脂质体作为免疫增强剂在动物疾病防治方面的应用现状
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摘要
脂质体作为药物递送系统,能够定向地将药物送至靶位,并能保持药物的活性避免其被降解;作为免疫调节剂,可以同时增强体液和细胞介导的免疫应答反应,能显著增强疫苗效果。论文通过总结近几年的有关文献,对脂质体作为药物递送系统和免疫调节剂在疾病治疗中的关键作用进行分析,对其作用机制及应用现状加以归纳总结,并探讨了现存问题以及未来展望。
As a drug delivery system,liposomes can deliver drugs to the target in a targeted manner and maintain the activity of the drug to prevent its degradation;As an immunomodulator,it can simultaneously enhance the humoral and cell-mediated immune responses,which can significantly enhance the vaccine effect.By summarizing the relevant literatures in recent years,this paper analyzed the key role of liposome as a drug delivery system and immunomodulator in the treatment of diseases,summarized its mechanism and application status,and explored existing problems and future prospects.
As a drug delivery system,liposomes can deliver drugs to the target in a targeted manner and maintain the activity of the drug to prevent its degradation;As an immunomodulator,it can simultaneously enhance the humoral and cell-mediated immune responses,which can significantly enhance the vaccine effect.By summarizing the relevant literatures in recent years,this paper analyzed the key role of liposome as a drug delivery system and immunomodulator in the treatment of diseases,summarized its mechanism and application status,and explored existing problems and future prospects.
引文
[1]Abu Lila A S,Ishida T.Liposomal delivery systems:design optimization and current applications[J].Biol Pharmace Bull,2017,40(1):1-10.
[2]Bozzuto G,Molinari A.Liposomes as nanomedical devices.[J].Int J Nanomed,2015(default):975-999.
[3]Etheridge M L,Campbell S A,Erdman A G,et al.The big picture on nanomedicine:the state of investigational and approved nanomedicine products[J].Nanomed Nanotechnol Biol Med,2013,9(1):1.
[4]Felice B,Prabhakaran M P,Rodríguez A P,et al.Drug delivery vehicles on a nano-engineering perspective[J].Materials Sci Engineer C Materials Biol Appl,2014,41:178.
[5]屠美.药用高分子材料及其应用[M].广东广州:华南理工大学出版社,2006:92-118.
[6]Mohan A,Narayanan S,Sethuraman S,et al.Novel resveratrol and 5-fluorouracil coencapsulated in PEGylated nanoliposomes improve chemotherapeutic efficacy of combination against head and neck squamous cell carcinoma.[J].Biomed Res Int,2015,2014(2014):424239.
[7]Eloy J O,Petrilli R,Trevizan L,et al.Immunoliposomes:A review on functionalization strategies and targets for drug delivery.[J].Colloids Surf B Biointerfaces,2017,159:454-467.
[8]Bozzuto G,Molinari A.Liposomes as nanomedical devices[J].Int J Nanomed,2015,10:975-999.
[9]Ogiso T,Yamaguchi T,Iwaki M,et al.Effect of positively and negatively charged liposomes on skin permeation of drugs[J].JDrug Target,2001,9(1):49.
[10]Douer D.Efficacy and safety of vincristine sulfate liposome injection in the treatment of adult acute lymphocytic leukemia.[J].Oncologist,2016,21(7):840-847.
[11]Carvalheiro M,Esteves M A,Santosmateus D,et al.Hemisynthetic trifluralin analogues incorporated in liposomes for the treatment of leishmanial infections.[J].Euro J Pharmac Biopharmac Official J Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E V,2015,93:346.
[12]Rajendran V,Rohra S,Raza M,et al.Stearylamine liposomal delivery of monensin in combination with free artemisinin eliminates blood stages of Plasmodium falciparum in culture and P.berghei infection in murine malaria[J].Antimicrob A-gent Chemother,2015,60(3):AAC.01796-15.
[13]卢宇,赵晓娟,黄叶娥,等.甘草次酸脂质体对OVA免疫小鼠免疫应答的影响[J].浙江农业学报,2015,27(8):1345-1349.
[14]徐诗英,邹勇,王习达,等.脂质体对草鱼出血病核酸疫苗免疫效果的影响[J].浙江农业学报,2012,24(4):555-558.
[15]李恩涛,李友英,高珍珍,等.甘草多糖及其脂质体增强免疫活性的比较[J].畜牧与兽医,2016,48(6):82-85.
[16]范云鹏,马琳,张为民,等.麦冬多糖脂质体增强雏鸡免疫功能的分析[J].畜牧兽医学报,2015,46(7):1246-1252.
