健脾益肾降浊方治疗慢性肾衰早中期脾肾气虚型临床研究
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摘要
目的:探讨健脾益肾降浊方在早中期脾肾气虚型慢性肾衰患者中的临床应用价值。方法:选取早中期慢性肾衰患者92例,随机分为两组,各46例。对照组:采用一般常规治疗,治疗组则在对照组基础上加用健脾益肾降浊方。对比两组患者的临床疗效。结果:与对照组相比,治疗组中医证候积分明显降低;治疗组中医证候疗效达到临床治愈标准的比率明显提升,总有效率95.65%;治疗组治疗后Scr(240.12±124.30)μmol/L、Ccr(58.70±24.65)mL/min、BUN(9.02±4.13)mmol/L较治疗前明显改善,且与对照组具有显著差异。结论:中药健脾益肾降浊方对于早中期脾肾气虚型慢性肾衰患者肾功能的改善及临床治疗效果的提升均具有十分重要的意义。
Objective:To probe into clinical application value of traditional Chinese medicine Jianpi Yishen Jiangzhuo prescription for early and mid chronic renal failure with deficiency.of spleen and kidney.Methods:From January2013 to December 2013,92 early and mid chronic renal failure patients were selected in our hospital.The patients were divided into study group and the control group randomly.There were 46 cases in each group.The patients in the control group were treated with conventional therapy generally.The patients in study group were treated with Jianpi Yishen Jiangzhuo prescription program.The clinical efficacy of the patients in two groups were compared and analyzed.Results:Compared with control group,the patients in study group the TCM syndrome score was decreased significantly;patients in study group the ratio of total efficiency was 95.65%,there were improved significantly;patients in study group after treatment,the renal function parameters,included Scr was(240.12±124.30)μmol/L,Ccr was(58.70±24.65)mL/min,BUN was(9.02 ± 4.13)mmol/L,there were improved significantly.Conclusions:Traditional Chinese medicine Jianpi Yishen Jiangzhuo prescription has great important significance for improving renal function and enhancing clinical effects for early and mid chronic renal failure patients with deficiency of spleen and kidney.It is suitable for clinical application and promotion.
Objective:To probe into clinical application value of traditional Chinese medicine Jianpi Yishen Jiangzhuo prescription for early and mid chronic renal failure with deficiency.of spleen and kidney.Methods:From January2013 to December 2013,92 early and mid chronic renal failure patients were selected in our hospital.The patients were divided into study group and the control group randomly.There were 46 cases in each group.The patients in the control group were treated with conventional therapy generally.The patients in study group were treated with Jianpi Yishen Jiangzhuo prescription program.The clinical efficacy of the patients in two groups were compared and analyzed.Results:Compared with control group,the patients in study group the TCM syndrome score was decreased significantly;patients in study group the ratio of total efficiency was 95.65%,there were improved significantly;patients in study group after treatment,the renal function parameters,included Scr was(240.12±124.30)μmol/L,Ccr was(58.70±24.65)mL/min,BUN was(9.02 ± 4.13)mmol/L,there were improved significantly.Conclusions:Traditional Chinese medicine Jianpi Yishen Jiangzhuo prescription has great important significance for improving renal function and enhancing clinical effects for early and mid chronic renal failure patients with deficiency of spleen and kidney.It is suitable for clinical application and promotion.
引文
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[2]牛振华,聂怀利,牛礼东.活肾丸联合西药治疗慢性肾功能衰竭疗效观察[J].陕西中医,2014,35(10):1305-1306.
[3]华跃如,王小琴,袁军,等.“补脾益肾法”治疗早期慢性肾脏病的随机对照临床研究[J].临床肾脏病杂志,2013,13(2):87-90.
[4]王海燕.肾脏病学[M].北京:人民卫生出版社,2009,1868-1880.
[5]中华人民共和国卫生部.中药新药临床研究指导原则[S].北京:中国医药科技出版,2002:164-166.
[6]王晓婷,张淑清,崔云,等.益肾健脾通络化痰汤治疗早中期慢性肾衰的临床观察[J].中国中医药科技,2014,21(5):567-568.
[7]吴斌玻,魏仲南.慢性肾功能衰竭的中医药治疗研究新进展[J].福建中医药大学学报,2011,21(112):125-127.
[8]赵先锋.关建国诊治慢性肾衰早、中期经验总结[J].辽宁中医杂志,2014,41(9):1834-1836.
[9]魏仲南,吴斌璇,唐娟.对比研究补肾祛毒汤治疗脾肾气虚型慢性肾衰的疗效[J].中华中医药学刊,2014,32(11):2684-2686.
[10]叶玉妹,张晓丹,蔡艳,等.肾衰方治疗慢性肾衰临床观察[J].辽宁中医杂志,2014,41(11):2343-2344.
[11]董小革.健脾益肾活血降浊法治疗慢性肾衰竭30例临床观察[J].河北中医,2010,32(8):1134-1135.
[12]赵珍,麻金木,黄和英子.肾衰Ⅰ号方治疗慢性肾脏病3期脾肾气虚湿瘀证临床研究[J].辽宁中医杂志,2013,40(7):1409-1411.