北京大学医学部中西医结合学科学术思想概述——北京大学医学部中西医结合学科发展历程
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摘要
<正>北京大学医学部中西医结合学科(下称"学科")于1956年建立,经过62年的发展,已成为集中西医结合教学、临床、研究为一体的、培养高水平研究人才的学科。学系现任主任是韩晶岩教授。一、学科沿革1956年,北京大学第一医院成立了中医科和针灸科,谢竹潘教授为学术带头人。1973年,基础部成立了中西医结合教研室,李顺成教授任教研室主任。1975年,北京大学第一医院组建了中医病房和中医研究室。1987年,基础部中西医结合教研室与北大医院中西医结合科联合成立中西医结合研究所。2000年,基础医学院的中西医结合教研室与药学院、化学院的部分科室联合成立了北京大学中医
引文
1 Li L,Pan C S,Yan L,et al.Ginsenoside Rg1 ameliorates rat myocardial ischemia-reperfusion injury by modulating energy metabolism pathways.Front Physiol,2018,9:78.
2 Cui Y C,Pan C S,Yan L,et al.Ginsenoside Rb1 protects againsischemia/reperfusion induced myocardial injury via energy metabolism regulation mediated by Rho A signaling pathway.Sci Rep,2017:7:44579.
3 Huang D D,Wei X H,Mu H N,et al.Total Salvianolic Acid Injection Prevents Ischemia/Reperfusion-Induced Myocardial Injury via Antioxidant Mechanism Involving Mitochondrial Respiratory Chain Through the Upregulation of Sirtuin1 and Sirtuin3.Shock,2018,doi:10.1097/SHK.
4 Lin S Q,Wei X H,Huang P,et al.Qi Shen Yi Qi Pills?prevents cardiac ischemia-reperfusion injury via energy modulation.Int J Cardiol,2013,168(2):967-974.
5 Cui Y C,Yan L,Pan C S,et al.The Contribution of Different Components in Qi Shen Yi Qi Pills?to Its Potential to Modulate Energy Metabolism in Protection of Ischemic Myocardial Injury.Front Physiol,2018,9:389.
6 Tu L,Pan C S,Wei X H,et al.Astragaloside IV protects heart from ischemia and reperfusion injury via energy regulation mechanism.Microcirculation,2013,20(8):736-747.
7 He K,Yan L,Pan C S,et al.ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia/reperfusion-induced myocardial injury.Am J Physiol Heart Circ Physiol,2014,307(12):H1764-1776.
8 Yang X Y,He K,Pan C S,et al.3,4-dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1αsubunit 10 to ameliorate cardiac reperfusion injury.Sci Rep,2015,5:10739.
9 Han J Y,Li Q,Ma Z Z,et al.The effects and mechanisms of compound Chinese medicine formula and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion.Pharmacol Ther,2017,177:146-173.
10 Chen Y Y,Li Q,Pan C S,et al.Qi Shen Yi Qi Pills,a compound in Chinese medicine,protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode.Sci Rep,2015,5:11802.
11 Sun H Y,Li Q,Liu Y Y,et al.Xiao-Yao-San,a Chinese medicine formula,ameliorates chronic unpredictable mild stress induced polycystic ovary in rat.Front Physiol,2017,8:729.
12 Ma L M,Pan C S,Yang N,et al.Post-treatment with Ma-Xing-Shi-Gan-Tang,a Chinese medicine formula,ameliorates lipopolysaccharideinduced lung microvessel hyperpermeability and inflammatory reaction in rat.Microcirculation,2014,21(7):649-663.
13 Li A,Dong L,Duan M L,et al.Emodin Improves Lipopolysaccharide-Induced Microcirculatory Disturbance in Rat Mesentery.Microcirculation,2013,20(7):617-628.
14 Dong L,Li A,Duan M L,et al.Paeonol improves lipopolysaccharide-induced microcirculatory disturbance in rat mesentery.World Journal of Traditional Chinese Medicine,2015,1(1):37-44.
