姜黄素抗氧化的初步机理研究
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摘要
姜黄素(curcumin, Cur)是一种多酚类食品添加剂,具有抗炎等生理功能。这可能与其抗氧化能力密切相关,但作用机制尚不明确。本研究通过对姜黄素作用细胞的检测,发现姜黄素提高细胞的总抗氧化能力,降低活性氧(reactive oxygen species,ROS)水平;同时抗氧化酶超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)的表达和活性均有上调。这些结果提示姜黄素可能通过对SOD和GPx的调节提高细胞的抗氧化能力,进而减少ROS造成的损伤。
引文
[1]杨长军,马云,李铁柱,崔群英.姜黄保健功效研究及市场前景分析[J].食品研究与开发,2016,37(06):218-220.
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[13]Collins,A.,Oxidative DNA damage,antioxidants,and cancer.BIOESSAYS 1999,21,238-246.
[14]Holdom,M.D.,Lechenne,B., Hay,R.J.,Hamilton,A.J.,Monod,M.,Production and characterization of recombinant Aspergillus fumigatus Cu,Zn superoxide dismutase andits recognition by immune human sera.J CLIN MICROBIOL 2000,38,558-562.
[15]Yang,Y.,Karakhanova,S.,Hartwig,W.,D'Haese,J.G.,et al.,Mitochondria and Mitochond rial ROS in Cancer:Novel Targets for Anticancer Therapy.J CELL PHYSIOL 2016,231,2570-2581.
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[11]Sanchez-Sanchez,B.,GutierrezHerrero,S.,Lopez-Ruano,G.,Prieto-Bermejo,R.,et al.,NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.CLIN CANCER RES 2014,20,4014-4025.
[18]Ha rrison,I.P.,Sele midis,S.,Understanding the biology of reactive oxygen species and their link to cancer:NADPH oxidases as novel pharmacological targets.Clin Exp Pharmacol Physiol 2014,41,533-542.
[19]曾瑜,刘婧,黄真真,潘兴昌,张立实.姜黄素对急性酒精性肝损伤小鼠抗氧化功能的影响[J].卫生研究,201 4,43(02):282-285
[2]王涵东,梁维邦,姜黄素的研究进展.江苏医药2014,40,1 193-1 194.
[3]Authority,E.F.S.,Scientific Opinion on the re-evaluation of curcumin(E 100)as a food additive.Efsa Journal 2010,8,n/a-n/a.
[4]Stig Bengmark,刘青.植物源保护剂姜黄素的研究进展[J].现代药物与临床,2009,24(01):22-31.
[5]Choudhuri T,Pal S,Agwarwal M L,et al.Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction[J].FEBS Lette rs,2002,512(1-3):0-340.
[6]Jose L Quiles,Mesa M D,Cesar L Ram i rezTortosa,et al.Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits.[J].Arteriosclerosis Thrombosis&Vascular Biology,2003,15(4):173-174.
[7]Trush M A,Kensler T W.An overview of the relationship between oxidative stress and chemical carcinogenesis[J].Free Radical Biology&Medicine,1991,10(3-4):201
[8]宫芸芸.氧化损伤与癌症的发生和预防[J].国外医学(卫生学分册),2000,(01):11-14.
[9]黄真真,曾瑜,贾贞超,张立实,姜黄素及其衍生物的抗氧化作用研究进展.预防医学情报杂志2016,32,1237-1240.
[10]SREEJAYAN,Rao M N A.Nitric Oxide Scavenging by Curcuminoids[J].Journal of Pharmacy&Pharmacology,2011,49(1):105-107.
[11]李军,熊琨,龚元,于翔.基于信号转导通路的姜黄素抗氧化机制研究进展[J].中草药,2016,47(13):2373-2380.
[12]Dreher D,Junod A F.Role of oxygen free radicals in cancer development[J].European Journal of Cancer,1996,32(1):0-38.
[13]Collins,A.,Oxidative DNA damage,antioxidants,and cancer.BIOESSAYS 1999,21,238-246.
[14]Holdom,M.D.,Lechenne,B., Hay,R.J.,Hamilton,A.J.,Monod,M.,Production and characterization of recombinant Aspergillus fumigatus Cu,Zn superoxide dismutase andits recognition by immune human sera.J CLIN MICROBIOL 2000,38,558-562.
[15]Yang,Y.,Karakhanova,S.,Hartwig,W.,D'Haese,J.G.,et al.,Mitochondria and Mitochond rial ROS in Cancer:Novel Targets for Anticancer Therapy.J CELL PHYSIOL 2016,231,2570-2581.
[16]Noto,H.,Goto,A.,Tsujimoto,T.,Noda,M.,Cancer risk in diabetic patients treated with metformin:a systematic review and metaanalysis.PLOS ONE 201 2,7,e3341 1.
[11]Sanchez-Sanchez,B.,GutierrezHerrero,S.,Lopez-Ruano,G.,Prieto-Bermejo,R.,et al.,NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.CLIN CANCER RES 2014,20,4014-4025.
[18]Ha rrison,I.P.,Sele midis,S.,Understanding the biology of reactive oxygen species and their link to cancer:NADPH oxidases as novel pharmacological targets.Clin Exp Pharmacol Physiol 2014,41,533-542.
[19]曾瑜,刘婧,黄真真,潘兴昌,张立实.姜黄素对急性酒精性肝损伤小鼠抗氧化功能的影响[J].卫生研究,201 4,43(02):282-285