双向启动子遗传调控位点研究
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摘要
人类基因组中存在"头对头"方式的基因对,两个基因5’端相邻并分别位于DNA的正负两条链上,其转录起始位点之间的距离不大于1 000bp。一般认为"头对头"基因对可能共享同一个启动子,即"双向启动子"。通过鉴定出1 190对"头对头"基因对,表达相似性结果显示比随机情况更倾向于共表达。"头对头"基因对的遗传调控位点研究显示,SNPs对"头对头"基因对存在不同的调控模式,有助于进一步理解双向启动子的调控机制,为进一步了解人类基因转录调控机制提供帮助。
"Head- to- head"gene pairs is a major class of gene pairs in human genome,that are on opposite strands with less than 1 000 base pairs seperating their transcription start sites. Head- to- head gene pairs may share promoter called "bidirectional promoters". The paper identifies 1 190"head- to- head"gene pairs,which perfer co- expression over random. The results of genetic regulation show that SNPs regulated "head- to- head"gene pairs in different patterns. That is contributed to understand regulational mechasim of bidirectional promoters.
"Head- to- head"gene pairs is a major class of gene pairs in human genome,that are on opposite strands with less than 1 000 base pairs seperating their transcription start sites. Head- to- head gene pairs may share promoter called "bidirectional promoters". The paper identifies 1 190"head- to- head"gene pairs,which perfer co- expression over random. The results of genetic regulation show that SNPs regulated "head- to- head"gene pairs in different patterns. That is contributed to understand regulational mechasim of bidirectional promoters.
引文
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[3]LI Yuanyuan,HUI Yu,ZONG Mingguo,et al.Systematic analysis of head-to-head gene organization:evolutionary conservation and potential biological relevance[J].PLoS Computational Biology,2006,2(7):e74.
[4]LIN J M,COLLINS P J,TRINKLEIN N D,et al.Transcription factor binding and modified histones in human bidirectional promoters[J].Genome Research,2007,17(6):818-827.
[5]WANG Zhong,GERSTEIN M,SNYDER M.RNA-Seq:a revolutionary tool for transcriptomics[J].Natuare Reviews Genetics,2009,10(1):57-63.
[6]ADLER,JEREMY PARMRYD I.Recent review on colocalization seem to misunderstand the Pearson correlation coefficient[J].Journal of Microscopy,2007,227(Pt 1):83-85.
[7]STRIMMER,KORBINIAN.Fdrtool:a versatile R package for estimating local and tail area-based false discovery rates[J].Bioinformatics,2008,24(12):1461-1462.
[2]ADACHI,NORITAKA,LIEBER M R.Bidirectional gene organization:a common architectural feature of the human genome[J].Cell,2002,109(7):807-809.
[3]LI Yuanyuan,HUI Yu,ZONG Mingguo,et al.Systematic analysis of head-to-head gene organization:evolutionary conservation and potential biological relevance[J].PLoS Computational Biology,2006,2(7):e74.
[4]LIN J M,COLLINS P J,TRINKLEIN N D,et al.Transcription factor binding and modified histones in human bidirectional promoters[J].Genome Research,2007,17(6):818-827.
[5]WANG Zhong,GERSTEIN M,SNYDER M.RNA-Seq:a revolutionary tool for transcriptomics[J].Natuare Reviews Genetics,2009,10(1):57-63.
[6]ADLER,JEREMY PARMRYD I.Recent review on colocalization seem to misunderstand the Pearson correlation coefficient[J].Journal of Microscopy,2007,227(Pt 1):83-85.
[7]STRIMMER,KORBINIAN.Fdrtool:a versatile R package for estimating local and tail area-based false discovery rates[J].Bioinformatics,2008,24(12):1461-1462.