微液滴生成方法研究进展
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摘要
微液滴在生物、化学、材料科学、工程等领域的应用十分广泛,液滴的生成方法越来越高效可控。从传统的制备微液滴的方法,到微流控芯片方法,再到近几年新出现的一些芯片外方法,微液滴的制备技术在数十年间不断发展和完善。本文首先简要回顾了制备微液滴的几种典型的传统方法和微流控芯片方法,重点介绍了一些近年来发展的新方法的原理、设备和应用,对这些方法的特点进行了总结,并对微液滴技术的未来发展提出了展望。
Microdroplets have been widely used in biology, chemistry, material science, and engineering, and the microdroplet generation methods are becoming more efficient and controllable. The development of the generation of microdroplets experienced traditional methods, microfluidic chip-based methods, and recently proposed off-chip methods. In this paper, we first briefly summarized the typical traditional methods and the microfluidic chip-based methods for microdroplet generation, and then emphatically introduced the principles, devices, and applications of the recently developed microdroplet generation methods. The advantages and disadvantages of these methods were discussed and the future development of microdroplet generation technology was also prospected.
Microdroplets have been widely used in biology, chemistry, material science, and engineering, and the microdroplet generation methods are becoming more efficient and controllable. The development of the generation of microdroplets experienced traditional methods, microfluidic chip-based methods, and recently proposed off-chip methods. In this paper, we first briefly summarized the typical traditional methods and the microfluidic chip-based methods for microdroplet generation, and then emphatically introduced the principles, devices, and applications of the recently developed microdroplet generation methods. The advantages and disadvantages of these methods were discussed and the future development of microdroplet generation technology was also prospected.
引文
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33 Handique K,Burke D T,Mastrangelo C H,Burns M A.Anal.Chem.,2000,72(17):4100-4109
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36 Thorsen T,Roberts R W,Arnold F H,Quake S R.Phys.Rev.Lett,2001,86(18):4163-4166
37 Ju M H,Zeng C F,Wang C Q,Zhang L X.Ind.Eng.Chem.Res.,2014,53(8):3084-3090
38 LV Ming-Ming,LIU Zhi-Gang,GUAN Ning,WANG Shu-Zhong.Shandong Sci.,2016,29(5):81-89吕明明,刘志刚,管宁,王树众.山东科学,2016,29(5):81-89
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40 FENG Xuan,ZHANG Zhi-Ling,PANG Dai-Wen.Chinese J.Anal.Chem.,2009,37(S1):271冯璇,张志凌,庞代文.分析化学,2009,37(S1):271
41 Xu H G,Liang H J.Chinese J.Chem.Phys.,2014,27(6):679-684
42 Cramer C,Fischer P,Windhab E J.Chem.Eng.Sci.,2004,59(15):3045-3058
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44 WANG Hao-Yuan,DENG Chao-Jun,WANG Han-Lin,HUANG Wei-Xing.J.Chem.Eng.Chin.Univ.,2017,31(2):291-298王號元,邓朝俊,王翰霖,黄卫星.高校化学工程学报,2017,31(2):291-298
45 Du W B,Li L,Nichols K P,Ismagilov R F.Lab Chip,2009,9(16):2286-2292
46 Vincent M E,Liu W S,Haney E B,Ismagilov R F.Chem.Soc.Rev.,2010,39(3):974-984
47 Thompson A M,Paguirigan A L,Kreutz J E,Radich J P,Chiu D T.Lab Chip,2014,14(17):3135-3142
48 Yamaguchi H,Maeki M,Yamashita K,Nakamura H,Miyazaki M,Maeda H.J.Biochem.,2013,153(4):339-346
49 Wu Y F,Tilley R D,Gooding J J.J.Am.Chem.Soc.,2019,141(3):1162-1170
50 Kaminski T S,Garstecki P.Chem.Soc.Rev.,2017,46(20):6210-6226
51 Sreejith K R,Ooi C H,Jin J,Dao D V,Nguyen N T.Lab Chip,2018,18(24):3717-3732
52 Zhang H Q,Xu Y,Fohlerova Z,Chang H L,Iliescu C,Neuzil P.TrAC-Trend.Anal.Chem.,2019,113:44-53
53 Araz M K,Tentori A M,Herr A E.J.Lab.Autom.,2013,18(5):350-366
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