抗生素制药菌渣的处理处置技术进展与分析
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摘要
通过文献查阅和对国内数十家典型抗生素制药企业实地调研,本文分析了近6年(2007—2012年)国内抗生素制药菌渣产量、市场份额、地域分布等情况,对抗生素处理处置方法进行了分析总结,包括堆肥、厌氧消化、酵母膏用品、菌渣水煤浆、菌渣活性炭技术。分析结果发现,目前国内的菌渣处理处置和资源化技术中堆肥、厌氧消化最受多数企业认可。然而,各类抗生素制药菌渣处理处置技术都会不同程度的产生相关污染物,残留抗生素效价在进行资源化利用时还需谨慎处理。
China is one of the largest antibiotics manufacture and usage country in the world, antibiotics bacterial residue appeared to be rising, and the resulting environmental pollution and health hazards also attracted more and more attention. Through literature research and investigation about dozes of domestic typical antibiotics pharmaceutical enterprises, domestic antibiotics bacterial residue yield, market share, regional distribution, the antibiotics treatment in nearly 6 years(2007—2012) were discussed. Disposal methods of antibiotics bacterial residue including composting, anaerobic digestion, yeast extract products, coal water slurry mixed with bacterial residue, and bacterial residue which were modified as an active carbon technology were analyzed comprehensively. The analysis results show that aerobic composting and anaerobic digestion are promising and approved among these domestic enterprises. However, all have varied degrees of relevant pollutants in different disposals of antibiotics bacterial residue. Antibiotics bacterial residue need be handled carefully in utilization of this resource.
China is one of the largest antibiotics manufacture and usage country in the world, antibiotics bacterial residue appeared to be rising, and the resulting environmental pollution and health hazards also attracted more and more attention. Through literature research and investigation about dozes of domestic typical antibiotics pharmaceutical enterprises, domestic antibiotics bacterial residue yield, market share, regional distribution, the antibiotics treatment in nearly 6 years(2007—2012) were discussed. Disposal methods of antibiotics bacterial residue including composting, anaerobic digestion, yeast extract products, coal water slurry mixed with bacterial residue, and bacterial residue which were modified as an active carbon technology were analyzed comprehensively. The analysis results show that aerobic composting and anaerobic digestion are promising and approved among these domestic enterprises. However, all have varied degrees of relevant pollutants in different disposals of antibiotics bacterial residue. Antibiotics bacterial residue need be handled carefully in utilization of this resource.
引文
[1]朱培,张建斌,陈代杰.抗生素制药菌渣处理的研究现状和建议[J].中国抗生素杂志,2013,38(9):647-673.
[2]成建华,张文莉.抗生素制药菌渣处理工艺设计[J].医药工程设计杂志,2003,24(2):31-34.
[3]阮南,黄莉静,徐萌.青霉菌渣固态发酵法生产菌体蛋白饲料的应用研究[J].河北工业科技,2006,23(2):79-80.
[4]张明峰.抗生素渣的营养价值及饲用效果[J].饲料博览,2000,13(3):40-41.
[5]农业部,卫生部.国家药品监督管理局公告第176号[J].饲料研究,2002(9):19.
[6]GB18597-2001.危险废物贮存污染控制标准[S].北京:中国标准出版社,2002:2-3.
[7]GB18598-2001.危险废物贮存污染控制标准[S].北京:中国标准出版社,2002:3-5.
[8]牟晋铭.抗生素制药菌渣处置技术评价及其残留抗生素去除的预测仿真[D].哈尔滨:哈尔滨工业大学,2013:15-19.
[9]焦永刚,马长捷,李敏霞.热解法处理抗生素发酵残渣的初步探究[J].工业安全与环保,2011,37(5):36-37.
[10]陈昆.土霉素菌渣热解液综合利用的研究[D].石家庄:河北科技大学,2013:46-47.
[11]王赟,韩娟,闫永胜.抗生素提取技术及研究进展[J].中国抗生素杂志,2009,34(11):641-643.
[12]Ramaswamy J,Prasher S O,Patel R M,et al.The effect of compositing on the degradation of a veterinary pharmaceutical[J].Bioresource Technol,2010,101(7):2294-2299.