15 Yuan Q,Liu Y Y,Sun K,et al.Improving effect of pre-treatment with Yiqifumai on LPS-induced microcirculatory disturbance in rat mesentery.Shock,2009,32(3):310-316.
16 Zhang Y P,Pan C S,Yan L,et al.Catalpol restores LPS-elicited rat microcirculation disorder by regulation of a network of signaling involving inhibition of TLR-4 and SRC.Am J Physiol Gastrointest Liver Physiol,2016,311(6):G1091-G1104.
17 Li C,Li Q,Liu Y Y,et al.Protective effects of Notoginsenoside R1 on intestinal ischemia/reperfusion injury in rats.Am J Physiol Gastrointest Liver Physiol,2014,306(2):G111-G122.
18 Mu H N,Li Q,Pan C S,et al.Caffeic Acid Attenuates Rat Liver Reperfusion Injury through Sirt3-Dependent Regulation of Mitochondrial Respiratory Chain.Free Radic Biol Med,2015,85:237-249.
19 Mu H N,Li Q,Fan J Y,et al.Caffeic acid attenuates rat liver injury after transplantation involving PDIA3-dependent regulation of NADPHoxidase.Free Radic Biol Med,2018,129:202-214.
20 Xu X S,Ma Z Z,Wang F,et al.The antioxidant cerebralcare granule?attenuates cerebral microcirculatory disturbance during ischemiareperfusion injury.Shock,2009,32(2):201-209.
21 Sun K,Hu Q,Zhou C H,et al.Cerebralcare Granule?,a Chinese herb compound preparation,improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion.J Ethnopharmacol,2010,130(2):398-406.
22 Wang F,Hu Q,Chen C H,et al.The Protective Effect of Cerebralcare Granule?on Brain Edema,Cerebral Microcirculatory Disturbance and Neuron Injury in a Focal Cerebral Ischemia Rat Model.Microcirculation,2012,19(3):260-272.
23 Huang P,Zhou C M,Hu Q,et al.Cerebralcare Granule?attenuates blood-brain barrier disruption after middle cerebral artery occlusion in rats.Exp Neurol,2012,237(2):453-463.
24 Chen Q F,Liu Y Y,Pan C S,et al.Angioedema and Hemorrhage After 4.5-Hour t PA(Tissue-Type Plasminogen Activator)Thrombolysis Ameliorated by T541 via Restoring Brain Microvascular Integrity.Stroke,2018,49(9):2211-2219.
2 Cui Y C,Pan C S,Yan L,et al.Ginsenoside Rb1 protects againsischemia/reperfusion induced myocardial injury via energy metabolism regulation mediated by Rho A signaling pathway.Sci Rep,2017:7:44579.
3 Huang D D,Wei X H,Mu H N,et al.Total Salvianolic Acid Injection Prevents Ischemia/Reperfusion-Induced Myocardial Injury via Antioxidant Mechanism Involving Mitochondrial Respiratory Chain Through the Upregulation of Sirtuin1 and Sirtuin3.Shock,2018,doi:10.1097/SHK.
4 Lin S Q,Wei X H,Huang P,et al.Qi Shen Yi Qi Pills?prevents cardiac ischemia-reperfusion injury via energy modulation.Int J Cardiol,2013,168(2):967-974.
5 Cui Y C,Yan L,Pan C S,et al.The Contribution of Different Components in Qi Shen Yi Qi Pills?to Its Potential to Modulate Energy Metabolism in Protection of Ischemic Myocardial Injury.Front Physiol,2018,9:389.
6 Tu L,Pan C S,Wei X H,et al.Astragaloside IV protects heart from ischemia and reperfusion injury via energy regulation mechanism.Microcirculation,2013,20(8):736-747.
7 He K,Yan L,Pan C S,et al.ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia/reperfusion-induced myocardial injury.Am J Physiol Heart Circ Physiol,2014,307(12):H1764-1776.
