富血小板血浆治疗肌腱病的研究进展
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摘要
肌腱损伤是运动医学常见疾病。受损的肌腱只能瘢痕修复,无法重建力学结构,再断裂发生率高。富血小板血浆(PRP)富含多种生长因子和细胞因子,能促进新生血管生成,提供受损组织细胞再生所需的血供和营养,并促进受损组织吸收新细胞和碎片。已有大量基础研究显示,PRP可以促进肌腱细胞的迁移、增殖、分化和分泌胞外基质,但PRP治疗肌腱病的临床研究结果仍争议较大。该文对PRP治疗肌腱病的基础及临床研究进展作一综述。
引文
[1]Thomopoulos S,Parks WC,Rifkin DB,et al.Mechanisms of tendon injury and repair[J].J Orthop Res,2015,33(6):832-839.
[2]Wu F,Nerlich M,Docheva D.Tendon injuries:basic science and new repair proposals[J].EFORT Open Rev,2017,2(7):332-342.
[3]Ben-Nafa W,Munro W.The effect of corticosteroid versus platelet-rich plasma injection therapies for the management of lateral epicondylitis:a systematic review[J].SICOT J,2018,4:11.
[4]Foster TE,Puskas BL,Mandelbaum BR,et al.Platelet-rich plasma:from basic science to clinical applications[J].Am JSports Med,2009,37(11):2259-2272.
[5]Zhou Y,Zhang J,Wu H,et al.The differential effects of leukocyte-containing and pure platelet-rich plasma(prp)on tendon stem/progenitor cells-implications of prp application for the clinical treatment of tendon injuries[J].Stem Cell Res Ther,2015,6:173.
[6]Giusti I,D’Ascenzo S,MancòA,et al.Platelet concentration in platelet-rich plasma affects tenocyte behavior in vitro[J].Biomed Res Int,2014,2014:630870.
[7]Zhang J,Wang JH.Prp treatment effects on degenerative tendinopathy-an in vitro model study[J].Muscles Ligaments Tendons J,2014,4(1):10-17.
[8]Boswell SG,Cole BJ,Sundman EA,et al.Platelet-rich plasma:a milieu of bioactive factors[J].Arthroscopy,2012,28(3):429-439.
[9]Pauly S,Klatte-Schulz F,Stahnke K,et al.The effect of autologous platelet rich plasma on tenocytes of the human rotator cuff[J].BMC Musculoskelet Disord,2018,19(1):422.
[10]de Almeida AM,Demange MK,Sobrado MF,et al.Patellar tendon healing with platelet-rich plasma:a prospective randomized controlled trial[J].Am J Sports Med,2012,40(6):1282-1288.
[11]Alsousou J,Ali A,Willett K,et al.The role of platelet-rich plasma in tissue regeneration[J].Platelets,2013,24(3):173-182.
[12]Chiu CH,Higashikawa R,Yeh WL,et al.Investigation of growth factor and tenocyte proliferation induced by platelet rich plasma(PRP)in a 3-chamber co-culture device[J].Micromachines(Basel),2018,9(9):E446.
[13]Howell K,Chien C,Bell R,et al.Novel model of tendon regeneration reveals distinct cell mechanisms underlying regenerative and fibrotic tendon healing[J].Sci Rep,2017,7:45238.
[14]Zhou Y,Wang JH.Prp treatment efficacy for tendinopathy:a review of basic science studies[J].Biomed Res Int,2016,2016(1):9103792.
[15]Chen L,Dong SW,Tao X.Autologous platelet-rich clot releasate stimulates proliferation and inhibits differentiation of adult rat tendon stem cells towards nontenocyte lineages[J].J Int Med Res,2012,40(4):1399-1409.
[16]Hilber F,Loibl M,Lang S,et al.Leukocyte-reduced platelet-rich plasma increases proliferation of tenocytes treated with prednisolone:a cell cycle analysis[J].Arch Orthop Trauma Surg,2017,137(10):1417-1422.
