低氧环境、运动训练对红细胞免疫功能影响的研究进展
|
摘要
红细胞生物学领域研究正在经历一场悄无声息的变革。长期以来,红细胞被认为是氧气的载体,现在正逐渐成为天然免疫反应的重要调节剂。红细胞结合并清除血循环中的趋化因子和病原体,同时根据环境的不同,红细胞可以促进免疫激活,也可以维持免疫静止。低氧训练一直是运动科学研究领域的热点,越来越多的研究发现,在低氧训练过程中运动员疾病易感性增加,免疫力发生改变,作为天然免疫重要组成部分的红细胞免疫如何改变值得探讨,究竟低氧坏境、运动训练与红细胞免疫之间有着怎样的联系。文章采用文献综述的方法,对国内外低氧、运动与红细胞免疫的研究进行总结与分析,为今后的研究提供理论参考。
Research in the field of erythrocyte biology is undergoing a quiet transformation. Red blood cells have long been recognized as carriers of oxygen and are now becoming important regulators of innate immune responses. Red blood cells bond and remove chemokines and pathogens in the blood circulation. At the same time, depending on the environment, red blood cells can promote immune activation and maintain immune quiescence. Hypoxia training has always been a hot topic in the field of sports science research. More and more studies have found that athletes' disease susceptibility increases and immunity changes during hypoxia training. Red blood cells are an important component of innate immunity. It is worth discussing about how to change erythrocyte immunity and what is the connection among hypoxic conditions, exercise training and red erythrocyte immunity. This paper summarizes and analyzes the research on hypoxia, exercise and erythrocyte immunity at home and abroad by means of literature review, which provides a theoretical reference for future research.
Research in the field of erythrocyte biology is undergoing a quiet transformation. Red blood cells have long been recognized as carriers of oxygen and are now becoming important regulators of innate immune responses. Red blood cells bond and remove chemokines and pathogens in the blood circulation. At the same time, depending on the environment, red blood cells can promote immune activation and maintain immune quiescence. Hypoxia training has always been a hot topic in the field of sports science research. More and more studies have found that athletes' disease susceptibility increases and immunity changes during hypoxia training. Red blood cells are an important component of innate immunity. It is worth discussing about how to change erythrocyte immunity and what is the connection among hypoxic conditions, exercise training and red erythrocyte immunity. This paper summarizes and analyzes the research on hypoxia, exercise and erythrocyte immunity at home and abroad by means of literature review, which provides a theoretical reference for future research.
引文
[1] Siegel I., Lin Liu T., Gleicher N.The red cell immune system[J]. Lancet,1981,2(8246):556-566.
[2] Barros M. M.,Yamamoto M.,Figueiredo M. S.,et al.Expression levels of CD47,CD35,CD55 and CD59 on red blood cells and fignal-regulatory protein-alpha, beta on monocytes from patients with warm autoimmune hemolytic anemia[J]. Transfusion, 2009, 49(1):154-160.
[3]郭峰.红细胞天然免疫与获得性免疫[J].自然杂志,2004,(4):194-199.
[4] Dai R. W.From engineering cybernetics to cyberspacefor woekshop of metasynthetic engineering[J].Chin J Nat,2005, 27(6):366-370.
[5] Gordon S.Macrophages and the immune response. In:Paul EW,editor. Fundamental immunology[M]. Philadelphia:Lippincott-Raven. 1999:533-545.
[6] Minasyan H. Mechanisms and pathways for the clearance of bacteria from blood circulation in health and disease[J]. Pathophysiology, 2016, 23:61-66.
[7] Lahoz-Beneytez J., Elemans M., Zhang Y., et al. Human neutrophil kinetics:modeling of stable isotope labeling data supports short blood neutrophil half-lives[J]. Blood,2016, 127:3431-3438.
[8] Schutze G. E., Buckingham S. C., Marshall G. S., et al.Human monocytic ehrlichiosis in children[J]. Pediatr Infect Dis. J., 2007, 26(6):475-479.
[9] Hayk M. Phagocytosis and oxycytosis:two anus of human innate immunity[J]. Immunologic Research, 2018,31:665-670.
[10]郭峰.红细胞天然免疫主干道理论与现代系统免疫学[J].自然杂志,2006(2):79-83.
