睡眠剥夺复合间断连续作业对静息态前扣带回功能连接的影响
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摘要
目的探讨睡眠剥夺复合间断连续作业对大脑静息态前扣带回功能连接的影响。方法 40名健康大学生参与36 h完全睡眠剥夺试验,并于睡眠剥夺期间每12 h中复合4 h连续作业任务。受试者分别于睡眠剥夺前后进行静息态功能磁共振成像扫描。以受试者双侧前扣带回作为种子点进行功能连接分析。结果在接受睡眠剥夺复合连续作业条件后,与左侧前扣带回功能连接增高的区域有左侧额中回、双侧额下回、右侧中央沟盖区、右侧颞上回等区域。与右侧前扣带回功能连接增高的区域为左侧额下回。相关分析发现睡眠剥夺后前扣带回与额叶皮质增高的连接与警觉度评分下降呈显著负相关。结论睡眠剥夺复合连续作业影响了与前扣带回相关的大脑信息交流,皮层间的功能连接增强可能是代偿反应的一种体现。
Objective To explore the effect of sleep deprivation combined with interrupted continuous operation on functional connectivity of the anterior cingulate gyrus of the resting human brain.Methods Forty healthy college students participated in the 36-hour total sleep deprivation test,and there was a 4-hour continuous task every 12 hours during sleep deprivation. Resting state functional magnetic resonance imaging( fc MRI) scanning was performed before and after sleep deprivation. Functional connectivity analysis was performed on subjects with the bilateral anterior cingulate gyrus as the seed site. Results The left frontal gyrus,bilateral lower frontal gyrus,right central sulcus cover area and right superior temporal gyrus were among the areas with increased functional connectivity of the left anterior cingulate gyrus after sleep deprivation. The area with higher functional connectivity to the right anterior cingulate cortex was the left inferior frontal gyrus.Conclusion Sleep deprivation combined with continuous operation affects the exchange of brain information related to the anterior cingulate gyrus,and the enhancement of the functional connection between the ACC and prefrontal cortex may be a manifestation of the compensatory response.
Objective To explore the effect of sleep deprivation combined with interrupted continuous operation on functional connectivity of the anterior cingulate gyrus of the resting human brain.Methods Forty healthy college students participated in the 36-hour total sleep deprivation test,and there was a 4-hour continuous task every 12 hours during sleep deprivation. Resting state functional magnetic resonance imaging( fc MRI) scanning was performed before and after sleep deprivation. Functional connectivity analysis was performed on subjects with the bilateral anterior cingulate gyrus as the seed site. Results The left frontal gyrus,bilateral lower frontal gyrus,right central sulcus cover area and right superior temporal gyrus were among the areas with increased functional connectivity of the left anterior cingulate gyrus after sleep deprivation. The area with higher functional connectivity to the right anterior cingulate cortex was the left inferior frontal gyrus.Conclusion Sleep deprivation combined with continuous operation affects the exchange of brain information related to the anterior cingulate gyrus,and the enhancement of the functional connection between the ACC and prefrontal cortex may be a manifestation of the compensatory response.
引文
[1]王晓璐,高翔,许敏鹏,等.基于睡眠剥夺模型的脑力疲劳检测方法研究[J].生物医学工程学杂志,2015(3):497.
[2]宋国萍,苗丹民,皇甫恩.睡眠剥夺对警觉能力的影响[J].人类工效学,2005,11(4):17.
[3]杨遥,刘静,徐江涛.睡眠剥夺对认知功能的影响研究进展[J].现代生物医学进展,2013,13(4):791.
[4]贺旭,林建华,洪军,等.睡眠剥夺对认知功能的影响[J].中国组织工程研究,2001,5(13):79.
[5]彭丽,徐津,叶远鹏,等.潜艇环境对艇员认知功能和作业能力的影响[J].心理科学,2017(4):934.
[6]SPM8.Statistical parametric mapping(SPM).2008.http://www.fil.ion.ucl.ac.uk/spm/
[7]WHITFIELDGABRIELI S,NIETOCASTANON A.Conn:A functional connectivity toolbox for correlated and anticorrelated brain networks[J].Brain Connect,2012,2(3):125.
[8]SHAO Y,QI J,FAN M,et al.Compensatory neural responses after 36 hours of total sleep deprivation and its relationship with executive control function[J].Soc Behav Personal,2009,37(9):1239.
[9]DRUMMOND S P,GILLIN J C,BROWN G G.Increased cerebral response during a divided attention task following sleep deprivation[J].J Sleep Res,2001,10(2):85.
[10]HSIEH S,CHENG I C,TSAI L L.Immediate error correction process following sleep deprivation[J].J Sleep Res,2007,16(2):137.
[2]宋国萍,苗丹民,皇甫恩.睡眠剥夺对警觉能力的影响[J].人类工效学,2005,11(4):17.
[3]杨遥,刘静,徐江涛.睡眠剥夺对认知功能的影响研究进展[J].现代生物医学进展,2013,13(4):791.
[4]贺旭,林建华,洪军,等.睡眠剥夺对认知功能的影响[J].中国组织工程研究,2001,5(13):79.
[5]彭丽,徐津,叶远鹏,等.潜艇环境对艇员认知功能和作业能力的影响[J].心理科学,2017(4):934.
[6]SPM8.Statistical parametric mapping(SPM).2008.http://www.fil.ion.ucl.ac.uk/spm/
[7]WHITFIELDGABRIELI S,NIETOCASTANON A.Conn:A functional connectivity toolbox for correlated and anticorrelated brain networks[J].Brain Connect,2012,2(3):125.
[8]SHAO Y,QI J,FAN M,et al.Compensatory neural responses after 36 hours of total sleep deprivation and its relationship with executive control function[J].Soc Behav Personal,2009,37(9):1239.
[9]DRUMMOND S P,GILLIN J C,BROWN G G.Increased cerebral response during a divided attention task following sleep deprivation[J].J Sleep Res,2001,10(2):85.
[10]HSIEH S,CHENG I C,TSAI L L.Immediate error correction process following sleep deprivation[J].J Sleep Res,2007,16(2):137.