亚临床甲状腺功能减退症对妊娠结局及新生儿甲状腺功能的影响
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摘要
目的对孕妇妊娠期合并亚临床甲状腺功能减退症(甲减)对妊娠结局以及新生儿甲状腺功能的影响进行探析。方法将2017年2月-2018年2月深圳市宝安区妇幼保健院产科收治的55例亚临床甲减孕妇纳入探究组,选取同期60例正常孕妇纳入对照组,对比分析两组妊娠结局,并掌握两组新生儿甲状腺功能情况。结果探究组剖宫产率29. 09%,对照组为8. 33%,差异有统计学意义(P <0. 05);探究组早产、胎儿窘迫、低体重胎儿等发生率均高于对照组,差异有统计学意义(P <0. 05);通过测定,两组新生儿亚临床甲减发生率、TSH水平差异均有统计学意义(P <0. 05);亚临床甲减用药孕妇的新生儿甲状腺功能减退发生率为8. 33%,低于未用药孕妇的23. 81%(P <0. 05)。结论妊娠期孕妇合并亚临床甲减会对妊娠结局和新生儿甲状腺功能造成影响,产前应密切监测孕妇病情,尽早诊疗,确保母婴安全。
Objective To investigate and analyze the effect of pregnancy outcome and thyroid function of neonates in pregnancy with subclinical hypothyroidism( hypothyroidism). Methods 55 cases pregnant women with subclinical hypothyroidism treated in our hospital February 2017-February 2018 were included in the study group. At the same time,60 cases normal pregnant women were included in the control group. The pregnancy outcomes and thyroid function of newborn were compared. Results The cesarean section rate( 29. 09%) in the study group and( 8. 33%) in the control group were statistically significant( P < 0. 05). The incidence rates of premature birth,fetal distress and low birth weight were higher in the study group than those in the control group( P < 0. 05). By measurement,the incidence rate of subclinical hypothyroidism and TSH level of neonates in both groups were different,which had statistical significance( P < 0. 05). Conclusion The subclinical hypothyroidism may have an impact on pregnancy outcome and thyroid function of newborn babies. Prenatal monitoring should be carried out to ensure the safety of mother and baby.
Objective To investigate and analyze the effect of pregnancy outcome and thyroid function of neonates in pregnancy with subclinical hypothyroidism( hypothyroidism). Methods 55 cases pregnant women with subclinical hypothyroidism treated in our hospital February 2017-February 2018 were included in the study group. At the same time,60 cases normal pregnant women were included in the control group. The pregnancy outcomes and thyroid function of newborn were compared. Results The cesarean section rate( 29. 09%) in the study group and( 8. 33%) in the control group were statistically significant( P < 0. 05). The incidence rates of premature birth,fetal distress and low birth weight were higher in the study group than those in the control group( P < 0. 05). By measurement,the incidence rate of subclinical hypothyroidism and TSH level of neonates in both groups were different,which had statistical significance( P < 0. 05). Conclusion The subclinical hypothyroidism may have an impact on pregnancy outcome and thyroid function of newborn babies. Prenatal monitoring should be carried out to ensure the safety of mother and baby.
引文
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[3] Liu Y,Chen H,Jing C,et al. The Association Between Maternal Subclinical Hypothyroidism and Growth,Development,and Childhood Intelligence:A Meta-analysis[J]. Journal of Clinical Research in Pediatric Endocrinology,2018,10(2):153-161.
[4] Kang MJ,Hwang IT,Chung HR. Excessive Iodine Intake and Subclinical Hypothyroidism in Children and Adolescents Aged 6-19 Years:Results of the Sixth Korean National Health and Nutrition Examination Survey,2013-2015[J]. Thyroid:Official Journal of the American Thyroid Association,2018,28(6):773-779.
[5]中华医学会内分泌学分会.妊娠和产后甲状腺疾病诊治指南[J].中华内分泌代谢杂志,2012,28(5):354-367.
[6] Maraka S,Singh Ospina NM,Mastorakos G,et al.Subclinical Hypothyroidism in Women Planning Conception and During Pregnancy:Who Should Be Treated and How[J]. Journal of the Endocrine Society,2018,2(6):533-546.
[7]邓彩云.亚临床甲状腺功能异常的妊娠结局和对新生儿的影响[J].中国卫生标准管理,2017,8(15):37-38.
[8]宋群英.妊娠合并甲状腺疾病对新生儿生长发育情况及甲状腺功能指标的影响[J].河北医药,2017,39(16):2493-2495,2498.
[9]刘玉芳,张晓梅,柴三葆,等.妊娠期亚临床甲状腺功能减退症对妊娠结局和后代的影响[J].中华内分泌代谢杂志,2017,33(3):269-272.
[10]魏雯,刘萍,郭海荣.妊娠期亚临床甲状腺功能减退症及TPO-Ab对妊娠结局的影响[J].中国妇幼保健,2018(5):1189-1190.
[2] Siru R,Alfonso H,Chubb SAP,et al. Subclinical?thyroid dysfunction and circulating thyroid hormones are not associated with bone turnover markers or incident hip fracture in older men[J]. Clinical Endocrinology,2018,89(1):93-99.
[3] Liu Y,Chen H,Jing C,et al. The Association Between Maternal Subclinical Hypothyroidism and Growth,Development,and Childhood Intelligence:A Meta-analysis[J]. Journal of Clinical Research in Pediatric Endocrinology,2018,10(2):153-161.
[4] Kang MJ,Hwang IT,Chung HR. Excessive Iodine Intake and Subclinical Hypothyroidism in Children and Adolescents Aged 6-19 Years:Results of the Sixth Korean National Health and Nutrition Examination Survey,2013-2015[J]. Thyroid:Official Journal of the American Thyroid Association,2018,28(6):773-779.
[5]中华医学会内分泌学分会.妊娠和产后甲状腺疾病诊治指南[J].中华内分泌代谢杂志,2012,28(5):354-367.
[6] Maraka S,Singh Ospina NM,Mastorakos G,et al.Subclinical Hypothyroidism in Women Planning Conception and During Pregnancy:Who Should Be Treated and How[J]. Journal of the Endocrine Society,2018,2(6):533-546.
[7]邓彩云.亚临床甲状腺功能异常的妊娠结局和对新生儿的影响[J].中国卫生标准管理,2017,8(15):37-38.
[8]宋群英.妊娠合并甲状腺疾病对新生儿生长发育情况及甲状腺功能指标的影响[J].河北医药,2017,39(16):2493-2495,2498.
[9]刘玉芳,张晓梅,柴三葆,等.妊娠期亚临床甲状腺功能减退症对妊娠结局和后代的影响[J].中华内分泌代谢杂志,2017,33(3):269-272.
[10]魏雯,刘萍,郭海荣.妊娠期亚临床甲状腺功能减退症及TPO-Ab对妊娠结局的影响[J].中国妇幼保健,2018(5):1189-1190.