[13]张红娟.林可霉素菌渣与牛粪联合堆肥实验研究[J].环境工程学报,2011,11(5):231-234.
[14]李路平.制药行业下脚料生产有机肥的质量评价[J].河南科技学院学报,2009,37(3):29-31.
[15]王桂珍,李兆君,张树清,等.土霉素在鸡粪好氧堆肥过程中的降解及其对相关参数的影响[J].环境科学,2013,34(2):795-796.
[16]刘维华,赵君,车畅.四环素类抗生素对堆肥腐熟度的影响[J].黑龙江医药.2013,26(2):244-245.
[17]张红娟.抗生素制药菌渣堆肥处理研究[D].郑州:郑州大学,2010:34-35.
[18]Dolliver H,Gupta S,Noll S.Antibiotics degradation during manure composting[J].J Environ Qual,2008,37(3):1245-1253.
[19]Kakimoto T,Funamizu N.Antibiotics effect of amoxicillin on the feces composting process and reactivation of bacterial by intermittent feeding of feces[J].Bioresource Technol,2007,98(18):3555-3560.
[20]Kakimoto T,Funamizu N.Factors affecting the degradation of amoxicillin in composting toilet[J].Chemosphere,2007,66(11):2219-2224.
[21]Alvarez J A,Otero L,Lema J M,et al.The effect and fate of antibioticss during the anaerobic digestion of pig manure[J].Biores Technol,2010,101(22):8581-8586.
[22]Ferndezan J,Perez M,Romero L I.Effect of substrate concentration on dry mesophilic anaerobic digestion of pyrogenic fraction of municipal solid waste[J].Biores Technol,2008,99(14):6075-6080.
[23]苏建文,王俊超,许尚营,等.红霉素菌渣厌氧消化实验研究[J].中国沼气,2013,31(5):25-28.
[24]何品晶,管冬兴,吴铎,等.氨氮和林可霉素对有机厌氧消化的抑制效应[J].化工学报,2011,62(5):1389-1394.
[25]徐颂等,何品晶,吴铎,等.含固率和接种比对林可霉素菌渣厌氧消化的影响[J].中国环境科学,2010,30(3):362-368.
[26]孟蕾.全省三成多抗生素制药菌渣将被转化[N].河北日报,2012,7(18):1.
[27]孟蕾.抗生素制药菌渣消“毒”变“宝”[N].河北日报,2013,8(26):5.
[28]朱培,张建斌,李继安,等.多级厌氧法处理螺旋霉素工业发酵菌渣效果的研究[J].环境工程学报,2014,2(8):703-708.
[29]Nocek J E,Holt M G,Oppy J.Effects of supplementation with yeast culture and enzymatically hydrolyzed yeast on performance of early lactation dairy cattle[J].Am J Food Technol,2011,6(2):103-116.
[30]李秀环.用青霉素菌渣制备酵母膏、酵母粉代用品的方法及应用[J].工艺技术,2007,4(1):37-38.
[31]王冰.青霉素菌渣制取饲料酵母与酵母膏的工艺研究[D].黑龙江:哈尔滨工业大学,2013:60-61.
[32]马玉龙,张作义.泰乐菌素菌渣酶制剂对肉鸡饲喂效果的研究[J].中国饲料,2011,34(10):39-40.
[33]韩淑云.泰乐菌渣中菌丝体提取及其在培养基上的应用[J].北京农业,2012,9(3):8-10.
[34]苗云霞.水煤浆制备工艺研究[J].河北化工,2009,32(7):27-28.
[35]贾传凯,王燕芳,王秀月.水煤浆技术的应用与发展趋势[J].2011(4):55-56.
[36]张晔.抗生素制药菌渣与煤粉配合成浆性能及燃烧动力学研究[D].淮南:安徽理工大学,2010:23-24.
[37]唐海峰,王俊峰.制红霉素废渣吸附水中Pb2+的试验研究[J].金属矿山,2011,8(9):155-158.
[38]占金宝,苏海佳.青霉菌丝体分子印迹吸附膜对Cr3+的吸附性能[J].北京化工大学学报,2010,4(37):94-96.
[39]胡波.改性菌丝体对Ni2+的吸附特性研究[J].环境污染治理技术与设备,2003,4(10):23-26.
