丙硫氧嘧啶对老年甲状腺功能亢进病人临床症状的改善作用
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摘要
目的探讨丙硫氧嘧啶治疗老年甲状腺功能亢进病人的临床疗效,并研究其对改善病人生活质量的影响。方法选取2014年5月至2016年5月我院临床确诊后进行治疗的老年甲状腺功能亢进病人102例,采用随机数字表法分成2组,每组51例。对照组给予甲巯咪唑进行治疗,观察组应用丙硫氧嘧啶进行治疗。比较2组症状改善情况、生活质量、甲状腺功能以及不良反应情况。结果治疗后观察组心悸、多汗、多食、体质量减轻、心理健康和躯体健康评分均明显优于对照组,差异有统计学意义(P<0.05)。观察组治疗后游离三碘甲状腺原氨酸(FT3)、促甲状腺素受体抗体(TRAb)水平与对照组比较,差异无统计学意义(P>0.05)。2组不良反应比较,差异无统计学意义(P>0.05)。结论采用丙硫氧嘧啶治疗老年甲状腺功能亢进病人,能够较好地改善老年病人的症状,提高病人生活质量。
Objective To explore the clinical efficacy of propylthiouracil in the treatment of elderly patients with hyperthyroidism,and to assess its effect on the improvement of quality of life.Methods A total of 102 elderly patients with hyperthyroidism who were diagnosed and treated in our hospital from May 2014 to May 2016 were selected and randomly divided into two groups,with 51 cases in each group. The patients in the control group were given methimazole,and the patients in the observation group were given propylthiouracil. The clinical symptoms,scores of quality of life,thyroid function and adverse reactions were observed and compared between the two groups. Results The scores of palpitation,hyperidrosis,hyperphagia,weight loss,mental health and physical health in the observation group after treatment were more significantly improved than those in the control group( P<0. 05). There were no significant differences in the levels of FT3 and TRAb between the two groups after treatment( P<0. 05).There was no significant difference in the incidence rate of adverse reactions between two groups( P> 0. 05). Conclusions The application of propylthiouracil in the treatment of elderly patients with hyperthyroidism can significantly improve the symptoms and quality of life.
Objective To explore the clinical efficacy of propylthiouracil in the treatment of elderly patients with hyperthyroidism,and to assess its effect on the improvement of quality of life.Methods A total of 102 elderly patients with hyperthyroidism who were diagnosed and treated in our hospital from May 2014 to May 2016 were selected and randomly divided into two groups,with 51 cases in each group. The patients in the control group were given methimazole,and the patients in the observation group were given propylthiouracil. The clinical symptoms,scores of quality of life,thyroid function and adverse reactions were observed and compared between the two groups. Results The scores of palpitation,hyperidrosis,hyperphagia,weight loss,mental health and physical health in the observation group after treatment were more significantly improved than those in the control group( P<0. 05). There were no significant differences in the levels of FT3 and TRAb between the two groups after treatment( P<0. 05).There was no significant difference in the incidence rate of adverse reactions between two groups( P> 0. 05). Conclusions The application of propylthiouracil in the treatment of elderly patients with hyperthyroidism can significantly improve the symptoms and quality of life.
引文
[1]南海燕,张桂玲,刘涛,等.丙硫氧嘧啶联合中医辨证治疗甲状腺功能亢进症临床观察[J].河北医药,2015,37(9):1358-1360.
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[3]Kartamihardja AH,Massora S.The influence of antithyroid drug discontinuation to the therapeutic efficacy of(131)I in Hyperthyroidism[J].World J Nucl Med,2016,15(2):81-84.
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[5]张秋生,喻美玲.丙硫氧嘧啶联合不同剂量普萘洛尔治疗甲状腺功能亢进症合并心房纤颤的临床疗效观察[J].实用心脑肺血管病杂志,2015,23(4):72-74.
[6]祖桂君,戚霁,贾岩,等.中西结合治疗甲状腺功能亢进症的临床效果及预防复发的研究[J].四川中医,2015,33(3):67-69.
[7]Muthukumar S,Sadacharan D,Ravikumar K,et al.A prospective study on cardiovascular dysfunction in patients with hyperthyroidism and its reversal after surgical cure[J].World J Surg,2016,40(3):622-628.
[8]刘健彤,赵景深.甲状腺功能亢进症的临床药物应用[J].中国地方病防治杂志,2016,31(3):356.
[9]梁绮婷.柴胡栀子汤治疗甲状腺功能亢进症的临床疗效观察[J].四川中医,2017,35(5):128-131.
[10]Listewnik MH,Listewnik MJ,Miazgowski T,et al.Thyroid peroxidase antibodies in non-autoimmune hyperthyroidism treated with radioactive iodine[J].Exp Clin Endocrinol Diabetes,2016,124(9):572-576.
[2]陈娟,张立清,于晶峰.逍遥散合六君子汤联合丙硫氧嘧啶对甲状腺功能亢进的影响[J].中医药导报,2016,22(14):91-93.
[3]Kartamihardja AH,Massora S.The influence of antithyroid drug discontinuation to the therapeutic efficacy of(131)I in Hyperthyroidism[J].World J Nucl Med,2016,15(2):81-84.
[4]王叶菊,曹小清,李翊嘉.甲硫咪唑和丙基硫氧嘧啶治疗老年甲状腺功能亢进疗效比较[J].实用老年医学,2016,30(9):749-751.
[5]张秋生,喻美玲.丙硫氧嘧啶联合不同剂量普萘洛尔治疗甲状腺功能亢进症合并心房纤颤的临床疗效观察[J].实用心脑肺血管病杂志,2015,23(4):72-74.
[6]祖桂君,戚霁,贾岩,等.中西结合治疗甲状腺功能亢进症的临床效果及预防复发的研究[J].四川中医,2015,33(3):67-69.
[7]Muthukumar S,Sadacharan D,Ravikumar K,et al.A prospective study on cardiovascular dysfunction in patients with hyperthyroidism and its reversal after surgical cure[J].World J Surg,2016,40(3):622-628.
[8]刘健彤,赵景深.甲状腺功能亢进症的临床药物应用[J].中国地方病防治杂志,2016,31(3):356.
[9]梁绮婷.柴胡栀子汤治疗甲状腺功能亢进症的临床疗效观察[J].四川中医,2017,35(5):128-131.
[10]Listewnik MH,Listewnik MJ,Miazgowski T,et al.Thyroid peroxidase antibodies in non-autoimmune hyperthyroidism treated with radioactive iodine[J].Exp Clin Endocrinol Diabetes,2016,124(9):572-576.