新型氰化物中毒解毒剂二甲基三硫研究进展
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摘要
<正>氰化物是一种常见的化工原料,在工农业生产中均有应用,亦是公认的剧毒化合物。由于氰化物中毒具有突发性、高致死以及进展快速等特点,为了应对意外氰化物暴露事件的发生,大量针对性的研究从未停止,包括氰化物中毒事故的发生模式[1]、应急医学诊治措施[2-3]、中毒病人的护理管理[4-5]、应急检测技术[6]、给药途径[7]以及特效药物开发等,其中抗氰药物的研发一直是应对职业中毒、火灾以及化学恐怖事件的研究重点[8-14],现有研究发现传统的抗氰药
引文
[1] 陈月, 李春晨. 基于事故树分析方法的氰化物中毒事故模式研究[J]. 辽宁化工, 2016,(7):863-864.
[2] World Health Organization. Interim guidance document,Initial clinical management of chemically contaminated patients[EB/OL].(2013-02-13)[2014-10-24] http://www.who.int/environmental_health_emergencies/deliberate_events/Initial_Management_of_Contaminated_Patients.pdf?ua=1.
[3] 冯晓妍, 吴敏. 突发氰化物灾害性事故临床医学救援对策[J]. 西部中医药, 2014, 27(9):63-65.
[4] 杜菊媛. 4例急性氰化物中毒患者的护理[J]. 护理学报, 2013,19(22):54-55.
[5] 刘敏晓, 周国花, 王怡红,等. 急性氰化物中毒的气道管理[J]. 中华劳动卫生职业病杂志, 2010,28(2):152-153.
[6] 徐虹, 宋寅生, 曹文婷,等. 氰化物中毒应急检测方法的研究[J]. 中国卫生检验杂志, 2015,25(11):1705-1707.
[7] Nagasawa HT, Goon DJ, Crankshaw DL, et al. Novel, orally effective cyanide antidotes[J]. J Med Chem, 2007, 50(26):6462-6464.
[8] Weger NP. Treatment of cyanide poisoning with 4-dimethylaminophenol (DMAP)—Experimental and clinical overview[J]. Fundam Appl Toxicol, 1983, 3(5):387-396.
[9] 梁庆久, 王翠华. 高锰酸钾静脉注射治疗氰化物中毒的研究[J]. 河北科技师范学院学报, 1988,2(1):13-15.
[10] Tulsawani R, Kumar D, Bhattacharya R. Effect of pre-treatment of α-ketoglutarate on cyanide-induced toxicity and alterations in various physiological variables in rodents[J]. Biomed Environ Sci, 2007, 20(1):56-63.
[11] Lavon O, Bentur Y. Does amyl nitrite have a role in the management of pre-hospital mass casualty cyanide poisoning?[J]. Clin Toxicol, 2010, 48(6):477.
[12] Reade MC, Davies SR, Morley PT, et al. Review article: management of cyanide poisoning[J]. Emerg Med Australas, 2012, 24(3):225-238.
[13] 邹仲敏, 程晋, 叶枫,等. 美国氰化物中毒救治药物研发项目及其进展[J]. 军事医学, 2012, 36(6):465-470.
[14] 周文霞, 刘港, 张永祥. 化学威胁的医学对抗:抗毒药物研究现状和进展[J]. 中国药理学与毒理学杂志, 2016, 30(12):1411-1418.
[15] Petrikovics I, Budai M, Kovacs K, et al. Past, present and future of cyanide antagonism research: From the early remedies to the current therapies[J]. World J Methodol, 2015, 5(2):88-100.
[16] 左晨艳, 杨波波, 吴婷,等. 氰化物中毒及解毒的研究进展[J]. 毒理学杂志, 2016,30(4):311-316.
[17] Petrikovics I, Kovacs K. Formulations of dimethyl trisulfide for use as a cyanide antidote, WO/2015/157750[P]. 2015.
[18] 盛华刚. 薤白的化学成分和药理作用研究进展[J]. 药学研究, 2013, 32(1):42-44.
[19] 王鸿梅, 冯静. 韭菜挥发油中化学成分的研究[J]. 天津医科大学学报, 2002, 8(2):191-192.
[20] Sreekumar R, Al-Attabi Z, Deeth HC, et al. Volatile sulfur compounds produced by probiotic bacteria in the presence of cysteine or methionine[J]. Lett Appl Microbiol, 2010, 48(6):777-782.