[17]张立梅.脂质体包被ALV-J gp85蛋白疫苗制备及其免疫效果研究[D].山东泰安:山东农业大学,2014.
[18]Bo R,Zheng S,Xing J,et al.The immunological activity of Lycium barbarumpolysaccharides liposome in vitro and adjuvanticity against PCV2in vivo[J].Int J Biol Macromol,2016,85:294.
[19]Maji M,Mazumder S,Bhattacharya S,et al.A lipid based antigen delivery system efficiently facilitates MHC class-I antigen presentation in dendritic cells to stimulate CD8+T cells[J].Sci Reports,2016,6:27206.
[20]Reed S G,Orr M T,Fox C B.Key roles of adjuvants in modern vaccines[J].Nat Med,2013,19(12):1597-608.
[2]Bozzuto G,Molinari A.Liposomes as nanomedical devices.[J].Int J Nanomed,2015(default):975-999.
[3]Etheridge M L,Campbell S A,Erdman A G,et al.The big picture on nanomedicine:the state of investigational and approved nanomedicine products[J].Nanomed Nanotechnol Biol Med,2013,9(1):1.
[4]Felice B,Prabhakaran M P,Rodríguez A P,et al.Drug delivery vehicles on a nano-engineering perspective[J].Materials Sci Engineer C Materials Biol Appl,2014,41:178.
[5]屠美.药用高分子材料及其应用[M].广东广州:华南理工大学出版社,2006:92-118.
[6]Mohan A,Narayanan S,Sethuraman S,et al.Novel resveratrol and 5-fluorouracil coencapsulated in PEGylated nanoliposomes improve chemotherapeutic efficacy of combination against head and neck squamous cell carcinoma.[J].Biomed Res Int,2015,2014(2014):424239.
[7]Eloy J O,Petrilli R,Trevizan L,et al.Immunoliposomes:A review on functionalization strategies and targets for drug delivery.[J].Colloids Surf B Biointerfaces,2017,159:454-467.
[8]Bozzuto G,Molinari A.Liposomes as nanomedical devices[J].Int J Nanomed,2015,10:975-999.
[9]Ogiso T,Yamaguchi T,Iwaki M,et al.Effect of positively and negatively charged liposomes on skin permeation of drugs[J].JDrug Target,2001,9(1):49.
[10]Douer D.Efficacy and safety of vincristine sulfate liposome injection in the treatment of adult acute lymphocytic leukemia.[J].Oncologist,2016,21(7):840-847.
[11]Carvalheiro M,Esteves M A,Santosmateus D,et al.Hemisynthetic trifluralin analogues incorporated in liposomes for the treatment of leishmanial infections.[J].Euro J Pharmac Biopharmac Official J Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E V,2015,93:346.
[12]Rajendran V,Rohra S,Raza M,et al.Stearylamine liposomal delivery of monensin in combination with free artemisinin eliminates blood stages of Plasmodium falciparum in culture and P.berghei infection in murine malaria[J].Antimicrob A-gent Chemother,2015,60(3):AAC.01796-15.
[13]卢宇,赵晓娟,黄叶娥,等.甘草次酸脂质体对OVA免疫小鼠免疫应答的影响[J].浙江农业学报,2015,27(8):1345-1349.
[14]徐诗英,邹勇,王习达,等.脂质体对草鱼出血病核酸疫苗免疫效果的影响[J].浙江农业学报,2012,24(4):555-558.
[15]李恩涛,李友英,高珍珍,等.甘草多糖及其脂质体增强免疫活性的比较[J].畜牧与兽医,2016,48(6):82-85.
[16]范云鹏,马琳,张为民,等.麦冬多糖脂质体增强雏鸡免疫功能的分析[J].畜牧兽医学报,2015,46(7):1246-1252.
[17]张立梅.脂质体包被ALV-J gp85蛋白疫苗制备及其免疫效果研究[D].山东泰安:山东农业大学,2014.
[18]Bo R,Zheng S,Xing J,et al.The immunological activity of Lycium barbarumpolysaccharides liposome in vitro and adjuvanticity against PCV2in vivo[J].Int J Biol Macromol,2016,85:294.
[19]Maji M,Mazumder S,Bhattacharya S,et al.A lipid based antigen delivery system efficiently facilitates MHC class-I antigen presentation in dendritic cells to stimulate CD8+T cells[J].Sci Reports,2016,6:27206.
[20]Reed S G,Orr M T,Fox C B.Key roles of adjuvants in modern vaccines[J].Nat Med,2013,19(12):1597-608.