[11]郭峰.免疫原快速激活系统血液固有免疫反应研究思路的演变与创新[J].中国医药生物技术,2010,5(1):15-18.
[12]郭峰.现代系统免疫学的形成与发展[J].中国免疫学杂志,2010(1):88-91.
[13] Sica A., Melillo G., Varesio L. Hypoxia:a double-edged sword of immunity[J]. J. Mol. Med., 2011, 89:657-665.
[14] Webster K. A. Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia[J]. J. Exp. Biol.,2003, 206:2911-2922.
[15] Cooper M. D., Alder M. N. The evolution of adaptive immune systems[J]. J. Cell, 2006, 124:815-822.
[16]司本辉,张庆成,吴康智,等.急进高原战士低氧环境对红细胞免疫功能影响的研究[J].高原医学杂志,2000,10(3):37-39.
[17]宋济范,周晶萍,叶俊雄,等.高原地区人群红细胞免疫粘附功能观察[J].高原医学杂志,1995,5(6):12-14.
[18]石泉贵.现代红细胞免疫学[M].上海:第二军医大学出版社,2002:262-264.
[19]刘兰,褚以德,陆天顺,等.高原地区红细胞免疫功能的观察[J].高原医学杂志.1998,8(1):53-55.
[20]杜智敏,刘崇礼.高海拔地区不同年龄正常人红细胞免疫功能测定及分析[J].高原医学杂志,1999,9(1):38-39.
[21]杜智敏,刘崇礼.高原地区不同移居时间正常人红细胞免疫功能测定[J].解放军预防医学医学杂志,1999,17(3):219.
[22]石泉贵.快速进入高原对世居藏族红细胞免疫粘附功能的影响[J].西南国防医药,2000, 10(5):303-304.
[23]司本辉,张庆成,吴康智,等.急进高原战士低氧环境对红细胞免疫功能影响的研究[J].高原医学杂志,2000,10(3):37-39.
[24]杨沛,陈伟,龚敏,等.高压氧治疗后红细胞免疫功能的变化及临床意义[J].中国现代医学杂志.2003,13(6):14-16.
[25]陈勇锐,孟淼,张军,等.模拟常压失事潜艇环境人血细胞表面CD55、CD59分布的变化.中国应用生理学杂志[J].2007,23(2):226-228.
[26] Morera D., Mackenzie S.A. Is there a direct role for erythrocytes in the immune response?[J]Vet. Res., 2011,42:89.
[27]胡琪琛,郭峰,翁玉泉,等.训练及不同强度运动队红细胞免疫功能的影响[J].中国免疫学杂志,1995,8(11):24-25.
[28]裴新贞.长时间大强度运动后SD大鼠红细胞免疫功能的变化[J].深训中西医结合杂志,2001,5(3):264-268.
[29]姜振,柏建清.不同负荷跑台训练大鼠红细胞免疫功能及血浆β-内啡肽的变化[J].中国组织工程研究与临床康复. 2007,11(24):4726-4729.
[30]叶路,董小青.急性运动对小鼠红细胞免疫粘附功能的影响[J].中国运动医学杂志,1998,17(2):157.
[31]宋亚军.力竭运动对小鼠红细胞免疫功能的影响[J].北京体育大学学报,2000,2(3):24-30.
[32]陈愉宁,张盈华,张利朝,等.健康人跑步前后红细胞免疫功能的变化[J].中国运动医学杂志,1999,18(3):226-227.
[33]张利朝,张盈华,陈愉宁,等.健康人运动前后红细胞免疫功能与细胞数的变化及关系[J].细胞与分子生物学杂志,2001,17(2):197-199.
[34]宋亚军,郝梅.恒定功率不同持续时间运动队红细胞免疫功能的影响[J].体育与科学,1999,5(3):15-19.
[35]裴新贞,程悦.不同游泳运动时间训练对大鼠红细胞免疫粘附功能的影响[C].北京:2002年第九届全国运动医学学术会议,2002:57.
[36]黄海,郝选明,胡晓燕,等.红细胞免疫功能对定量负荷特点的实验研究[J].中国运动医学杂志,1999,18(4):375-377.
