新型抗菌树脂材料研究进展
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摘要
复合树脂材料目前被广泛应用于牙体缺损的修复治疗,以恢复牙齿的正常形态和色泽。但目前临床使用的树脂材料常缺乏有效的抗菌性能,远期治疗效果常因修复材料与牙体组织不密合、菌斑滞留、形成继发龋等影响使用寿命。近年来,合成具有抗菌活性的复合树脂材料是口腔修复材料研究的一个热点,对于抗菌剂的加入,其种类、方式、机制等也开展了大量的研究。文章就近年来抗菌性树脂材料的研究进展做一综述。
Composite resin materials are widely used in the repair and treatment of dental defects to restore the normal shape and color of teeth. However,the resin materials used in clinical practice often lack effective antibacterial properties,and the long-term treatment effect often affects the service life due to the reasons such as the incompatibility between the repair materials and dental tissues,the retention of plaque,and the formation of secondary caries. In recent years,the synthesis of composite resin with antibacterial activity is a hot topic of dental restorative material research,and the types,ways and mechanisms of antibacterial agents have also been researched.In this paper,the research progress of antimicrobial resin materials in recent years is reviewed
Composite resin materials are widely used in the repair and treatment of dental defects to restore the normal shape and color of teeth. However,the resin materials used in clinical practice often lack effective antibacterial properties,and the long-term treatment effect often affects the service life due to the reasons such as the incompatibility between the repair materials and dental tissues,the retention of plaque,and the formation of secondary caries. In recent years,the synthesis of composite resin with antibacterial activity is a hot topic of dental restorative material research,and the types,ways and mechanisms of antibacterial agents have also been researched.In this paper,the research progress of antimicrobial resin materials in recent years is reviewed
引文
[1]Al-Dulaijan YA,Cheng L,Weir MD,et al.Novel rechargeable calcium phosphate nanocomposite with antibacterial activity to suppress biofilm acids and dental caries[J].J Dent,2018,72:44-52.
[2]石鑫,陆海波,毛靖,等.口腔抗菌树脂材料抗菌模式的研究现状与进展[J].中华口腔医学杂志,2016,51(9):566-569.
[3]Charville GW,Hetrick EM,Geer CB,et al.Reduced bacterial adhesion to fibrinogen-coated substrates via nitric oxide release[J].Biomaterials,2008,29(30):4039-4044.
[4]Lu Y,Slomberg DL,Schoenfisch MH.Nitric oxide-releasing chitosan oligosaccharides as antibacterial agents[J].Biomaterials,2014,35(5):1716-1724.
[5]Backlund CJ,Worley BV,Schoenfisch MH.Anti-biofilm action of nitric oxide-releasing alkyl-modified poly(amidoamine)dendrimers against streptococcus mutans[J].Acta Biomater,2016,29:198-205.
[6]Trivedi P,Nune KC,Misra RDK,et al.Cellular response of Escherichia coli to Mg-2Zn-2Gd alloy with different grain structure:mechanism of disruption of colonisation[J].Mater Technol,2016,31:836-844.
[7]He T,Zhu W,Wang X,et al.Polydopamine assisted immobilisation of copper(Ⅱ)on titanium for antibacterial applications[J].Mater Technol,2015,30(B2):B68-B72.
[8]Nune C,Xu W,Misra RD.The impact of grafted modification of silicone surfaces with quantum-sized materials on protein adsorption and bacterial adhesion[J].J Biomed Mater Res A,2012,100(12):3197-3204.
[9]Campoccia D,Montanaro L,Agheli H,et al.Study of staphylococcus aureus adhesion on a novel nanostructured surface by chemiluminometry[J].Int J Artif Organs,2006,29(6):622-629.
[10]Misra RDK,Girase B,Depan D,et al.Hybrid nanoscale architecture for enhancement of antimicrobial activity:immobilization of silver nanoparticles on thiol-functionalized polymer crystallized on carbon nanotubes[J].Adv Eng Mater,2012,14:B93-B100.
[11]Perdikaki A,Galeou A,Pilatos G,et al.Ag and Cu monometallic and Ag/Cu bimetallic nanoparticle-graphene composites with enhanced antibacterial performance[J].ACS Appl Mate Interfaces,2016,8(41):27498-27510.
