摘要
心血管疾病是全球"头号杀手",其主要病理基础是动脉粥样硬化。血脂康以特制红曲为原料,对改善动脉粥样硬化具有积极意义。血脂康除能安全、有效降低血脂外,近年来其降脂以外的心血管获益也备受关注。研究表明,血脂康通过调节内皮功能、保护内皮祖细胞、改善氧化应激和减轻炎症反应等多种机制发挥抗动脉粥样硬化作用,本文从以上几方面综述血脂康抗动脉粥样硬化、心血管保护的研究进展。
Cardiovascular disease(CVD) has been one of the leading causes of mortality worldwide,and atherosclerosis(As) is a common pathogenic basis for CVD. Xuezhikang is a purified extract of fermented red yeast rice with benefits to improvement of As. Apart from being a safe and effective lipid-lowering drug,Xuezhikang has drawn growing awareness due to its cardiovascular protection beyond lipid modulation. Studies have shown that Xuezhikang exerts its anti-atherosclerotic function via mechanisms as the following: regulation of endothelial function,protection for endothelial progentitor cells,alleviation of oxidative stress and attenuation of inflammation.This article reviews the research progress of Xuezhikang on cardiovascular protection against atherosclerosis from the above aspects.
引文
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