祛瘀汤治疗晚期非小细胞肺癌高凝状态气虚血瘀证的临床研究
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摘要
目的:探讨祛瘀汤对非小细胞肺癌(NSCLC)高凝状态气虚血瘀证的改善作用。方法:NSCLC合并血液高凝状态患者80例,按照随机数字表法分为观察组和对照组各40例,两组均给予常规抗肿瘤及对症处理,观察组给予祛瘀汤口服,以两周为1个疗程。观察治疗前后血小板、血凝指标、中医症候积分及KPS评分变化。结果:治疗后对照组的血浆FBI、DD、FDP水平较治疗前升高,而观察组较治疗前明显降低。对照组治疗后中医症候积分与治疗前比较差异无统计学意义。观察组治疗后中医症候总积分较治疗前明显改善,主要体现在体倦乏力和舌暗瘀斑方面。观察组中医症候疗效总有效率为92.5%。两组治疗前后KPS评分比较差异无统计学意义。结论:祛瘀汤在改善NSCLC患者的血液高凝状态方面效果明显,并可明显缓解中医症候。
Objective:To investigate the improvement effect of the Quyu prescriptions in treatment of advanced non-small cell lung cancer(NSCLC)with high coagulation state Qi-deficiency blood stasis.Methods:Selected 80 cases of advanced NSCLC patients divided into observation group and control group(n=40),according to random number table method.The two groups were given conventional anti-tumor and symptomatic treatment,the observation group was given Quyu prescriptions,with 2weeks for a period of treatment.Observed the blood platelet indexes,coagulation indexes and TCM symptom integral and KPS score before and after treatment.Results:The FBI,plasma DD,FDP level of the control group after treatment was higher than that of the before treatment,the observation group was significantly lower than that of the before treatment,the difference had statistical significance.The TCM symptom integral of the control group after treatment had no statistically significant difference compared with the before treatment.The total TCM symptom integral of the observation group after treatment was obviously improved,mainly reflected in the body tired weakness and tongue dark and ecchymosis,had statistically significant difference.The the total effective rate of the observation group was 92.5%.The KPS score of the two groups before and after treatment has no statistically significant difference.Conclusion:The Quyu prescriptions can obviously improving the high blood coagulation state of the patients with NSCLC,and can obviously relieve symptoms of TCM,worthy of clinical popularization and application.
Objective:To investigate the improvement effect of the Quyu prescriptions in treatment of advanced non-small cell lung cancer(NSCLC)with high coagulation state Qi-deficiency blood stasis.Methods:Selected 80 cases of advanced NSCLC patients divided into observation group and control group(n=40),according to random number table method.The two groups were given conventional anti-tumor and symptomatic treatment,the observation group was given Quyu prescriptions,with 2weeks for a period of treatment.Observed the blood platelet indexes,coagulation indexes and TCM symptom integral and KPS score before and after treatment.Results:The FBI,plasma DD,FDP level of the control group after treatment was higher than that of the before treatment,the observation group was significantly lower than that of the before treatment,the difference had statistical significance.The TCM symptom integral of the control group after treatment had no statistically significant difference compared with the before treatment.The total TCM symptom integral of the observation group after treatment was obviously improved,mainly reflected in the body tired weakness and tongue dark and ecchymosis,had statistically significant difference.The the total effective rate of the observation group was 92.5%.The KPS score of the two groups before and after treatment has no statistically significant difference.Conclusion:The Quyu prescriptions can obviously improving the high blood coagulation state of the patients with NSCLC,and can obviously relieve symptoms of TCM,worthy of clinical popularization and application.
引文
[1]曹洪明,王旭,肖慧杰,等.高凝状态与肺癌之间的关系[J].临床和实验医学杂志,2013,12(7):553-556.
[2]潘倩雄.纤维蛋白原、vWF及D-二聚体与肺癌关系的临床研究[J].检验医学与临床,2010,7(4):291-292.
[3]韩啸东,张侠,刘畅,等.非小细胞肺癌患者血液高凝状态的临床调查[J].现代生物医学进展,2015,10(5):882-886.
