fMRI动态功能连接方法及其在癫痫中的应用
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摘要
功能磁共振成像(functional magnetic resonance imaging,f MRI)研究大脑功能连接主要基于连接稳定性这一假设.实际上,fMRI数据具有动态性,即使在相同的实验条件下,也显示出随时间变化的模式.首先介绍了大脑连接动态性的依据,然后综述了近几年f MRI数据动态功能连接的方法,并总结了这些方法在癫痫中的研究成果,最后指出了该领域中存在的问题及未来的研究方向.
The study of brain functional connectivity with functional magnetic resonance imaging( f MRI)was based on the assumption of connectivity stability. Actually,the data are dynamic,showing evidence of time-varying connectivity patterns,even under the same experimental condition. In this paper,the basis of the dynamic functional connectivity of the brain was first introduced,then the method of the dynamical functional connectivity of f MRI data in recent years was reviewed,and the research results of these methods in epilepsy were summarized. Finally,the open question and the future prospect were pointed out in this field.
The study of brain functional connectivity with functional magnetic resonance imaging( f MRI)was based on the assumption of connectivity stability. Actually,the data are dynamic,showing evidence of time-varying connectivity patterns,even under the same experimental condition. In this paper,the basis of the dynamic functional connectivity of the brain was first introduced,then the method of the dynamical functional connectivity of f MRI data in recent years was reviewed,and the research results of these methods in epilepsy were summarized. Finally,the open question and the future prospect were pointed out in this field.
引文
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[3]RICHARDSON M P.Large scale brain models of epilepsy:dynamics meets connectomics[J].J Neurol Neurosurg Psychiatry,2012,83(12):1238-1248.
[4]ENGEL J J,THOMPSON P M,STERN J M,et al.Connectomics and epilepsy[J].Current Opinion in Neurology,2013,26(2):186.
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[7]STEFAN H,LOPES D S.Epileptic neuronal networks:methods of identification and clinical relevance[J].Frontiers in Neurology,2013,4:8.
[8]GOTMAN J.Epileptic networks studied with EEG‐f MRI[J].Epilepsia,2008,49:42-51.
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[15]PEDERSEN M,OMIDVAMIA A,CURWOOD E K,et al.The dynamics of functional connectivity in neocortical focal epilepsy[J].Neuro Image:Clinical,2017,15:209-214.
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[19]GRATTON G,COOPER P,FABIANI M,et al.Dynamics of cognitive control:theoretical bases,paradigms,and a view for the future[J].Psychophysiology,2018,55(3):e13016.
[20]HUTCHISON R M,WOMELSDOR T,GATI J S,et al.Resting-state networks show dynamic functional connectivity in awake humans and anesthetized macaques[J].Hunan Brain Mapping,2013,34(9):2154-2177.
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[25]SAKOGLU U,PEARLSON G D,KIEHL K A,et al.Amethod for evaluating dynamic functional network connectivity and task-modulation:application to schizophrenia[J].Magnetic Resonance Materials in Physics,Biology and Medicine,2010,23(5/6):351-366.
[26]SHEN K,HUTCHISON R M,BEZGIN G.Resting-state functional connectivity dynamics are influenced by network structure[C]∥Toronto,[s.n.]:Canadian Association for Neuroscience Annual Meeting,2013.
[27]ALLEN E A,DAMARAJU E,PLIS S M,et al.Tracking whole-brain connectivity dynamics in the resting state[J].Cerebral Cortex,2014,24(3):663-676.
[28]BASSETT D S,WYMBS N F,PORTER M A,et al.Dynamic reconfiguration of human brain networks during learning[J].Proceedings of the National Academy of Sciences,2011,108(18):7641-7646.
[29]JONES D T,VEMURI P,MURPHY M C,et al.Nonstationarity in the“resting brain's”modular architecture[J].Plo S One,2012,7(6):e39731.
[30]KINNISON J,PADMALA S,CHOI J M,et al.Network analysis reveals increased integration during emotional and motivational processing[J].Journal of Neuroscience,2012,32(24):8361-8372.
[31]CRIBBEN I,HARALDSDOTTIR R,ATLAS L Y,et al.Dynamic connectivity regression:determining staterelated changes in brain connectivity[J].Neuroimage,2012,61(4):907-920.
