甲状腺癌患者血清TNF-α、IL-17水平与疾病状态及患者生活质量的相关性研究
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摘要
目的探讨甲状腺癌患者血清肿瘤坏死因子-α(TNF-α)和白细胞介素-17(IL-17)水平与疾病病理状态及患者生活质量的关系。方法选取90例甲状腺癌患者,利用酶联免疫吸附方法(ELISA)检测血清TNF-α和IL-17水平,比较不同病理条件下的水平差异。采用肿瘤患者生活质量评分(QOL)标准对患者进行评分,探讨患者TNF-α和IL-17水平与其生活质量及肿瘤预后的关系。结果甲状腺癌淋巴结转移患者TNF-α和IL-17水平均显著增高,二者水平随着TNM分期的增高或细胞分化程度的降低亦均显著升高;患者QOL数值与其血清中TNF-α和IL-17水平均呈负相关;TNM分期、TNF-α和IL-17血清水平是疾病预后不良的独立危险因素。结论甲状腺癌患者血清TNF-α和IL-17水平与其临床病理状态及生活质量密切相关,是该病预后不良的危险因素。
Objective To investigate the relationship between serum tumor necrosis factor-α(TNF-α)and interleukin-17(IL-17)levels and disease pathological status and quality of life in patients with thyroid cancer.Methods Ninety patients with thyroid cancer were enrolled.The levels of serum TNF-αand IL-17 were measured by enzyme-linked immunosorbent assay(ELISA),and the differences in pathological conditions were compared.Patients were scored using the Quality of Life Score(QOL)criteria for cancer patients to investigate the relationship between TNF-αand IL-17 levels and their quality of life and tumor prognosis.ResultsThe levels of TNF-αand IL-17 in lymph node metastasis of thyroid carcinoma were significantly increased.The levels of TNM and the degree of cell differentiation were significantly increased.The QOL values of patients and their serum TNF-αand IL-17 levels were negatively correlated;TNM stage,TNF-αand IL-17 serum levels were independent risk factors for poor prognosis.Conclusion The levels of serum TNF-αand IL-17 in patients with thyroid cancer are closely related to their clinicopathological status and quality of life,which is a risk factor for poor prognosis of this disease.
Objective To investigate the relationship between serum tumor necrosis factor-α(TNF-α)and interleukin-17(IL-17)levels and disease pathological status and quality of life in patients with thyroid cancer.Methods Ninety patients with thyroid cancer were enrolled.The levels of serum TNF-αand IL-17 were measured by enzyme-linked immunosorbent assay(ELISA),and the differences in pathological conditions were compared.Patients were scored using the Quality of Life Score(QOL)criteria for cancer patients to investigate the relationship between TNF-αand IL-17 levels and their quality of life and tumor prognosis.ResultsThe levels of TNF-αand IL-17 in lymph node metastasis of thyroid carcinoma were significantly increased.The levels of TNM and the degree of cell differentiation were significantly increased.The QOL values of patients and their serum TNF-αand IL-17 levels were negatively correlated;TNM stage,TNF-αand IL-17 serum levels were independent risk factors for poor prognosis.Conclusion The levels of serum TNF-αand IL-17 in patients with thyroid cancer are closely related to their clinicopathological status and quality of life,which is a risk factor for poor prognosis of this disease.
引文
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[11]胡金华,张耀晴,艾瑞华,等.分化型甲状腺癌患者血清TNF-α、IL-6和VEGF表达与侵袭转移的相关性分析[J].现代肿瘤医学,2015,23(6):771-774.
[12]MARTINEZ-REZA I,DIAZ L,GARCIA-BECERRA R.Preclinical and clinical aspects of TNF-αand its receptors TNFR1and TNFR2 in breast cancer[J].J Biomed Sci,2017,24(1):90.
[13]AMATYA N,GARG A V,GAFFEN S L.IL-17signaling:the yin and the yang[J].Trends Immunol,2017,38(5):310-322.