[21] Rockwood GA, Thompson DE, Petrikovics I. Dimethyl trisulfide: A novel cyanide countermeasure[J].Toxicol Ind Health, 2016, 32(12):2009.
[22] Kovacs K, Duke AC, Shifflet M, et al. Parenteral dosage form development and testing of dimethyl trisulfide, as an antidote candidate to combat cyanide intoxication[J]. Pharm Dev Technol, 2017, 22(8):1-6.
[23] Bartling CM, Andre JC, Howland CA, et al. Stability characterization of a polysorbate 80-dimethyl trisulfide formulation, a cyanide antidote candidate[J]. Drugs RD, 2016, 16(1):109-127.
[24] Kovacs K, Jayanna PK, Duke A, et al. A lipid base formulation for intramuscular administration of a novel sulfur donor for cyanide antagonism[J]. Curr Drug Deliv, 2016, 13(8):1351-1357.
[25] Deleon SM, Downey JD, Hildenberger DM, et al. DMTS is an effective treatment in both inhalation and injection models for cyanide poisoning using unanesthetized mice[J]. Clin Toxicol, 2017, 56(5):1-10.
[26] Silva DD, Lee S, Duke A, et al. Intravascular residence time determination for the cyanide antidote dimethyl trisulfide in rat by using liquid-liquid extraction coupled with high performance liquid chromatography[J]. J Anal Methods Chem,2016,2016(2):1-6.
[27] Kiss L, Bocsik A, Walter FR, et al. In vitro and in vivo blood-brain barrier penetration studies with the novel cyanide antidote candidate dimethyl trisulfide in mice[J]. Toxicol Sci, 2017, 160(2):398-407.
[28] Manandhar E, Maslamani N, Petrikovics I, et al. Determination of dimethyl trisulfide in rabbit blood using stir bar sorptive extraction gas chromatography-mass spectrometry[J]. J Chromatogr A, 2016, 1461:10-17.
[29] Kiss L, Holmes S, Chou CE, et al. Method development for detecting the novel cyanide antidote dimethyl trisulfide from blood and brain, and its interaction with blood[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1044-1045:149-157.
[30] Dong X, Kiss L, Petrikovics I, et al. Reaction of dimethyl trisulfide with hemoglobin[J]. Chem Res Toxicol, 2017, 30(9):1661-1663.
[31] Hall RL. Recent progress in the consideration of flavoring ingredients under the Food Additives Amendment[J].Food Technal, 1960,14(10):488-495.
[2] World Health Organization. Interim guidance document,Initial clinical management of chemically contaminated patients[EB/OL].(2013-02-13)[2014-10-24] http://www.who.int/environmental_health_emergencies/deliberate_events/Initial_Management_of_Contaminated_Patients.pdf?ua=1.
[3] 冯晓妍, 吴敏. 突发氰化物灾害性事故临床医学救援对策[J]. 西部中医药, 2014, 27(9):63-65.
[4] 杜菊媛. 4例急性氰化物中毒患者的护理[J]. 护理学报, 2013,19(22):54-55.
[5] 刘敏晓, 周国花, 王怡红,等. 急性氰化物中毒的气道管理[J]. 中华劳动卫生职业病杂志, 2010,28(2):152-153.
[6] 徐虹, 宋寅生, 曹文婷,等. 氰化物中毒应急检测方法的研究[J]. 中国卫生检验杂志, 2015,25(11):1705-1707.
[7] Nagasawa HT, Goon DJ, Crankshaw DL, et al. Novel, orally effective cyanide antidotes[J]. J Med Chem, 2007, 50(26):6462-6464.
[8] Weger NP. Treatment of cyanide poisoning with 4-dimethylaminophenol (DMAP)—Experimental and clinical overview[J]. Fundam Appl Toxicol, 1983, 3(5):387-396.
[9] 梁庆久, 王翠华. 高锰酸钾静脉注射治疗氰化物中毒的研究[J]. 河北科技师范学院学报, 1988,2(1):13-15.
[10] Tulsawani R, Kumar D, Bhattacharya R. Effect of pre-treatment of α-ketoglutarate on cyanide-induced toxicity and alterations in various physiological variables in rodents[J]. Biomed Environ Sci, 2007, 20(1):56-63.