[32]YAESOUBI M,ALLEN E A,MILLER R L,et al.Dynamic coherence analysis of resting f MRI data to jointly capture state-based phase,frequency,and time-domain information[J].Neuroimage,2015,120:133-142.
[33]DECO G,JIRSA V K,MCINTOSH A R.Emerging concepts for the dynamical organization of resting-state activity in the brain[J].Nature Reviews Neuroscience,2010,12(1):nrn2961.
[34]CHEN J E,RUBINOV M,CHANG C.Methods and considerations for dynamic analysis of functional MRimaging data[J].Neuroimaging Clinics,2017,27(4):547-560.
[35]FAIR D A,COHEN A L,POWER J D,et al.Functional brain networks develop from a“local to distributed”organization[J].PLo S Computational Biology,2009,5(5):e1000381.
[36]CHIANG S,CASSESE A,GUINDANI M,et al.Timedependence of graph theory metrics in functional connectivity analysis[J].Neuroimage,2016,125:601-615.
[37]HELLYER P J,BARRY E F,PELLIZZON A,et al.Protein synthesis is associated with high-speed dynamics and broad-band stability of functional hubs in the brain[J].Neuro Image,2017,155:209-216.
[38]GREICIUS M.Resting-state functional connectivity in neuropsychiatric disorders[J].Current Opinion in Neurology,2008,21(4):424-430.
[39]MENON V.Large-scale brain networks and psychopathology:a unifying triple network model[J].Trends in Cognitive Sciences,2011,15(10):483-506.
[40]PEDERSEN M,OMIDVARNIA A,CURWOOD E K,et al.The dynamics of functional connectivity in neocortical focal epilepsy[J].Neuro Image:Clinical,2017,15:209-214.
[41]OMIDVARNIA A,PEDERSEN M,VAUGHAN D N,et al.Dynamic coupling between f MRJ local connectivity and interictal EEG in focal epilepsy:a wavelet analysis approach[J].Human Brain Mapping,2017,38(11):5356-5374.
[42]ESPINOZA-VALDEZ A,GONZALEZ-GARRIDO A A,LUNA B,et al.Epiletic brain reorganization dynamics on the basis of the probability of connections[J].Neuroreport,2016,27(1):1-5.
[43]LIAO W,ZHANG Z,MANTINI D,et al.Dynamical intrinsic functional architecture of the brain during absence seizures[J].Brain Structure and Function,2014,219(6):2001-2015.
[44]MARUSAK H A,THOMASON M E,ELRAHAL F,et al.Mindfulness and dynamic functional neural connectivity in children and adolescents[J].Behavioural Brain Research,2018,336:211-218.
[45]DU Y,PEARLSON G D,LIN D,et al.Identifying dynamic functional connectivity biomarkers using GIG-ICA:application to schizophrenia,schizoaffective disorder,and psychotic bipolar disorder[J].Human Brain Mapping,2017,38(5):2683-2708.
[46]FUKUNAGA M,HOROVITZ S G,GELDEREN P V,et al.Large-amplitude,spatially correlated fluctuations in BOLD f MRI signals during extended rest and early sleep stages[J].Magnetic Resonance Imaging,2006,24(8):979-992.
[47]BARNES A,BULLMORE E T,SUCKLING J.Endogenous human brain dynamics recover slowly following cognitive effort[J].Plo S One,2009,4(8):e6626.
[48]ROBINSON L F,LA P V,KUSHNIR Y.Detecting shifts in correlation and variability with application to ENSO-monsoon rainfall relationships[J].Theoretical and Applied Climatology,2008,94(3):215-224.
[2]KRAMER M A,CASH S S.Epilepsy as a disorder of cortical network organization[J].The Neuroscientist,2012,18(4):360-372.
[3]RICHARDSON M P.Large scale brain models of epilepsy:dynamics meets connectomics[J].J Neurol Neurosurg Psychiatry,2012,83(12):1238-1248.
[4]ENGEL J J,THOMPSON P M,STERN J M,et al.Connectomics and epilepsy[J].Current Opinion in Neurology,2013,26(2):186.
[5]CAEYENBERGHS K,POWELL H W,THOMAS R H,et al.Hyperconnectivity in juvenile myoclonic epilepsy:a network analysis[J].Neuro Image:Clinical,2015,7:98-104.
[6]LAUFS H.Functional imaging of seizures and epilepsy:evolution from zones to networks[J].Current Opinion in Neurology,2012,25(2):194-200.
