益气宣肺汤联合雾化吸入治疗老年慢性支气管炎的疗效分析
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摘要
目的:探讨益气宣肺汤联合雾化吸入对老年慢性支气管炎患者疗效及对肺功能的影响。方法:118例明确诊断老年性慢性支气管炎患者随机分为对照组与观察组,每组各59例。对照组予以雾化吸入为基础的西医常规治疗,观察组在对照组治疗基础上联合益气宣肺汤治疗,疗程均为10d。分别结合两组患者治疗前后症状积分及相关辅助检查变化情况综合评价临床疗效,同时比较治疗前后两组患者FVC(最大肺活量)、FEV1(第1秒用力呼气容积)及FEV1/FVC(第1秒用力呼气容积占用力肺活量的百分比)等肺功能指标间差异。另观察并比较两组患者治疗过程中药物相关不良事件发生率以评价安全性。结果:与对照组相比,观察组患者治疗总有效率显著升高,两组间差异显著(P<0.05)。治疗后两组患者FVC、FEV1及FEV1/FVC等指标较治疗前均有显著改善,且观察组患者改善程度较对照组患者显著,差异有统计学意义(P<0.05)。两组不良事件发生率间未见显著差异。结论:益气宣肺汤联合雾化吸入在提高老年慢性支气管炎患者临床治疗有效率的同时,对改善患者肺功能水平也具有显著的促进作用。
Objective:To investigate the effect of Yiqi Xuanfei decoction combined with atomization inhalation on the curative effect and pulmonary function of the elderly patients with chronic bronchitis.Methods:118 cases of senile chronic bronchitis were randomly divided into the control group and the observation group,with 59 cases in each group.The control group was treated with the conventional treatment of western medicine based on nebulization and inhalation,and the observation group was treated with Yiqi Xuanfei decoction on the basis of the control group.The treatment course was 10 d.Two groups of patients before and after treatment were combined with comprehensive evaluation of changes of symptoms and auxiliary examination of clinical curative effect,and compare the two groups before and after treatment FVC(FVC),FEV1(section 1 s,forced expiratory volume)and FEV1/FVC(section 1 s,forced expiratory volume percentage of forced vital capacity)and pulmonary function index difference.The drug related adverse events were also observed and compared in the two groups in order to evaluate the safety.Results:Compared with the control group,the total effective rate of treatment was significantly higher in the observation group,and the difference between the two groups was significant(P<0.05).After treatment,two groups of patients FVC,FEV1 and FEV1/FVC and other indicators were significantly improved compared with before treatment,and the improvement degree of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of two groups of adverse events.Conclusion:Yiqi Xuanfei decoction combined with aerosol inhalation can improve the clinical treatment efficiency of elderly patients with chronic bronchitis and improve the lung function of patients.
Objective:To investigate the effect of Yiqi Xuanfei decoction combined with atomization inhalation on the curative effect and pulmonary function of the elderly patients with chronic bronchitis.Methods:118 cases of senile chronic bronchitis were randomly divided into the control group and the observation group,with 59 cases in each group.The control group was treated with the conventional treatment of western medicine based on nebulization and inhalation,and the observation group was treated with Yiqi Xuanfei decoction on the basis of the control group.The treatment course was 10 d.Two groups of patients before and after treatment were combined with comprehensive evaluation of changes of symptoms and auxiliary examination of clinical curative effect,and compare the two groups before and after treatment FVC(FVC),FEV1(section 1 s,forced expiratory volume)and FEV1/FVC(section 1 s,forced expiratory volume percentage of forced vital capacity)and pulmonary function index difference.The drug related adverse events were also observed and compared in the two groups in order to evaluate the safety.Results:Compared with the control group,the total effective rate of treatment was significantly higher in the observation group,and the difference between the two groups was significant(P<0.05).After treatment,two groups of patients FVC,FEV1 and FEV1/FVC and other indicators were significantly improved compared with before treatment,and the improvement degree of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of two groups of adverse events.Conclusion:Yiqi Xuanfei decoction combined with aerosol inhalation can improve the clinical treatment efficiency of elderly patients with chronic bronchitis and improve the lung function of patients.
