从业20年以上影像医师眼底疾病发生情况及眼底结构变化
摘要
目的观察从业20年以上影像医师的眼底疾病发生情况及眼底结构变化。方法选择从业20年以上的影像医师68例纳入医师组,同期同龄健康体检者71例纳入对照组。对两组观察对象进行裂隙灯检查、眼部彩超检查、光学相干断层扫描(OCT)检查,对比两组多种眼底疾病发生率及眼底结构参数。结果医师组玻璃膜疣、玻璃体后脱离、特发性黄斑前膜的患病率分别为23.5%、58.8%、13.2%,均高于对照组(P均<0.05);医师组年龄相关性黄斑变性患病率为4.4%,与对照组差异无统计学意义。医师组视盘上1/4象限、下1/4象限、颞侧1/4象限的视神经纤维层厚度及360°均值均低于对照组(P均<0.05)。医师组黄斑区立方体体积和立方体平均厚度均低于对照组(P均<0.05)。结论从业20年以上的影像医师多种眼底疾病(如玻璃膜疣、玻璃体后脱离、特发性黄斑前膜)患病率增高,视神经纤维层厚度变薄,黄斑区立方体体积和立方体平均厚度减小。
引文
[1] 汪枫桦,孙晓东,许迅.老年性黄斑变性不同分期的光相干断层扫描图像特征[J].中华眼底病杂志,2012,28(3):295-297.
[2] 李善雨.特发性黄斑前膜的诊断与治疗进展[J].中国实用眼科杂志,2013,31(12):1511-1514.
[3] 中华医学会眼科学分会眼底病学组.中国老年性黄斑变性临床诊断治疗路径[J].中华眼底病杂志,2013,29(4):343-355.
[4] Gandorfer A. Pharmacologic vitreolysis[J]. Dev Ophthalmol, 2007,39:149-156.
[5] 张承芬.眼底病学[M].北京:人民卫生出版社,2006:321.
[6] Bu SC, Kuijer R, Li XR, et al. Idiopathic epiretinal membrane[J]. Retina, 2014,34(12):2317-2335.
[7] 曾纯,蔡善君.RPE细胞光损伤机制的研究进展[J].医学综述,2012,28(3):295-297.
[8] Roehlecke C, Schaller A, Knels L, et al. The influence of sublethal blue light exposure on human RPE cells[J]. Mol Vis, 2009,21(15):1929-1938.
[9] 陈长征,车颖,邢怡桥,等.应用二维电泳法对视网膜色素上皮细胞光损伤后蛋白质组学的初步研究[J].中华眼底病杂志,2007,23(6):418-421.
[10] Anderson DH, Mullins RF, Hageman GS, et al. A role for local inf1ammation in the formation of drusen in the aging eye[J]. Am J Ophthalmol, 2002,134(3):411-431.
[11] 冀向宁,王志学,王文英,等.光学相干断层成像在糖尿病视网膜病变临床前期观察中的应用[J].中国全科医学,2014,17(3):350-352.
[12] 王文英,冀向宁,王志学,等.视觉对比敏感度和OCT在焊工体检中的应用[J].中华眼外伤职业眼病杂志,2015,37(8):596-600.
[13] Del Olmo-Aguados, Manso AG, Osborne N. Light might directly affect retinal ganglion cell mitochondria to potentially influence function[J]. Photochem Photobiol, 2012,88(6):1346-1355.
[14] Osborne NN, Nunez AC, Del OS. The effect of visual blue light on mitochondrial function associated with retinal ganglions cells[J]. Exp Eye Res, 2014,128:8-14.
[15] Wang S, Wang B, Feng Y, et al. 17β-estradiol ameliorates light- induced retinal damage in Sprague -Dawley rats by reducing oxidative stress[J]. J Mol Neurosci, 2015,55(1):141-151.
[16] 杨晓伟.可见光诱导视网膜神经节细胞凋亡机制的研究进展[J].交通医学,2015,29(4):333-337.
[17] Mandal MN, Patlolla JM, Zheng L, et al. Curcumin protects retinal cells from light-and oxidant stress-induced cell death[J]. Free Radic Biol Med, 2009,46(5):672-679.
[18] Sheline CT, Zhou YD, Bai S. Light -induced photoreceptor and RPE degeneration involve Zinc toxicity and are attenuated by pyruvate, nicotinamide, or cyclic light[J]. Mol Vis, 2010,16(280/84):2639-2652.
[2] 李善雨.特发性黄斑前膜的诊断与治疗进展[J].中国实用眼科杂志,2013,31(12):1511-1514.
[3] 中华医学会眼科学分会眼底病学组.中国老年性黄斑变性临床诊断治疗路径[J].中华眼底病杂志,2013,29(4):343-355.
[4] Gandorfer A. Pharmacologic vitreolysis[J]. Dev Ophthalmol, 2007,39:149-156.
[5] 张承芬.眼底病学[M].北京:人民卫生出版社,2006:321.
[6] Bu SC, Kuijer R, Li XR, et al. Idiopathic epiretinal membrane[J]. Retina, 2014,34(12):2317-2335.
[7] 曾纯,蔡善君.RPE细胞光损伤机制的研究进展[J].医学综述,2012,28(3):295-297.
[8] Roehlecke C, Schaller A, Knels L, et al. The influence of sublethal blue light exposure on human RPE cells[J]. Mol Vis, 2009,21(15):1929-1938.
[9] 陈长征,车颖,邢怡桥,等.应用二维电泳法对视网膜色素上皮细胞光损伤后蛋白质组学的初步研究[J].中华眼底病杂志,2007,23(6):418-421.
[10] Anderson DH, Mullins RF, Hageman GS, et al. A role for local inf1ammation in the formation of drusen in the aging eye[J]. Am J Ophthalmol, 2002,134(3):411-431.
[11] 冀向宁,王志学,王文英,等.光学相干断层成像在糖尿病视网膜病变临床前期观察中的应用[J].中国全科医学,2014,17(3):350-352.
[12] 王文英,冀向宁,王志学,等.视觉对比敏感度和OCT在焊工体检中的应用[J].中华眼外伤职业眼病杂志,2015,37(8):596-600.
[13] Del Olmo-Aguados, Manso AG, Osborne N. Light might directly affect retinal ganglion cell mitochondria to potentially influence function[J]. Photochem Photobiol, 2012,88(6):1346-1355.
[14] Osborne NN, Nunez AC, Del OS. The effect of visual blue light on mitochondrial function associated with retinal ganglions cells[J]. Exp Eye Res, 2014,128:8-14.
[15] Wang S, Wang B, Feng Y, et al. 17β-estradiol ameliorates light- induced retinal damage in Sprague -Dawley rats by reducing oxidative stress[J]. J Mol Neurosci, 2015,55(1):141-151.
[16] 杨晓伟.可见光诱导视网膜神经节细胞凋亡机制的研究进展[J].交通医学,2015,29(4):333-337.
[17] Mandal MN, Patlolla JM, Zheng L, et al. Curcumin protects retinal cells from light-and oxidant stress-induced cell death[J]. Free Radic Biol Med, 2009,46(5):672-679.
[18] Sheline CT, Zhou YD, Bai S. Light -induced photoreceptor and RPE degeneration involve Zinc toxicity and are attenuated by pyruvate, nicotinamide, or cyclic light[J]. Mol Vis, 2010,16(280/84):2639-2652.