芍药苷药理作用研究进展
摘要
通过对近10年芍药苷药理作用相关文献的研究,从抗肿瘤、抗氧化、抗抑郁、免疫调节和补血等方面概述了芍药苷药理作用的研究进展。目前芍药苷的研究多集中在对信号通路的调控和细胞因子活性的调节,但芍药苷不同生物学效应之间的信号通路网络和关键靶点尚未阐明。因此,进一步探索芍药苷作用的信号转导机制和作用靶点,认识中药方剂中不同活性单体之间的配伍规律,可能是今后芍药苷及其他中药活性成分的重要研究方向。参考文献31篇。
引文
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[15]李伟,王景霞,葛阳,等.芍药苷对血虚肝郁证模型大鼠海马谷氨酸及其不同类型受体mRNA表达的影响[J].中华中医药杂志,2016,31(4):1241-1244.
[16]屈胜胜,张建军,黄银峰,等.芍药苷、芍药内酯苷对放射线辐照法致血虚小鼠的补血作用[J].中国中药杂志,2014,39(15):2952-2955.
[17]郭平,王继峰,王升启.芍药苷对放射线致血虚证小鼠骨髓EPO和G-CSF基因表达的影响[J].山东中医药大学学报,2005,29(3):236-239.
[18]郭平,宋卓彦,王升启.芍药苷对辐射致血虚小鼠骨髓蛋白质表达的影响[J].中药药理与临床,2007,23(4):17-19.
[19]郭平,郭霞.芍药苷对血虚证小鼠骨髓细胞白介素及其受体基因表达的作用[J].中药药理与临床,2009,25(5):25-27.
[20]晁二涛,白海,王存邦,等.芍药苷对骨髓间充质干细胞增殖的影响[J].中国组织工程研究,2015,19(1):101-107.
[21] WANG P,WANG W,SHI Q,et al. Paeoniflorin amelio-rates acute necrotizing pancreatitis and pancreatitis-ind-uced acute renal injury[J]. Mol Med Rep,2016,14(2):1123-1131.
[22] JIA Z,HE J. Paeoniflorin ameliorates rheumatoid arthr-itis in rat models through oxidative stress,inflammationand cyclooxygenase 2[J]. Exp Ther Med,2016,11(2):655-659.
[23]刘家齐,赵正晓,魏颖,等.芍药苷对哮喘模型小鼠气道炎症趋化因子及受体的干预作用[J].中国实验动物学报,2016,24(5):460-464.
[24]袁娜,朱明燕,杨宏发,等.芍药苷对脂多糖诱导的THP-1细胞炎症因子分泌和ABCA1表达的影响[J].中国动脉硬化杂志,2017,25(9):895-898.
[25]李越峰,徐富菊,张泽国,等.芍药苷改善睡眠作用机制研究[J].中国临床药理学杂志,2015,31(1):56-58.
[26] CHEN C R,SUN Y,LUO Y J,et al. Paeoniflorin prom-otes non-rapid eye movement sleep via adenosine A1receptors[J]. J Pharmacol Exp Ther,2016,356(1):64-73.
[27] WANG Y,DAI J,ZHU Y,et al. Paeoniflorin regulatesosteoclastogenesis and osteoblastogenesis via manipulat-ing NF-κB signaling pathway both in vitro and in vi-vo[J]. Oncotarget,2018,9(7):7372-7388.
[28] CHEN A,WANG H,ZHANG Y. Paeoniflorin exerts ne-uroprotective effects against glutamate-induced PC12 ce-llular cytotoxicity by inhibiting apoptosis[J]. Internati-onal Journal of Molecular Medicine,2017,40(3):825-833.
[29] ZHANG Y,WANG L L,WU Y,et al. Paeoniflorin atte-nuates hippocampal damage in a rat model of vasculardementia[J]. Experimental&Therapeutic Medicine,2016,12(6):3729.
[30] ZHOU J,WANG L,WANG J,et al. Paeoniflorin andalbiflorin attenuate neuropathic pain via MAPK pathwayin chronic constriction injury rats[J]. Evidence-BasedComplementray and Alternative Medicine,2016,2016(3):1-11.
[31] LIU Z Q,JIANG Z H,CHAN K,et al.Pharmacokineticinteraction of paeoniflorin and sinomenine:pharmacoki-netic parameters and tissue distribution characteristicsin rats and protein binding ability in vitro[J]. J Phar-macol Sci,2005,99(4):381-391.
[2]孙丽荣,曹雄,侯凤青,等.芍药苷研究进展[J].中国中药杂志,2008,33(18):2028-2032.
[3]葛永斌,程孝中,燕傲蕾,等.芍药苷抗肿瘤作用机制研究进展[J].中药材,2015,38(3):636-639.
[4]李跃军,卓德斌.芍药苷对5-氟尿嘧啶耐药的CD44阳性胃癌细胞的抑制作用[J].中国普通外科杂志,2014,23(4):521-524.
[5] WU Q,CHEN G L,LI Y J,et al. Paeoniflorin inhibitsmacrophage-mediated lung cancer metastasis[J]. Chin JNat Med,2015,13(12):925-932.
[6] YANG N,CUI H,HAN F,et al. Paeoniflorin inhibits hu-man pancreatic cancer cell apoptosis via suppression ofMMP-9 and ERK signaling[J]. Oncol Lett,2016,12(2):1471-1476.
