植物提取物和中药配方治疗包虫病研究进展
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摘要
包虫病是一种全球性人畜共患性寄生虫病,其治疗手段主要为手术治疗,但手术存在治疗不彻底、易二次感染等问题,因此药物辅助治疗也必不可少。阿苯达唑被认为是目前最有效的治疗药物之一,但其毒副作用大、血药浓度低、易产生耐药性。植物性药物有副作用少、价格低廉、与人体兼容性好等优点,寻找可有效治疗包虫病的草药或植物提取物,已成为防治研究的重要课题。本文概述了植物提取物和中药配方在体内外治疗包虫病的研究进展,以期为植物性药物在治疗包虫病方面提供参考。
Echinococcosis(hydatid disease)is a global zoonotic parasitic disease. At present,surgery remains the preferred treatment for this disease,but there are problems such as incomplete treatment and secondary infection. Therefore,adjuvant therapy of drugs is also essential. Albendazole is considered to be one of the most effective drug,but it has many side effects. In contrast,botanicals have fewer side effects,low cost,and high availability in the treatment of a wide range of diseases. Therefore,searching for herbs or plant extracts effectively treating echinococcosis has become an important topic. This paper summarizes the research progress in plant extracts and traditional Chinese materia medica in treatment of hydatid disease in vitro and in vivo,in order to provide reference for the treatment of echinococcosis by plant drugs.
Echinococcosis(hydatid disease)is a global zoonotic parasitic disease. At present,surgery remains the preferred treatment for this disease,but there are problems such as incomplete treatment and secondary infection. Therefore,adjuvant therapy of drugs is also essential. Albendazole is considered to be one of the most effective drug,but it has many side effects. In contrast,botanicals have fewer side effects,low cost,and high availability in the treatment of a wide range of diseases. Therefore,searching for herbs or plant extracts effectively treating echinococcosis has become an important topic. This paper summarizes the research progress in plant extracts and traditional Chinese materia medica in treatment of hydatid disease in vitro and in vivo,in order to provide reference for the treatment of echinococcosis by plant drugs.
引文
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[2]Moazeni M,Mohseni M.Sumac(L.):scolicidal activity on hydatid cyst protoscolices[J].Surg Sci,2012,3(9):452-456.
[3]Mahboubi M,Haghi G.Antimicrobial activity and chemical composition of Mentha pulegium L.essential oil[J].J Ethnopharmacol,2008,119(2):325.
[4]Okeola VO,Adaramoye OA,Nneji CM,et al.Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds(black cumin)in mice infected with Plasmodium yoelli nigeriensis[J].Parasitol Res,2011,108(6):1507-1512.
[5]Khan R,Zakir M,Afaq SH,et al.Activity of solvent extracts of Prosopis spicigera,Zingiber officinale and Trachyspermum ammi against multidrug resistant bacterial and fungal strains[J].J Infect Dev Ctries,2010,4(5):292.
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[7]茹炜炜,梁幼生.青蒿素类药物抗寄生虫作用研究进展[J].中国血吸虫病防治杂志,2006,18(1):78-80.
[8]畅灵丽,王光西.青蒿琥酯抗寄生虫作用研究进展[J].寄生虫病与感染性疾病,2007,5(3):164-166.
[9]郑海亚,文丽梅,吕国栋,等.青蒿琥酯体外抗细粒棘球蚴活性氧对DNA作用机制影响的研究[J].中国病原生物学杂志,2017,12(8):751-756.
[10]蒲秀英,傅宣英,王琪,等.青蒿琥酯治疗小鼠继发性棘球蚴病的效果观察[J].中国病原生物学杂志,2005,18(5):336-338.
[11]蒲秀瑛,傅宣英,王琪,等.青蒿琥酯治疗小鼠继发性棘球蚴病后机体免疫转归及肝脏中部分酶活性的变化[J].疾病预防控制通报,2006,21(1):12-15
[12]张宏伟,彭心宇,吴向未,等.3种不同剂量的青蒿琥酯抗小鼠细粒棘球蚴疾病作用的比较[J].中国人兽共患病学报,2015,31(1):41-44.
[13]张宏伟,彭心宇,张示杰,等.青蒿琥酯联合阿苯达唑预防小鼠囊型包虫病术后复发的研究[J].中国病原生物学杂志,2010,5(5):368-372.
[14]程时磊.藏药砂生槐总生物碱对肝泡型包虫病模型免疫指标的影响[D].西宁:青海大学,2017.
[15]胡春晖,张发斌.Box-Behnken响应面法优化砂生槐子中总生物碱的提取工艺[J].中成药,2016,38(9):2063-2066.
[16]胡春晖,杨涛,李永平,等.砂生槐子总生物碱纯化工艺的优化[J].中成药,2016,38(10):2157-2162.
[17]雒艳萍.砂生槐种子生物碱抗包虫效应及机制研究[D].兰州:兰州大学,2017.
[18]潘汝翀,张发斌,程时磊,等.砂生槐生物碱治疗继发性小鼠肝包虫病的实验研究[J].中国病原生物学杂志,2018,13(3):254-258.
[19]赵婷,王长虹,王峥涛.骆驼蓬属植物中生物碱类化学成分及其药理活性研究进展[J].国际药学研究杂志,2010,37(5):333-339.
