间充质干细胞治疗变应性鼻炎的研究进展
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摘要
变应性鼻炎(AR)是一种常见的过敏性疾病,严重影响患者的生活质量。Th1/Th2失衡是AR发病的免疫学基础,抑制Th2优势是治疗AR的切入点。间充质干细胞(MSCs)是一种具有多向分化潜能的成体干细胞,具有低免疫原特性以及免疫调节能力。本文综述MSC在AR治疗中的研究及其可能机制,期待能为探寻AR治疗新方法提供数据支持。
Allergic rhinitis( AR) is a common allergic disease,which seriously affect the quality of life of patients. Th1/Th2 imbalance is the immunological basis for the pathogenesis of AR,and the suppression of Th2 response is the breakthrough point in the treatment of AR. Mesenchymal stem cells( MSCs) are adult stem cells with multiple differentiation potential,and possess negative immunogenicity and immunomodulation ability. This article reviews the research of MSC in AR therapy and the possible mechanism,and expects to provide data for exploring new methods of AR treatment.
Allergic rhinitis( AR) is a common allergic disease,which seriously affect the quality of life of patients. Th1/Th2 imbalance is the immunological basis for the pathogenesis of AR,and the suppression of Th2 response is the breakthrough point in the treatment of AR. Mesenchymal stem cells( MSCs) are adult stem cells with multiple differentiation potential,and possess negative immunogenicity and immunomodulation ability. This article reviews the research of MSC in AR therapy and the possible mechanism,and expects to provide data for exploring new methods of AR treatment.
引文
[1]中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南(2015年,天津)[J].中华耳鼻咽喉头颈外科杂志,2016,51(1):6-24.
[2]SEIDMAN M D,GURGEL R K,LIN S Y,et al.Clinical practice guideline:allergic rhinitis[J].Otolaryngol Head Neck Surg,2015,152(1 Suppl):S1-S43.
[3]WHEELER A W,WORONIECKI S R.Modern approaches to therapeutic vaccination as treatment for type 1 respirator hypersensitivity(allergy)treatment[J].Expert Rev Vaccines,2006,5(1):27-31.
[4]GALLI S J,TSAI M,PILIPONSKY A M.The development of allergic inflammation[J].Nature,2008,454(7203):445.
[5]潘刚强,袁岳沙,陈杰,等.Th1/Th2细胞因子在过敏性鼻炎患者表达水平研究[J].检验医学与临床,2010,7(22):2472-2473.
[6]FRIEDENSTEIN A J,PETRAKOVA K V,KUROLESOVA A I,et al.Heterotopic of bone marrow.Analysis of precursor cells for osteogenic and hematopoietic tissues[J].Transplantation,1968,6(2):230-247.
[7]PROCKOP D J.Marrow stromal cells as stem cells for nonhematopoietic tissues[J].Science,1997,276(5309):71-74.
[8]易桥,卢燕勤,黄宏宇,等.间充质干细胞在免疫调节过程中的作用与应用进展[J].中国组织工程研究,2016,20(41):6216-6224.
[9]RIBEIRO A,LARANJEIRA P,MENDES S,et al.Mesenchymal stem cells from umbilical cord matrix,adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B,natural killer and T cells[J].Stem Cell Res Ther,2013,4(5):125.
[10]WATERMAN R S,TOMCHUCK S L,HENKLE S L,et al.A new mesenchymal stem cell(MSC)paradigm:Polarization into a proinflammatory MSC1 or an immunosuppressive MSC2 phenotype[J].PLoS One,2010,5(4):10088.
[11]UCCELLI A,MORETTA L,PISTOIA V.Mesenchymal stem cells in health and disease[J].Nat Rev Immunol,2008,8(9):726.
[12]杨燕美,江小霞,温宁.间充质干细胞免疫调控功能及临床应用[J].中国组织工程研究,2017,21(17):2776-2782.
[13]CHO K S,PARK H K,PARK H Y,et al.IFATS collection:Immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model[J].Stem Cells,2009,27(1):259-265.
[14]李冠雪.脂肪来源间充质干细胞(ADSC)调控变应性鼻炎模型鼠T细胞免疫状态的研究[D].广州:南方医科大学,2013.