[40]高勤.土霉素菌渣活性炭的制备及应用研究[D].河北:河北科技大学,2012:38-39.
[41]段二红,郭斌,周保华,等.一种金属改性抗生素活性炭吸附-催化氧化二氧化硫的方法:CN,201210358542.7[P].2013-01-02.
[42]Miyata M,Ihara I,Yoshid G,et al.Electrochemical oxidation of tetracycline antibioticss using a Ti/Ir O2 anode for wastewater treatment of animal husbandry[J].Water Sci Technol,2011,63(3):456-461.
[43]Zhang G Y,Ma D C,Peng C N,et al.Process characteristics of hydrothermal treatment of antibiotics residue for solid biofuel[J].Chem Eng J,2014,252(2014):230-238.
[44]Saaty T L.The Analytic Hierarchy Hierarchy Process[M].New York:Mc Graw-Hill,1980(7):67-78.
[45]Peak N,Knapp C W,Yang R K,et al.Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotics use strategies[J].Environ Microb,2010,9(1):143-149.
[46]Chee Sanford J C,Aminov R I,Krapac I J,et al.Occurrence and diversity of tetracycline resistance genes in lagoons and groundwater underlying two swine production facilities[J].Appl Environ Microb,2001,67(4):1494-1502.
[2]成建华,张文莉.抗生素制药菌渣处理工艺设计[J].医药工程设计杂志,2003,24(2):31-34.
[3]阮南,黄莉静,徐萌.青霉菌渣固态发酵法生产菌体蛋白饲料的应用研究[J].河北工业科技,2006,23(2):79-80.
[4]张明峰.抗生素渣的营养价值及饲用效果[J].饲料博览,2000,13(3):40-41.
[5]农业部,卫生部.国家药品监督管理局公告第176号[J].饲料研究,2002(9):19.
[6]GB18597-2001.危险废物贮存污染控制标准[S].北京:中国标准出版社,2002:2-3.
[7]GB18598-2001.危险废物贮存污染控制标准[S].北京:中国标准出版社,2002:3-5.
[8]牟晋铭.抗生素制药菌渣处置技术评价及其残留抗生素去除的预测仿真[D].哈尔滨:哈尔滨工业大学,2013:15-19.
[9]焦永刚,马长捷,李敏霞.热解法处理抗生素发酵残渣的初步探究[J].工业安全与环保,2011,37(5):36-37.
[10]陈昆.土霉素菌渣热解液综合利用的研究[D].石家庄:河北科技大学,2013:46-47.
[11]王赟,韩娟,闫永胜.抗生素提取技术及研究进展[J].中国抗生素杂志,2009,34(11):641-643.
[12]Ramaswamy J,Prasher S O,Patel R M,et al.The effect of compositing on the degradation of a veterinary pharmaceutical[J].Bioresource Technol,2010,101(7):2294-2299.
[13]张红娟.林可霉素菌渣与牛粪联合堆肥实验研究[J].环境工程学报,2011,11(5):231-234.
[14]李路平.制药行业下脚料生产有机肥的质量评价[J].河南科技学院学报,2009,37(3):29-31.
[15]王桂珍,李兆君,张树清,等.土霉素在鸡粪好氧堆肥过程中的降解及其对相关参数的影响[J].环境科学,2013,34(2):795-796.
[16]刘维华,赵君,车畅.四环素类抗生素对堆肥腐熟度的影响[J].黑龙江医药.2013,26(2):244-245.
[17]张红娟.抗生素制药菌渣堆肥处理研究[D].郑州:郑州大学,2010:34-35.
[18]Dolliver H,Gupta S,Noll S.Antibiotics degradation during manure composting[J].J Environ Qual,2008,37(3):1245-1253.
[19]Kakimoto T,Funamizu N.Antibiotics effect of amoxicillin on the feces composting process and reactivation of bacterial by intermittent feeding of feces[J].Bioresource Technol,2007,98(18):3555-3560.
[20]Kakimoto T,Funamizu N.Factors affecting the degradation of amoxicillin in composting toilet[J].Chemosphere,2007,66(11):2219-2224.
