含有5-氟尿嘧啶的稀土多金属氧酸盐的合成及体外抗癌活性
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摘要
以H_4SiW_(12)O_(40)为原料,合成了两种含有稀土铕、钕和5-氟尿嘧啶的多金属氧酸盐:K_(11)(C_4H_4FN_2O_2)_2Eu(SiW_(11)O_(39))_2·20H_2O(简写为FEuSiW)和K_(11)(C_4H_4FN_2O_2)_2Nd(SiW_(11)O_(39))_2·18H_2O (简写为FNdSiW),并采用~1H NMR、IR、XRD和TG-DTA对其结构进行了的表征。
Taking H_4SiW_(12)O_(40) as material, the paper synthesizes tow polyoxometalates containing rare earth Nd, Eu and 5-fluorouracil. They are K_(11)(C_4H_4FN_2O_2)_2Eu(SiW_(11)O_(39))_2.20 H_2O(simplified as FEuSiW) and K_(11)(C_4H_4FN_2O_2)_2Nd(SiW_(11)O_39)_2·18 H_2O(simplified as FNdSiW). Their structure are characterized with ~HNMR, IR, XRD and TG-DTA.
Taking H_4SiW_(12)O_(40) as material, the paper synthesizes tow polyoxometalates containing rare earth Nd, Eu and 5-fluorouracil. They are K_(11)(C_4H_4FN_2O_2)_2Eu(SiW_(11)O_(39))_2.20 H_2O(simplified as FEuSiW) and K_(11)(C_4H_4FN_2O_2)_2Nd(SiW_(11)O_39)_2·18 H_2O(simplified as FNdSiW). Their structure are characterized with ~HNMR, IR, XRD and TG-DTA.
引文
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[2]SUZUKI K,JEONG J,YANMAGUCHI K,et al.Photoredox catalysis for oxygenation/deoxygenation between sulfides and sulfoxides by visible-light-responsive polyoxometalates [J].New J.Chem.,2016,(40):1014-1021.
[3]MARTIN-SABI M,SORIANO-LO′ PEZ J,WINTER R S,et al.Redox tuning the Weakley-type polyoxometalate archetype for the oxygen evolution reaction [J].Nature Catalysis,2018,(1):208-213.
[4]FU L,GAO H,YAN M,et al.Polyoxometalate-Based Organic–Inorganic Hybrids as Antitumor Drugs [J].Small,2015,(11):2938-2945.
[5]HUANG T,XIE Z,WU Q,et al.Temperature-dependent gel-type ionic liquid compounds based on vanadium-substituted polyoxometalates with Keggin structure [J].Dalton Trans.,2016,(45):3958-3963.
[6]XIE Z,WU H,WU Q,et al.Synthesis and performance of solid proton conductor molybdovanadosilicic acid [J].RSC Advances,2018,(8):13984-13988.
[7]ZHAO J W,LI H L,MA X,et al.Degradable Organically-Derivatized Polyoxometalate with Enhanced Activity against Glioblastoma Cell Line [J].Scientific Reports,2016,(6):26406.
[8]FENG C,GAN Q,LIU X,et al.Synthesis and antitumor activities of rare earth substituted phosphotungstates containing 5-fluorouracil[J].Journal of Rare Earths,2012,30(5):467-472.
[9]LIU J Y,ZHOU W,SFERRUZZA A D,et al.Quantitation of dihydropyrimidine dehydrogenase (DPD) mRNA expression levels in normal colon and colorectal cancer tumor paraffin-embedded tissue specimens[J].Anticancer Drugs,2003,(14):563-567.
[10]MALET-MARTINO M,MARTINO R.Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine,UFT,S-1):a review [J].Oncologist,2002,7(4):288-323.
[11]OMURA K.Clinical implication of dihydropyrimidine dehydrogenase activity in 45-Fu based chemotherapy:mutations in the DPD gene,and DPD inhibitory fluoropyrimiduneds[J].Inter.J.Clin.Oncol.,2003,8(30):132-138.
[12]YIN Ping,HU Maolin,YAN Xiaowei,et al.Synthesis,Crystal Structure and Anticarcinogenic Activity of Four 5-Fluorouracil-dipeptide Derivatives[J].Acta Chimica Sinica,2008,(66):1693-1699.
[13]ASADI Z,NASROLLAHI N,KARBALAEI-HEIDARI H,et al.Investigation of the complex structure,comparative DNA-binding and DNA cleavage of two water-soluble mono-nuclear lanthanum(III) complexes and cytotoxic activity of chitosan-coated magnetic nanoparticles as drug delivery for the complexes[J].Spectrochim Acta A,2017,(178):125-135.
[14]TAHA M,KHAN I,COUTINHO J A P.Complexation and molecular modeling studies of europium(III)–gallic acid–amino acid complexes[J].J Inorg Biochem,2016,(157):25-33.
[15]MANAIYARKARASI R,CHINNATHAMBI S,KARTHIKEYAN S,et al.Paclitaxel conjugated Fe3O4@LaF3:Ce3+,Tb3+nanoparticles as bifunctional targeting carriers for Cancer theranostics application[J].Journal of Magnetism and Magnetic Materials,2016,(399):207-215.
[16]PEACOCK R D,WEAKLEY T R.Heteropolytungstate complexes of the lanthaide elements[J].J Chem Soc A,1971,(12):1836-1839.
[17]LIU X,WANG S,FENG C.Synthesis and Anticancer Properties of Rare Earth Substituted Tungstophosphoric Polyoxometalate Containing 5-Fluorouracil[J].Chin J Chem,2010,(28):2411-2415.
[18]WU X,HUANG T,TONG X,et al.Thermoregulated polyoxometalate-based ionic-liquid gel electrolytes[J].RSC Adv,2015,5(28):21973-21977.
[19]WU X,TONG X,WU Q,et al.Reversible pase transformation-type electrolyte based on layered shape polyoxometalate [J].J Mater Chem A,2014,(2):5780-5784.
[20]FENG C,GAN Q,LIU X,et al.Synthesis and antitumor activities of rare earth substituted phosphotungstates containing 5-fluorouracil [J].J Rare Earths,2012,30(5):467-472.
[21]YIN Q,LIAO J,WANG C,et al.Preparation,characterization and catalytic activity of three-dimensionally ordered macroporous H3PW12O40-SiO2 functionalized materials[J].Acta Chim.Sinica (in Chin.),2007,65(19):2103-2108.
[22]Haraguchi N,Okaue Y,Isobe T,et al.Stabilization of Tetravalent Cerium upon Coordination of Unsaturated Heteropolytungstate Anions[J].Inorg Chem,1994,(33):1015-1020.
[23]WANG J,YAN Q,DU X,et al.Synthesis,crystal structures and properties of three rare earth substituted germanotungstates:M/[α-GeW11O39] (M=Nd,Eu,and Tb)[J].Inorg Chim Acta,2008,(361):2701-2706.