疫苗预防流感流行的研究进展
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摘要
2017年11月份我国进入冬季流感高峰季节以来,至2018年3月份今年冬春季的流感高峰已经过去。在今年流感流行期间,无论流感样病例占门急诊病例总数百分比,还是流感病毒检测阳性率都高于往年同期水平。本文从流感病毒基因角度来阐述疫苗预防流感的最新进展。
Since our country entered the winter flu peak season in November 2017, the winter flu peak has passed in March 2018. During this year's flu epidemic, both influenza-like cases taken a percentage of the total number of emergency cases and influenza virus detection rates were higher than in previous years. This paper describes the latest progress of vaccine against influenza from the perspective of influenza virus gene.
Since our country entered the winter flu peak season in November 2017, the winter flu peak has passed in March 2018. During this year's flu epidemic, both influenza-like cases taken a percentage of the total number of emergency cases and influenza virus detection rates were higher than in previous years. This paper describes the latest progress of vaccine against influenza from the perspective of influenza virus gene.
引文
[1]卫生部国家卫生和计划生育委员会,国家中医药管理局,流行性感冒诊断与治疗指南编撰专家组.流行性感冒诊断与治疗指南(2011年版)[J].社区医学杂志,2011,34,(10):725.
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[13]Raphael Dolin MD.流行性感冒的流行病学[J].https://www.uptodate.com/contents/zh-Hans/epidemiology-of-influenza?search=%E6%B5%81%E6%84%9F&source=search_result&selectedTitle=1~39&usage_type=default&display_rank=1
[14]金青青,茅海燕,孙逸.乙型流感病毒Victoria系和Yamagata系HAl基因的分子进化研究[J].中华流行病学杂志,2013,34(4):366.
[15]中国疾病预防控制中心传染病预防控制处.中国季节性流感疫苗应用技术指南(2014-2015)[J].传染病专报,2015,3(29):1.
[16]World Health Organization.Recommended composition of influenza virus vaccines for use in the 2018-2019 northern hemisphere influenza season.Available from:http://www.who.int/influenza/vaccines/virus/recommendations/2018_19_north/en/
[17]Coffield AB,Maciosek MV,McGinnis JM,et al.Priorities among recommended clinical preventive services[J].Am J Prev Med,21(1):1-9.
[18]Barberis I,Myles P,Ault SK,et al.History and evolution of influenza control through vaccination:from the first monovalent vaccine to universal vaccines[J].J Prev Med Hyg,2016,57(3):115-120.
[19]Belshe RB,Ambrose CS,Yi T.Safety and efficacy of live attenuated influenza vaccine in children 2-7 years of age[J].Vaccine,2008,26(4):10-16.
[20]Pebody R,Warburton F,Andrews N,et al.Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom:2014/15 end of season results[J].Euro Surveill,2015,20(36).
[21]Amy Lingel,Brianna L,Bullard&Eric A,et al.Efficacy of an Adenoviral Vectored Multivalent Centralized Influenza Vaccine.www.nature.com/scientificreports.
[22]Kumar P,Khanna M,Kumar B,et al.A conserved matrix epitope based DNA vaccine protects mice against influenza A virus challenge[J].Antiviral Res,2012,93(1):78-85.
[23]Khanna M,Sharma S,Kumar B,et al.Protective immunity based on the conserved hemagglutinin stalk domain and its prospects for universal influenza vaccine development[J].Biomed Res Int,2014:546274.
[24]Steel J,Lowen AC,Wang TT,et al.Influenza virus vaccine based on the conserved hemagglutinin stalk domain[J].MBio,2010,1(1).
[25]Schwartzman LM,Cathcart AL,Pujanauski LM,et al.An intranasal virus-like particle vaccine broadly protects mice from multiple subtypes of influenza Avirus[J].MBio,2015,6(4):01044.