[21]Alvarez J A,Otero L,Lema J M,et al.The effect and fate of antibioticss during the anaerobic digestion of pig manure[J].Biores Technol,2010,101(22):8581-8586.
[22]Ferndezan J,Perez M,Romero L I.Effect of substrate concentration on dry mesophilic anaerobic digestion of pyrogenic fraction of municipal solid waste[J].Biores Technol,2008,99(14):6075-6080.
[23]苏建文,王俊超,许尚营,等.红霉素菌渣厌氧消化实验研究[J].中国沼气,2013,31(5):25-28.
[24]何品晶,管冬兴,吴铎,等.氨氮和林可霉素对有机厌氧消化的抑制效应[J].化工学报,2011,62(5):1389-1394.
[25]徐颂等,何品晶,吴铎,等.含固率和接种比对林可霉素菌渣厌氧消化的影响[J].中国环境科学,2010,30(3):362-368.
[26]孟蕾.全省三成多抗生素制药菌渣将被转化[N].河北日报,2012,7(18):1.
[27]孟蕾.抗生素制药菌渣消“毒”变“宝”[N].河北日报,2013,8(26):5.
[28]朱培,张建斌,李继安,等.多级厌氧法处理螺旋霉素工业发酵菌渣效果的研究[J].环境工程学报,2014,2(8):703-708.
[29]Nocek J E,Holt M G,Oppy J.Effects of supplementation with yeast culture and enzymatically hydrolyzed yeast on performance of early lactation dairy cattle[J].Am J Food Technol,2011,6(2):103-116.
[30]李秀环.用青霉素菌渣制备酵母膏、酵母粉代用品的方法及应用[J].工艺技术,2007,4(1):37-38.
[31]王冰.青霉素菌渣制取饲料酵母与酵母膏的工艺研究[D].黑龙江:哈尔滨工业大学,2013:60-61.
[32]马玉龙,张作义.泰乐菌素菌渣酶制剂对肉鸡饲喂效果的研究[J].中国饲料,2011,34(10):39-40.
[33]韩淑云.泰乐菌渣中菌丝体提取及其在培养基上的应用[J].北京农业,2012,9(3):8-10.
[34]苗云霞.水煤浆制备工艺研究[J].河北化工,2009,32(7):27-28.
[35]贾传凯,王燕芳,王秀月.水煤浆技术的应用与发展趋势[J].2011(4):55-56.
[36]张晔.抗生素制药菌渣与煤粉配合成浆性能及燃烧动力学研究[D].淮南:安徽理工大学,2010:23-24.
[37]唐海峰,王俊峰.制红霉素废渣吸附水中Pb2+的试验研究[J].金属矿山,2011,8(9):155-158.
[38]占金宝,苏海佳.青霉菌丝体分子印迹吸附膜对Cr3+的吸附性能[J].北京化工大学学报,2010,4(37):94-96.
[39]胡波.改性菌丝体对Ni2+的吸附特性研究[J].环境污染治理技术与设备,2003,4(10):23-26.
[40]高勤.土霉素菌渣活性炭的制备及应用研究[D].河北:河北科技大学,2012:38-39.
[41]段二红,郭斌,周保华,等.一种金属改性抗生素活性炭吸附-催化氧化二氧化硫的方法:CN,201210358542.7[P].2013-01-02.
[42]Miyata M,Ihara I,Yoshid G,et al.Electrochemical oxidation of tetracycline antibioticss using a Ti/Ir O2 anode for wastewater treatment of animal husbandry[J].Water Sci Technol,2011,63(3):456-461.
[43]Zhang G Y,Ma D C,Peng C N,et al.Process characteristics of hydrothermal treatment of antibiotics residue for solid biofuel[J].Chem Eng J,2014,252(2014):230-238.
[44]Saaty T L.The Analytic Hierarchy Hierarchy Process[M].New York:Mc Graw-Hill,1980(7):67-78.
[45]Peak N,Knapp C W,Yang R K,et al.Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotics use strategies[J].Environ Microb,2010,9(1):143-149.
[46]Chee Sanford J C,Aminov R I,Krapac I J,et al.Occurrence and diversity of tetracycline resistance genes in lagoons and groundwater underlying two swine production facilities[J].Appl Environ Microb,2001,67(4):1494-1502.