毛细支气管炎患儿临床严重程度与哮喘发生的相关因素分析
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摘要
目的分析毛细支气管炎患儿临床严重程度与哮喘发生的关系及其高危因素。方法回顾性分析齐河县人民医院自2012年7月至2104年7月收治的120例毛细支气管炎患儿的临床资料,分析其哮喘的发生率与毛细支气管炎疾病类型的关系,同时应用Logistic法分析毛细支气管炎患儿发生哮喘的高危因素。结果该组患儿哮喘发生率为28.33%,其中轻型毛细支气管炎患儿哮喘发生率为25.00%,重型毛细支气管炎患儿哮喘发生率为39.29%,两者哮喘发生率相比差异具有统计学意义(χ~2=4.03,P<0.05)。重型毛细支气管炎、父母亲吸烟、过敏性原阳性、过敏性鼻炎及家族哮喘史与哮喘发生有显著相关性(χ~2值分别为0.579、8.774、9.146、5.704、36.729,OR值分别为3.821、5.830、6.531、4.321、26.592;95%CI分别为1.157~12.498、1.775~18.221、1.720~18.231、1.281~109.251、8.014~111.251;均P<0.05)。结论被动吸烟、哮喘家族史以及过敏性体质可作为导致重型毛细支气管炎患儿发展为哮喘的高危因素,应对此类高危因素引起重视,从根本上降低哮喘发生率。
Objective To explore the relationship between clinical severity of capillary bronchitis in children and asthma and high risk factors for the development of asthma.Methods A retrospective analysis was conducted on the clinical data of 120 cases of capillary bronchitis in children admitted in Qihe County People's Hospital from July 2012 to July 2104 to analyze the relationship between the incidence of asthma and the types of capillary bronchitis.Logistic analysis was carried out to analyze the high risk factors of asthma in children with capillary bronchitis.Results The incidence of asthma in children was 28.33%.It was 25.00%in children with mild capillary bronchitis and 39.29%in those with severe bronchitis,and the difference was significant(x~2 = 4.03,P <0.05).Severe capillary bronchitis,parental smoking,allergic original positive,allergic rhinitis and family history of asthma were significantly correlated with asthma(x~2 value was 0.579,8.774,9.146,5.704 and 36.729,respectively,OR value was 3.821,5.830,6.531,4.321 and 26.592,respectively,95%CI was 1.157-12.498,1.775-18.221,1.720-18.231,1.281-109.251 and 8.014- 111.251,respectively,all P<0.05).Conclusion Passive smoking,family history of asthma and allergic constitution may be high risk factors for severe capillary bronchitis developing asthma,so they should be paid much attention to reduce the incidence of asthma fundamentally.
Objective To explore the relationship between clinical severity of capillary bronchitis in children and asthma and high risk factors for the development of asthma.Methods A retrospective analysis was conducted on the clinical data of 120 cases of capillary bronchitis in children admitted in Qihe County People's Hospital from July 2012 to July 2104 to analyze the relationship between the incidence of asthma and the types of capillary bronchitis.Logistic analysis was carried out to analyze the high risk factors of asthma in children with capillary bronchitis.Results The incidence of asthma in children was 28.33%.It was 25.00%in children with mild capillary bronchitis and 39.29%in those with severe bronchitis,and the difference was significant(x~2 = 4.03,P <0.05).Severe capillary bronchitis,parental smoking,allergic original positive,allergic rhinitis and family history of asthma were significantly correlated with asthma(x~2 value was 0.579,8.774,9.146,5.704 and 36.729,respectively,OR value was 3.821,5.830,6.531,4.321 and 26.592,respectively,95%CI was 1.157-12.498,1.775-18.221,1.720-18.231,1.281-109.251 and 8.014- 111.251,respectively,all P<0.05).Conclusion Passive smoking,family history of asthma and allergic constitution may be high risk factors for severe capillary bronchitis developing asthma,so they should be paid much attention to reduce the incidence of asthma fundamentally.
引文
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[2]Bacharier L B,Cohen R,Schweiger T,et al.Determinants of asthma after severe respiratory syncytial virus bronchiolitis[J].J Allergy Clin Immunol,2012,130(1):91-100.
[3]邓华,符州.毛细支气管炎后支气管哮喘发生的相关因素[J].实用儿科临床杂志,2009,24(4):274-276.
[4]Sakellaropoulou A,Emporiadou M,Aivazis V,et al.Acute bronchiolitis in a paediatric emergency department of Northern Greece.Comparisons between two decades[J].Arch Med Sci,2012,8(3):509-514.
[5]Lin H W,Lin S C.Environmental factors association between asthma and acute bronchiolitis in young children:a perspective cohort study[J].Eur J Pediatr,2012,171(11):1645-1650.