[15]肖二彬,赵宝建,张驰.脂肪间充质干细胞可调节变应性鼻炎T细胞的免疫状态[J].中国组织工程研究,2016,20(10):1373-1381.
[16]FU Q L,CHOW Y Y,SUN S J,et al.Mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhinitis[J].Allergy,2012,67(10):1215-1222.
[17]SUN Y Q,DENG M X,HE J,et al.Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice[J].Stem Cells,2012,30(12):2692.
[18]GENC D,ZIBANDEH N,NAIN E,et al.Dental follicle mesenchymal stem cells downregulate th2 mediated immune response in asthmatic patients mononuclear cells[J].Clin Exp Allergy,2018,48(6):663-678.
[19]SAMIVEL R,KIM E H,CHUNG Y J,et al.Immunomodulatory effect of tonsil-derived mesenchymal stem cells in a mouse model of allergic rhinitis[J].Am J Rhinol Allergy,2015,29(4):262-267.
[20]YANG C,LI J,LIN H,et al.Nasal mucosa derived-mesenchymal stem cells from mice reduce inflammation via modulating immune responses[J].PLoS One,2015,10(3):118849.
[21]LI C,FU Y,WANG Y,et al.Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats[J].Cell Biochem Funct,2017,35(7):420-425.
[22]FRANCOIS M,ROMIEUMOUREZ R,LI M,et al.Human MSCsuppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation[J].Mol Ther,2012,20(1):187-195.
[23]ENGLISH K.Mechanisms of mesenchymal stromal cell immunomodulation[J].Immunol Cell Biol,2013,91(1):19-26.
[24]ALIPOUR R,MASOUMI K M,HASHEMIBENI B,et al.Indoleamine 2,3-dioxygenase is dispensable for the immunomodulatory function of stem cells from human exfoliated deciduous teeth[J].Cell J,2017,18(4):597-608.
[25]CHO K S,LEE J H,PARK M K,et al.Prostaglandin E2 and transforming growth factor-βplay a critical role in suppression of allergic airway inflammation by adipose-derived stem cells[J].PLoS One,2015,10(7):131813.
[26]YANG H,SUN J,YAN L,et al.Human umbilical cord-derived mesenchymal stem cells suppress proliferation of PHA-activated lymphocytes in vitro,by inducing CD4+CD25 high CD45RA+,regulatory T cell production and modulating cytokine secretion[J/OL].Cell Immunol,2016,302:26-31.2016-04-01[2018-05-22].https://linkinghub.elsevier.com/retrieve/pii/S0008-8749(16)30002-8.
[27]ALIPOUR R,ADIB M,MASOUMI K M,et al.Comparing the immunoregulatory effects of stem cells from human exfoliated deciduous teeth and bone marrow-derived mesenchymal stem cells[J].Iran J Allergy Asthma Immunol,2013,12(4):331-344.
[28]NEMETH K,KEANE-MYERS A,BROWN J M,et al.Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma[J].Proc Natl Acad Sci U S A,2010,107(12):5652-5657.
[2]SEIDMAN M D,GURGEL R K,LIN S Y,et al.Clinical practice guideline:allergic rhinitis[J].Otolaryngol Head Neck Surg,2015,152(1 Suppl):S1-S43.
[3]WHEELER A W,WORONIECKI S R.Modern approaches to therapeutic vaccination as treatment for type 1 respirator hypersensitivity(allergy)treatment[J].Expert Rev Vaccines,2006,5(1):27-31.
[4]GALLI S J,TSAI M,PILIPONSKY A M.The development of allergic inflammation[J].Nature,2008,454(7203):445.
[5]潘刚强,袁岳沙,陈杰,等.Th1/Th2细胞因子在过敏性鼻炎患者表达水平研究[J].检验医学与临床,2010,7(22):2472-2473.
[6]FRIEDENSTEIN A J,PETRAKOVA K V,KUROLESOVA A I,et al.Heterotopic of bone marrow.Analysis of precursor cells for osteogenic and hematopoietic tissues[J].Transplantation,1968,6(2):230-247.
[7]PROCKOP D J.Marrow stromal cells as stem cells for nonhematopoietic tissues[J].Science,1997,276(5309):71-74.
[8]易桥,卢燕勤,黄宏宇,等.间充质干细胞在免疫调节过程中的作用与应用进展[J].中国组织工程研究,2016,20(41):6216-6224.