[12]王洁,孟翔峰.纳米银的抗菌机制研究[J].现代口腔医学杂志,2013,27(5):304-308.
[13]Kasraei S,Sami L,Hendi S,et al.Antibacterial properties of composite resins incorporating silver and zinc oxide nanoparticles on Streptococcus mutans and Lactobacillus[J].2014,39(2):109-114.
[14]Melo MA,Orrego S,Weir MD,et al.Designing multiagent dental materials for enhanced resistance to biofilm damage at the bonded interface[J].ACS Appl Mater Interfaces,2016,8(18):11779-11787.
[15]Mankovskaia A,Lévesque CM,Prakki A.Catechin-incorporated dental copolymers inhibit growth of Streptococcus mutans[J].J Appl Oral Sci,2013,21(2):203-207.
[16]Chatzistavrou X,Lefkelidou A,Papadopoulou L,et al.Bactericidal and bioactive dental composites[J].Frontiers Physiol,2018,9:103.
[17]董波,李益玲,贾小可,等.氧化锌晶须改性光固化复合树脂的力学性能和抑菌性[J].中国体视学与图像分析,2014,19(4):354-358
[18]Aljabo A,Abou Neel EA,Knowles JC,et al.Development of dental composites with reactive fillers that promote precipitation of antibacterial-hydroxyapatite layers[J].Mater Sci Eng CMater Biol Appl,2016,60:285-292.
[19]Zhang JF,Wu R,Fan Y,et al.Antibacterial dental composites with chlorhexidine and mesoporous silica[J].J Dent Res,2014,93(12):1283-1289.
[20]Wang J,Dong X,Yu Q,et al.Incorporation of antibacterial agent derived deep eutectic solvent into an active dental composite[J].Dent Mater,2017,33(12):1445-1455.
[21]Xu X,Wang Y,Liao S,et al.Synthesis and characterization of antibacterial dental monomers and composites[J].J Biomed Mater Res B Appl Biomater,2012,100(4):1151-1162.
[22]Weng Y,Howard L,Guo X,et al.A novel antibacterial resin composite for improved dental restoratives[J].J Mater Sci Mater Med,2012,23(6):1553-1561.
[23]吴俊领,周凯运,朱婷,等.含长链烷基季铵盐的纳米抗菌无机填料的合成及其在牙科复合树脂中的应用研究[J].华西口腔医学杂志,2014,32(5):513-518.
[24]吴俊领,张强,孙睿男,等.含长链烷基季铵盐纳米抗菌无机填料的复合树脂对人牙菌斑生物膜的影响[J].华西口腔医2015336565-569.186学杂志,2015,33(6):565-569.181
[25]Hwang G,Koltisko B,Jin X,et al.Nonleachable imidazoliumincorporated composite for disruption of bacterial clustering,exopolysaccharide-matrix assembly,and enhanced biofilm removal[J].ACS Appl Mater Interfaces,2017,9(44):38270-38280.
[26]Zhang K,Cheng L,Weir MD,et al.Effects of quaternary ammonium chain length on the antibacterial and remineralizing effects of a calcium phosphate nanocomposite[J].Int J Oral Sci,2016,8(1):45-53.
[27]Wu J,Weir MD,Melo MA,et al.Development of novel selfhealing and antibacterial dental composite containing calcium phosphate nanoparticles[J].J Dent,2015,43(3):317-326.
[28]Wu J,Weir MD,Zhang Q,et al.Novel self-healing dental resin with microcapsules of polymerizable triethylene glycol dimethacrylate and N,N-dihydroxyethyl-p-toluidine[J].Dent Mater,2016,32(2):294-304.
[29]Wu J,Weir MD,Melo MA,et al.Effects of water-aging on selfhealing dental composite containing microcapsules[J].J Dent,2016,47:86-93.
[30]Cheng L,Weir MD,Xu HH,et al.Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles[J].Dent Mater,2012,28(5):561-572.