[17]Xu K,Al-Ani MK,Sun Y,et al.Platelet-rich plasma activates tendon-derived stem cells to promote regeneration of achilles tendon rupture in rats[J].J Tissue Eng Regen Med,2017,11(4):1173-1184.
[18]Zhou Z,Akinbiyi T,Xu L,et al.Tendon-derived stem/progenitor cell aging:defective self-renewal and altered fate[J].Aging Cell,2010,9(5):911-915.
[19]Intravia J,Allen DA,Durant TJ,et al.In vitro evaluation of the anti-bacterial effect of two preparations of platelet rich plasma compared with cefazolin and whole blood[J].Muscles Ligaments Tendons J,2014,4(1):79-84.
[20]Chianca V,Albano D,Messina C,et al.Rotator cuff calcific tendinopathy:from diagnosis to treatment[J].Acta Biomed,2018,89(1-S):186-196.
[21]Zhao JG,Zhao L,Jiang YX,et al.Platelet-rich plasma in arthroscopic rotator cuff repair:a meta-analysis of randomized controlled trials[J].Arthroscopy,2015,31(1):125-135.
[22]Hurley ET,Lim FD,Moran CJ.The efficacy of platelet-rich plasma and platelet-rich fibrin in arthroscopic rotator cuff repair:a meta-analysis of randomized controlled trials[J].Am J Sports Med,2019,47(3):753-761.
[23]Verhaegen F,Brys P,Debeer P.Rotator cuff healing after needling of a calcific deposit using platelet-rich plasma augmentation:a randomized,prospective clinical trial[J].JShoulder Elbow Surg,2016,25(2):169-173.
[24]Deprés-Tremblay G,Chevrier A,Snow M,et al.Freeze-dried chitosan-platelet-rich plasma implants improve supraspinatus tendon attachment in a transosseous rotator cuff repair model in the rabbit[J].J Biomater Appl,2019,33(6):792-807.
[25]Kesikburun S,Tan AK,Yilmaz B,et al.Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy:a randomized controlled trial with 1-year follow-up[J].Am J Sports Med,2013,41(11):2609-2616.
[26]Rha DW,Park GY,Kim YK,et al.Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease:a randomized controlled trial[J].Clin Rehabil,2013,27(2):113-122.
[27]Shams A,El-Sayed M,Gamal O,et al.Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears[J].Eur J Orthop Surg Traumatol,2016,26(8):837-842.
[28]Kuffler DP.Differing efficacies of autologous platelet-rich plasma in reducing pain following rotator-cuff injury in a single patient[J].J Pain Res,2018,11:2239-2245.
[29]Chen X,Jones IA,Park C,et al.The efficacy of platelet-rich plasma on tendon and ligament healing:a systematic review and meta-analysis with bias assessment[J].Am JSports Med,2017,46(8):2020-2032.
[30]Palacio EP,Schiavetti RR,Kanematsu M,et al.Effects of platelet-rich plasma on lateral epicondylitis of the elbow:prospective randomized controlled trial[J].Rev Bras Ortop,2016,51(1):90-95.
[31]Mi B,Liu G,Zhou W,et al.Platelet rich plasma versus steroid on lateral epicondylitis:meta-analysis of randomized clinical trials[J].Phys Sportsmed,2017,45(2):97-104.
[32]Mishra AK,Skrepnik NV,Edwards SG,et al.Efficacy of platelet-rich plasma for chronic tennis elbow:a double-blind,prospective,multicenter,randomized controlled trial of 230patients[J].Am J Sports Med,2014,42(2):463-471.
[33]Merolla G,Dellabiancia F,Ricci A,et al.Arthroscopic debridement versus platelet-rich plasma injection:a prospective,randomized,comparative study of chronic lateral epicondylitis with a nearly 2-year follow-up[J].Arthroscopy,2017,33(7):1320-1329.
[34]Liddle AD,Rodríguez-Merchán EC.Platelet-rich plasma in the treatment of patellar tendinopathy:a systematic review[J].Am J Sports Med,2015,43(10):2583-2590.
[35]Abate M,Di Carlo L,Verna S,et al.Synergistic activity of platelet rich plasma and high volume image guided injection for patellar tendinopathy[J].Knee Surg Sports Traumatol Arthrosc,2018,26(12):3645-3651.
