桑叶化学成分及生物活性研究进展
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摘要
桑叶是常用的传统中药,具有疏散风热、清肺润燥、清肝明目的功效,含黄酮、生物碱、氨基酸、多糖、甾类等多种化学成分,并表现出降血糖、抗炎、抗菌、抗病毒、抗衰老及抗癌等多种生物活性,被广泛应用于临床。本文就桑叶的化学成分和生物活性作用进行综述,并对桑叶的研究现状进行分析和展望,为该中药进一步开发和利用提供依据。
Mori Folium is a commonly used traditional Chinese medicine, which possesses the functions of dispersing wind heat, clearing lung and moistening dryness, clearing liver and improving eyesight, etc. Several different classes of compounds have been separated from Mori Folium, including flavonoids, alkaloids, amino acids, polysaccharides, steroids, etc. The modern pharmacological studies show that Mori Folium has various pharmacological actions, such as anti-diabetes, anti-inflammatory, anti-bacterial, anti-virus, anti-aging, anti-tumor and other activities, which is widely used in clinic. This article aims at reviewing the recent literature on chemical constituents and biological actions, and analyzing and expecting the research status of Mori Folium, so as to provide reference for its further development and utilization.
Mori Folium is a commonly used traditional Chinese medicine, which possesses the functions of dispersing wind heat, clearing lung and moistening dryness, clearing liver and improving eyesight, etc. Several different classes of compounds have been separated from Mori Folium, including flavonoids, alkaloids, amino acids, polysaccharides, steroids, etc. The modern pharmacological studies show that Mori Folium has various pharmacological actions, such as anti-diabetes, anti-inflammatory, anti-bacterial, anti-virus, anti-aging, anti-tumor and other activities, which is widely used in clinic. This article aims at reviewing the recent literature on chemical constituents and biological actions, and analyzing and expecting the research status of Mori Folium, so as to provide reference for its further development and utilization.
引文
[1]陈晓燕.桃仁.桑叶化学成分及生物活性研究[D].北京:北京协和医学院, 2014.
[2]国家药典委员会.中国药典(第一部)[M].北京:中国医药科技出版社, 2015:297-298.
[3]唐明敏.桑叶降糖有效物质基础及其作用机理研究[D].北京:北京中医药大学, 2016.
[4]Kimura T, Nakagawa K, Saito Y, et al. Determination of1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection[J]. J Agric Food Chem, 2004, 52(6):1415-1418.
[5]Basnet P, Kadota S, Terashima S, et al. Two new 2-arylbenzofuran derivatives from hypoglycemic activity-bearing fractions of Morus insignis[J]. Chem Pharm Bull, 1993, 47(1):1238-1243.
[6]李明.桑叶和桑枝的化学成分及生物活性研究[D].济南:山东大学, 2017.
[7]杨海霞,朱祥瑞,陆洪省.桑叶保健制品开发利用研究进展[J].科技通报, 2003, 19(1):72-76.
[8]姚佳,乔迪,郭鑫,等.桑叶中1-脱氧野尻霉素对糖尿病肾病大鼠的治疗作用[J].中国临床药理学与治疗学, 2018, 23(5):517-523.
[9]贺胜,周杏子,何海,等.桑叶生物碱类成分研究概况[J].中国实验方剂学杂志, 2015, 21(13):222-226.
[10] Asano N, Tomioka E, Kizu H, et al. Sugars with nitrogen in the ring isolated from the leaves of Morus bombycis[J]. Carbohydr Res, 1994, 253(6):235-245.
[11]韩伟立,张晓琦,轧霁,等.华桑叶水溶性化学成分研究[J].中成药, 2010, 32(4):639-641.
[12]顾关云.桑的化学成分和生物活性研究进展[J].现代药物与临床, 2007, 22(1):12-17.
[13]李正涛,花旭斌,朱秋平,等.桑叶汁饮料的开发[J].食品科技,2000,(1):44-45.
[14]王芳,励建荣.桑叶的化学成分、生理功能及应用研究进展[J].食品科学, 2005, 26(s1):111-117.
