闭角型青光眼患者红细胞免疫功能与EPO和ET-1的相关性
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摘要
目的:探讨闭角型青光眼患者红细胞免疫功能与血清促红细胞生成素(EPO)和血浆内皮素-1(ET-1)的相关性。方法:选取2017-06/10期间我院收治的闭角型青光眼患者30例(病例组)与眼部正常者30例(对照组)为研究对象。测定并比较两组受试者红细胞免疫功能、血清EPO和血浆ET-1浓度,分析之间的相关性。结果:病例组受试者红细胞C3b受体花环率明显低于对照组(10.81%±2.01%vs 18.06%±3.44%),红细胞免疫复合物花环率明显高于对照组(17.21±3.49%vs 11.74±2.14%),血清EPO浓度明显高于对照组(26.10±5.22 mU/mL vs 22.68±4.06mU/mL),血浆ET-1浓度明显高于对照组(70.85±7.16ng/L vs 58.43±5.09ng/L)。闭角型青光眼患者红细胞C3b受体花环率与血清EPO浓度呈显著正相关(r=0.271,P<0.05),与血浆ET-1浓度无明显相关性。结论:闭角型青光眼患者红细胞免疫功能与血清EPO浓度呈正相关。
·AIM: To investigate the correlation between erythrocyte immune function and serum erythropoietin(EPO) and plasma endothelin-1(ET-1) in patients with angle-closure glaucoma.·METHODS: Totally 30 patients with angle-closure glaucoma(case group) and 30 normal eyes(control group) were selected from our hospital from June 2017 to October 2017. The erythrocyte immune function, serum EPO and plasma ET-1 levels were measured and compared between the two groups.·RESULTS: The rosette rate of erythrocyte C3 b receptor in the case group was significantly lower than that in the control group(10.81%±2.01% vs 18.06%±3.44%), the rosette rate of erythrocyte immune complex was significantly higher than that in the control group(17.21%±3.49% vs 11.74%±2.14%), the serum EPO concentration was significantly higher than that in the control group(26.10%±5.22 mU/mL vs 22.68%±4.06 mU/mL), and the plasma ET-1 concentration was significantly higher than that in the control group(70.85%±7.16 ng/L vs 58. 43±5.09 ng/L). The rosette rate of erythrocyte C3 b receptor in patients with angle-closure glaucoma was positively correlated with serum EPO concentration(r=0.271, P<0.05), but not with plasma ET-1 concentration.·CONCLUSION: There is a positive correlation between erythrocyte immune function and serum EPO concentration in patients with angle-closure glaucoma.
·AIM: To investigate the correlation between erythrocyte immune function and serum erythropoietin(EPO) and plasma endothelin-1(ET-1) in patients with angle-closure glaucoma.·METHODS: Totally 30 patients with angle-closure glaucoma(case group) and 30 normal eyes(control group) were selected from our hospital from June 2017 to October 2017. The erythrocyte immune function, serum EPO and plasma ET-1 levels were measured and compared between the two groups.·RESULTS: The rosette rate of erythrocyte C3 b receptor in the case group was significantly lower than that in the control group(10.81%±2.01% vs 18.06%±3.44%), the rosette rate of erythrocyte immune complex was significantly higher than that in the control group(17.21%±3.49% vs 11.74%±2.14%), the serum EPO concentration was significantly higher than that in the control group(26.10%±5.22 mU/mL vs 22.68%±4.06 mU/mL), and the plasma ET-1 concentration was significantly higher than that in the control group(70.85%±7.16 ng/L vs 58. 43±5.09 ng/L). The rosette rate of erythrocyte C3 b receptor in patients with angle-closure glaucoma was positively correlated with serum EPO concentration(r=0.271, P<0.05), but not with plasma ET-1 concentration.·CONCLUSION: There is a positive correlation between erythrocyte immune function and serum EPO concentration in patients with angle-closure glaucoma.