[36]Gosens T,Den Oudsten BL,Fievez E,et al.Pain and activity levels before and after platelet-rich plasma injection treatment of patellar tendinopathy:a prospective cohort study and the influence of previous treatments[J].Int Orthop,2012,36(9):1941-1946.
[37]Dragoo JL,Wasterlain AS,Braun HJ,et al.Platelet-rich plasma as a treatment for patellar tendinopathy:a double-blind,randomized controlled trial[J].Am J Sports Med,2014,42(3):610-618.
[38]Filardo G,Kon E,Della Villa S,et al.Use of platelet-rich plasma for the treatment of refractory jumper’s knee[J].Int Orthop,2010,34(6):909-915.
[39]Vetrano M,Castorina A,Vulpiani MC,et al.Platelet-rich plasma versus focused shock waves in the treatment of jumper’s knee in athletes[J].Am J Sports Med,2013,41(4):795-803.
[40]Kaux JF,Bruyère O,Croisier JL,et al.One-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies[J].Acta Orthop Belg,2015,81(2):251-256.
[41]Cervellin M,de Girolamo L,Bait C,et al.Autologous platelet-rich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction:a randomized,controlled clinical study[J].Knee Surg Sports Traumatol Arthrosc,2012,20(1):114-120.
[42]Walters BL,Porter DA,Hobart SJ,et al.Effect of intraoperative platelet-rich plasma treatment on postoperative donor site knee pain in patellar tendon autograft anterior cruciate ligament reconstruction:a double-blind randomized controlled trial[J].Am J Sports Med,2018,46(8):1827-1835.
[43]Krogh TP,Bartels EM,Ellingsen T,et al.Comparative effectiveness of injection therapies in lateral epicondylitis:a systematic review and network meta-analysis of randomized controlled trials[J].Am J Sports Med,2013,41(6):1435-1446.
[44]de Vos RJ,Weir A,Tol JL,et al.No effects of prp on ultrasonographic tendon structure and neovascularisation in chronic midportion achilles tendinopathy[J].Br J Sports Med,2011,45(5):387-392.
[45]Boesen AP,Hansen R,Boesen MI,et al.Effect of high-volume injection,platelet-rich plasma,and sham treatment in chronic midportion achilles tendinopathy:a randomized double-blinded prospective study[J].Am J Sports Med,2017,45(9):2034-2043.
[2]Wu F,Nerlich M,Docheva D.Tendon injuries:basic science and new repair proposals[J].EFORT Open Rev,2017,2(7):332-342.
[3]Ben-Nafa W,Munro W.The effect of corticosteroid versus platelet-rich plasma injection therapies for the management of lateral epicondylitis:a systematic review[J].SICOT J,2018,4:11.
[4]Foster TE,Puskas BL,Mandelbaum BR,et al.Platelet-rich plasma:from basic science to clinical applications[J].Am JSports Med,2009,37(11):2259-2272.
[5]Zhou Y,Zhang J,Wu H,et al.The differential effects of leukocyte-containing and pure platelet-rich plasma(prp)on tendon stem/progenitor cells-implications of prp application for the clinical treatment of tendon injuries[J].Stem Cell Res Ther,2015,6:173.
[6]Giusti I,D’Ascenzo S,MancòA,et al.Platelet concentration in platelet-rich plasma affects tenocyte behavior in vitro[J].Biomed Res Int,2014,2014:630870.
[7]Zhang J,Wang JH.Prp treatment effects on degenerative tendinopathy-an in vitro model study[J].Muscles Ligaments Tendons J,2014,4(1):10-17.
[8]Boswell SG,Cole BJ,Sundman EA,et al.Platelet-rich plasma:a milieu of bioactive factors[J].Arthroscopy,2012,28(3):429-439.
[9]Pauly S,Klatte-Schulz F,Stahnke K,et al.The effect of autologous platelet rich plasma on tenocytes of the human rotator cuff[J].BMC Musculoskelet Disord,2018,19(1):422.
