月经状态及年龄对成年女性骨盆骨髓动态对比增强MRI灌注参数的影响
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摘要
目的探讨月经状态及年龄对成年女性骨盆骨髓动态对比增强磁共振成像(DCE-MRI)定量灌注参数的影响。资料与方法回顾性分析2017年1—12月中国医科大学肿瘤医院98名成年女性的DCE-MRI检查资料,测量其骨盆骨髓DCE-MRI定量灌注参数容量转移常数(K~(trans))、速率常数(K_(ep))、血管外细胞外容积分数(V_e)并取平均值。将受试者按照月经状态分为未绝经组和绝经组,分析两组DCE-MRI定量灌注参数的差异,并分析年龄与DCE-MRI定量灌注参数的相关性。结果未绝经组与绝经组患者K~(trans)、K_(ep)、V_e差异均有统计学意义(P<0.05);年龄与K~(trans)、K_(ep)、V_e均呈显著负相关(r=-0.587、-0.348、-0.386,P<0.01)。结论月经状态与年龄对成年女性骨盆骨髓DCE-MRI定量灌注参数有一定的影响。DCE-MRI定量灌注参数可反映成年女性骨盆骨髓微环境的改变。
Purpose To explore the effect of menstrual status and age on quantitative perfusion parameters of pelvic bone marrow dynamic contrast enhanced magnetic resonance imaging(DCE-MRI) in adult females. Materials and Methods DCE-MRI data of 98 adult females in China Medical University Cancer Hospital from January to December 2017 were retrospectively analyzed. Their pelvic bone marrow DCE-MRI quantitative perfusion parameters(K~(trans), K_(ep), V_e) were measured for the mean value. Subjects were divided into non-menopausal group and menopausal group according to their menstrual status. The differences in DCE-MRI quantitative perfusion parameters between the two groups were analyzed, and the correlation between age and DCE-MRI quantitative perfusion parameters was calculated. Results There was statistically significant difference in K~(trans), K_(ep) and V_e between the non-menopausal group and the menopausal group(P<0.05). Significant negative correlations were shown between age and K~(trans), K_(ep) and V_e(r=-0.587,-0.348,-0.386, P<0.01). Conclusion Menstrual status and age bear certain effects on pelvic bone marrow DCE-MRI quantitative perfusion parameters in adult females, and DCE-MRI quantitative perfusion parameters can reflect changes of pelvic bone marrow microenvironment in adult females.
Purpose To explore the effect of menstrual status and age on quantitative perfusion parameters of pelvic bone marrow dynamic contrast enhanced magnetic resonance imaging(DCE-MRI) in adult females. Materials and Methods DCE-MRI data of 98 adult females in China Medical University Cancer Hospital from January to December 2017 were retrospectively analyzed. Their pelvic bone marrow DCE-MRI quantitative perfusion parameters(K~(trans), K_(ep), V_e) were measured for the mean value. Subjects were divided into non-menopausal group and menopausal group according to their menstrual status. The differences in DCE-MRI quantitative perfusion parameters between the two groups were analyzed, and the correlation between age and DCE-MRI quantitative perfusion parameters was calculated. Results There was statistically significant difference in K~(trans), K_(ep) and V_e between the non-menopausal group and the menopausal group(P<0.05). Significant negative correlations were shown between age and K~(trans), K_(ep) and V_e(r=-0.587,-0.348,-0.386, P<0.01). Conclusion Menstrual status and age bear certain effects on pelvic bone marrow DCE-MRI quantitative perfusion parameters in adult females, and DCE-MRI quantitative perfusion parameters can reflect changes of pelvic bone marrow microenvironment in adult females.
引文
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[4]Biffar A,Dietrich O,Sourbron S,et al.Diffusion and perfusion imaging of bone marrow.Eur J Radiol,2010,76(3):323-328.
[5]Biffar A,Sourbron S,Dietrich O,et al.Combined diffusionweighted and dynamic contrast-enhanced imaging of patients with acute osteoporotic vertebral fractures.Eur J Radiol,2010,76(3):298-303.
[6]Barnes SL,Whisenant JG,Loveless ME,et al.Practical dynamic contrast enhanced MRI in small animal of cancer:data acquisition,data analysis,and interpretation.Pharmaceutics,2012,4(3):442-478.
[7]Sourbron SP,Buckley DL.Classic models for dynamic contrast-enhanced MRI.NMR Biomed,2013,26(8,SI):1004-1027.
[8]Zhu JQ,Xiong ZG,Zhang JL,et al.Comparison of semiquantitative and quantitative dynamic contrast-enhanced MRIevaluations of vertebral marrow perfusion in a rat osteoporosis model.BMC Musculoskelet Disord,2017,18(1):446.
[9]Zhu JQ,Zhang L,Wu X,et al.Reduction of longitudinal vertebral blood perfusion and its likely causes:a quantitative dynamic contrast-enhanced MR imaging study of a rat osteoporosis model.Radiology,2017,282(2):369-380.
[10]Griffith JF,Wang YX,Zhou H,et al.Reduced bone perfusion in osteoporosis:likely causes in an ovariectomy rat model.Radiology,2010,254(3):739-746.
[11]Lekontseva O,Chakrabarti S,Davidge ST.Endothelin in the female vasculature:a role in aging?Am J Physiol Regul Integr Comp Physiol,2010,298(3):509-516.
[12]Wang YX.,Griffith JF,Deng M,et al.Rapid increase in marrow fat content and decrease in marrow perfusion in lumbar vertebra following bilateral oophorectomy:an MRimaging-based prospective longitudinal study.Korean JRadiol,2015,16(1):154-159.
[13]Ito H.Clinical considerations of regenerative medicine in osteoporosis.Curr Osteoporos Rep,2014,12(2):230-234.
[14]李勤祥,查云飞,刘昌盛,等.年龄和椎体平面对成人胸腰椎DCE-MRI灌注参数的影响.临床放射学杂志,2013,32(4):543-547.
[15]张晓东,赵文吉,胡少勇,等.腰椎骨髓脂肪含量与年龄、性别、体重指数及腰围的相关性.中国医学影像学杂志,2015,(7):539-543.
[16]吴兴,汤光宇.骨质疏松骨髓微环境的影像研究进展.国际医学放射学杂志,2016,39(4):390-394.
[17]Valentinitsch A,Trebeschi S,Alarcon EA,et al.Regional analysis of age-related local bone loss in the spine of a healthy population using 3D voxel-based modeling.Bone,2017,103:233-240.
[18]Maciel JG,De Araujo IM,Carvalho AL,et al.Marrow fat quality differences by sex in healthy adults.J Clin Densitom,2017,20(1):106-113.
[19]Chen WT,Shih TT,Hu CJ,et al.Relationship between vertebral bone marrow blood perfusion and common carotid intima-media thickness in aging adults.J Magn Reson Imaging,2004,20(5):811-816.
[20]Prisby RD.Bone marrow blood vessel ossification and“microvascular dead space”in rat and human long bone.Bone,2014,(64):195-203.