[20]Di GC,Delmas F,Ollivier E,et al.In vitro activity of the betacarboline alkaloids harmane,harmine,and harmaline toward parasites of the species Leishmania infantum[J].Exp Parasitol,2004,106(3):67-74.
[21]王长虹,程雪梅,刘忠渊,等.骆驼蓬种子提取物及其β咔保啉生物碱对DNA拓扑异构酶Ⅱ活性的抑制作用[J].中国临床药理学杂志,2008,24(5):422-425.
[22]李红玲,赵军,马运芳,等.去氢骆驼蓬碱抗细粒棘球蚴原头节作用研究[J].中国病原生物学杂志,2014(11):995-999.
[23]李丽华,赵军,马运芳,等.去氢骆驼蓬碱和阿苯达唑联合治疗小鼠腹腔细粒棘球蚴病的实验研究[J].中国病原生物学杂志,2016,11(9):815-820
[24]Imanshahidi M,Hosseinzadeh H.Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent,berberine[J].Phytother Res,2008,22(8):999.
[25]Mahmoudvand H,Sharififar F,Sharifi I,et al.In vitro inhibitory effect of Berberis vulgaris(Berberidaceae)and its main component,berberine against different Leishmania species[J].Iran J Parasitol,2014,9(1):28-36.
[26]Mahmoudvand H,Dezaki ES,Sharififar F,et al.Protoscolecidal effect of Berberis vulgaris root extract and its main compound,berberine in cystic echinococcosis[J].Iran J Parasitol,2014,9(4):503-510.
[27]Mahmoudvand H,Mahmoudvand H,Oliaee RT,et al.In vitro protoscolicidal effects of Cinnamomum zeylanicum essential oil and its toxicity in mice[J].Pharmacogn Mag,2017,13(Suppl3):S652-S657.
[28]Rezaeifar M,Behfarnezhad M,Moradi M,et al.Antibacterial effects of various extracts of Amygdalus eburnea on some most common bacteria in burning[J].Pharm Lett,2016,8:110-112.
[29]Rezaeifar R,Ayatollahi Mousavi SA,Mehrabani M,et al.Evaluation of the antifungal effects of various extracts of Amygdalus eburnea on some fungal pathogens[J].Pharm Chem,2016,8:140-142.
[30]Mahmoudvand H,Ezzatkhah F,Sharififar F,et al.Antileishmanial and cytotoxic effects of essential oil and methanolic extract of Myrtus communis L.[J].Korean J Parasitol,2015,53(1):21-27.
[31]Moazeni M,Borji H,Saboor DM,et al.In vitro and in vivo antihydatid activity of a nano emulsion of Zataria multiflora essential oil[J].Res Vet Sci,2017,114:308-312.
[32]Faezeh F,Salome D,Abolfazl D,et al.Considering the antibacterial activity of Zataria multiflora Boiss essential oil treated with gamma-irradiation in vitro,and in vivo systems[J].Radiat Phys Chem,2015,106:145-150.
[33]Ali JA,Abbas FT,Mehdi HS,et al.Antifungal effect of Zataria multiflora essence on experimentally contaminated acryl resin plates with Candida albicans[J].Iran Red Crescent Med J,2015,17(1):e16552.
[34]Moradi M,Tajik H,Rohani SMR,et al.Antioxidant and antimicrobial effects of zein edible film impregnated with Zataria multiflora Boiss.essential oil and monolaurin[J].LWT-Food Sci Technol,2016,72:37-43.
[35]Saedi DE,Mahmoudvand H,Sharififar F,et al.Chemical composition along with anti-leishmanial and cytotoxic activity of Zataria multiflora[J].Pharmaceut Biol,2015,54(5):752-758.
[36]Moazeni M,Larki S,Oryan A,et al.Preventive and therapeutic effects of Zataria multiflora methanolic extract on hydatid cyst:an in vivo study[J].Vet Parasitol,2014,205(1/2):107.
[37]Moazeni M,Larki S,Pirmoradi G,et al.Scolicidal effect of the aromatic water of Zataria multiflora:an in vitro study[J].Comparative Clin Pathol,2015,24(5):1057-1062.
[38]Jahanbakhsh S,Azadpour M,Tavakoli KA,et al.Zataria multiflora Bioss:lethal effects of methanolic extract against protoscoleces of Echinococcus granulosus[J].J Parasitic Dis,2016,40(4):1289-1292.
[39]Elissondo MC,Pensel PE,Denegri GM.Could thymol have effectiveness on scolices and germinal layer of hydatid cysts?[J].Acta Tropica,2013,125(3):251-257.
[40]Kavoosi G,Purfard AM.Scolicidal effectiveness of essential oil from Zataria multiflora,and Ferula assafoetida:disparity between phenolic monoterpenes and disulphide compounds[J].Comparative Clin Pathol,2013,22(5):999-1005.
[41]BassoléIH,Lamien-Meda A,Bayala B,et al.Composition and antimicrobial activities of Lippia multiflora Moldenke,Mentha piperita L.and Ocimum basilicum L.essential oils and their major monoterpene alcohols alone and in combination[J].Molecules,2010,15(11):7825-7839.
[42]Maggiore MA,Albanese AA,Gende LB,et al.Anthelmintic effect of Mentha spp.essential oils on Echinococcus granulosus,protoscoleces and metacestodes[J].Parasitol Res,2012,110(3):1103.
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