壳聚糖抑菌性能的研究进展
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摘要
壳聚糖是一种天然碱性多糖,因其良好的生物相容性、抗微生物性、可降解性而被广泛应用于食品工程、医药行业、工业降解等领域。而对壳聚糖抑菌性的相关研究一直以来是其特性研究中的热点。本文回顾了从2000年至2018年国内外对壳聚糖抑菌性的研究情况,对其抑菌性影响因素及抑菌机制做了总结,提出了在抑菌性研究方面的问题和观点。以期为壳聚糖抑菌性进一步研究及应用提供理论基础和科学依据。
Chitosan(CTS) is a kind of natural alkalinity polysaccharide. It is widely used in food engineering, pharmaceuticals industry and industrial degradation because of its good biocompatibility, antimicrobial property and biodegradability. Studies on chitosan's antibacterial activity has been a hot spot in its property research. This essay retrospects domestic and oversea studies on chitosan's antibacterial activity from 2000 to 2018, summarizes its antibacterial factors and antibacterial mechanism while it also raises relevant problems and shares views on antibacterial research with aims to provide theoretic basis and scientific basis for further study and application of chitosan's antibacterial activity.
Chitosan(CTS) is a kind of natural alkalinity polysaccharide. It is widely used in food engineering, pharmaceuticals industry and industrial degradation because of its good biocompatibility, antimicrobial property and biodegradability. Studies on chitosan's antibacterial activity has been a hot spot in its property research. This essay retrospects domestic and oversea studies on chitosan's antibacterial activity from 2000 to 2018, summarizes its antibacterial factors and antibacterial mechanism while it also raises relevant problems and shares views on antibacterial research with aims to provide theoretic basis and scientific basis for further study and application of chitosan's antibacterial activity.
引文
[1]Coma V,Martial-Gros A,Garreau S,et al.Edible antimicrobial films based on chitosan matrix[J].Journal of Food Science,2002,67(3):1162-1169.
[2]张娣.壳聚糖抑菌作用研究进展[J].黑龙江生态工程职业学院学报,2014,27(3):17-18.
[3]宋献周,沈月新.不同平均分子量的-壳聚糖的抑菌作用[J].上海水产大学学报,2000,9(2):138-141.
[4]Shin Y,Yoo DI,Min K.Antimicrobial finishing of polypropylene nonwoven fabric by treatment with chitosan oligomer[J].Journal of Applied Polymer Science,2015,74(12):2911-2916.
[5]Zheng LY,Zhu JF.Study on antimicrobial activity of chitosan with different molecular weights[J].Carbohydrate Polymers,2003,54(4):527-530.
[6]Goy RC,Britto DD,Assis OBG.A review of the antimicrobial activity of chitosan[J].Polímeros,2009,19(3):241-247.
[7]谢勇,周南进,李弼民,等.不同浓度和p H值的壳聚糖对幽门螺杆菌抑菌作用的影响[J].中华微生物学和免疫学杂志,2002,22(1):17.
[8]杨声,冯小强,王廷璞,等.壳聚糖对大肠杆菌的抑制作用规律及抗菌机理初探[J].天然产物研究与开发,2007,19(1):39-43.
[9]刘楠,陈西广,刘成圣,等.壳聚糖抑菌性能研究进展[J].海洋科学,2005,29(10):90-92.
[10]Sekiguchi S,Miura Y,Kaneko H,et al.Molecular weight dependency of antimicrobial activity by chitosan oligomers[J].Food Hydrocolloids,1994:71-76.
[11]Suzuki K,Mikami T,Okawa Y,et al.Antitumor effect of hexa-N-acetylchitohexaose and chitohexaose[J].Carbohydr Res,1986,151(2):403-408.
[12]王鸿,沈月新.不同脱乙酰度壳聚糖的抑菌性[J].上海水产大学学报,2001,10(4):380-382.
[13]Feng XQ,Yang S,Li XF.Study on antibacterial activity of chitosan with different molecular weights to five common bacterium and mechanism[J].Natural Product Research&Development,2008,20(2):335-338.
[14]Kong M,Chen XG,Xing K,et al.Antimicrobial properties of chitosan and mode of action:A state of the art review[J].International Journal of Food Microbiology,2010,144(1):51-63.
[15]荆迎军,郝友进,渠晖,等.壳聚糖的抑菌活性分析及其抑菌机理的研究[J].中国抗生素杂志,2006,36(6):361-365,375.
[16]李明春,许涛,辛梅华.壳聚糖及其衍生物的抗菌活性研究进展[J].化工进展,2011,30(1):203-209.
[17]Jung J,Cavender G,Zhao Y.The contribution of acidulant to the antibacterial activity of acid soluble alpha-and beta-chitosan solutions and their films[J].Appl Microbiol Biotechnol,2014,98(1):425-435.