[37]郝选明,黄海,胡晓燕,等.红细胞免疫功能对有有氧运动的适应性变化特征[J].体育科学,1999,29(6):77-81.
[38]王蕾,高炳宏,陈佩杰.HiHiLo研究进展[J].中国运动医学杂志,2010,29(3):353-358.
[39] Tiollier E., Schmitt L., Bumat P., et al. Living high-training low altitude training:effects on mucosal immunity[J]. Eur. J. Appl. Physiol., 2005. 94:298-304
[40]姚大为.我国优秀速滑运动员IHT的生理生化及免疫监控体系研究[D].沈阳:东北师范大学博士学位论文.2013:6.
[41]高欢,李涛,高炳宏,等.3200mHiHiLo免疫和炎症反应应答特征及其对有氧能力的影响[J].体育科学,2018,38(4),54-60.
[42]金其贵,胡要娟,金爱娜.不同模式的低氧运动训练对大鼠肠道体液免疫功能的影响[J].中国运动医学杂志,2015,34(8):764-769
[43]张缨,周帆扬,胡杨,等.急性低氧暴露对足球运动员红细胞免疫功能及调节因子的影响[J].中国运动医学杂志,2004,23(2):130-132.
[44]周帆扬,张缨,胡杨,等.4周高住低训对红细胞免疫功能的影响[J].体育科学,2003,23(6):132-135.
[45]赵永才,高炳宏,丁树哲.高住低练对游泳运动员红细胞免疫分子表达及供能的影响[J].体育科学,2010,6(3):15-20.
[46]罗琳,张缨.高住高练低训对足球运动员红细胞CD35数量及活性变化的影响[J].中国运动医学杂志,2006,25(4):395-398.
[47]朱荣,张缨,王芳.不同低氧训练方式对红细胞调控T淋巴细胞免疫及其功能的影响[J].体育科学,2007,27(3):68-71.
[48]王玺,高炳宏.3周高住低训对优秀运动员红细胞免疫与免疫机能的影响[J].中国运动医学杂志,2014,33(11):1054-1059.
[49] Stoiber H., Pruenster M., Ammann C. G., et al. Complement-opsonized HIV:the free rider on its way to infection[J]. Mol. Immunol, 2005, 42(2):153-160.
[50] Lee K. C., Chang C.Y., Chuang Y. C., et al. Measurement of human erythrocyte C4d to erythrocyte complement receptor 1 ratio in cardiac transplant recipients with acute symptomatic allograft failure[J] Transplant Proc.,2008, 40(8):2638-2642.
[51]李玉周,王蕊,张缨.不同低氧训练方式对大鼠红细胞免疫调节因子及其功能的影响[J].西安体育学院学报,2009,26(2):202-205.
[52] De Back D. Z., Kostova M.,Van karaaij T. K., et al. Of macrophages and red blood cells;a complex love story[J].Front. Physiol., 2014, 5:9.
[53] Luck A., Igor E., Nilam S. As Modulators of Innate Immuntity The Evolving Erythrocyte:Red Blood Cell[J].J.Immunol., 2018, 201:1243-1351.
[54]李红,章晓霜.艾灸对运动员红细胞免疫功能与T细胞亚群的影响[J].中国针灸,2013,33(5):415-418.
[55]田军,邵媛仙,李素芳.不同血清锌水平小儿外周血T淋巴细胞亚群及红细胞免疫状态的变化研究[J].实用预防医学,2017,24(6):741-742.
[2] Barros M. M.,Yamamoto M.,Figueiredo M. S.,et al.Expression levels of CD47,CD35,CD55 and CD59 on red blood cells and fignal-regulatory protein-alpha, beta on monocytes from patients with warm autoimmune hemolytic anemia[J]. Transfusion, 2009, 49(1):154-160.
[3]郭峰.红细胞天然免疫与获得性免疫[J].自然杂志,2004,(4):194-199.
[4] Dai R. W.From engineering cybernetics to cyberspacefor woekshop of metasynthetic engineering[J].Chin J Nat,2005, 27(6):366-370.
[5] Gordon S.Macrophages and the immune response. In:Paul EW,editor. Fundamental immunology[M]. Philadelphia:Lippincott-Raven. 1999:533-545.
