基于数据库分析SPP1在肺鳞癌中的表达及意义
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摘要
目的基于数据库分析分泌性磷蛋白1(SPP1)在肺鳞癌中的表达及意义。方法通过检索Oncomine和cBioPortal数据库中关于SPP1的信息,并对目前数据库中资料进行二次分析,分析其在肺鳞癌中的作用。结果 Oncomine数据库中共有4个研究涉及SPP1在肺鳞癌组织和正常组织中的表达,共包括184个样本,荟萃4个结果发现,SPP1在肺鳞癌中较正常组织高表达,差异具有统计学意义(P=2.84×10~(-7))。通过cBioPortal数据库分析,在oncoprint选项中发现501例中晚期肺鳞癌的样本中有39例SPP1高表达(7.8%)。SPP1表达量与肺鳞癌总体生存率存在相关性,SPP1高表达5年生存率为29.1%,而SPP1低表达5年生存率为49.3%,差异具有统计学意义(P<0.05)。结论通过对Oncomine和cBioPortal数据库中肿瘤相关基因信息的深入检索,提出SPP1在肺鳞癌组织中高表达,且与肺鳞癌预后有关,其将为肿瘤药物的开发提供重要理论依据。
Objective To analyze the expression and significance of secretory phosphoprotein 1(SPP1) in lung squamous cell carcinoma based on database. Methods By searching the information about SPP1 in Oncomine and cBioPortal databases, and secondary analysis of the data in the current database, the role of SPP1 in squamous cell lung cancer was analyzed. Results Four studies involved the expression of SPP1 in lung squamous cell carcinomas and normal tissues, there were 184 samples in Oncomine database. The Meta-analysis of four results showed that SPP1 was more expressed in lung squamous cell carcinomas than that in normal tissues, the difference was statistically significant(P=2.84×10~(-7)). Through the analysis of cBioPortal database, 39 cases(7.8%) of 501 samples of advanced lung squamous cell carcinomas were found to have high expression level of SPP1 under oncoprint option. The expression level of SPP1 was correlated with the overall survival rate of lung squamous cell carcinoma, the 5-year survival rate level of high expression of SPP1 was 29.1%, while the 5-year survival rate of low expression of SPP1 was 49.3%, and the difference was statistically significant(P <0.05).Conclusion Through the in-depth searching of Oncomine and cBioPortal database oncogene information, it is proposed that SPP1 is highly expressed in lung squamous cell carcinomas and is related to the prognosis of lung squamous cell carcinomas, which will provide an important theoretical basis for the development of cancer drugs.
Objective To analyze the expression and significance of secretory phosphoprotein 1(SPP1) in lung squamous cell carcinoma based on database. Methods By searching the information about SPP1 in Oncomine and cBioPortal databases, and secondary analysis of the data in the current database, the role of SPP1 in squamous cell lung cancer was analyzed. Results Four studies involved the expression of SPP1 in lung squamous cell carcinomas and normal tissues, there were 184 samples in Oncomine database. The Meta-analysis of four results showed that SPP1 was more expressed in lung squamous cell carcinomas than that in normal tissues, the difference was statistically significant(P=2.84×10~(-7)). Through the analysis of cBioPortal database, 39 cases(7.8%) of 501 samples of advanced lung squamous cell carcinomas were found to have high expression level of SPP1 under oncoprint option. The expression level of SPP1 was correlated with the overall survival rate of lung squamous cell carcinoma, the 5-year survival rate level of high expression of SPP1 was 29.1%, while the 5-year survival rate of low expression of SPP1 was 49.3%, and the difference was statistically significant(P <0.05).Conclusion Through the in-depth searching of Oncomine and cBioPortal database oncogene information, it is proposed that SPP1 is highly expressed in lung squamous cell carcinomas and is related to the prognosis of lung squamous cell carcinomas, which will provide an important theoretical basis for the development of cancer drugs.
引文
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[2]FEDARKO NS,JAIN A,KARADAG A,et al.Elevated serum bone sialoprotein and osteopontin in colon,breast,prostate,and lung cancer[J].Clin Cancer Res,2001,7(12):4060-4066.
[3]TORRE LA,SIEGEL RL,JEMAL A.Lung cancer statistics[J].Adv Exp Med Biol,2016,893:1-19.
[4]AKHURST T,MACMANUS M,HICKS RJ.Lung cancer[J].Pet Clinics,2015,10(2):147-158.
[5]WAI PY,KUO PC.The role of Osteopontin in tumor metastasis[J].JSurg Res,2004,121(2):228-241.
[6]刘超武,续力云,陈军,等.浸润性肺腺癌组织上调表达基因的筛选及验证[J].浙江医学,2018,40(3):224-230.
[7]LI S,YANG R,SUN X,et al.Identification of SPP1 as a promising biomarker to predict clinical outcome of lung adenocarcinoma individuals[J]Gene,2018,679:398-404.
[8]何嵘,刘永煜.OPN在肺鳞癌组织中高表达及其临床意义[J].中国癌症杂志,2015,25(10):812-816.
[9]LEIGHL NB,REKHTMAN N,BIERMANN WA,et al.Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors:American Society of Clinical Oncology endorsement of the College of American Pathologists/Internati[J].J Clin Oncol,2014,32(32):3673-3679.