[14]KIM B S,PARK Y J,CHUNG Y.Targeting IL-17in autoimmunity and inflammation[J].Arch Pharm Res,2016,39(11):1537-1547.
[15]叶卫丰,贺敏,苏建荣.IL-17和IL-35在甲状腺癌患者血清中的水平及临床意义[J].临床和实验医学杂志,2015(1):32-35.
[16]刘杨,吴高松,王文斌,等.血清IL-17、IL-35及SIL-2R表达水平与甲状腺癌发生发展的关系[J].肿瘤防治研究,2016,43(9):789-791.
[17]杨迪,李璇,姚岐,等.TNF-α表达水平与甲状腺癌患者无瘤生存期的相关性分析[J].牡丹江医学院学报,2016,37(1):55-57.
[2]王征,李伟汉,张浩.老年患者甲状腺结节与甲状腺功能的相关性[J].中国老年学杂志,2013,33(21):5346-5347.
[3]熊专,孙晖,万姗,等.不同性质甲状腺结节临床特征的分析[J].华中科技大学学报:医学版,2014(4):444-448.
[4]计玉芳.甲状腺超声检查联合甲状腺功能指标在良恶性甲状腺癌中的诊断价值[J].医学临床研究,2015,32(12):2330-2333.
[5]李仁拴,李伟,苗满园,等.全腔镜甲状腺切除术治疗分化型甲状腺癌的疗效及其对患者认知功能的影响[J].广西医科大学学报,2017,34(1):103-105.
[6]章幂,章佳新.白细胞介素17、信号转导和转录激活因子3及存活蛋白基因在甲状腺乳头状癌中的研究进展[J].医学综述,2016,22(4):729-733.
[7]张毅,董剑达,季敬章,等.甲状腺癌患者血清IL-8和IL-17表达水平及其临床意义[J].中国现代医生,2015,53(32):11-13.
[8]张海涛,薛伶俐.IL-17、IL-35在甲状腺癌患者血清中的表达及临床意义[J].中国现代医生,2016,54(15):99-101.
[9]王新征,刘金彪,侯永强,等.分化型甲状腺癌组织中HSP70与TNF-α的表达及与临床病理的相关性[J].中国老年学杂志,2015(1):112-113.
[10]BECAREVIC M.TNF-alpha and annexin A2:inflammation in thrombotic primary antiphospholipid syndrome[J].Rheumatol Int,2016,36(12):1649-1656.
[11]胡金华,张耀晴,艾瑞华,等.分化型甲状腺癌患者血清TNF-α、IL-6和VEGF表达与侵袭转移的相关性分析[J].现代肿瘤医学,2015,23(6):771-774.
[12]MARTINEZ-REZA I,DIAZ L,GARCIA-BECERRA R.Preclinical and clinical aspects of TNF-αand its receptors TNFR1and TNFR2 in breast cancer[J].J Biomed Sci,2017,24(1):90.
[13]AMATYA N,GARG A V,GAFFEN S L.IL-17signaling:the yin and the yang[J].Trends Immunol,2017,38(5):310-322.
[14]KIM B S,PARK Y J,CHUNG Y.Targeting IL-17in autoimmunity and inflammation[J].Arch Pharm Res,2016,39(11):1537-1547.
[15]叶卫丰,贺敏,苏建荣.IL-17和IL-35在甲状腺癌患者血清中的水平及临床意义[J].临床和实验医学杂志,2015(1):32-35.
[16]刘杨,吴高松,王文斌,等.血清IL-17、IL-35及SIL-2R表达水平与甲状腺癌发生发展的关系[J].肿瘤防治研究,2016,43(9):789-791.
[17]杨迪,李璇,姚岐,等.TNF-α表达水平与甲状腺癌患者无瘤生存期的相关性分析[J].牡丹江医学院学报,2016,37(1):55-57.