[11] Lavon O, Bentur Y. Does amyl nitrite have a role in the management of pre-hospital mass casualty cyanide poisoning?[J]. Clin Toxicol, 2010, 48(6):477.
[12] Reade MC, Davies SR, Morley PT, et al. Review article: management of cyanide poisoning[J]. Emerg Med Australas, 2012, 24(3):225-238.
[13] 邹仲敏, 程晋, 叶枫,等. 美国氰化物中毒救治药物研发项目及其进展[J]. 军事医学, 2012, 36(6):465-470.
[14] 周文霞, 刘港, 张永祥. 化学威胁的医学对抗:抗毒药物研究现状和进展[J]. 中国药理学与毒理学杂志, 2016, 30(12):1411-1418.
[15] Petrikovics I, Budai M, Kovacs K, et al. Past, present and future of cyanide antagonism research: From the early remedies to the current therapies[J]. World J Methodol, 2015, 5(2):88-100.
[16] 左晨艳, 杨波波, 吴婷,等. 氰化物中毒及解毒的研究进展[J]. 毒理学杂志, 2016,30(4):311-316.
[17] Petrikovics I, Kovacs K. Formulations of dimethyl trisulfide for use as a cyanide antidote, WO/2015/157750[P]. 2015.
[18] 盛华刚. 薤白的化学成分和药理作用研究进展[J]. 药学研究, 2013, 32(1):42-44.
[19] 王鸿梅, 冯静. 韭菜挥发油中化学成分的研究[J]. 天津医科大学学报, 2002, 8(2):191-192.
[20] Sreekumar R, Al-Attabi Z, Deeth HC, et al. Volatile sulfur compounds produced by probiotic bacteria in the presence of cysteine or methionine[J]. Lett Appl Microbiol, 2010, 48(6):777-782.
[21] Rockwood GA, Thompson DE, Petrikovics I. Dimethyl trisulfide: A novel cyanide countermeasure[J].Toxicol Ind Health, 2016, 32(12):2009.
[22] Kovacs K, Duke AC, Shifflet M, et al. Parenteral dosage form development and testing of dimethyl trisulfide, as an antidote candidate to combat cyanide intoxication[J]. Pharm Dev Technol, 2017, 22(8):1-6.
[23] Bartling CM, Andre JC, Howland CA, et al. Stability characterization of a polysorbate 80-dimethyl trisulfide formulation, a cyanide antidote candidate[J]. Drugs RD, 2016, 16(1):109-127.
[24] Kovacs K, Jayanna PK, Duke A, et al. A lipid base formulation for intramuscular administration of a novel sulfur donor for cyanide antagonism[J]. Curr Drug Deliv, 2016, 13(8):1351-1357.
[25] Deleon SM, Downey JD, Hildenberger DM, et al. DMTS is an effective treatment in both inhalation and injection models for cyanide poisoning using unanesthetized mice[J]. Clin Toxicol, 2017, 56(5):1-10.
[26] Silva DD, Lee S, Duke A, et al. Intravascular residence time determination for the cyanide antidote dimethyl trisulfide in rat by using liquid-liquid extraction coupled with high performance liquid chromatography[J]. J Anal Methods Chem,2016,2016(2):1-6.
[27] Kiss L, Bocsik A, Walter FR, et al. In vitro and in vivo blood-brain barrier penetration studies with the novel cyanide antidote candidate dimethyl trisulfide in mice[J]. Toxicol Sci, 2017, 160(2):398-407.
[28] Manandhar E, Maslamani N, Petrikovics I, et al. Determination of dimethyl trisulfide in rabbit blood using stir bar sorptive extraction gas chromatography-mass spectrometry[J]. J Chromatogr A, 2016, 1461:10-17.
[29] Kiss L, Holmes S, Chou CE, et al. Method development for detecting the novel cyanide antidote dimethyl trisulfide from blood and brain, and its interaction with blood[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1044-1045:149-157.
[30] Dong X, Kiss L, Petrikovics I, et al. Reaction of dimethyl trisulfide with hemoglobin[J]. Chem Res Toxicol, 2017, 30(9):1661-1663.
[31] Hall RL. Recent progress in the consideration of flavoring ingredients under the Food Additives Amendment[J].Food Technal, 1960,14(10):488-495.