[31]Cheng L,Zhang K,Zhou CC,et al.One-year water-ageing of calcium phosphate composite containing nano-silver and quaternary ammonium to inhibit biofilms[J].Int J Oral Sci,2016,8(3):172-181.
[32]Zhang N,Ma J,Melo MA,et al.Protein-repellent and antibacterial dental composite to inhibit biofilms and caries[J].J Dent,2015,43(2):225-234.
[33]Zhang N,Zhang K,Melo MA,et al.Effects of long-term wateraging on novel anti-biofilm and protein-repellent dental composite[J].Int J Mol Sci,2017,18(1).Pii:E186.
[34]Cao W,Zhang Y,Wang X,et al.Development of a novel resinbased dental material with dual biocidal modes and sustained release of Ag+ions based on photocurable core-shell AgBr/cationic polymer nanocomposites[J].J Mater Sci Mater Med,2017,28(7):103.
[35]Cheng L,Zhang K,Zhang N,et al.Developing a new generation of antimicrobial and bioactive dental resins[J].J Dent Res,2017,96(8):855-863.
[2]石鑫,陆海波,毛靖,等.口腔抗菌树脂材料抗菌模式的研究现状与进展[J].中华口腔医学杂志,2016,51(9):566-569.
[3]Charville GW,Hetrick EM,Geer CB,et al.Reduced bacterial adhesion to fibrinogen-coated substrates via nitric oxide release[J].Biomaterials,2008,29(30):4039-4044.
[4]Lu Y,Slomberg DL,Schoenfisch MH.Nitric oxide-releasing chitosan oligosaccharides as antibacterial agents[J].Biomaterials,2014,35(5):1716-1724.
[5]Backlund CJ,Worley BV,Schoenfisch MH.Anti-biofilm action of nitric oxide-releasing alkyl-modified poly(amidoamine)dendrimers against streptococcus mutans[J].Acta Biomater,2016,29:198-205.
[6]Trivedi P,Nune KC,Misra RDK,et al.Cellular response of Escherichia coli to Mg-2Zn-2Gd alloy with different grain structure:mechanism of disruption of colonisation[J].Mater Technol,2016,31:836-844.
[7]He T,Zhu W,Wang X,et al.Polydopamine assisted immobilisation of copper(Ⅱ)on titanium for antibacterial applications[J].Mater Technol,2015,30(B2):B68-B72.
[8]Nune C,Xu W,Misra RD.The impact of grafted modification of silicone surfaces with quantum-sized materials on protein adsorption and bacterial adhesion[J].J Biomed Mater Res A,2012,100(12):3197-3204.
[9]Campoccia D,Montanaro L,Agheli H,et al.Study of staphylococcus aureus adhesion on a novel nanostructured surface by chemiluminometry[J].Int J Artif Organs,2006,29(6):622-629.
[10]Misra RDK,Girase B,Depan D,et al.Hybrid nanoscale architecture for enhancement of antimicrobial activity:immobilization of silver nanoparticles on thiol-functionalized polymer crystallized on carbon nanotubes[J].Adv Eng Mater,2012,14:B93-B100.
[11]Perdikaki A,Galeou A,Pilatos G,et al.Ag and Cu monometallic and Ag/Cu bimetallic nanoparticle-graphene composites with enhanced antibacterial performance[J].ACS Appl Mate Interfaces,2016,8(41):27498-27510.
[12]王洁,孟翔峰.纳米银的抗菌机制研究[J].现代口腔医学杂志,2013,27(5):304-308.
[13]Kasraei S,Sami L,Hendi S,et al.Antibacterial properties of composite resins incorporating silver and zinc oxide nanoparticles on Streptococcus mutans and Lactobacillus[J].2014,39(2):109-114.
[14]Melo MA,Orrego S,Weir MD,et al.Designing multiagent dental materials for enhanced resistance to biofilm damage at the bonded interface[J].ACS Appl Mater Interfaces,2016,8(18):11779-11787.
[15]Mankovskaia A,Lévesque CM,Prakki A.Catechin-incorporated dental copolymers inhibit growth of Streptococcus mutans[J].J Appl Oral Sci,2013,21(2):203-207.