[18]Jeon Y,Park P,Kim S.Antimicrobial effect of chitooligosaccharides produced by bioreactor[J].Carbohydrate Polymers,2001,44(1):71-76.
[19]Gill AO,Delaquis P,Russo P,et al.Evaluation of antilisterial action of cilantro oil on vacuum packed ham[J].International Journal of Food Microbiology,2002,73(1):83-92.
[20]Coma V,Deschamps A,Martial-Gros A.Bioactive packaging materials from edible chitosan polymer-antimicrobial activity assessment on dairy-related contaminants[J].Journal of Food Science,2003,68(9):2788-2792.
[21]Dutta PK,Tripathi S,Mehrotra GK,et al.Perspectives for chitosan based antimicrobial films in food applications[J].Food Chemistry,2009,114(4):1173-1182.
[22]胡瑛,杜予民,刘慧.壳聚糖抗菌性与分子量和环境介质相关性研究[J].分析科学学报,2003(4):305-308.
[23]陈威,吴清平,张菊梅,等.壳聚糖抑菌机制的初步研究[J].微生物学报,2008,48(2):164-168.
[24]Bingjun Q,Jung J,Zhao Y.Impact of acidity and metal ion on the antibacterial activity and mechanisms of beta-and alpha-chitosan[J].Appl Biochem Biotechnol,2015,175(6):2972-2985.
[25]Phaechamud T.Hydrophobically modified chitosans and their pharmaceutical applications[J].Journal of pharmaceutical Science and Technology,2008,1:2-9.
[26]徐连敏.壳聚糖纳米粒的研究进展[J].国际药学研究杂志,2002,29(6):329-332.
[27]Qi L,Xu Z,Jiang X,et al.Preparation and antibacterial activity of chitosan nanoparticles[J].Carbohydr Res,2004,339(16):2693-2700.
[28]丁德润,沈勇.壳聚糖衍生物及其纳米粒的抗菌性能研究[J].印染,2005,31(14):12-14.
[29]Hadwiger LA,Kendra DF,Fristensky BW,et al.Chitosan both activates genes in plants and inhibits RNA synthesis in fungi[J].Chitin in Nature and Technology,1986:209-214.
[30]冯小强,李小芳,杨声,等.壳聚糖对细菌细胞膜及膜蛋白的作用[J].食品科学,2009,(13):84-88.
[31]Helander IM,Nurmiaho-Lassila EL,Ahvenainen R,et al.Chitosan disrupts the barrier properties of the outer membrane of gram-negative bacteria[J].Int J Food Microbiol,2001,71(2-3):235-244.
[32]李晓芳,冯小强,杨声.壳聚糖对革兰氏阴性菌抑菌机理的初步研究[J].食品科学,2010,31(13):148-153.
[33]路振香,路颖,商常发,等.壳聚糖对5种细菌体外的抑制试验[J].动物医学进展,2006,27(3):62-64.
[34]郑连英,朱江峰,孙昆山.壳聚糖的抗菌性能研究[J].材料科学与工程,2000,18(2):22-24.
[35]Xiao FL,Yun LG,Dong ZY,et al.Antibacterial action of chitosan and carboxymethylated chitosan[J].Journal of Applied Polymer Science,2015,79(7):1324-1335.
[2]张娣.壳聚糖抑菌作用研究进展[J].黑龙江生态工程职业学院学报,2014,27(3):17-18.
[3]宋献周,沈月新.不同平均分子量的-壳聚糖的抑菌作用[J].上海水产大学学报,2000,9(2):138-141.
[4]Shin Y,Yoo DI,Min K.Antimicrobial finishing of polypropylene nonwoven fabric by treatment with chitosan oligomer[J].Journal of Applied Polymer Science,2015,74(12):2911-2916.
[5]Zheng LY,Zhu JF.Study on antimicrobial activity of chitosan with different molecular weights[J].Carbohydrate Polymers,2003,54(4):527-530.
[6]Goy RC,Britto DD,Assis OBG.A review of the antimicrobial activity of chitosan[J].Polímeros,2009,19(3):241-247.
[7]谢勇,周南进,李弼民,等.不同浓度和p H值的壳聚糖对幽门螺杆菌抑菌作用的影响[J].中华微生物学和免疫学杂志,2002,22(1):17.
[8]杨声,冯小强,王廷璞,等.壳聚糖对大肠杆菌的抑制作用规律及抗菌机理初探[J].天然产物研究与开发,2007,19(1):39-43.
[9]刘楠,陈西广,刘成圣,等.壳聚糖抑菌性能研究进展[J].海洋科学,2005,29(10):90-92.
