碱性成纤维细胞生长因子联合纳米银烧烫伤贴治疗烧伤后期残余创面的疗效观察
|
摘要
目的:探讨碱性成纤维细胞生长因子联合纳米银烧烫伤贴治疗烧伤后期残余创面的临床效果。方法:选择2014年1月-2018年1月在笔者医院治疗的烧伤患者160例,随机分为对照组和观察组,每组各80例。对照组采用生理盐水清创及1%SD-Ag冷霜外敷;观察组采用碱性成纤维细胞生长因子联合纳米银烧烫伤贴治疗,比较两组患者的残余创面愈合速度、创面愈合时间、视觉模拟疼痛评分(visual analogue score,VAS)、残余创面细菌清除率及不良反应情况。结果:观察组治疗7d、14d、21d后残余创面愈合率均明显高于对照组,差异具有统计学意义(P<0.05)。观察组残余创面愈合时间、VAS评分明显少于对照组,差异均具有统计学意义(P<0.05)。观察组治疗14d后创面细菌阴转率明显高于对照组,差异具有统计学意义(P<0.05)。两组患者在治疗期间均未出现明显不良反应。结论:碱性成纤维细胞生长因子联合纳米银烧烫伤贴治疗大面积烧伤后期残余创面可有效减轻患者疼痛,清除创面细菌,加速创面修复,减少不良情况的发生。
Objective To investigate the clinical effect of basic fibroblast growth factor(bFGF) combined with nano-silver burn and scald patch in the treatment of residual wounds after extensive burn. Methods One hundred and sixty patients with burns who were treated in our hospital from January 2014 to January 2018 were randomly divided into the control group and the observation group, with 80 cases in each group. The patients in the control group were treated with saline debridement and1% SD-Ag cold cream. The patients in the observation group were treated with basic fibroblast growth factor and nano silver burn scald. The rate of residual wound healing, time of wound healing, visual analogue score(VAS), bacterial clearance rate of residual wound and adverse reactions were compared between the two groups. Results The healing rate of residual wounds in the observation group after 7 d, 14 d and 21 d of treatment was significantly higher than those in the control group, and the differences were statistically significant(P<0.05). The healing time and VAS score of residual wounds in the observation group were significantly less than those in the control group(P<0.05). The bacterial negative conversion rate of wound in the observation group was significantly higher than that in the control group after 14 days of treatment(P<0.05). There were no significant adverse reactions during the treatment period between the two groups. Conclusion Combination of basic fibroblast growth factor and nano silver burn patch can effectively relieve pain, remove bacteria, accelerate wound repair and reduce the occurrence of adverse conditions.
Objective To investigate the clinical effect of basic fibroblast growth factor(bFGF) combined with nano-silver burn and scald patch in the treatment of residual wounds after extensive burn. Methods One hundred and sixty patients with burns who were treated in our hospital from January 2014 to January 2018 were randomly divided into the control group and the observation group, with 80 cases in each group. The patients in the control group were treated with saline debridement and1% SD-Ag cold cream. The patients in the observation group were treated with basic fibroblast growth factor and nano silver burn scald. The rate of residual wound healing, time of wound healing, visual analogue score(VAS), bacterial clearance rate of residual wound and adverse reactions were compared between the two groups. Results The healing rate of residual wounds in the observation group after 7 d, 14 d and 21 d of treatment was significantly higher than those in the control group, and the differences were statistically significant(P<0.05). The healing time and VAS score of residual wounds in the observation group were significantly less than those in the control group(P<0.05). The bacterial negative conversion rate of wound in the observation group was significantly higher than that in the control group after 14 days of treatment(P<0.05). There were no significant adverse reactions during the treatment period between the two groups. Conclusion Combination of basic fibroblast growth factor and nano silver burn patch can effectively relieve pain, remove bacteria, accelerate wound repair and reduce the occurrence of adverse conditions.
引文
[1]刘薇,彭金霞,蔡希雯.点状皮片移植联合冲洗治疗大面积烧伤残余创面的效果观察[J].海南医学,2017,28(23):3925-3926.
[2]Thatcher JE,Squiers JJ,Kanick SC,et al.Imaging techniques for clinical burn assessment with a focus on multispectral imaging[J].Adv Wound Care(New Rochelle),2016,5(8):360-378.
[3]Kanno E,Tanno H,Suzuki A,et al.Reconsideration of iodine in wound irrigation:the effects on Pseudomonas aeruginosa biofilmformation[J].J Wound Care,2016,25(6):335-339.