[9]RIBEIRO A,LARANJEIRA P,MENDES S,et al.Mesenchymal stem cells from umbilical cord matrix,adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B,natural killer and T cells[J].Stem Cell Res Ther,2013,4(5):125.
[10]WATERMAN R S,TOMCHUCK S L,HENKLE S L,et al.A new mesenchymal stem cell(MSC)paradigm:Polarization into a proinflammatory MSC1 or an immunosuppressive MSC2 phenotype[J].PLoS One,2010,5(4):10088.
[11]UCCELLI A,MORETTA L,PISTOIA V.Mesenchymal stem cells in health and disease[J].Nat Rev Immunol,2008,8(9):726.
[12]杨燕美,江小霞,温宁.间充质干细胞免疫调控功能及临床应用[J].中国组织工程研究,2017,21(17):2776-2782.
[13]CHO K S,PARK H K,PARK H Y,et al.IFATS collection:Immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model[J].Stem Cells,2009,27(1):259-265.
[14]李冠雪.脂肪来源间充质干细胞(ADSC)调控变应性鼻炎模型鼠T细胞免疫状态的研究[D].广州:南方医科大学,2013.
[15]肖二彬,赵宝建,张驰.脂肪间充质干细胞可调节变应性鼻炎T细胞的免疫状态[J].中国组织工程研究,2016,20(10):1373-1381.
[16]FU Q L,CHOW Y Y,SUN S J,et al.Mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhinitis[J].Allergy,2012,67(10):1215-1222.
[17]SUN Y Q,DENG M X,HE J,et al.Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice[J].Stem Cells,2012,30(12):2692.
[18]GENC D,ZIBANDEH N,NAIN E,et al.Dental follicle mesenchymal stem cells downregulate th2 mediated immune response in asthmatic patients mononuclear cells[J].Clin Exp Allergy,2018,48(6):663-678.
[19]SAMIVEL R,KIM E H,CHUNG Y J,et al.Immunomodulatory effect of tonsil-derived mesenchymal stem cells in a mouse model of allergic rhinitis[J].Am J Rhinol Allergy,2015,29(4):262-267.
[20]YANG C,LI J,LIN H,et al.Nasal mucosa derived-mesenchymal stem cells from mice reduce inflammation via modulating immune responses[J].PLoS One,2015,10(3):118849.
[21]LI C,FU Y,WANG Y,et al.Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats[J].Cell Biochem Funct,2017,35(7):420-425.
[22]FRANCOIS M,ROMIEUMOUREZ R,LI M,et al.Human MSCsuppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation[J].Mol Ther,2012,20(1):187-195.
[23]ENGLISH K.Mechanisms of mesenchymal stromal cell immunomodulation[J].Immunol Cell Biol,2013,91(1):19-26.
[24]ALIPOUR R,MASOUMI K M,HASHEMIBENI B,et al.Indoleamine 2,3-dioxygenase is dispensable for the immunomodulatory function of stem cells from human exfoliated deciduous teeth[J].Cell J,2017,18(4):597-608.
[25]CHO K S,LEE J H,PARK M K,et al.Prostaglandin E2 and transforming growth factor-βplay a critical role in suppression of allergic airway inflammation by adipose-derived stem cells[J].PLoS One,2015,10(7):131813.
[26]YANG H,SUN J,YAN L,et al.Human umbilical cord-derived mesenchymal stem cells suppress proliferation of PHA-activated lymphocytes in vitro,by inducing CD4+CD25 high CD45RA+,regulatory T cell production and modulating cytokine secretion[J/OL].Cell Immunol,2016,302:26-31.2016-04-01[2018-05-22].https://linkinghub.elsevier.com/retrieve/pii/S0008-8749(16)30002-8.
[27]ALIPOUR R,ADIB M,MASOUMI K M,et al.Comparing the immunoregulatory effects of stem cells from human exfoliated deciduous teeth and bone marrow-derived mesenchymal stem cells[J].Iran J Allergy Asthma Immunol,2013,12(4):331-344.
[28]NEMETH K,KEANE-MYERS A,BROWN J M,et al.Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma[J].Proc Natl Acad Sci U S A,2010,107(12):5652-5657.