[6] Minasyan H. Mechanisms and pathways for the clearance of bacteria from blood circulation in health and disease[J]. Pathophysiology, 2016, 23:61-66.
[7] Lahoz-Beneytez J., Elemans M., Zhang Y., et al. Human neutrophil kinetics:modeling of stable isotope labeling data supports short blood neutrophil half-lives[J]. Blood,2016, 127:3431-3438.
[8] Schutze G. E., Buckingham S. C., Marshall G. S., et al.Human monocytic ehrlichiosis in children[J]. Pediatr Infect Dis. J., 2007, 26(6):475-479.
[9] Hayk M. Phagocytosis and oxycytosis:two anus of human innate immunity[J]. Immunologic Research, 2018,31:665-670.
[10]郭峰.红细胞天然免疫主干道理论与现代系统免疫学[J].自然杂志,2006(2):79-83.
[11]郭峰.免疫原快速激活系统血液固有免疫反应研究思路的演变与创新[J].中国医药生物技术,2010,5(1):15-18.
[12]郭峰.现代系统免疫学的形成与发展[J].中国免疫学杂志,2010(1):88-91.
[13] Sica A., Melillo G., Varesio L. Hypoxia:a double-edged sword of immunity[J]. J. Mol. Med., 2011, 89:657-665.
[14] Webster K. A. Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia[J]. J. Exp. Biol.,2003, 206:2911-2922.
[15] Cooper M. D., Alder M. N. The evolution of adaptive immune systems[J]. J. Cell, 2006, 124:815-822.
[16]司本辉,张庆成,吴康智,等.急进高原战士低氧环境对红细胞免疫功能影响的研究[J].高原医学杂志,2000,10(3):37-39.
[17]宋济范,周晶萍,叶俊雄,等.高原地区人群红细胞免疫粘附功能观察[J].高原医学杂志,1995,5(6):12-14.
[18]石泉贵.现代红细胞免疫学[M].上海:第二军医大学出版社,2002:262-264.
[19]刘兰,褚以德,陆天顺,等.高原地区红细胞免疫功能的观察[J].高原医学杂志.1998,8(1):53-55.
[20]杜智敏,刘崇礼.高海拔地区不同年龄正常人红细胞免疫功能测定及分析[J].高原医学杂志,1999,9(1):38-39.
[21]杜智敏,刘崇礼.高原地区不同移居时间正常人红细胞免疫功能测定[J].解放军预防医学医学杂志,1999,17(3):219.
[22]石泉贵.快速进入高原对世居藏族红细胞免疫粘附功能的影响[J].西南国防医药,2000, 10(5):303-304.
[23]司本辉,张庆成,吴康智,等.急进高原战士低氧环境对红细胞免疫功能影响的研究[J].高原医学杂志,2000,10(3):37-39.
[24]杨沛,陈伟,龚敏,等.高压氧治疗后红细胞免疫功能的变化及临床意义[J].中国现代医学杂志.2003,13(6):14-16.
[25]陈勇锐,孟淼,张军,等.模拟常压失事潜艇环境人血细胞表面CD55、CD59分布的变化.中国应用生理学杂志[J].2007,23(2):226-228.
[26] Morera D., Mackenzie S.A. Is there a direct role for erythrocytes in the immune response?[J]Vet. Res., 2011,42:89.
[27]胡琪琛,郭峰,翁玉泉,等.训练及不同强度运动队红细胞免疫功能的影响[J].中国免疫学杂志,1995,8(11):24-25.
[28]裴新贞.长时间大强度运动后SD大鼠红细胞免疫功能的变化[J].深训中西医结合杂志,2001,5(3):264-268.
[29]姜振,柏建清.不同负荷跑台训练大鼠红细胞免疫功能及血浆β-内啡肽的变化[J].中国组织工程研究与临床康复. 2007,11(24):4726-4729.
[30]叶路,董小青.急性运动对小鼠红细胞免疫粘附功能的影响[J].中国运动医学杂志,1998,17(2):157.
[31]宋亚军.力竭运动对小鼠红细胞免疫功能的影响[J].北京体育大学学报,2000,2(3):24-30.
[32]陈愉宁,张盈华,张利朝,等.健康人跑步前后红细胞免疫功能的变化[J].中国运动医学杂志,1999,18(3):226-227.
