FGF5在绒山羊毛囊发育研究中的应用进展
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摘要
成纤维生长因子5(FGF5)是羊毛抑制生长基因,主要调控毛囊周期性发育,在毛囊的生长过程中均有表达。在鼠、兔、猫和狗等其他动物的研究中均表明FGF5与毛被的长短有关。探索FGF5基因在绒山羊品种改良和分子育种方面的作用已成为研究热点。有研究证实FGF5是抑制毛发生长和体内诱导退行期毛囊分泌的信号蛋白,因此敲除FGF5能促进绒山羊绒的生长,增加绒产量和提高绒品质。文章主要对近年来FGF5基因在绒山羊毛囊生长发育中的最新研究进行综述和展望。
Fibroblast growth factor 5( FGF5) is a growth inhibitory gene of wool. It is expressed continuously during the growth of hair follicle and regulates the periodical development of hair follicle. The studies of mice,rabbits,cats,dogs and other animals have shown that the function of FGF5 is related to the length of hair. It has become a hot research topic to explore the role of FGF5 gene in the species improvement and molecular breeding of cashmere goat. Some studies have confirmed that FGF5 is a signaling protein that inhibits hair growth and induces hair follicle secretion in vivo in catagen phase. Therefore,the cashmere growth,yield and quality can be increased by knocking out FGF5. In this paper,the recent research progress of FGF5 gene in hair follicle growth and development of cashmere goats is reviewed and prospected.
Fibroblast growth factor 5( FGF5) is a growth inhibitory gene of wool. It is expressed continuously during the growth of hair follicle and regulates the periodical development of hair follicle. The studies of mice,rabbits,cats,dogs and other animals have shown that the function of FGF5 is related to the length of hair. It has become a hot research topic to explore the role of FGF5 gene in the species improvement and molecular breeding of cashmere goat. Some studies have confirmed that FGF5 is a signaling protein that inhibits hair growth and induces hair follicle secretion in vivo in catagen phase. Therefore,the cashmere growth,yield and quality can be increased by knocking out FGF5. In this paper,the recent research progress of FGF5 gene in hair follicle growth and development of cashmere goats is reviewed and prospected.
引文
[1]ORNITZ D M,ITOH N.Fibroblast growth factors[J].Genome Biol,2001,2(3):1.
[2]POWERS C J,MCLESKEY S W,WELLSTEIN A.Fibroblast growth factors,their receptors and signaling[J].Endocr Relat Cancer,2000,7(3):165-197.
[3]谭亚清,刘德虎.人酸性成纤维细胞生长因子的研究进展[J].生物技术通报,2013,29(5):22-27.
[4]SOULET L,CHEVET E,LEMAITRE G,et al.FGFs and their receptors,in vitro and in vivo studies:new FGF receptor in the brain,FGF-1 in muscle,and the use of functional analogues of low-affinity heparin-binding growth factor receptors in tissue repair[J].Mol Reprod Dev,1994,39(1):49-54.
[5]ITOH N,ORNITZ D M.Evolution of the Fgf and Fgfr gene families[J].Trends Genet,2004,20(11):563-569.
[6]ZHAN X,CULPEPPER A,REDDY M,et al.Human oncogenes detected by a defined medium culture assay[J].Oncocene,1987,1(4):369-376.
[7]韩萨茹拉,高爱琴,李金泉,等.成纤维细胞生长因子(FGF)研究进展[J].安徽农业科学,2009,37(7):3008-3010.
[8]李金泉,尹俊等.绒山羊绒毛生长调控机理研究进展[J].中国食草动物,2001,3(3):41-43.
[9]何永新.太行黑山羊FGF5基因CDs区的克隆、序列特征及其表达规律研究[D].杨凌:西北农林科技大学,2010.
[10]HARMON C S,NEVINS T D.Hair fibre production by human hair follicles in whole-organ culture[J].Br J Dermatol,1994,130(4):415-423
[11]PAUS R,COTSARELIS G.The biology of hair follicles[J].N Engl J Med,1999,341(7):491-497.
[12]MOORE G P,DU CROS D L,ISAACS K,et al.Hair growth induction:roles of growth factors[J].Ann N Y Acad Sci,1991,642(1):308-325.
[13]马馨,陈洋,姜怀志.哺乳动物毛囊结构特征及调控机制[J].中国草食动物科学,2013,33(1):53-56
[14]KRUGLUGER W,ROHRBACHER W,LACIAK K,et al.Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells[J].Exp Dermatol,2005,14(8):580-585.
[15]GAT U,DASGUPTA R,DEGENSTEIN L,et al.De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin[J].Cell,1998,95(5):605-614.
[16]HEBERT J M,ROSENQUIST T,GOTZ J,et al.FGF5 as a regulator of the hair growth cycle:evidence from targeted and spontaneous mutations[J].Cell,1994,78(6):1017-1025.
[17]SUZUKI S,KATO T,TAKIMOTO H,et al.Localization of rat FGF-5 protein in skin macrophage-like cells and FGF-5S protein in hair follicle:possible involvement of two Fgf-5 gene products in hair growth cycle regulation[J].J Invest Dermatol,1998,111(6):963-972.
[18]ITO C,SAITOH Y,FUJITA Y,et al.Decapeptide with fibroblast growth factor(FGF)-5 partial sequence inhibits hair growth suppressing activity of FGF-5[J].J Cell Physiol,2003,197(2):272-283.
[19]高爱琴.成纤维细胞生长因子5(FGF5)基因c DNA克隆及在不同品种绵羊和山羊中的多态性研究[D].呼和浩特:内蒙古农业大学,2005.
[20]HOUSLEYD J,VENTA P J.The long and the short of it:evidence that FGF5 is a major determinant of canine“hair”-itability[J].Anim Genet,2006,37(4):309-315.
