血清FGF19、IL-17及LP(a)对预测1型糖尿病患者微血管病变的价值
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摘要
本研究旨在初步分析1型糖尿病患者血清FGF19、IL-17及LP(a)水平对患者微血管病变的预测价值,选取了1型糖尿病患者206例纳入研究并收集患者血清标本,采用酶联免疫法测定FGF19、IL-17及LP(a)水平。结果显示,1型糖尿病患者的FGF19、IL-17及LP(a)水平增高,不同年龄组患者的FGF19、IL-17及LP(a)水平有统计学差异,且FGF19水平与LP(a)水平呈正相关,LP(a)水平与IL-17水平呈正相关。此外,联合检测FGF19、IL-17及LP(a)水平对预测微血管病变比单独检测FGF19对预测微血管病变具有一定的筛检价值。结果提示,检测FGF19、IL-17及LP(a)水平对评估1型糖尿病患者的病情有重要临床意义;单独检测FGF19抗体以及联合检测三种指标均可预测微血管病变。
The purpose of this study was to preliminarily analyze the predictive value of serum FGF19,IL-17 and LP( a) levels in patients with type 1 diabetes mellitus for patients with microangiopathy. 206 patients with type 1 diabetes were enrolled in the study and serum samples were collected. The levels of FGF19,IL-17 and LP( a) were measured by enzymelinked immunosorbent assay( ELISA) and analyzed for their association with the prognosis of microangiopathy. The FGF19,IL-17 and LP( a) levels were higher in the pateints,and the FGF19,IL-17 and LP( a) levels were different in different age. There was a positive correlation with LP( a) level,and LP( a) level was positively correlated with IL-17 level. In addition,the combined detection of fibroblast growth factor 19,IL-17 and LP( a) levels has a good screening value than that of the detection of fibroblast growth factor 19 alone. Therefore,FGF19,IL-17 and LP( a) levels are important to evaluate the condition of type 1 diabetes mellitus,and the detection of FGF19 antibody alone and the combined detection of these indicators can predict microangiopathy.
The purpose of this study was to preliminarily analyze the predictive value of serum FGF19,IL-17 and LP( a) levels in patients with type 1 diabetes mellitus for patients with microangiopathy. 206 patients with type 1 diabetes were enrolled in the study and serum samples were collected. The levels of FGF19,IL-17 and LP( a) were measured by enzymelinked immunosorbent assay( ELISA) and analyzed for their association with the prognosis of microangiopathy. The FGF19,IL-17 and LP( a) levels were higher in the pateints,and the FGF19,IL-17 and LP( a) levels were different in different age. There was a positive correlation with LP( a) level,and LP( a) level was positively correlated with IL-17 level. In addition,the combined detection of fibroblast growth factor 19,IL-17 and LP( a) levels has a good screening value than that of the detection of fibroblast growth factor 19 alone. Therefore,FGF19,IL-17 and LP( a) levels are important to evaluate the condition of type 1 diabetes mellitus,and the detection of FGF19 antibody alone and the combined detection of these indicators can predict microangiopathy.
引文
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[2]梁梦璐,胡永华.1型糖尿病病因流行病学研究进展[J].中华疾病控制杂志,2013,17(4):349-53.
[3]宋倩倩,方启晨.FGF19---新的代谢调节因子[J].医学综述,2012,18(21):3553-6.
[4]戴小波,孙万邦.IL-17免疫调节作用的研究进展[J].检验医学与临床,2011,8(6):732-5.
[5]汤荣华,黄建军.类风湿性关节炎患者血清GM-CSF、IL-6、IL-17和TNF-α的水平测定及临床意义[J].检验医学,2013,28(3):173-7.
[6]谭萨萨.前列地尔辅助治疗早期糖尿病肾病疗效及对血清中炎症因子水平影响[J].临床军医杂志,2018,10(1):102-4.
[7]张海荣,鄢高亮,孔文杰,等.冠心病合并2型糖尿病患者血清BDNF的浓度变化及临床意义[J].东南大学学报(医学版),2016,35(3):360-4.
[8]潘航,冷蔚玲,杨丹,等.糖尿病患者血清炎症小体与颈动脉内中膜厚度的相关性分析[J].检验医学与临床,2017,14(19):2818-20.
[9]周丽荣,潘燕,朱树贞.HCY、APN和LP在老年Ⅱ型糖尿病患者中表达意义的探讨[J].检验医学与临床,2016,13(9):1241-2.
[10]张渭芳,苏岑,赵康仁,等.血清Lp-PLA2含量对早期无症状糖尿病周围神经病变的筛查价值[J].江苏大学学报(医学版),2017,27(4):324-6.
[11]董丽,杨丽霞,茹雪.血脂、胆红素、尿酸水平对诊断2型糖尿病合并冠心病的意义[J].中南医学科学杂志,2017,45(5):436-7,45.
[12]张敏,邓仁生,文茜,等.血清胱抑素C、血脂及高敏C反应蛋白与糖尿病视网膜病变的相关性研究[J].中南医学科学杂志,2017,45(01):24-6+41.
[13]诸骏仁,高润霖,赵水平,等.中国成人血脂异常防治指南(2016年修订版)[J].中国循环杂志,2016,31(10):937-53.
[14]郝亚平,包玉倩.成纤维细胞生长因子19(FGF19)与脂代谢的研究进展[J].复旦学报(医学版),2014,41(05):693-6.
[15]刘兴宇,甄艳凤,崔建忠,等.Hb A1c水平与脑出血合并糖尿病患者迟发性脑水肿的相关性研究[J].中国现代医学杂志,2017,27(10):94-7.