[4]罗纯,张建军,胡玲,等.银杏叶注射液治疗晚期肺癌患者血液高凝状态的疗效观察[J].医学研究与教育,2014,31(6):53-56.
[5]阎丽珠.注射用血栓通改善中晚期非小细胞肺癌高凝状态的临床研究[J].广西中医药,2014,37(1):32-33.
[6]李麒.活血化瘀法改善原发性支气管肺癌高凝状态临床观察[J].辽宁中医药大学学报,2013,15(8):182-185.
[7]张晓伟,史立英.肺癌患者凝血功能改变的临床意义[J].中国实验诊断学,2013,17(9):1720-1721.
[8]辛庆锋.低分子肝素治疗晚期肺癌合并血液高凝状态的临床观察[J].肿瘤基础与临床,2015,28(2):162-163.
[9]胡玲,苏雷,张迎舟,等.银杏叶提取物注射液对肺癌化疗患者血液高凝状态的影响[J].中国实验方剂学杂志,2014,20(19):194-197.
[10]张翔,周建伟,顾芳红,等.补阳还五汤治疗中晚期非小细胞肺癌血液高凝状态的疗效观察[J].实用肿瘤学杂志,2013,27(5):414-416.
[11]邓生明,陆用莲,林小清,等.益气活血方对中晚期非小细胞肺癌高凝状态作用运用分析[J].中医临床研究,2012,4(18):74-75.
[12]胡艳,侯安继.益气活血方对中晚期非小细胞肺癌高凝状态作用的临床研究[J].辽宁中医杂志,2011,38(12):2330-2332.
[13]张立侠,曹艳军,张侠,等.121例肺癌患者血液高凝状态的临床研究[J].医学综述,2012,18(14):2285-2288.
[14]张月莉,粱红,沈维敏,等.凝血指标与肺癌患者预后的关系[J].上海医学,2013,36(12):1031-1037.
[2]潘倩雄.纤维蛋白原、vWF及D-二聚体与肺癌关系的临床研究[J].检验医学与临床,2010,7(4):291-292.
[3]韩啸东,张侠,刘畅,等.非小细胞肺癌患者血液高凝状态的临床调查[J].现代生物医学进展,2015,10(5):882-886.
[4]罗纯,张建军,胡玲,等.银杏叶注射液治疗晚期肺癌患者血液高凝状态的疗效观察[J].医学研究与教育,2014,31(6):53-56.
[5]阎丽珠.注射用血栓通改善中晚期非小细胞肺癌高凝状态的临床研究[J].广西中医药,2014,37(1):32-33.
[6]李麒.活血化瘀法改善原发性支气管肺癌高凝状态临床观察[J].辽宁中医药大学学报,2013,15(8):182-185.
[7]张晓伟,史立英.肺癌患者凝血功能改变的临床意义[J].中国实验诊断学,2013,17(9):1720-1721.
[8]辛庆锋.低分子肝素治疗晚期肺癌合并血液高凝状态的临床观察[J].肿瘤基础与临床,2015,28(2):162-163.
[9]胡玲,苏雷,张迎舟,等.银杏叶提取物注射液对肺癌化疗患者血液高凝状态的影响[J].中国实验方剂学杂志,2014,20(19):194-197.
[10]张翔,周建伟,顾芳红,等.补阳还五汤治疗中晚期非小细胞肺癌血液高凝状态的疗效观察[J].实用肿瘤学杂志,2013,27(5):414-416.
[11]邓生明,陆用莲,林小清,等.益气活血方对中晚期非小细胞肺癌高凝状态作用运用分析[J].中医临床研究,2012,4(18):74-75.
[12]胡艳,侯安继.益气活血方对中晚期非小细胞肺癌高凝状态作用的临床研究[J].辽宁中医杂志,2011,38(12):2330-2332.
[13]张立侠,曹艳军,张侠,等.121例肺癌患者血液高凝状态的临床研究[J].医学综述,2012,18(14):2285-2288.
[14]张月莉,粱红,沈维敏,等.凝血指标与肺癌患者预后的关系[J].上海医学,2013,36(12):1031-1037.