PCT、CRP检查在重症细菌感染患者中的临床价值分析
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摘要
目的分析血清降钙素原(PCT)、C反应蛋白(CRP)检查在重症细菌感染患者中的临床价值。方法 50例重症细菌感染患者作为观察组,同期在本院检查的健康体检者50例作为对照组,两组研究对象均采用电化学发光法检测PCT、CRP水平。对比两组患者的PCT、CRP检测水平,两组患者的阳性检出率,观察组治疗前后的PCT、CRP水平变化情况。结果观察组PCT水平为(5.29±2.96)ng/ml、CRP水平为(75.62±18.56)mg/L,均高于对照组的(0.43±0.12)ng/ml、(14.02±5.72)mg/L,差异均具有统计学意义(P<0.05)。观察组PCT、CRP阳性检出率分别为94.00%、80.00%,明显高于对照组的4.00%、16.00%,差异均具有统计学意义(P<0.05)。观察组治疗后48、72 h的PCT、CRP水平均低于治疗前,治疗后72 h的PCT、CRP水平低于治疗后48 h,差异均具有统计学意义(P<0.05)。结论 PCT、CRP在重症细菌感染诊断中具有一定的应用价值,对PCT、CRP水平进行监测有利于对患者治疗效果进行评估。
Objective To analyze the clinical value of serum procalcitonin(PCT) and C-reactive protein(CRP) in patients with severe bacterial infection. Methods A total of 50 patients with severe bacterial infection as observation group, and concurrent 50 healthy persons examined in our hospital as control group. The levels of PCT and CRP were measured by electrochemical luminescence in both groups. The levels of PCT and CRP and the positive detection rate were compared in the two groups. The changes of PCT and CRP levels before and after treatment in the observation group were compared. Results The observation group had higher PCT as(5.29±2.96) ng/ml and CRP as(75.62±18.56) mg/L than(0.43±0.12) ng/ml and(14.02±5.72) mg/L in the control group,and the difference was statistically significant(P<0.05). The observation group had obviously higher positive detection rate of PCT and CRP respectively as 94.00% and 80.00% than 4.00% and 16.00% in the control group,and their difference was statistically significant(P<0.05). The PCT and CRP levels in the observation group were lower than those before treatment, and the PCT and CRP levels at 72 h after treatment were lower than 48 h after treatment. Their difference was statistically significant(P<0.05). Conclusion PCT and CRP have certain application value in the diagnosis of severe bacterial infections, and monitoring the levels of PCT and CRP is conducive to evaluating the treatment effect of patients.
Objective To analyze the clinical value of serum procalcitonin(PCT) and C-reactive protein(CRP) in patients with severe bacterial infection. Methods A total of 50 patients with severe bacterial infection as observation group, and concurrent 50 healthy persons examined in our hospital as control group. The levels of PCT and CRP were measured by electrochemical luminescence in both groups. The levels of PCT and CRP and the positive detection rate were compared in the two groups. The changes of PCT and CRP levels before and after treatment in the observation group were compared. Results The observation group had higher PCT as(5.29±2.96) ng/ml and CRP as(75.62±18.56) mg/L than(0.43±0.12) ng/ml and(14.02±5.72) mg/L in the control group,and the difference was statistically significant(P<0.05). The observation group had obviously higher positive detection rate of PCT and CRP respectively as 94.00% and 80.00% than 4.00% and 16.00% in the control group,and their difference was statistically significant(P<0.05). The PCT and CRP levels in the observation group were lower than those before treatment, and the PCT and CRP levels at 72 h after treatment were lower than 48 h after treatment. Their difference was statistically significant(P<0.05). Conclusion PCT and CRP have certain application value in the diagnosis of severe bacterial infections, and monitoring the levels of PCT and CRP is conducive to evaluating the treatment effect of patients.
引文
[1]李子博,刘伟谦,付祖姣,等.降钙素原与C反应蛋白检测在细菌性感染中的临床应用.中国现代医学杂志, 2014, 24(25):80-83.
[2]刘海华,陶晓根.降钙素原对重症患者抗感染治疗指导价值的临床研究.安徽医学, 2015, 36(11):1342-1345.
[3]万荣.超敏C-反应蛋白与血清降钙素原联合检测在儿童重症感染性疾病中的临床意义.中国妇幼保健, 2017, 32(20):5041-5043.
[4]李晶,葛鹏,赵晓强,等.降钙素原与C-反应蛋白检测细菌性感染的应用研究.中华医院感染学杂志, 2016, 26(1):40-42.
[5]景富春,张素梅,高英,等.血清PCT与CRP检测在肝硬化并肺部感染患者诊治中的临床价值.检验医学与临床, 2016, 13(11):1457-1458.
[6]刘宗英.细菌性肺炎患者血清降钙素原、超敏C反应蛋白和白细胞介素6检测的临床诊断价值.中国医药指南, 2014, 13(12):190-191.
[7]钱香,马建锋.血清降钙素原与C-反应蛋白联合检测对恶性肿瘤患者早期感染诊断的临床价值.中国实验诊断学, 2017,21(3):399-402.
[8]宫爱华,赵成艳,李晓兰. CD64指数与PCT、CRP联合检测在呼吸道感染疾病中的诊断价值.中国微生态学杂志, 2016,28(10):1187-1190.
[2]刘海华,陶晓根.降钙素原对重症患者抗感染治疗指导价值的临床研究.安徽医学, 2015, 36(11):1342-1345.
[3]万荣.超敏C-反应蛋白与血清降钙素原联合检测在儿童重症感染性疾病中的临床意义.中国妇幼保健, 2017, 32(20):5041-5043.
[4]李晶,葛鹏,赵晓强,等.降钙素原与C-反应蛋白检测细菌性感染的应用研究.中华医院感染学杂志, 2016, 26(1):40-42.
[5]景富春,张素梅,高英,等.血清PCT与CRP检测在肝硬化并肺部感染患者诊治中的临床价值.检验医学与临床, 2016, 13(11):1457-1458.
[6]刘宗英.细菌性肺炎患者血清降钙素原、超敏C反应蛋白和白细胞介素6检测的临床诊断价值.中国医药指南, 2014, 13(12):190-191.
[7]钱香,马建锋.血清降钙素原与C-反应蛋白联合检测对恶性肿瘤患者早期感染诊断的临床价值.中国实验诊断学, 2017,21(3):399-402.
[8]宫爱华,赵成艳,李晓兰. CD64指数与PCT、CRP联合检测在呼吸道感染疾病中的诊断价值.中国微生态学杂志, 2016,28(10):1187-1190.