[33]张利朝,张盈华,陈愉宁,等.健康人运动前后红细胞免疫功能与细胞数的变化及关系[J].细胞与分子生物学杂志,2001,17(2):197-199.
[34]宋亚军,郝梅.恒定功率不同持续时间运动队红细胞免疫功能的影响[J].体育与科学,1999,5(3):15-19.
[35]裴新贞,程悦.不同游泳运动时间训练对大鼠红细胞免疫粘附功能的影响[C].北京:2002年第九届全国运动医学学术会议,2002:57.
[36]黄海,郝选明,胡晓燕,等.红细胞免疫功能对定量负荷特点的实验研究[J].中国运动医学杂志,1999,18(4):375-377.
[37]郝选明,黄海,胡晓燕,等.红细胞免疫功能对有有氧运动的适应性变化特征[J].体育科学,1999,29(6):77-81.
[38]王蕾,高炳宏,陈佩杰.HiHiLo研究进展[J].中国运动医学杂志,2010,29(3):353-358.
[39] Tiollier E., Schmitt L., Bumat P., et al. Living high-training low altitude training:effects on mucosal immunity[J]. Eur. J. Appl. Physiol., 2005. 94:298-304
[40]姚大为.我国优秀速滑运动员IHT的生理生化及免疫监控体系研究[D].沈阳:东北师范大学博士学位论文.2013:6.
[41]高欢,李涛,高炳宏,等.3200mHiHiLo免疫和炎症反应应答特征及其对有氧能力的影响[J].体育科学,2018,38(4),54-60.
[42]金其贵,胡要娟,金爱娜.不同模式的低氧运动训练对大鼠肠道体液免疫功能的影响[J].中国运动医学杂志,2015,34(8):764-769
[43]张缨,周帆扬,胡杨,等.急性低氧暴露对足球运动员红细胞免疫功能及调节因子的影响[J].中国运动医学杂志,2004,23(2):130-132.
[44]周帆扬,张缨,胡杨,等.4周高住低训对红细胞免疫功能的影响[J].体育科学,2003,23(6):132-135.
[45]赵永才,高炳宏,丁树哲.高住低练对游泳运动员红细胞免疫分子表达及供能的影响[J].体育科学,2010,6(3):15-20.
[46]罗琳,张缨.高住高练低训对足球运动员红细胞CD35数量及活性变化的影响[J].中国运动医学杂志,2006,25(4):395-398.
[47]朱荣,张缨,王芳.不同低氧训练方式对红细胞调控T淋巴细胞免疫及其功能的影响[J].体育科学,2007,27(3):68-71.
[48]王玺,高炳宏.3周高住低训对优秀运动员红细胞免疫与免疫机能的影响[J].中国运动医学杂志,2014,33(11):1054-1059.
[49] Stoiber H., Pruenster M., Ammann C. G., et al. Complement-opsonized HIV:the free rider on its way to infection[J]. Mol. Immunol, 2005, 42(2):153-160.
[50] Lee K. C., Chang C.Y., Chuang Y. C., et al. Measurement of human erythrocyte C4d to erythrocyte complement receptor 1 ratio in cardiac transplant recipients with acute symptomatic allograft failure[J] Transplant Proc.,2008, 40(8):2638-2642.
[51]李玉周,王蕊,张缨.不同低氧训练方式对大鼠红细胞免疫调节因子及其功能的影响[J].西安体育学院学报,2009,26(2):202-205.
[52] De Back D. Z., Kostova M.,Van karaaij T. K., et al. Of macrophages and red blood cells;a complex love story[J].Front. Physiol., 2014, 5:9.
[53] Luck A., Igor E., Nilam S. As Modulators of Innate Immuntity The Evolving Erythrocyte:Red Blood Cell[J].J.Immunol., 2018, 201:1243-1351.
[54]李红,章晓霜.艾灸对运动员红细胞免疫功能与T细胞亚群的影响[J].中国针灸,2013,33(5):415-418.
[55]田军,邵媛仙,李素芳.不同血清锌水平小儿外周血T淋巴细胞亚群及红细胞免疫状态的变化研究[J].实用预防医学,2017,24(6):741-742.