自动滴定法与手动滴定法测定药品含量的差异性研究
摘要
目的研究分析自动滴定法与手动滴定法测定药品含量的差异。方法 2016年10月通过用自动滴定法和手动滴定法测定我所的阿司匹林、苯甲酸钠、烟酸片、维生素B6、维C银翘片、盐酸左旋咪唑、尼莫地平片、氯化钠注射液8种药品,并进行F检验和t检验分析两种滴定方法的差异性,结合RSD值的计算确定精密度。结果自动滴定法和手动滴定法测定阿司匹林、苯甲酸钠、烟酸片、维生素B6、维C银翘片、盐酸左旋咪唑、尼莫地平片、氯化钠注射液8种药品对比差异不明显,而自动滴定法测定药品的精密度和手动滴定法比较,明显较高,P<0.05,有统计学意义。结论药品含量测定应用自动滴定法精密度高,值得药品检验推广应用。
引文
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[2]卓静,张新勇,葛雪松,等.电位滴定法与手动滴定法测定富马酸亚铁肢囊含量的比较[J].中国药师,2013,16(1):151,155.
[3]Li J,Ye J,Zhang P,et al.[Comparison of different continuous positive airway pressure titration methods for obstructive sleep apnea hypopnea syndrome[J].Zhonghua er bi yan hou tou jing wai ke za zhi=Chinese journal of otorhinolaryngology head and neck surgery,2014,49(10):839-843.
[4]Grolier J P E,Rio J M D.Isothermal Titration Calorimetry:Application of the Gibbs-Duhem Equation to the Study of the Relationship Between.Forward and Reverse Titrations[J].Journal of Solution Chemistry,2015,44(5):987-1003.
[5]Her tel J,Locatelli F,Spasovski G,et al.Randomized,Double-Blind,Placebo-Controlled,Withdrawal Study of Colestilan after Dose Titration in Chronic Kidney Disease Dialysis Patients with Hyperphosphatemia[J].Nephron,2015,130(4).
[6]Soto D,Urdaneta J,Pernia K.Characterization of Native and Modified Starches by Potentiometric Titration[J].Journal of Applied Chemistry,2014,2014.