肾心康胶囊联合温脾泄浊汤在肾功能衰竭患者中的应用及对炎症因子的影响研究
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摘要
目的:探讨肾心康胶囊联合温脾泄浊汤对慢性肾功能衰竭疗效及对炎症因子影响性。方法:选取96例慢性肾功能衰竭患者,按入组顺序随机分成2组,每组48例,对照组常规西医治疗,研究组在对照组基础上加用肾心康胶囊联合温脾泄浊汤治疗,观察不同方法治疗后在疗效、炎症因子和中医临床症状体征积分变化情况。结果:研究组显效率43.75%、总有效率85.42%,显著优于对照组显效率27.08%、总有效率68.75%(P<0.05);两组治疗末较治疗前SCr、BUN、UA、、IL-6、TNF-α显著下降,Ccr显著升高(P<0.05),研究组治疗末中医临床症状体征积分显著低于治疗前(P<0.05);以上指标研究组治疗末均显著优于对照组(P<0.05)。结论:肾心康胶囊联合温脾泄浊汤能提高慢性肾功能衰竭疗效,抑制炎症反应。
Objective:To investigate the effect of Shenxinkang capsule combined with Wenpi Xiezhuo decoction on chronic renal failure and its influence on inflammatory factors.Methods:96 patients with chronic renal failure were randomly divided into two groups,each group of 48 cases,the control group of conventional western medicine treatment,the study group on the basis of the control group plus Shenxinkang capsule combined with Wenpi Xiezhuo decoction,to observe the effect of different methods on the curative effect,inflammatory factors and clinical symptoms and signs of traditional Chinese medicine.Results:The total effective rate was 85.75%,the effective rate was27.08% and the total effective rate was 68.75%(P <0.05).The levels of SCr,BUN,UA and IL-6 in the two groups were significantly higher than those in the control group(P<0.05).The scores of clinical symptoms and signs in the treatment group were significantly lower than those before treatment(P <0.05).The above indexes were significantly better than those in the control group(P<0.05).Conclusion:Shenxinkang capsule combined with Wenpi Xiezhuo decoction can improve the curative effect of chronic renal failure and inhibit the inflammatory reaction.
Objective:To investigate the effect of Shenxinkang capsule combined with Wenpi Xiezhuo decoction on chronic renal failure and its influence on inflammatory factors.Methods:96 patients with chronic renal failure were randomly divided into two groups,each group of 48 cases,the control group of conventional western medicine treatment,the study group on the basis of the control group plus Shenxinkang capsule combined with Wenpi Xiezhuo decoction,to observe the effect of different methods on the curative effect,inflammatory factors and clinical symptoms and signs of traditional Chinese medicine.Results:The total effective rate was 85.75%,the effective rate was27.08% and the total effective rate was 68.75%(P <0.05).The levels of SCr,BUN,UA and IL-6 in the two groups were significantly higher than those in the control group(P<0.05).The scores of clinical symptoms and signs in the treatment group were significantly lower than those before treatment(P <0.05).The above indexes were significantly better than those in the control group(P<0.05).Conclusion:Shenxinkang capsule combined with Wenpi Xiezhuo decoction can improve the curative effect of chronic renal failure and inhibit the inflammatory reaction.
引文
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[10]郑海生,王荣,刘凯,等.中医固脾肾泄浊法与西医治疗慢性肾功能衰竭的meta分析[J].时珍国医国药,2013,24(6):1428-1430.
[2]李宏良,皮持衡,贺支支,等.肾衰泄浊汤对慢性肾功能衰竭患者血清肿瘤坏死因子-α白介素-6水平及肾功能的影响[J].中医药学刊,2015,23(5):845-847.
[3]高连波,高红华,王正则,等.急性脑卒中患者肾功能损伤及危险因素分析[J].陕西医学杂志,2014,43(1):44-45.
[4]安建静,孙岚云.孙岚云主任治疗慢性肾功能衰竭经验总结[J].陕西中医,2016,37(3):340-341.
[5]杨晓晖,龙泓竹.糖尿病肾脏病的诊断和治疗[J].中华全科医学,2017,15(6):915-916.
[6]杨雪莲,李列平.川芎嗪注射液、α-酮酸联合左旋氨氯地平治疗慢性肾功能衰竭的临床观察[J].中国药房,2016,27(24):3371-3373.
[7]周楠楠,朱燃,赵雪梅,等.天麻素、黄芪总皂苷和芍药苷对阿尔茨海默病模型小鼠脑内β-淀粉样多肽表达的影响及其机制[J].中华病理学杂志,2016,45(11):780-785.
[8]杨洪雁,杜智恒,白秀娟.水蛭药理作用的研究进展[J].东北农业大学学报,2012,43(3):128-133.
[9]黄莺,张晓青,李龙,等.水蛭提取液对凝血酶诱导血管内皮细胞释放凝血因子的影响[J].中国中西医结合急救杂志,2011,18(2):75-77.
[10]郑海生,王荣,刘凯,等.中医固脾肾泄浊法与西医治疗慢性肾功能衰竭的meta分析[J].时珍国医国药,2013,24(6):1428-1430.