蛋白电泳联合免疫球蛋白检测对慢性肾脏疾病的诊断价值
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摘要
目的探讨血清蛋白电泳及血清、尿液免疫球蛋白检测对慢性肾脏疾病的诊断价值。方法选取2015年12月至2017年12月就诊与我院肾脏内科的98例慢性肾脏疾病患者,及同期其他科室102例非肾脏疾病患者,进行血清蛋白电泳、血清免疫球蛋白G(Imunoglobulin G,IgG)、血清免疫球蛋白A(Immunoglobulin A,IgA)、血清免疫球蛋白M(Immunoglobulin M,IgM)及尿液白蛋白(albumin, Alb)、尿液IgG、尿液α1微球蛋白(α1-Microglobulin,α1M)测定。结果慢性肾脏疾病组在血清蛋白电泳α1带、α2带、β带、检测结果明显高于非肾脏疾病组(P <0.05),γ带检测结果明显低于非肾脏疾病组(P <0.05),慢性肾脏疾病组血清中IgG的检测结果明显低于非肾脏疾病组(P <0. 01),慢性肾脏疾病组尿液中微量蛋白的检测结果均明显高于非肾脏疾病组(P <0.01),血清蛋白电泳中白蛋白带与血清及尿液中免疫球蛋白IgG含量存在一定的负相关性。结论血清蛋白电泳联合血清、尿液免疫球蛋白检测对慢性肾脏疾病的诊断有重要的临床意义。
Objective To explore the diagnostic value of serum protein electrophoresis,serum immunoglobulin and urine immunoglobulin detection in kidney disease. Methods 98 patients and 102 healthy person were recruited in the study and the serum protein electrophoresis test was conducted, also the serum and urine immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM)were measured. Results In the renal disease group, the densities of band al, α2 and β were significantly higher while band γ were significantly lower,and the IgG band of serum immunoglobulin were higher than the control group(P <0.05). The serum IgG and urine microprotein were significantly lower than the control group(P < 0. 01).There was a negative correlation between the band A of serum protein electrophoresis and the IgG level of immunoglobulin detection. Conclusion The protein electrophoresis combined with immunoglobulin detection have a significant diagnostic value in the renal disease.
Objective To explore the diagnostic value of serum protein electrophoresis,serum immunoglobulin and urine immunoglobulin detection in kidney disease. Methods 98 patients and 102 healthy person were recruited in the study and the serum protein electrophoresis test was conducted, also the serum and urine immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM)were measured. Results In the renal disease group, the densities of band al, α2 and β were significantly higher while band γ were significantly lower,and the IgG band of serum immunoglobulin were higher than the control group(P <0.05). The serum IgG and urine microprotein were significantly lower than the control group(P < 0. 01).There was a negative correlation between the band A of serum protein electrophoresis and the IgG level of immunoglobulin detection. Conclusion The protein electrophoresis combined with immunoglobulin detection have a significant diagnostic value in the renal disease.
引文
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[8]韩文涛.肾脏疾病患者采用生化免疫检查的临床效果分析[J].黑龙江医药,2017,30(1):142-144.
[9] HILL N R,FATOBA S T, OKE J L, et al. Global prevalence of chronic kidney disease-a systematic review and meta-analysis[J].PLoS One,2016,11(7):e0158765.
[10] KOMENDA P, FERGUSON T W, MACDONALD K, et al. Costeffectiveness of primary screening for CKD:a systematic review[J].Am J Kidney Dis,2014,63:789-797.
[2] JHA V, GARCIA-GARCIA G, ISEKI K, et al. Chronic kidney disease:global dimension and perspectives[J]. Lancet,2013,382(9888):260-272.
[3]鲁鸿昊,刘玉兰,董振南,等.血清同型半胱氨酸及相关指标在肾脏疾病中的临床应用价值[J].标记免疫分析与临床,2013,20(2):79-81.
[4] LANTINGA M A,DRENTH J P, GEVERS T J, et al. Diagnostic criteria in renal and hepatic cyst infection[J]. Nephrol Dial Transplant,2015,30(5):744-751.
[5]姜柏庆.尿微量白蛋白检测在肾脏疾病早期诊断中的价值[J].世界最新医学信息文摘,2017,17(85):143-146.
[6] WOUTERS 0 J, 0'DONOGHUE D J, RITCHIE J, et al. Early chronic kidney disease:diagnosis, management and models of care[J].Nat Rev Nephrol,2015,11(8);491-502.
[7]曾秀雅,陈海明,王燕凤,等.四项指标联合检测在肾脏疾病早期诊断中的应用[J].中国卫生标准管理,2017,8(23):119-122.
[8]韩文涛.肾脏疾病患者采用生化免疫检查的临床效果分析[J].黑龙江医药,2017,30(1):142-144.
[9] HILL N R,FATOBA S T, OKE J L, et al. Global prevalence of chronic kidney disease-a systematic review and meta-analysis[J].PLoS One,2016,11(7):e0158765.
[10] KOMENDA P, FERGUSON T W, MACDONALD K, et al. Costeffectiveness of primary screening for CKD:a systematic review[J].Am J Kidney Dis,2014,63:789-797.