[10]de Almeida AM,Demange MK,Sobrado MF,et al.Patellar tendon healing with platelet-rich plasma:a prospective randomized controlled trial[J].Am J Sports Med,2012,40(6):1282-1288.
[11]Alsousou J,Ali A,Willett K,et al.The role of platelet-rich plasma in tissue regeneration[J].Platelets,2013,24(3):173-182.
[12]Chiu CH,Higashikawa R,Yeh WL,et al.Investigation of growth factor and tenocyte proliferation induced by platelet rich plasma(PRP)in a 3-chamber co-culture device[J].Micromachines(Basel),2018,9(9):E446.
[13]Howell K,Chien C,Bell R,et al.Novel model of tendon regeneration reveals distinct cell mechanisms underlying regenerative and fibrotic tendon healing[J].Sci Rep,2017,7:45238.
[14]Zhou Y,Wang JH.Prp treatment efficacy for tendinopathy:a review of basic science studies[J].Biomed Res Int,2016,2016(1):9103792.
[15]Chen L,Dong SW,Tao X.Autologous platelet-rich clot releasate stimulates proliferation and inhibits differentiation of adult rat tendon stem cells towards nontenocyte lineages[J].J Int Med Res,2012,40(4):1399-1409.
[16]Hilber F,Loibl M,Lang S,et al.Leukocyte-reduced platelet-rich plasma increases proliferation of tenocytes treated with prednisolone:a cell cycle analysis[J].Arch Orthop Trauma Surg,2017,137(10):1417-1422.
[17]Xu K,Al-Ani MK,Sun Y,et al.Platelet-rich plasma activates tendon-derived stem cells to promote regeneration of achilles tendon rupture in rats[J].J Tissue Eng Regen Med,2017,11(4):1173-1184.
[18]Zhou Z,Akinbiyi T,Xu L,et al.Tendon-derived stem/progenitor cell aging:defective self-renewal and altered fate[J].Aging Cell,2010,9(5):911-915.
[19]Intravia J,Allen DA,Durant TJ,et al.In vitro evaluation of the anti-bacterial effect of two preparations of platelet rich plasma compared with cefazolin and whole blood[J].Muscles Ligaments Tendons J,2014,4(1):79-84.
[20]Chianca V,Albano D,Messina C,et al.Rotator cuff calcific tendinopathy:from diagnosis to treatment[J].Acta Biomed,2018,89(1-S):186-196.
[21]Zhao JG,Zhao L,Jiang YX,et al.Platelet-rich plasma in arthroscopic rotator cuff repair:a meta-analysis of randomized controlled trials[J].Arthroscopy,2015,31(1):125-135.
[22]Hurley ET,Lim FD,Moran CJ.The efficacy of platelet-rich plasma and platelet-rich fibrin in arthroscopic rotator cuff repair:a meta-analysis of randomized controlled trials[J].Am J Sports Med,2019,47(3):753-761.
[23]Verhaegen F,Brys P,Debeer P.Rotator cuff healing after needling of a calcific deposit using platelet-rich plasma augmentation:a randomized,prospective clinical trial[J].JShoulder Elbow Surg,2016,25(2):169-173.
[24]Deprés-Tremblay G,Chevrier A,Snow M,et al.Freeze-dried chitosan-platelet-rich plasma implants improve supraspinatus tendon attachment in a transosseous rotator cuff repair model in the rabbit[J].J Biomater Appl,2019,33(6):792-807.
[25]Kesikburun S,Tan AK,Yilmaz B,et al.Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy:a randomized controlled trial with 1-year follow-up[J].Am J Sports Med,2013,41(11):2609-2616.
[26]Rha DW,Park GY,Kim YK,et al.Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease:a randomized controlled trial[J].Clin Rehabil,2013,27(2):113-122.
[27]Shams A,El-Sayed M,Gamal O,et al.Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears[J].Eur J Orthop Surg Traumatol,2016,26(8):837-842.
[28]Kuffler DP.Differing efficacies of autologous platelet-rich plasma in reducing pain following rotator-cuff injury in a single patient[J].J Pain Res,2018,11:2239-2245.