[15]欧阳臻,陈钧,李永辉.桑叶多糖的分离纯化及组成研究[J].食品科学, 2005, 26(3):181-184.
[16]盖英萍,牟志美,冀宪领,等.桑叶多糖的提取与分析[J].蚕业科学, 2005, 31(1):31-35.
[17]吕庆,夏玮,张文清,等.桑叶多糖的分离纯化与分析[J].食品与发酵工业, 2007, 33(7):167-170.
[18]罗晶洁,王尉,曹学丽.桑叶多糖的分离纯化及对α-葡萄糖苷酶的抑制活性[J].食品科学, 2011, 32(3):112-116.
[19]邹盛勤,陈武.桑叶的化学成分、药理活性及应用研究进展[J].林产化工通讯, 2003, 37(1):22-25.
[20]季涛.桑叶防治糖尿病的效应成分群及其作用机制研究[D].南京:南京中医药大学, 2016.
[21]陈福君,林一星,许春泉,等.桑的药理研究(Ⅱ)──桑叶、桑枝、桑白皮抗炎药理作用的初步比较研究[J].沈阳药科大学学报, 1995, 12(3):222-224.
[22]秦雪娟,马成.桑叶与菊花配伍退热机制实验研究[J].新中医,2013, 45(11):133-135.
[23]樊黎生.桑叶抑菌效果的探讨[J].天然产物研究与开发, 2001,13(4):30-32.
[24]陈佳佳,刘凡,廖森泰,等.桑叶提取物抑菌活性及抑菌稳定性研究[J].食品工业科技, 2012, 33(9):88-91.
[25]徐立.桑树植物化学成分及活性研究[D].重庆:西南大学, 2006.
[26]苏方华.桑叶的化学成分及临床应用研究进展[J].中国医药导报, 2010, 7(14):9-12.
[27]何新苗,孟磊,李欣,等.药桑叶多糖的体外抗氧化活性研究[J].新疆医科大学学报, 2018, 41(6):747-750, 755.
[28]应芝.桑叶多糖提取分离、结构鉴定及其降血糖活性的初步研究[D].杭州:浙江工商大学, 2009.
[29] Sunyeou K, Gao J J, Kang H K. Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukaemia(HL-60)cell line[J]. Bio Pharm Bull, 2000, 23(4):451-455.
[30] Tsuruoka T, Fukuyasu H, Ishii M, et al. Inhibition of mouse tumor metastasis with nojirimycin-related compounds[J]. J Antibiot(Tokyo), 1996, 49(2):155-161.
[31]齐刚,王继锋,齐凤军,等.桑叶提取物联合有氧运动治疗肥胖型2型糖尿病临床研究[J].中医学报, 2018, 33(7):1230-1235.
[32]俞燕芳,黄金枝,石旭平,等.我国桑叶食品开发研究进展[J].食品安全质量检测学报, 2018, 9(7):1572-1578.
[33]宁军权,李芳红,梁嘉俊,等.食用桑叶粗蛋白粉的制备及蛋白质营养与加工特性评价[J].蚕业科学, 2018, 44(3):435-441.
[2]国家药典委员会.中国药典(第一部)[M].北京:中国医药科技出版社, 2015:297-298.
[3]唐明敏.桑叶降糖有效物质基础及其作用机理研究[D].北京:北京中医药大学, 2016.
[4]Kimura T, Nakagawa K, Saito Y, et al. Determination of1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection[J]. J Agric Food Chem, 2004, 52(6):1415-1418.
[5]Basnet P, Kadota S, Terashima S, et al. Two new 2-arylbenzofuran derivatives from hypoglycemic activity-bearing fractions of Morus insignis[J]. Chem Pharm Bull, 1993, 47(1):1238-1243.
[6]李明.桑叶和桑枝的化学成分及生物活性研究[D].济南:山东大学, 2017.
[7]杨海霞,朱祥瑞,陆洪省.桑叶保健制品开发利用研究进展[J].科技通报, 2003, 19(1):72-76.
[8]姚佳,乔迪,郭鑫,等.桑叶中1-脱氧野尻霉素对糖尿病肾病大鼠的治疗作用[J].中国临床药理学与治疗学, 2018, 23(5):517-523.