引文
1姚小磊, 彭俊, 李建超, 等.原发性开角型青光眼患者眼底荧光血管造影及血液流变学改变与中医证型关系的研究.湖南中医药大学学报 2016;36(11):41-45
2 Ho H, Ozaki M, Mizoguchi T, et al. Angle-closure glaucoma in Asians:comparison of biometric and anterior segment parameters between Japanese and Chinese subjects. Graefes Arch Clin Exp Ophthalmol 2015;253(4):601-608
3黄翠玲, 李华, 吕莎, 等.原发性急性闭角型青光眼患者外周血IL-2和IL-6水平与视神经损伤相关性分析.国际眼科杂志 2015;15(9):1583-1586
4杜非凡, 吴志鸿.高度近视合并原发性开角型青光眼的临床特点研究进展.眼科新进展 2017; 37(7) : 697-700
5 Rieck J. The pathogenesis of glaucoma in the interplay with the immune system. Invest Ophthalmol Vis Sci 2013;54(3):2393-2409
6谢静, 王辉, 袁思奇, 等.新生血管性青光眼患者血清及房水血管内皮生长因子与促红细胞生成素的表达研究.中国全科医学 2016;19(33):4073-4078
7温积权, 曹永葆, 汪怿, 等.曲伏前列腺素滴眼液对原发性开角型青光眼患者眼压及血浆内皮素-1的影响.中国临床药理学杂志 2016;32(22):2056-2058, 2062
8徐丽华.原发性青光眼患者血清多种元素及一氧化氮、促红细胞生成素及外周血T细胞亚群变化研究.临床合理用药杂志 2012;5(13):61-62
9饶毅峰, 朱平, 何川鄂, 等.重组人促红细胞生成素对血液透析患者营养状况和免疫功能的影响.现代生物医学进展 2017;17(15):2888-2891
10 Zhou M, Chen S, Wang W, et al. Levels of erythropoietin and vascular endothelial growth factor in surgery-required advanced neovascular glaucoma eyes before and after intravitreal injection of bevacizumab. Invest Ophthalmol Vis Sci 2013;54(6):3874-3879
11陈丽平. EPO治疗慢性肾衰患者对铁调素、FDP及红细胞免疫的影响.基因组学与应用生物学 2017;36(11) : 4516-4522
12 Aktas Z, Unlu M, Uludag K, et al. The effect of systemic erythropoietin treatment on retinal nerve fiber layer parameters in patients with chronic renal failure undergoing peritoneal dialysis. J Glaucoma 2015;24(3):214-218
13周小芳, 郭春荣, 张伟妃, 等.慢性肾功能衰竭(CRF)中医辨证与实验室指标相关性的研究进展.中华中医药学刊 2016;34(8):1907-1910
14宋书朋.促红素联合左卡尼汀纠正慢性肾功能衰竭患者肾性贫血的临床疗效分析.中国医药指南 2016;14(31):68
15 Kuehn MH. Immune phenomena in glaucoma and conformational disorders:why is the second eye not involved?J Glaucoma 2014;23(8 Suppl 1):S59-S61
16 Chen HY, Chang YC, Chen WC, et al. Association between plasma endothelin-1 and severity of different types of glaucoma. J Glaucoma 2013;22(2):117-122
17 Wróbel-Dudzińska D, Kosior-Jarecka E, ?ukasik U, et al. Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene. J Ophthalmol 2015;2015:368792
18闫庆慧, 张爽, 谢志, 等.原发性闭角型青光眼人工晶状体植入术后血液流变学和血浆中内皮素-1的研究.齐齐哈尔医学院学报 2016;37(16):2031-2033
19 Yoshida K, Ohguro I, Ohguro H. Black currant anthocyanins normalized abnormal levels of serum concentrations of endothelin-1 in patients with glaucoma. J Ocul Pharmacol Ther 2013;29(5):480-487
20 Pavlenko TA, Chesnokova NB, Davydova HG, et al. Level of tear endothelin-1 and plasminogen in patients with glaucoma and proliferative diabetic retinopathy. Vestn Oftalmol 2013;29(4):20-23