[16]Chatzistavrou X,Lefkelidou A,Papadopoulou L,et al.Bactericidal and bioactive dental composites[J].Frontiers Physiol,2018,9:103.
[17]董波,李益玲,贾小可,等.氧化锌晶须改性光固化复合树脂的力学性能和抑菌性[J].中国体视学与图像分析,2014,19(4):354-358
[18]Aljabo A,Abou Neel EA,Knowles JC,et al.Development of dental composites with reactive fillers that promote precipitation of antibacterial-hydroxyapatite layers[J].Mater Sci Eng CMater Biol Appl,2016,60:285-292.
[19]Zhang JF,Wu R,Fan Y,et al.Antibacterial dental composites with chlorhexidine and mesoporous silica[J].J Dent Res,2014,93(12):1283-1289.
[20]Wang J,Dong X,Yu Q,et al.Incorporation of antibacterial agent derived deep eutectic solvent into an active dental composite[J].Dent Mater,2017,33(12):1445-1455.
[21]Xu X,Wang Y,Liao S,et al.Synthesis and characterization of antibacterial dental monomers and composites[J].J Biomed Mater Res B Appl Biomater,2012,100(4):1151-1162.
[22]Weng Y,Howard L,Guo X,et al.A novel antibacterial resin composite for improved dental restoratives[J].J Mater Sci Mater Med,2012,23(6):1553-1561.
[23]吴俊领,周凯运,朱婷,等.含长链烷基季铵盐的纳米抗菌无机填料的合成及其在牙科复合树脂中的应用研究[J].华西口腔医学杂志,2014,32(5):513-518.
[24]吴俊领,张强,孙睿男,等.含长链烷基季铵盐纳米抗菌无机填料的复合树脂对人牙菌斑生物膜的影响[J].华西口腔医2015336565-569.186学杂志,2015,33(6):565-569.181
[25]Hwang G,Koltisko B,Jin X,et al.Nonleachable imidazoliumincorporated composite for disruption of bacterial clustering,exopolysaccharide-matrix assembly,and enhanced biofilm removal[J].ACS Appl Mater Interfaces,2017,9(44):38270-38280.
[26]Zhang K,Cheng L,Weir MD,et al.Effects of quaternary ammonium chain length on the antibacterial and remineralizing effects of a calcium phosphate nanocomposite[J].Int J Oral Sci,2016,8(1):45-53.
[27]Wu J,Weir MD,Melo MA,et al.Development of novel selfhealing and antibacterial dental composite containing calcium phosphate nanoparticles[J].J Dent,2015,43(3):317-326.
[28]Wu J,Weir MD,Zhang Q,et al.Novel self-healing dental resin with microcapsules of polymerizable triethylene glycol dimethacrylate and N,N-dihydroxyethyl-p-toluidine[J].Dent Mater,2016,32(2):294-304.
[29]Wu J,Weir MD,Melo MA,et al.Effects of water-aging on selfhealing dental composite containing microcapsules[J].J Dent,2016,47:86-93.
[30]Cheng L,Weir MD,Xu HH,et al.Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles[J].Dent Mater,2012,28(5):561-572.
[31]Cheng L,Zhang K,Zhou CC,et al.One-year water-ageing of calcium phosphate composite containing nano-silver and quaternary ammonium to inhibit biofilms[J].Int J Oral Sci,2016,8(3):172-181.
[32]Zhang N,Ma J,Melo MA,et al.Protein-repellent and antibacterial dental composite to inhibit biofilms and caries[J].J Dent,2015,43(2):225-234.
[33]Zhang N,Zhang K,Melo MA,et al.Effects of long-term wateraging on novel anti-biofilm and protein-repellent dental composite[J].Int J Mol Sci,2017,18(1).Pii:E186.
[34]Cao W,Zhang Y,Wang X,et al.Development of a novel resinbased dental material with dual biocidal modes and sustained release of Ag+ions based on photocurable core-shell AgBr/cationic polymer nanocomposites[J].J Mater Sci Mater Med,2017,28(7):103.
[35]Cheng L,Zhang K,Zhang N,et al.Developing a new generation of antimicrobial and bioactive dental resins[J].J Dent Res,2017,96(8):855-863.