引文
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[8]杨琼芳,方双燕,季巧英,等.慢性阻塞性肺疾病急性加重合并肺栓塞患者的临床表现和辅助检查特征分析[J].浙江医学,2016,38(22):1831-1833.
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[10]Kim V,Zhao H,Boriek A M,et al.Persistent andnewly developed chronic bronchitis are associated with worse outcomes in chronic obstructive pulmonary disease[J].Annals of the American Thoracic Society,2016,13(7):1016.
[11]Dechristopher L R,Uribarri J,Tucker K L.Intake of high fructose corn syrup sweetened soft drinks is associated with prevalent chronic bronchitis in U.S.Adults,ages20-55y[J].Nutrition Journal,2015,14(1):107.
[12]侯瑞蕊,徐舒畅,张学新,等.夏季穴位贴伏及冬季序贯膏干预脾肾阳虚型慢性支气管炎疗效研究[J].陕西中医,2014,35(4):394-396.
[13]吴成建,于素平,彭真,等.化痰止咳汤治疗慢性支气管炎临床研究[J].中医学报,2016,31(9):1281-1283.
[14]张华山.益气宣肺经验方联合穴位敷贴治疗老年慢性支气管炎急性发作的临床研究[J].中医临床研究,2017,9(3):61-64.
[15]刘舜禹,王振涛.王振涛教授辨治“善太息”经验[J].中医学报,2017,32(6):953-955.
[2]Nafees A A,Fatmi Z,Kadir M M,et al.Chronic bronchitis and chronic obstructive pulmonary disease(COPD)among textile workers in karachi,pakistan[J].Coll Physicians Surg Pak,2016,26(5):384-389.
[3]王佳.益气宣肺汤治疗慢阻肺缓解期之经验探析[J].亚太传统医药,2017,13(11):78-79.
[4]Kim V,Oros M,Durra H,et al.Chronic bronchitis and current smoking are associated with more goblet cells in moderate to severe COPD and smokers without airflow obstruction[J].Plos One,2015,10(2):e0116108.
[5]李苏英.消积镇咳方联合西药治疗小儿急性支气管炎临床观察[J].中国中医急症,2015,24(8):1453-1455.
[6]Kim V,Crapo J,Zhao H,et al.Comparison between an alternative and the classic definition of chronic bronchitis in COPD Gene.[J].Annals of the American Thoracic Society,2015,12(3):332.
[7]Anderson W H,Coakley R D,Button B,et al.The relationship of mucus concentration(hydration)to mucus osmotic pressure and transport in chronic bronchitis[J].American Journal of Respiratory&Critical Care Medicine,2015,192(2):182-190.
[8]杨琼芳,方双燕,季巧英,等.慢性阻塞性肺疾病急性加重合并肺栓塞患者的临床表现和辅助检查特征分析[J].浙江医学,2016,38(22):1831-1833.
[9]Accordini S,Corsico A G,Calciano L,et al.The impact of asthma,chronic bronchitis and allergic rhinitis on allcause hospitalizations and limitations in daily activities:a population-based observational study[J].BMC Pulmonary Medicine,2015,15(1):1-9.
[10]Kim V,Zhao H,Boriek A M,et al.Persistent andnewly developed chronic bronchitis are associated with worse outcomes in chronic obstructive pulmonary disease[J].Annals of the American Thoracic Society,2016,13(7):1016.
[11]Dechristopher L R,Uribarri J,Tucker K L.Intake of high fructose corn syrup sweetened soft drinks is associated with prevalent chronic bronchitis in U.S.Adults,ages20-55y[J].Nutrition Journal,2015,14(1):107.
[12]侯瑞蕊,徐舒畅,张学新,等.夏季穴位贴伏及冬季序贯膏干预脾肾阳虚型慢性支气管炎疗效研究[J].陕西中医,2014,35(4):394-396.
[13]吴成建,于素平,彭真,等.化痰止咳汤治疗慢性支气管炎临床研究[J].中医学报,2016,31(9):1281-1283.
[14]张华山.益气宣肺经验方联合穴位敷贴治疗老年慢性支气管炎急性发作的临床研究[J].中医临床研究,2017,9(3):61-64.
[15]刘舜禹,王振涛.王振涛教授辨治“善太息”经验[J].中医学报,2017,32(6):953-955.