[21]DROGEMULLER C,RUFENACHT S,WICHERT B,et al.Mutations within the FGF5 gene are associated with hair length in cats[J].Anim Genet,2007,38(3):218-221.
[22]李春笑,蒋美山,陈仕毅,等.兔成纤维细胞生长因子5(FGF5)基因SNP及其与产毛量的相关分析[J].遗传,2008,30(7):893-899.
[23]梁东.FGF5基因对水貂毛长性状的影响研究[D].北京:中国农业科学院,2011.
[24]HE X L,YUAN C,CHEN Y L.Isolation,characterization,and expression analysis of FGF5 isoforms in cashmere goat[J].Small Ruminant Res,2014,116(2/3):111-117.
[25]王丙萍.靶除FGF5基因体细胞克隆绒山羊的研究[D].呼和浩特:内蒙古农业大学,2014.
[26]WANG T,ZHANG Y,WANG H D,et al.Alpaca fiber growth is mediated by microRNA let-7b via down-regulation of target gene FGF5[J].Genet Mol Res,2015,14(4):13754-13763.
[2]POWERS C J,MCLESKEY S W,WELLSTEIN A.Fibroblast growth factors,their receptors and signaling[J].Endocr Relat Cancer,2000,7(3):165-197.
[3]谭亚清,刘德虎.人酸性成纤维细胞生长因子的研究进展[J].生物技术通报,2013,29(5):22-27.
[4]SOULET L,CHEVET E,LEMAITRE G,et al.FGFs and their receptors,in vitro and in vivo studies:new FGF receptor in the brain,FGF-1 in muscle,and the use of functional analogues of low-affinity heparin-binding growth factor receptors in tissue repair[J].Mol Reprod Dev,1994,39(1):49-54.
[5]ITOH N,ORNITZ D M.Evolution of the Fgf and Fgfr gene families[J].Trends Genet,2004,20(11):563-569.
[6]ZHAN X,CULPEPPER A,REDDY M,et al.Human oncogenes detected by a defined medium culture assay[J].Oncocene,1987,1(4):369-376.
[7]韩萨茹拉,高爱琴,李金泉,等.成纤维细胞生长因子(FGF)研究进展[J].安徽农业科学,2009,37(7):3008-3010.
[8]李金泉,尹俊等.绒山羊绒毛生长调控机理研究进展[J].中国食草动物,2001,3(3):41-43.
[9]何永新.太行黑山羊FGF5基因CDs区的克隆、序列特征及其表达规律研究[D].杨凌:西北农林科技大学,2010.
[10]HARMON C S,NEVINS T D.Hair fibre production by human hair follicles in whole-organ culture[J].Br J Dermatol,1994,130(4):415-423
[11]PAUS R,COTSARELIS G.The biology of hair follicles[J].N Engl J Med,1999,341(7):491-497.
[12]MOORE G P,DU CROS D L,ISAACS K,et al.Hair growth induction:roles of growth factors[J].Ann N Y Acad Sci,1991,642(1):308-325.
[13]马馨,陈洋,姜怀志.哺乳动物毛囊结构特征及调控机制[J].中国草食动物科学,2013,33(1):53-56
[14]KRUGLUGER W,ROHRBACHER W,LACIAK K,et al.Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells[J].Exp Dermatol,2005,14(8):580-585.
[15]GAT U,DASGUPTA R,DEGENSTEIN L,et al.De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin[J].Cell,1998,95(5):605-614.
[16]HEBERT J M,ROSENQUIST T,GOTZ J,et al.FGF5 as a regulator of the hair growth cycle:evidence from targeted and spontaneous mutations[J].Cell,1994,78(6):1017-1025.
[17]SUZUKI S,KATO T,TAKIMOTO H,et al.Localization of rat FGF-5 protein in skin macrophage-like cells and FGF-5S protein in hair follicle:possible involvement of two Fgf-5 gene products in hair growth cycle regulation[J].J Invest Dermatol,1998,111(6):963-972.
[18]ITO C,SAITOH Y,FUJITA Y,et al.Decapeptide with fibroblast growth factor(FGF)-5 partial sequence inhibits hair growth suppressing activity of FGF-5[J].J Cell Physiol,2003,197(2):272-283.
[19]高爱琴.成纤维细胞生长因子5(FGF5)基因c DNA克隆及在不同品种绵羊和山羊中的多态性研究[D].呼和浩特:内蒙古农业大学,2005.
[20]HOUSLEYD J,VENTA P J.The long and the short of it:evidence that FGF5 is a major determinant of canine“hair”-itability[J].Anim Genet,2006,37(4):309-315.
[21]DROGEMULLER C,RUFENACHT S,WICHERT B,et al.Mutations within the FGF5 gene are associated with hair length in cats[J].Anim Genet,2007,38(3):218-221.
[22]李春笑,蒋美山,陈仕毅,等.兔成纤维细胞生长因子5(FGF5)基因SNP及其与产毛量的相关分析[J].遗传,2008,30(7):893-899.
[23]梁东.FGF5基因对水貂毛长性状的影响研究[D].北京:中国农业科学院,2011.
[24]HE X L,YUAN C,CHEN Y L.Isolation,characterization,and expression analysis of FGF5 isoforms in cashmere goat[J].Small Ruminant Res,2014,116(2/3):111-117.
[25]王丙萍.靶除FGF5基因体细胞克隆绒山羊的研究[D].呼和浩特:内蒙古农业大学,2014.
[26]WANG T,ZHANG Y,WANG H D,et al.Alpaca fiber growth is mediated by microRNA let-7b via down-regulation of target gene FGF5[J].Genet Mol Res,2015,14(4):13754-13763.