[7]STEFAN H,LOPES D S.Epileptic neuronal networks:methods of identification and clinical relevance[J].Frontiers in Neurology,2013,4:8.
[8]GOTMAN J.Epileptic networks studied with EEG‐f MRI[J].Epilepsia,2008,49:42-51.
[9]LIAO W,ZHANG Z,PAN Z,et al.Altered functional connectivity and small-world in mesial temporal lobe epilepsy[J].Plo S One,2010,5(1):e8525.
[10]VLOOSWIJK M C,JANSEN J F,KROM M C,et al.Functional MRI in chronic epilepsy:associations with cognitive impairment[J].The Lancet Neurology,2010,9(10):1018-1027.
[11]VLOOSWIJK M C,VAESSEN M J,JANSEN J F,et al.Loss of network efficiency associated with cognitive decline in chronic epilepsy[J].Neurology,2011,77(10):938-944.
[12]ZHANG Z,LIAO W,CHEN H,et al.Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy[J].Brain,2011,134(10):2912-2928.
[13]BISWAL B,ZERRIN Y F,HAUGHTON V M,et al.Functional connectivity in the motor cortex of resting human brain using echo-planar mri[J].Magnetic Resonance in Medicine,1995,34(4):537-541.
[14]LIU F,WANG Y,LI M,et al.Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic-clonic seizure[J].Human Brain Mapping,2017,38(2):957-973.
[15]PEDERSEN M,OMIDVAMIA A,CURWOOD E K,et al.The dynamics of functional connectivity in neocortical focal epilepsy[J].Neuro Image:Clinical,2017,15:209-214.
[16]OMIDVAMIA A,PEDERSEN M,VAUGHAN D N,et al.Dynamic coupling between fmri local connectivity and interictal Eeg in focal epilepsy:a wavelet analysis approach[J].Human Brain Mapping,2017,38(11):5356-5374.
[17]ESPINOZA-VALBEZ A,GONZALEZ-GARRIDO A A,LUNAL B,et al.Epileptic brain reorganization dynamics on the basis of the probability of connections[J].Neuroreport,2016,27(1):1-5.
[18]CALHOUN V D,MILLER R,PEARLSON G,et al.The chronnectome:time-varying connectivity networks as the next frontier in f MRI data discovery[J].Neuron,2014,84(2):262-274.
[19]GRATTON G,COOPER P,FABIANI M,et al.Dynamics of cognitive control:theoretical bases,paradigms,and a view for the future[J].Psychophysiology,2018,55(3):e13016.
[20]HUTCHISON R M,WOMELSDOR T,GATI J S,et al.Resting-state networks show dynamic functional connectivity in awake humans and anesthetized macaques[J].Hunan Brain Mapping,2013,34(9):2154-2177.
[21]ALLEN J J,COHEN M X.Deconstructing the“resting”state:exploring the temporal dynamics of frontal alpha asymmetry as an endophenotype for depression[J].Frontiers in Human Neuroscience,2010,4:232.
[22]CHANG C,GLOVER G H.Time-frequency dynamics of resting-state brain connectivity measured with f MRI[J].Neuroimage,2010,50(1):81-98.
[23]HANDWERKER D A,ROOPCHANSINGH V,GONZALEZ-CASTILLO J,et al.Periodic changes in f MRI connectivity[J].Neuroimage,2012,63(3):1712-1719.
[24]HUTCHISON R M,WOMELSDORF T,GATI J S,et al.Resting‐state networks show dynamic functional connectivity in awake humans and anesthetized macaques[J].Human Brain Mapping,2013,34(9):2154-2177.
[25]SAKOGLU U,PEARLSON G D,KIEHL K A,et al.Amethod for evaluating dynamic functional network connectivity and task-modulation:application to schizophrenia[J].Magnetic Resonance Materials in Physics,Biology and Medicine,2010,23(5/6):351-366.
[26]SHEN K,HUTCHISON R M,BEZGIN G.Resting-state functional connectivity dynamics are influenced by network structure[C]∥Toronto,[s.n.]:Canadian Association for Neuroscience Annual Meeting,2013.
[27]ALLEN E A,DAMARAJU E,PLIS S M,et al.Tracking whole-brain connectivity dynamics in the resting state[J].Cerebral Cortex,2014,24(3):663-676.
