下肢深静脉血栓形成患者血浆C-反应蛋白、D二聚体及白介素-6联合检测的临床价值
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摘要
目的为探讨下肢深静脉血栓形成(DVT)患者血浆C-反应蛋白(CRP)、D二聚体(D-D)及白细胞介素6(IL-6)联合检测的临床价值。方法采用胶乳增强免疫比浊法及化学发光分析法对50例下肢深静脉血栓形成患者及100例健康体检者血浆CRP、D-D及IL-6水平分别进行检测并对结果进行比较。结果下肢DVT患者血浆CRP、D-D及IL-6水平明显高于健康对照者,差异有统计学意义(P <0.01)。结论急性炎性反应因子在下肢DVT中起重要作用,联合检测血浆CRP、D-D及IL-6对下肢DVT的早期诊断、疗效监测、和预后判断有重要的临床价值。
Objective To investigate the plasma C-reactive protein(CRP),D-dimer(D-D) and interleukin-6(IL-6) clinical value in patients with deep venous thrombosis(DVT) of lower limbs combined detection.Methods Using latex enhanced turbidimetric method and chemiluminescence analysis of 50 cases with DVT of lower limbs patients and 100 cases healthy persons plasma CRP,D-D and IL-6 were respectively detected and compared.Results DVT of lower limbs patients with plasma CRP,D-D and IL-6 levels were significantly higher than healthy controls,the difference was statistically significant(P < 0.01).Conclusion Acute inflammatory reaction factors plays an important role in the formation of DVT of lower limbs.The plasma CRP,D-D and IL-6 joint detection of in early diagnosis,curative effect monitoring and prognosis judgment has certain clinical value of DVT of lower limbs.
Objective To investigate the plasma C-reactive protein(CRP),D-dimer(D-D) and interleukin-6(IL-6) clinical value in patients with deep venous thrombosis(DVT) of lower limbs combined detection.Methods Using latex enhanced turbidimetric method and chemiluminescence analysis of 50 cases with DVT of lower limbs patients and 100 cases healthy persons plasma CRP,D-D and IL-6 were respectively detected and compared.Results DVT of lower limbs patients with plasma CRP,D-D and IL-6 levels were significantly higher than healthy controls,the difference was statistically significant(P < 0.01).Conclusion Acute inflammatory reaction factors plays an important role in the formation of DVT of lower limbs.The plasma CRP,D-D and IL-6 joint detection of in early diagnosis,curative effect monitoring and prognosis judgment has certain clinical value of DVT of lower limbs.
引文
[1]芦琳,王秀丽.下肢深静脉血栓形成患者抗凝蛋白缺陷的临床研究[J].中国临床医学,2005,14(6):1101-1103.
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[6]王瑞胜,王景璋.王红宇.CRP与IL-6在急性下肢静脉血栓形成中的意义[J].河南外科学杂志,2011,17(3):36-37.
[2]RODRIGUES CA,FERRAROTTO R,KALIL FILHO R,et al.Venous thromboembolism and cancer:a systematic review[J].J Thromb Thrombolysis.2010,30(1):67-68.
[3]TICHELAAR YI,KLUIN-NELEMANS HJ,MEIJER K.Infections and inflammatory diseases as risk factors for venous thrombosis:a systematic review[J].Thromb Haemost,2012,107(5):827-828..
[4]ENGBERS MJ,VAN HYLCKAMA VLIEG A,ROSENDAAL FR.Venous thrombosis in the elderly:incidence risk factors and risk groups[J].J Thromb Haemost,2010.8(10):2105-2106.
[5]侍冬成.吴蔚.赵钢.等.D-二聚体峰值变化与下肢骨折、骨盆骨折患者深静脉血栓的关系研究.[J].重庆医学,2011,40(13):1291-1292.
[6]王瑞胜,王景璋.王红宇.CRP与IL-6在急性下肢静脉血栓形成中的意义[J].河南外科学杂志,2011,17(3):36-37.