8 Yang X Y,He K,Pan C S,et al.3,4-dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1αsubunit 10 to ameliorate cardiac reperfusion injury.Sci Rep,2015,5:10739.
9 Han J Y,Li Q,Ma Z Z,et al.The effects and mechanisms of compound Chinese medicine formula and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion.Pharmacol Ther,2017,177:146-173.
10 Chen Y Y,Li Q,Pan C S,et al.Qi Shen Yi Qi Pills,a compound in Chinese medicine,protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode.Sci Rep,2015,5:11802.
11 Sun H Y,Li Q,Liu Y Y,et al.Xiao-Yao-San,a Chinese medicine formula,ameliorates chronic unpredictable mild stress induced polycystic ovary in rat.Front Physiol,2017,8:729.
12 Ma L M,Pan C S,Yang N,et al.Post-treatment with Ma-Xing-Shi-Gan-Tang,a Chinese medicine formula,ameliorates lipopolysaccharideinduced lung microvessel hyperpermeability and inflammatory reaction in rat.Microcirculation,2014,21(7):649-663.
13 Li A,Dong L,Duan M L,et al.Emodin Improves Lipopolysaccharide-Induced Microcirculatory Disturbance in Rat Mesentery.Microcirculation,2013,20(7):617-628.
14 Dong L,Li A,Duan M L,et al.Paeonol improves lipopolysaccharide-induced microcirculatory disturbance in rat mesentery.World Journal of Traditional Chinese Medicine,2015,1(1):37-44.
15 Yuan Q,Liu Y Y,Sun K,et al.Improving effect of pre-treatment with Yiqifumai on LPS-induced microcirculatory disturbance in rat mesentery.Shock,2009,32(3):310-316.
16 Zhang Y P,Pan C S,Yan L,et al.Catalpol restores LPS-elicited rat microcirculation disorder by regulation of a network of signaling involving inhibition of TLR-4 and SRC.Am J Physiol Gastrointest Liver Physiol,2016,311(6):G1091-G1104.
17 Li C,Li Q,Liu Y Y,et al.Protective effects of Notoginsenoside R1 on intestinal ischemia/reperfusion injury in rats.Am J Physiol Gastrointest Liver Physiol,2014,306(2):G111-G122.
18 Mu H N,Li Q,Pan C S,et al.Caffeic Acid Attenuates Rat Liver Reperfusion Injury through Sirt3-Dependent Regulation of Mitochondrial Respiratory Chain.Free Radic Biol Med,2015,85:237-249.
19 Mu H N,Li Q,Fan J Y,et al.Caffeic acid attenuates rat liver injury after transplantation involving PDIA3-dependent regulation of NADPHoxidase.Free Radic Biol Med,2018,129:202-214.
20 Xu X S,Ma Z Z,Wang F,et al.The antioxidant cerebralcare granule?attenuates cerebral microcirculatory disturbance during ischemiareperfusion injury.Shock,2009,32(2):201-209.
21 Sun K,Hu Q,Zhou C H,et al.Cerebralcare Granule?,a Chinese herb compound preparation,improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion.J Ethnopharmacol,2010,130(2):398-406.
22 Wang F,Hu Q,Chen C H,et al.The Protective Effect of Cerebralcare Granule?on Brain Edema,Cerebral Microcirculatory Disturbance and Neuron Injury in a Focal Cerebral Ischemia Rat Model.Microcirculation,2012,19(3):260-272.
23 Huang P,Zhou C M,Hu Q,et al.Cerebralcare Granule?attenuates blood-brain barrier disruption after middle cerebral artery occlusion in rats.Exp Neurol,2012,237(2):453-463.
24 Chen Q F,Liu Y Y,Pan C S,et al.Angioedema and Hemorrhage After 4.5-Hour t PA(Tissue-Type Plasminogen Activator)Thrombolysis Ameliorated by T541 via Restoring Brain Microvascular Integrity.Stroke,2018,49(9):2211-2219.