[10]Sekiguchi S,Miura Y,Kaneko H,et al.Molecular weight dependency of antimicrobial activity by chitosan oligomers[J].Food Hydrocolloids,1994:71-76.
[11]Suzuki K,Mikami T,Okawa Y,et al.Antitumor effect of hexa-N-acetylchitohexaose and chitohexaose[J].Carbohydr Res,1986,151(2):403-408.
[12]王鸿,沈月新.不同脱乙酰度壳聚糖的抑菌性[J].上海水产大学学报,2001,10(4):380-382.
[13]Feng XQ,Yang S,Li XF.Study on antibacterial activity of chitosan with different molecular weights to five common bacterium and mechanism[J].Natural Product Research&Development,2008,20(2):335-338.
[14]Kong M,Chen XG,Xing K,et al.Antimicrobial properties of chitosan and mode of action:A state of the art review[J].International Journal of Food Microbiology,2010,144(1):51-63.
[15]荆迎军,郝友进,渠晖,等.壳聚糖的抑菌活性分析及其抑菌机理的研究[J].中国抗生素杂志,2006,36(6):361-365,375.
[16]李明春,许涛,辛梅华.壳聚糖及其衍生物的抗菌活性研究进展[J].化工进展,2011,30(1):203-209.
[17]Jung J,Cavender G,Zhao Y.The contribution of acidulant to the antibacterial activity of acid soluble alpha-and beta-chitosan solutions and their films[J].Appl Microbiol Biotechnol,2014,98(1):425-435.
[18]Jeon Y,Park P,Kim S.Antimicrobial effect of chitooligosaccharides produced by bioreactor[J].Carbohydrate Polymers,2001,44(1):71-76.
[19]Gill AO,Delaquis P,Russo P,et al.Evaluation of antilisterial action of cilantro oil on vacuum packed ham[J].International Journal of Food Microbiology,2002,73(1):83-92.
[20]Coma V,Deschamps A,Martial-Gros A.Bioactive packaging materials from edible chitosan polymer-antimicrobial activity assessment on dairy-related contaminants[J].Journal of Food Science,2003,68(9):2788-2792.
[21]Dutta PK,Tripathi S,Mehrotra GK,et al.Perspectives for chitosan based antimicrobial films in food applications[J].Food Chemistry,2009,114(4):1173-1182.
[22]胡瑛,杜予民,刘慧.壳聚糖抗菌性与分子量和环境介质相关性研究[J].分析科学学报,2003(4):305-308.
[23]陈威,吴清平,张菊梅,等.壳聚糖抑菌机制的初步研究[J].微生物学报,2008,48(2):164-168.
[24]Bingjun Q,Jung J,Zhao Y.Impact of acidity and metal ion on the antibacterial activity and mechanisms of beta-and alpha-chitosan[J].Appl Biochem Biotechnol,2015,175(6):2972-2985.
[25]Phaechamud T.Hydrophobically modified chitosans and their pharmaceutical applications[J].Journal of pharmaceutical Science and Technology,2008,1:2-9.
[26]徐连敏.壳聚糖纳米粒的研究进展[J].国际药学研究杂志,2002,29(6):329-332.
[27]Qi L,Xu Z,Jiang X,et al.Preparation and antibacterial activity of chitosan nanoparticles[J].Carbohydr Res,2004,339(16):2693-2700.
[28]丁德润,沈勇.壳聚糖衍生物及其纳米粒的抗菌性能研究[J].印染,2005,31(14):12-14.
[29]Hadwiger LA,Kendra DF,Fristensky BW,et al.Chitosan both activates genes in plants and inhibits RNA synthesis in fungi[J].Chitin in Nature and Technology,1986:209-214.
[30]冯小强,李小芳,杨声,等.壳聚糖对细菌细胞膜及膜蛋白的作用[J].食品科学,2009,(13):84-88.
[31]Helander IM,Nurmiaho-Lassila EL,Ahvenainen R,et al.Chitosan disrupts the barrier properties of the outer membrane of gram-negative bacteria[J].Int J Food Microbiol,2001,71(2-3):235-244.
[32]李晓芳,冯小强,杨声.壳聚糖对革兰氏阴性菌抑菌机理的初步研究[J].食品科学,2010,31(13):148-153.
[33]路振香,路颖,商常发,等.壳聚糖对5种细菌体外的抑制试验[J].动物医学进展,2006,27(3):62-64.
[34]郑连英,朱江峰,孙昆山.壳聚糖的抗菌性能研究[J].材料科学与工程,2000,18(2):22-24.
[35]Xiao FL,Yun LG,Dong ZY,et al.Antibacterial action of chitosan and carboxymethylated chitosan[J].Journal of Applied Polymer Science,2015,79(7):1324-1335.