骆驼蓬生物碱抗炎和免疫调节的药理作用机制研究进展
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摘要
综述骆驼蓬生物碱的抗炎和免疫作用机制研究进展。骆驼蓬属植物的化学成分主要为生物碱类成分,具有DNA拓扑异构酶活性及细胞毒作用,对淋巴细胞、细胞因子有免疫作用,同时具有抗炎和镇痛作用。
This paper reviews the progress of anti-inflammatory and immune effects of the alkaloids extracted from Peganum harmala. The chemical constituents of Peganum are mainly alkaloids,which have the following functions: DNA topoisomerase activity and cytotoxicity; immunity to lymphocytes and cytokines; anti-inflammatory and analgesic effects.
This paper reviews the progress of anti-inflammatory and immune effects of the alkaloids extracted from Peganum harmala. The chemical constituents of Peganum are mainly alkaloids,which have the following functions: DNA topoisomerase activity and cytotoxicity; immunity to lymphocytes and cytokines; anti-inflammatory and analgesic effects.
引文
[1]LI S,CHENG X,WANG C.A review on traditional uses,phytochemistry,pharmacology,pharmacokinetics and toxicology of the genus Peganum[J].J Ethnopharmacol,2017,203(5):127-162.
[2]樊峥嵘,姚新生.骆驼蓬属(Peganum)植物成分及药理作用[J].沈阳药学院学报,1992,9(2):144-151.
[3]WANG K B,LI D H,BAO Y,et al.Structurally Diverse Alkaloids from the Seeds of Peganum harmala[J].J Nat Prod,2017,80(2):551-559.
[4]SHAO H,HUANG X,ZHANG Y,et al.Main alkaloids of Peganum harmala L.and their different effects on dicot and monocot crops[J].Molecules,2013,18(3):2623-2634.
[5]张晓双,孙建宁,于慧灵,等.骆驼蓬总碱对血管性痴呆大鼠学习记忆的影响[J].中药材,2015,38(11):2353-2357.
[6]张庆丽,敖恩宝力格.骆驼蓬总生物碱的体外抗肿瘤作用[J].医学信息,2012,25(1):120-121.
[7]PATEL K,GADEWAR M,TRIPATHI R,et al.A review on medicinal importance,pharmacological activity and bioanalytical aspects of betacarboline alkaloid“Harmine”[J].Asian Pac J Trop Biomed,2012,2(8):660-664.
[8]MOLOUDIZARGARI M,MIKAILI P,AGHAJANSHAKERI S,et al.Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids[J].Pharmacogn Rev,2013,7(14):199-212.
[9]MINA C N,FARZAEI M H,GHOLAMREZA A.Medicinal properties of Peganum harmala L.in traditional Iranian medicine and modern phytotherapy:a review[J].J Tradit Chin Med,2015,35(1):104-109.
[10]LI Y,LIANG F,JIANG W,et al.DH334,a beta-carboline anticancer drug,inhibits the CDK activity of buddingyeast[J].Cancer Biol Ther,2007,6(8):1193-1199.
[11]KHAN F A,MAALIK A,IQBAL Z,et al.Recent pharmacological developments inβ-carboline alkaloid“harmaline”[J].Eur JPharmacol,2013,721(1-3):391-394.
[12]王长虹,程雪梅,刘忠渊,等.骆驼蓬种子提取物及其β-咔保啉生物碱对DNA拓扑异构酶Ⅱ活性的抑制作用[J].中国临床药理学杂志,2008,24(5):422-425.
[13]SOBHANI A M,EBRAHIMI S A,MAHMOUDIAN M.An in vitro evaluation of human DNA topoisomerase I inhibition by Peganum harmala L.seeds extract and itsβ-carboline alkaloids[J].J Pharm Pharm Sci,2002,5(1):19-23.
[14]SONG Y,KESUMA D,WANG J,et al.Specific inhibition of cyclindependent kinases and cell proliferation by harmine[J].Biochem Biophys Res Commun,2004,317(1):128-132.
[15]JAHANIANI F,EBRAHIMI S A,RAHBAR-ROSHANDEL N,et al.Xanthomicrol is the main cytotoxic component of dracocephalum kotschyii and a potential anti-cancer agent[J].Phytochemistry,2005,66(13):1581-1592.
[16]HOUSE R V,THOMAS P T,BHARGAVA H N.Comparison of the hallucinogenic indole alkaloids ibogaine and harmaline for Potential immunomodulatory activity[J].Pharmacology,1995,51(5):56-65.
[17]边棣,李观海,张洪泉.去氢骆驼蓬碱对小鼠免疫系统功能的影响[J].中国药理学报,1987,8(5):177-180;
[18]LAMCHOURI F,ZEMZAMI M,JOSSANG A,et al.Cytotoxicity of alkaloids isolated from peganum harmala seeds[J].Pak J Pharm Sci,2013,26(4):699-706.
[19]曾灿丽,马桂芝,滕亮,等.骆驼蓬生物碱对银屑病模型小鼠的作用[J].中成药,2013,35(2):219-225.
[20]刘锦莲,郭学芝,刘得玺,等.驼蓬总碱治疗寻常型银屑病的疗效及电镜观察[J].中国皮肤病杂志,1991,5(3):141-142.
[21]许晏,王松,朱明,等.去氢骆驼蓬碱体外杀菌作用的研究[J].新疆医科大学学报,2003,26(3):252-253.