[28]BASSETT D S,WYMBS N F,PORTER M A,et al.Dynamic reconfiguration of human brain networks during learning[J].Proceedings of the National Academy of Sciences,2011,108(18):7641-7646.
[29]JONES D T,VEMURI P,MURPHY M C,et al.Nonstationarity in the“resting brain's”modular architecture[J].Plo S One,2012,7(6):e39731.
[30]KINNISON J,PADMALA S,CHOI J M,et al.Network analysis reveals increased integration during emotional and motivational processing[J].Journal of Neuroscience,2012,32(24):8361-8372.
[31]CRIBBEN I,HARALDSDOTTIR R,ATLAS L Y,et al.Dynamic connectivity regression:determining staterelated changes in brain connectivity[J].Neuroimage,2012,61(4):907-920.
[32]YAESOUBI M,ALLEN E A,MILLER R L,et al.Dynamic coherence analysis of resting f MRI data to jointly capture state-based phase,frequency,and time-domain information[J].Neuroimage,2015,120:133-142.
[33]DECO G,JIRSA V K,MCINTOSH A R.Emerging concepts for the dynamical organization of resting-state activity in the brain[J].Nature Reviews Neuroscience,2010,12(1):nrn2961.
[34]CHEN J E,RUBINOV M,CHANG C.Methods and considerations for dynamic analysis of functional MRimaging data[J].Neuroimaging Clinics,2017,27(4):547-560.
[35]FAIR D A,COHEN A L,POWER J D,et al.Functional brain networks develop from a“local to distributed”organization[J].PLo S Computational Biology,2009,5(5):e1000381.
[36]CHIANG S,CASSESE A,GUINDANI M,et al.Timedependence of graph theory metrics in functional connectivity analysis[J].Neuroimage,2016,125:601-615.
[37]HELLYER P J,BARRY E F,PELLIZZON A,et al.Protein synthesis is associated with high-speed dynamics and broad-band stability of functional hubs in the brain[J].Neuro Image,2017,155:209-216.
[38]GREICIUS M.Resting-state functional connectivity in neuropsychiatric disorders[J].Current Opinion in Neurology,2008,21(4):424-430.
[39]MENON V.Large-scale brain networks and psychopathology:a unifying triple network model[J].Trends in Cognitive Sciences,2011,15(10):483-506.
[40]PEDERSEN M,OMIDVARNIA A,CURWOOD E K,et al.The dynamics of functional connectivity in neocortical focal epilepsy[J].Neuro Image:Clinical,2017,15:209-214.
[41]OMIDVARNIA A,PEDERSEN M,VAUGHAN D N,et al.Dynamic coupling between f MRJ local connectivity and interictal EEG in focal epilepsy:a wavelet analysis approach[J].Human Brain Mapping,2017,38(11):5356-5374.
[42]ESPINOZA-VALDEZ A,GONZALEZ-GARRIDO A A,LUNA B,et al.Epiletic brain reorganization dynamics on the basis of the probability of connections[J].Neuroreport,2016,27(1):1-5.
[43]LIAO W,ZHANG Z,MANTINI D,et al.Dynamical intrinsic functional architecture of the brain during absence seizures[J].Brain Structure and Function,2014,219(6):2001-2015.
[44]MARUSAK H A,THOMASON M E,ELRAHAL F,et al.Mindfulness and dynamic functional neural connectivity in children and adolescents[J].Behavioural Brain Research,2018,336:211-218.
[45]DU Y,PEARLSON G D,LIN D,et al.Identifying dynamic functional connectivity biomarkers using GIG-ICA:application to schizophrenia,schizoaffective disorder,and psychotic bipolar disorder[J].Human Brain Mapping,2017,38(5):2683-2708.
[46]FUKUNAGA M,HOROVITZ S G,GELDEREN P V,et al.Large-amplitude,spatially correlated fluctuations in BOLD f MRI signals during extended rest and early sleep stages[J].Magnetic Resonance Imaging,2006,24(8):979-992.
[47]BARNES A,BULLMORE E T,SUCKLING J.Endogenous human brain dynamics recover slowly following cognitive effort[J].Plo S One,2009,4(8):e6626.
[48]ROBINSON L F,LA P V,KUSHNIR Y.Detecting shifts in correlation and variability with application to ENSO-monsoon rainfall relationships[J].Theoretical and Applied Climatology,2008,94(3):215-224.