[2]World Health Organization.季节性流感.2018.1.[N].http://www.who.int/mediacentre/factsheets/fs211/zh/
[3]World Health Organization.Number of specimens positive for influenza by subtype.http://apps.who.int/flumart/Default?ReportNo=1
[4]C D C.我国进入今冬流感流行高峰季节.2017.11.16 h t t p://w w w.chinacdc.cn/jkzt/crb/bl/lxxgm/ymjz/201712/t20171226_157314.html
[5]C D C.近期我国季节性流感流行情况与防治知识问答中.2018.1.8.http://www.chinacdc.cn/jkzt/crb/bl/lxxgm/cswd/201801/t20180108_158017.html
[6]CDC.我国内地流感疫情和防控问答.2018.3.2 http://www.chinacdc.cn/yyrdgz/201803/t20180302_159420.html
[7]王玉光,谷晓红,马家驹.2017-2018年北京地区流行性感冒病证特征及应对策略[J].北京中医药,2018,37(1):3.
[8]Nicole M,Bouvier,Peter Palese.The biology of influenza Viruses[J].Vaccine,2008,26(l 4):49-53.
[9]George F,Gao.From“A”IV to“Z”IKV:Attacks from Emerging and Re-emerging Pathogens[J].Cell 172,2018:1157.
[10]国家卫生和计划生育委员会,国家中医药管理局.流行性感冒诊疗方案[J].中国感染控制杂志,2018,17(2):95-98.http://www.chinaivdc.cn/cnic/zyzx/lgzb/201803/t20180306_159451.htm
[11]曾晓旭,王大燕,舒跃龙.B型流行性感冒病毒基因进化研究进展[J].中华预防医学杂志,2013,47(7):657.
[12]John Treanor MD.Influenza Vaccine-Outmaneuvering Antigenic Shift and Drift.www.nejm.org
[13]Raphael Dolin MD.流行性感冒的流行病学[J].https://www.uptodate.com/contents/zh-Hans/epidemiology-of-influenza?search=%E6%B5%81%E6%84%9F&source=search_result&selectedTitle=1~39&usage_type=default&display_rank=1
[14]金青青,茅海燕,孙逸.乙型流感病毒Victoria系和Yamagata系HAl基因的分子进化研究[J].中华流行病学杂志,2013,34(4):366.
[15]中国疾病预防控制中心传染病预防控制处.中国季节性流感疫苗应用技术指南(2014-2015)[J].传染病专报,2015,3(29):1.
[16]World Health Organization.Recommended composition of influenza virus vaccines for use in the 2018-2019 northern hemisphere influenza season.Available from:http://www.who.int/influenza/vaccines/virus/recommendations/2018_19_north/en/
[17]Coffield AB,Maciosek MV,McGinnis JM,et al.Priorities among recommended clinical preventive services[J].Am J Prev Med,21(1):1-9.
[18]Barberis I,Myles P,Ault SK,et al.History and evolution of influenza control through vaccination:from the first monovalent vaccine to universal vaccines[J].J Prev Med Hyg,2016,57(3):115-120.
[19]Belshe RB,Ambrose CS,Yi T.Safety and efficacy of live attenuated influenza vaccine in children 2-7 years of age[J].Vaccine,2008,26(4):10-16.
[20]Pebody R,Warburton F,Andrews N,et al.Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom:2014/15 end of season results[J].Euro Surveill,2015,20(36).
[21]Amy Lingel,Brianna L,Bullard&Eric A,et al.Efficacy of an Adenoviral Vectored Multivalent Centralized Influenza Vaccine.www.nature.com/scientificreports.
[22]Kumar P,Khanna M,Kumar B,et al.A conserved matrix epitope based DNA vaccine protects mice against influenza A virus challenge[J].Antiviral Res,2012,93(1):78-85.
[23]Khanna M,Sharma S,Kumar B,et al.Protective immunity based on the conserved hemagglutinin stalk domain and its prospects for universal influenza vaccine development[J].Biomed Res Int,2014:546274.
[24]Steel J,Lowen AC,Wang TT,et al.Influenza virus vaccine based on the conserved hemagglutinin stalk domain[J].MBio,2010,1(1).
[25]Schwartzman LM,Cathcart AL,Pujanauski LM,et al.An intranasal virus-like particle vaccine broadly protects mice from multiple subtypes of influenza Avirus[J].MBio,2015,6(4):01044.