[29]Chen X,Jones IA,Park C,et al.The efficacy of platelet-rich plasma on tendon and ligament healing:a systematic review and meta-analysis with bias assessment[J].Am JSports Med,2017,46(8):2020-2032.
[30]Palacio EP,Schiavetti RR,Kanematsu M,et al.Effects of platelet-rich plasma on lateral epicondylitis of the elbow:prospective randomized controlled trial[J].Rev Bras Ortop,2016,51(1):90-95.
[31]Mi B,Liu G,Zhou W,et al.Platelet rich plasma versus steroid on lateral epicondylitis:meta-analysis of randomized clinical trials[J].Phys Sportsmed,2017,45(2):97-104.
[32]Mishra AK,Skrepnik NV,Edwards SG,et al.Efficacy of platelet-rich plasma for chronic tennis elbow:a double-blind,prospective,multicenter,randomized controlled trial of 230patients[J].Am J Sports Med,2014,42(2):463-471.
[33]Merolla G,Dellabiancia F,Ricci A,et al.Arthroscopic debridement versus platelet-rich plasma injection:a prospective,randomized,comparative study of chronic lateral epicondylitis with a nearly 2-year follow-up[J].Arthroscopy,2017,33(7):1320-1329.
[34]Liddle AD,Rodríguez-Merchán EC.Platelet-rich plasma in the treatment of patellar tendinopathy:a systematic review[J].Am J Sports Med,2015,43(10):2583-2590.
[35]Abate M,Di Carlo L,Verna S,et al.Synergistic activity of platelet rich plasma and high volume image guided injection for patellar tendinopathy[J].Knee Surg Sports Traumatol Arthrosc,2018,26(12):3645-3651.
[36]Gosens T,Den Oudsten BL,Fievez E,et al.Pain and activity levels before and after platelet-rich plasma injection treatment of patellar tendinopathy:a prospective cohort study and the influence of previous treatments[J].Int Orthop,2012,36(9):1941-1946.
[37]Dragoo JL,Wasterlain AS,Braun HJ,et al.Platelet-rich plasma as a treatment for patellar tendinopathy:a double-blind,randomized controlled trial[J].Am J Sports Med,2014,42(3):610-618.
[38]Filardo G,Kon E,Della Villa S,et al.Use of platelet-rich plasma for the treatment of refractory jumper’s knee[J].Int Orthop,2010,34(6):909-915.
[39]Vetrano M,Castorina A,Vulpiani MC,et al.Platelet-rich plasma versus focused shock waves in the treatment of jumper’s knee in athletes[J].Am J Sports Med,2013,41(4):795-803.
[40]Kaux JF,Bruyère O,Croisier JL,et al.One-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies[J].Acta Orthop Belg,2015,81(2):251-256.
[41]Cervellin M,de Girolamo L,Bait C,et al.Autologous platelet-rich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction:a randomized,controlled clinical study[J].Knee Surg Sports Traumatol Arthrosc,2012,20(1):114-120.
[42]Walters BL,Porter DA,Hobart SJ,et al.Effect of intraoperative platelet-rich plasma treatment on postoperative donor site knee pain in patellar tendon autograft anterior cruciate ligament reconstruction:a double-blind randomized controlled trial[J].Am J Sports Med,2018,46(8):1827-1835.
[43]Krogh TP,Bartels EM,Ellingsen T,et al.Comparative effectiveness of injection therapies in lateral epicondylitis:a systematic review and network meta-analysis of randomized controlled trials[J].Am J Sports Med,2013,41(6):1435-1446.
[44]de Vos RJ,Weir A,Tol JL,et al.No effects of prp on ultrasonographic tendon structure and neovascularisation in chronic midportion achilles tendinopathy[J].Br J Sports Med,2011,45(5):387-392.
[45]Boesen AP,Hansen R,Boesen MI,et al.Effect of high-volume injection,platelet-rich plasma,and sham treatment in chronic midportion achilles tendinopathy:a randomized double-blinded prospective study[J].Am J Sports Med,2017,45(9):2034-2043.