[9]贺胜,周杏子,何海,等.桑叶生物碱类成分研究概况[J].中国实验方剂学杂志, 2015, 21(13):222-226.
[10] Asano N, Tomioka E, Kizu H, et al. Sugars with nitrogen in the ring isolated from the leaves of Morus bombycis[J]. Carbohydr Res, 1994, 253(6):235-245.
[11]韩伟立,张晓琦,轧霁,等.华桑叶水溶性化学成分研究[J].中成药, 2010, 32(4):639-641.
[12]顾关云.桑的化学成分和生物活性研究进展[J].现代药物与临床, 2007, 22(1):12-17.
[13]李正涛,花旭斌,朱秋平,等.桑叶汁饮料的开发[J].食品科技,2000,(1):44-45.
[14]王芳,励建荣.桑叶的化学成分、生理功能及应用研究进展[J].食品科学, 2005, 26(s1):111-117.
[15]欧阳臻,陈钧,李永辉.桑叶多糖的分离纯化及组成研究[J].食品科学, 2005, 26(3):181-184.
[16]盖英萍,牟志美,冀宪领,等.桑叶多糖的提取与分析[J].蚕业科学, 2005, 31(1):31-35.
[17]吕庆,夏玮,张文清,等.桑叶多糖的分离纯化与分析[J].食品与发酵工业, 2007, 33(7):167-170.
[18]罗晶洁,王尉,曹学丽.桑叶多糖的分离纯化及对α-葡萄糖苷酶的抑制活性[J].食品科学, 2011, 32(3):112-116.
[19]邹盛勤,陈武.桑叶的化学成分、药理活性及应用研究进展[J].林产化工通讯, 2003, 37(1):22-25.
[20]季涛.桑叶防治糖尿病的效应成分群及其作用机制研究[D].南京:南京中医药大学, 2016.
[21]陈福君,林一星,许春泉,等.桑的药理研究(Ⅱ)──桑叶、桑枝、桑白皮抗炎药理作用的初步比较研究[J].沈阳药科大学学报, 1995, 12(3):222-224.
[22]秦雪娟,马成.桑叶与菊花配伍退热机制实验研究[J].新中医,2013, 45(11):133-135.
[23]樊黎生.桑叶抑菌效果的探讨[J].天然产物研究与开发, 2001,13(4):30-32.
[24]陈佳佳,刘凡,廖森泰,等.桑叶提取物抑菌活性及抑菌稳定性研究[J].食品工业科技, 2012, 33(9):88-91.
[25]徐立.桑树植物化学成分及活性研究[D].重庆:西南大学, 2006.
[26]苏方华.桑叶的化学成分及临床应用研究进展[J].中国医药导报, 2010, 7(14):9-12.
[27]何新苗,孟磊,李欣,等.药桑叶多糖的体外抗氧化活性研究[J].新疆医科大学学报, 2018, 41(6):747-750, 755.
[28]应芝.桑叶多糖提取分离、结构鉴定及其降血糖活性的初步研究[D].杭州:浙江工商大学, 2009.
[29] Sunyeou K, Gao J J, Kang H K. Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukaemia(HL-60)cell line[J]. Bio Pharm Bull, 2000, 23(4):451-455.
[30] Tsuruoka T, Fukuyasu H, Ishii M, et al. Inhibition of mouse tumor metastasis with nojirimycin-related compounds[J]. J Antibiot(Tokyo), 1996, 49(2):155-161.
[31]齐刚,王继锋,齐凤军,等.桑叶提取物联合有氧运动治疗肥胖型2型糖尿病临床研究[J].中医学报, 2018, 33(7):1230-1235.
[32]俞燕芳,黄金枝,石旭平,等.我国桑叶食品开发研究进展[J].食品安全质量检测学报, 2018, 9(7):1572-1578.
[33]宁军权,李芳红,梁嘉俊,等.食用桑叶粗蛋白粉的制备及蛋白质营养与加工特性评价[J].蚕业科学, 2018, 44(3):435-441.