[22]NENAAH G.Antibacterial and antifungal activities of(beta)-carboline alkaloids of Peganum harmala(L)seeds and their combination effects[J].Fitoterapia,2010,81(7):779-782.
[23]BENSALEM S,SOUBHYE J,ALDIB I,et al.Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L.(Zygophyllaceae)[J].J Ethnopharmacol,2014,154(2):361-369.
[24]FAROUK L,LAROUBI A,ABOUFATIMA R,et al.Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.possible mechanisms involved[J].J Ethnopharmacol,2008,115(3):449-454.
[2]樊峥嵘,姚新生.骆驼蓬属(Peganum)植物成分及药理作用[J].沈阳药学院学报,1992,9(2):144-151.
[3]WANG K B,LI D H,BAO Y,et al.Structurally Diverse Alkaloids from the Seeds of Peganum harmala[J].J Nat Prod,2017,80(2):551-559.
[4]SHAO H,HUANG X,ZHANG Y,et al.Main alkaloids of Peganum harmala L.and their different effects on dicot and monocot crops[J].Molecules,2013,18(3):2623-2634.
[5]张晓双,孙建宁,于慧灵,等.骆驼蓬总碱对血管性痴呆大鼠学习记忆的影响[J].中药材,2015,38(11):2353-2357.
[6]张庆丽,敖恩宝力格.骆驼蓬总生物碱的体外抗肿瘤作用[J].医学信息,2012,25(1):120-121.
[7]PATEL K,GADEWAR M,TRIPATHI R,et al.A review on medicinal importance,pharmacological activity and bioanalytical aspects of betacarboline alkaloid“Harmine”[J].Asian Pac J Trop Biomed,2012,2(8):660-664.
[8]MOLOUDIZARGARI M,MIKAILI P,AGHAJANSHAKERI S,et al.Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids[J].Pharmacogn Rev,2013,7(14):199-212.
[9]MINA C N,FARZAEI M H,GHOLAMREZA A.Medicinal properties of Peganum harmala L.in traditional Iranian medicine and modern phytotherapy:a review[J].J Tradit Chin Med,2015,35(1):104-109.
[10]LI Y,LIANG F,JIANG W,et al.DH334,a beta-carboline anticancer drug,inhibits the CDK activity of buddingyeast[J].Cancer Biol Ther,2007,6(8):1193-1199.
[11]KHAN F A,MAALIK A,IQBAL Z,et al.Recent pharmacological developments inβ-carboline alkaloid“harmaline”[J].Eur JPharmacol,2013,721(1-3):391-394.
[12]王长虹,程雪梅,刘忠渊,等.骆驼蓬种子提取物及其β-咔保啉生物碱对DNA拓扑异构酶Ⅱ活性的抑制作用[J].中国临床药理学杂志,2008,24(5):422-425.
[13]SOBHANI A M,EBRAHIMI S A,MAHMOUDIAN M.An in vitro evaluation of human DNA topoisomerase I inhibition by Peganum harmala L.seeds extract and itsβ-carboline alkaloids[J].J Pharm Pharm Sci,2002,5(1):19-23.
[14]SONG Y,KESUMA D,WANG J,et al.Specific inhibition of cyclindependent kinases and cell proliferation by harmine[J].Biochem Biophys Res Commun,2004,317(1):128-132.
[15]JAHANIANI F,EBRAHIMI S A,RAHBAR-ROSHANDEL N,et al.Xanthomicrol is the main cytotoxic component of dracocephalum kotschyii and a potential anti-cancer agent[J].Phytochemistry,2005,66(13):1581-1592.
[16]HOUSE R V,THOMAS P T,BHARGAVA H N.Comparison of the hallucinogenic indole alkaloids ibogaine and harmaline for Potential immunomodulatory activity[J].Pharmacology,1995,51(5):56-65.
[17]边棣,李观海,张洪泉.去氢骆驼蓬碱对小鼠免疫系统功能的影响[J].中国药理学报,1987,8(5):177-180;
[18]LAMCHOURI F,ZEMZAMI M,JOSSANG A,et al.Cytotoxicity of alkaloids isolated from peganum harmala seeds[J].Pak J Pharm Sci,2013,26(4):699-706.
[19]曾灿丽,马桂芝,滕亮,等.骆驼蓬生物碱对银屑病模型小鼠的作用[J].中成药,2013,35(2):219-225.
[20]刘锦莲,郭学芝,刘得玺,等.驼蓬总碱治疗寻常型银屑病的疗效及电镜观察[J].中国皮肤病杂志,1991,5(3):141-142.
[21]许晏,王松,朱明,等.去氢骆驼蓬碱体外杀菌作用的研究[J].新疆医科大学学报,2003,26(3):252-253.
[22]NENAAH G.Antibacterial and antifungal activities of(beta)-carboline alkaloids of Peganum harmala(L)seeds and their combination effects[J].Fitoterapia,2010,81(7):779-782.
[23]BENSALEM S,SOUBHYE J,ALDIB I,et al.Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L.(Zygophyllaceae)[J].J Ethnopharmacol,2014,154(2):361-369.
[24]FAROUK L,LAROUBI A,ABOUFATIMA R,et al.Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.possible mechanisms involved[J].J Ethnopharmacol,2008,115(3):449-454.