2 Ho H, Ozaki M, Mizoguchi T, et al. Angle-closure glaucoma in Asians:comparison of biometric and anterior segment parameters between Japanese and Chinese subjects. Graefes Arch Clin Exp Ophthalmol 2015;253(4):601-608
3黄翠玲, 李华, 吕莎, 等.原发性急性闭角型青光眼患者外周血IL-2和IL-6水平与视神经损伤相关性分析.国际眼科杂志 2015;15(9):1583-1586
4杜非凡, 吴志鸿.高度近视合并原发性开角型青光眼的临床特点研究进展.眼科新进展 2017; 37(7) : 697-700
5 Rieck J. The pathogenesis of glaucoma in the interplay with the immune system. Invest Ophthalmol Vis Sci 2013;54(3):2393-2409
6谢静, 王辉, 袁思奇, 等.新生血管性青光眼患者血清及房水血管内皮生长因子与促红细胞生成素的表达研究.中国全科医学 2016;19(33):4073-4078
7温积权, 曹永葆, 汪怿, 等.曲伏前列腺素滴眼液对原发性开角型青光眼患者眼压及血浆内皮素-1的影响.中国临床药理学杂志 2016;32(22):2056-2058, 2062
8徐丽华.原发性青光眼患者血清多种元素及一氧化氮、促红细胞生成素及外周血T细胞亚群变化研究.临床合理用药杂志 2012;5(13):61-62
9饶毅峰, 朱平, 何川鄂, 等.重组人促红细胞生成素对血液透析患者营养状况和免疫功能的影响.现代生物医学进展 2017;17(15):2888-2891
10 Zhou M, Chen S, Wang W, et al. Levels of erythropoietin and vascular endothelial growth factor in surgery-required advanced neovascular glaucoma eyes before and after intravitreal injection of bevacizumab. Invest Ophthalmol Vis Sci 2013;54(6):3874-3879
11陈丽平. EPO治疗慢性肾衰患者对铁调素、FDP及红细胞免疫的影响.基因组学与应用生物学 2017;36(11) : 4516-4522
12 Aktas Z, Unlu M, Uludag K, et al. The effect of systemic erythropoietin treatment on retinal nerve fiber layer parameters in patients with chronic renal failure undergoing peritoneal dialysis. J Glaucoma 2015;24(3):214-218
13周小芳, 郭春荣, 张伟妃, 等.慢性肾功能衰竭(CRF)中医辨证与实验室指标相关性的研究进展.中华中医药学刊 2016;34(8):1907-1910
14宋书朋.促红素联合左卡尼汀纠正慢性肾功能衰竭患者肾性贫血的临床疗效分析.中国医药指南 2016;14(31):68
15 Kuehn MH. Immune phenomena in glaucoma and conformational disorders:why is the second eye not involved?J Glaucoma 2014;23(8 Suppl 1):S59-S61
16 Chen HY, Chang YC, Chen WC, et al. Association between plasma endothelin-1 and severity of different types of glaucoma. J Glaucoma 2013;22(2):117-122
17 Wróbel-Dudzińska D, Kosior-Jarecka E, ?ukasik U, et al. Risk Factors in Normal-Tension Glaucoma and High-Tension Glaucoma in relation to Polymorphisms of Endothelin-1 Gene and Endothelin-1 Receptor Type A Gene. J Ophthalmol 2015;2015:368792
18闫庆慧, 张爽, 谢志, 等.原发性闭角型青光眼人工晶状体植入术后血液流变学和血浆中内皮素-1的研究.齐齐哈尔医学院学报 2016;37(16):2031-2033
19 Yoshida K, Ohguro I, Ohguro H. Black currant anthocyanins normalized abnormal levels of serum concentrations of endothelin-1 in patients with glaucoma. J Ocul Pharmacol Ther 2013;29(5):480-487
20 Pavlenko TA, Chesnokova NB, Davydova HG, et al. Level of tear endothelin-1 and plasminogen in patients with glaucoma and proliferative diabetic retinopathy. Vestn Oftalmol 2013;29(4):20-23