[7] ZHANG J,WANG F,WANG H,et al. Paeoniflorin inhi-bits proliferation of endometrial cancer cells via activat-ing MAPK and NF-κB signaling pathways[J]. Exp TherMed,2017,14(6):5445-5451.
[8] NIE X H,OU-YANG GANG J,XING Y,et al. Paeoniflo-rin inhibits human glioma cells via STAT3 degradationby the ubiquitin-proteasome pathway[J]. Drug Des DevelTher,2015,9:5611-5622.
[9] ZHOU Z,WANG S,SONG C,et al. Paeoniflorin preventshypoxia-induced epithelial-mesenchymal transition in hu-man breast cancer cells[J]. Onco Targets Ther,2016,9:2511-2518.
[10]包钰婷,郭在培,王小雪,等.芍药苷抗氧化应激机制研究进展[J].中国麻风皮肤病杂志,2017,33(6):374-377.
[11] ZHAO Y,ZHOU G,WANG J,et al. Paeoniflorin protectsagainst ANIT-induced cholestasis by ameliorating oxid-ative stress in rats[J]. Food Chem Toxicol,2013,58:242-248.
[12]刘玲,邱相君,和素娜,等.芍药苷对LPS脑损伤模型小鼠氧化应激和能量代谢的影响[J].中国中药杂志,2015,40(14):2871-2875.
[13] LI J,HUANG S,HUANG W,et al. Paeoniflorin ameli-orates interferon-alpha-induced neuroinflammation anddepressive-like behaviors in mice[J]. Oncotarget,2017,8(5):8264-8282.
[14] HUANG H,ZHAO J,JIANG L,et al. Paeoniflorin impr-oves menopause depression in ovariectomized rats underchronic unpredictable mild stress[J]. Int J Clin ExpMed,2015,8(4):5103-5111.
[15]李伟,王景霞,葛阳,等.芍药苷对血虚肝郁证模型大鼠海马谷氨酸及其不同类型受体mRNA表达的影响[J].中华中医药杂志,2016,31(4):1241-1244.
[16]屈胜胜,张建军,黄银峰,等.芍药苷、芍药内酯苷对放射线辐照法致血虚小鼠的补血作用[J].中国中药杂志,2014,39(15):2952-2955.
[17]郭平,王继峰,王升启.芍药苷对放射线致血虚证小鼠骨髓EPO和G-CSF基因表达的影响[J].山东中医药大学学报,2005,29(3):236-239.
[18]郭平,宋卓彦,王升启.芍药苷对辐射致血虚小鼠骨髓蛋白质表达的影响[J].中药药理与临床,2007,23(4):17-19.
[19]郭平,郭霞.芍药苷对血虚证小鼠骨髓细胞白介素及其受体基因表达的作用[J].中药药理与临床,2009,25(5):25-27.
[20]晁二涛,白海,王存邦,等.芍药苷对骨髓间充质干细胞增殖的影响[J].中国组织工程研究,2015,19(1):101-107.
[21] WANG P,WANG W,SHI Q,et al. Paeoniflorin amelio-rates acute necrotizing pancreatitis and pancreatitis-ind-uced acute renal injury[J]. Mol Med Rep,2016,14(2):1123-1131.
[22] JIA Z,HE J. Paeoniflorin ameliorates rheumatoid arthr-itis in rat models through oxidative stress,inflammationand cyclooxygenase 2[J]. Exp Ther Med,2016,11(2):655-659.
[23]刘家齐,赵正晓,魏颖,等.芍药苷对哮喘模型小鼠气道炎症趋化因子及受体的干预作用[J].中国实验动物学报,2016,24(5):460-464.
[24]袁娜,朱明燕,杨宏发,等.芍药苷对脂多糖诱导的THP-1细胞炎症因子分泌和ABCA1表达的影响[J].中国动脉硬化杂志,2017,25(9):895-898.
[25]李越峰,徐富菊,张泽国,等.芍药苷改善睡眠作用机制研究[J].中国临床药理学杂志,2015,31(1):56-58.
[26] CHEN C R,SUN Y,LUO Y J,et al. Paeoniflorin prom-otes non-rapid eye movement sleep via adenosine A1receptors[J]. J Pharmacol Exp Ther,2016,356(1):64-73.
[27] WANG Y,DAI J,ZHU Y,et al. Paeoniflorin regulatesosteoclastogenesis and osteoblastogenesis via manipulat-ing NF-κB signaling pathway both in vitro and in vi-vo[J]. Oncotarget,2018,9(7):7372-7388.
[28] CHEN A,WANG H,ZHANG Y. Paeoniflorin exerts ne-uroprotective effects against glutamate-induced PC12 ce-llular cytotoxicity by inhibiting apoptosis[J]. Internati-onal Journal of Molecular Medicine,2017,40(3):825-833.
[29] ZHANG Y,WANG L L,WU Y,et al. Paeoniflorin atte-nuates hippocampal damage in a rat model of vasculardementia[J]. Experimental&Therapeutic Medicine,2016,12(6):3729.
[30] ZHOU J,WANG L,WANG J,et al. Paeoniflorin andalbiflorin attenuate neuropathic pain via MAPK pathwayin chronic constriction injury rats[J]. Evidence-BasedComplementray and Alternative Medicine,2016,2016(3):1-11.
[31] LIU Z Q,JIANG Z H,CHAN K,et al.Pharmacokineticinteraction of paeoniflorin and sinomenine:pharmacoki-netic parameters and tissue distribution characteristicsin rats and protein binding ability in vitro[J]. J Phar-macol Sci,2005,99(4):381-391.