al. Association betw een ambient air pollution and hospital emergency admissions for respiratory and cardiovascular diseases in Beijing:a time series study[J]. Biomed Environ Sci,2015,28(5):352-363.
[14]Jalaludin B,Morgan G,Lincoln D,et al. Associations betw een ambient air pollution and daily emergency department attendances for cardiovascular disease in the elderly(65+years),Sydney,Australia[J]. J Expo Sci Environ Epidemiol,2006,16(3):225-237.
[15]Brook RD,Kousha T. Air pollution and emergency department visits for hypertension in Edmonton and Calgary,Canada:A case-crossover Study[J]. Am J Hypertens,2015,28(9):1121-1126.
[16]Xie J,He M,Zhu W. Acute effects of outdoor air pollution on emergency department visits due to five clinical subtypes of coronary heart diseases in shanghai,china[J]. J Epidemiol,2014,24(6):452-459.
[17] Szyszkowicz M,Porada E,Tremblay N,et al. Sulfur dioxide and emergency department visits for stroke and seizure[J]. Stroke Res Treat,2012,2012:824724.doi:10. 1155/2012/824724.
[18]Samoli E,Aga E,Touloumi G,et al. Short-term effects of nitrogen dioxide on mortality:an analysis w ithin the APHEA project[J]. Eur Respir J,2006,27(6):1129-1138.
[19]Pintaric'S,Zeljkovic'I,Pehnec G,et al. Impact of meteorological parameters and air pollution on emergency department visits for cardiovascular diseases in the city of Zagreb,Croatia[J]. Arh Hig Rada Toksikol,2016,67(3):240-246.
[20]Yu IT,Qiu H,Wang X,et al. Synergy between particles and nitrogen dioxide on emergency hospital admissions for cardiac diseases in Hong Kong[J]. Int J Cardiol,2013,168(3):2831-2836.
[21]Metzger KB,Tolbert PE,Klein M,et al. Ambient air pollution and cardiovascular emergency department visits[J]. Epidemiology,2004,15(1):46-56.
[22]Solimini AG,Renzi M. Association between air pollution and emergency room visits for atrial fibrillation[J]. Int J Environ Res Public Health,2017,14(6):661-667.
[2]Shang Y,Sun Z,Cao J,et al. Systematic review of Chinese studies of short-term exposure to air pollution and daily mortality[J]. Environ Int,2013,54:100-111.doi:10. 1016/j. envint. 2013. 01. 010.
[3] Beelen R,Raaschou-Nielsen O,Stafoggia M,et al.Effects of long-term exposure to air pollution on naturalcause mortality:an analysis of 22 European cohorts w ithin the multicentre ESCAPE project[J]. Lancet,2014,383(9919):785-795.
[4]Lai HK,Tsang H,Wong CM. Meta-analysis of adverse health effects due to air pollution in Chinese populations[J]. BMC Public Health,2013,13:360. doi:10.1186/1471-2458-13-360.
[5] Weichenthal S,Hoppin JA,Reeves F. Obesity and the cardiovascular health effects of fine particulate air pollution[J]. Obesity(Silver Spring),2014,22(7):1580-1589.
[6]崔亮亮,李新伟,张扬,等. 2013年1月山东省济南市灰霾期间急性呼吸系统危重症状的研究分析[J].疾病监测,2014,29(11):852-856.CUI Liangliang,LI Xinw ei,ZHANG Yang,et al. Impact of dust haze on acute and severe respiratory symptoms in Jinan,Shandong,January 2013[J]. Disease Surveillance,2014,29(11):852-856.
[7]崔亮亮,周敬文,张军,等.灰霾期间常见一般和危重症状的急性效应分析[J].环境与健康杂志,2014,31(7):600-603.CUI Liangliang,ZHOU Jingw en,ZHANG Jun,et al.Analysis of acute symptoms in common and critically ill patients during haze event[J]. Journal of Environment and Health,2014,31(7):600-603.
[8]崔亮亮,李新伟,耿兴义,等. 2013年济南市大气PM2. 5污染及雾霾事件对儿童门诊量影响的时间序列分析[J].环境与健康杂志,2015,32(6):489-493.CUI Liangliang,LI Xinw ei,Geng Xingyi,et al. Effectsof PM2. 5and haze event on hospital visiting of children in Ji'nan,2013:a time series analysis[J]. Journal of Environment and Health,2015,32(6):489-493.
[9]Cui LL,Zhang J,Zhang J,et al. Acute respiratory and cardiovascular health effects of an air pollution event,January 2013,Jinan,China[J]. Public Health,2016,131:99-102. doi:10. 1016/j. puhe. 2015. 11. 003.
[10]Liu P,Wang X,Fan J,et al. Effects of air pollution on hospital emergency room visits for respiratory diseases:urban-suburban differences in eastern China[J]. Int J Environ Res Public Health,2016,13(3):231-240.
[11]Verbeke T. Generalized Additive Models:an Introduction w ith R by S. N. Wood[J]. Journal of the Royal Statistical Society:Series A(Statistics in Society),2007,170:262. doi:10. 1111/j. 1467-985X. 2006.00455_15. x.
[12] Hurvich,CM,Simonoff,JS,Tsai C. Smoothing parameter selection in nonparametric regression using an improved Akaike information criterion[J]. Journal of the Royal Statistical Society:Series B(Statistical M ethodology), 1998, 60:271-293. doi:10. 1111/1467-9868. 00125.
[13] Zhang Y,Wang SG,Ma YX,et al. Association betw een ambient air pollution and hospital emergency admissions for respiratory and cardiovascular diseases in Beijing:a time series study[J]. Biomed Environ Sci,2015,28(5):352-363.
[14]Jalaludin B,Morgan G,Lincoln D,et al. Associations betw een ambient air pollution and daily emergency department attendances for cardiovascular disease in the elderly(65+years),Sydney,Australia[J]. J Expo Sci Environ Epidemiol,2006,16(3):225-237.
[15]Brook RD,Kousha T. Air pollution and emergency department visits for hypertension in Edmonton and Calgary,Canada:A case-crossover Study[J]. Am J Hypertens,2015,28(9):1121-1126.
[16]Xie J,He M,Zhu W. Acute effects of outdoor air pollution on emergency department visits due to five clinical subtypes of coronary heart diseases in shanghai,china[J]. J Epidemiol,2014,24(6):452-459.
[17] Szyszkowicz M,Porada E,Tremblay N,et al. Sulfur dioxide and emergency department visits for stroke and seizure[J]. Stroke Res Treat,2012,2012:824724.doi:10. 1155/2012/824724.
[18]Samoli E,Aga E,Touloumi G,et al. Short-term effects of nitrogen dioxide on mortality:an analysis w ithin the APHEA project[J]. Eur Respir J,2006,27(6):1129-1138.
[19]Pintaric'S,Zeljkovic'I,Pehnec G,et al. Impact of meteorological parameters and air pollution on emergency department visits for cardiovascular diseases in the city of Zagreb,Croatia[J]. Arh Hig Rada Toksikol,2016,67(3):240-246.
[20]Yu IT,Qiu H,Wang X,et al. Synergy between particles and nitrogen dioxide on emergency hospital admissions for cardiac diseases in Hong Kong[J]. Int J Cardiol,2013,168(3):2831-2836.
[21]Metzger KB,Tolbert PE,Klein M,et al. Ambient air pollution and cardiovascular emergency department visits[J]. Epidemiology,2004,15(1):46-56.
[22]Solimini AG,Renzi M. Association between air pollution and emergency room visits for atrial fibrillation[J]. Int J Environ Res Public Health,2017,14(6):661-667.