[4]王磊.重组牛碱性成纤维细胞生长因子凝胶联合纳米银敷料促进烧伤创面修复78例[J].中国药业,2015,24(17):117-118.
[5]廖米荣,王慧利,郭正祥,等.浸浴结合银离子敷料治疗大面积烧伤感染患者残余创面的疗效分析[J].中华医院感染学杂志,2017,27(22):5192-5195.
[6]Willy C,Stichling M,Müller M,et al.Acute therapeutic measures for limb salvage Part 2:Debridement,lavage techniques and antiinfectious strategies[J].Unfallchirurg,2016,119(5):388-399.
[7]周伟明.复方多粘菌素B软膏联合纳米银医用抗菌敷料治疗大面积烧伤残余创面的临床研究[J].中国现代药物应用,2015,9(3):124-125.
[8]杜伟力.中药浸浴联合换药治疗大面积深度烧伤后残余创面的临床疗效[J].世界中医药,2018,13(7):1697-1699.
[9]Desroche N,Dropet C,Janod P,et al.Antibacterial properties And reduction of MRSA biofilm with a dressing combining Polyabsorbent fibres and a silver matrix[J].J Wound Care,2016,25(10):577-584.
[10]Bozzetti C,Nizzoli R,Tiseo M,et al.ALK and ROS1 rearrangements Certified by fluorescence in situ hybridization in cytological smears from Advanced non-small cell lung cancer patients[J].Diagn Cytopathol,2015,43(11):941-946.
[11]蒋瑞明,张元海,叶春江,等.纳米银烧伤敷料与磺胺嘧啶银乳膏治疗深Ⅱ度烧伤患者创面感染的研究[J].中华医院感染学杂志,2015,25(22):5228-5230.
[12]陈文峰,王利平.纳米银烧烫伤贴膜联合生肌玉红膏治疗褥疮的效果分析[J].中国现代药物应用,2016,10(5):189-190.
[13]李云青,柏雪.皮生长因子与纳米银烧烫伤贴联合应用治疗深Ⅱ度烧伤创面的疗效观察[J].医学信息,2015,28(45):109-110.
[14]慈海,熊伟.碱性成纤维细胞生长因子联合纳米银敷料促进烧伤残余创面愈合的效果观察[J].山东医药,2017,57(26):78-80.
[15]刘洋,张宜澜,黄亚兰,等.人工真皮联合碱性成纤维细胞生长因子在瘢痕和皮肤深度创面整复中的临床应用[J].中华烧伤杂志,2016,32(4):198-203.
[16]李庆福,王永功,王买全,等.重组牛碱性成纤维细胞生长因子外用凝胶治疗复发性阿弗他口腔溃疡疗效观察[J].中华实用诊断与治疗杂志,2012,26(12):1211-1212.
[2]Thatcher JE,Squiers JJ,Kanick SC,et al.Imaging techniques for clinical burn assessment with a focus on multispectral imaging[J].Adv Wound Care(New Rochelle),2016,5(8):360-378.
[3]Kanno E,Tanno H,Suzuki A,et al.Reconsideration of iodine in wound irrigation:the effects on Pseudomonas aeruginosa biofilmformation[J].J Wound Care,2016,25(6):335-339.
[4]王磊.重组牛碱性成纤维细胞生长因子凝胶联合纳米银敷料促进烧伤创面修复78例[J].中国药业,2015,24(17):117-118.
[5]廖米荣,王慧利,郭正祥,等.浸浴结合银离子敷料治疗大面积烧伤感染患者残余创面的疗效分析[J].中华医院感染学杂志,2017,27(22):5192-5195.
[6]Willy C,Stichling M,Müller M,et al.Acute therapeutic measures for limb salvage Part 2:Debridement,lavage techniques and antiinfectious strategies[J].Unfallchirurg,2016,119(5):388-399.
[7]周伟明.复方多粘菌素B软膏联合纳米银医用抗菌敷料治疗大面积烧伤残余创面的临床研究[J].中国现代药物应用,2015,9(3):124-125.
[8]杜伟力.中药浸浴联合换药治疗大面积深度烧伤后残余创面的临床疗效[J].世界中医药,2018,13(7):1697-1699.
[9]Desroche N,Dropet C,Janod P,et al.Antibacterial properties And reduction of MRSA biofilm with a dressing combining Polyabsorbent fibres and a silver matrix[J].J Wound Care,2016,25(10):577-584.
[10]Bozzetti C,Nizzoli R,Tiseo M,et al.ALK and ROS1 rearrangements Certified by fluorescence in situ hybridization in cytological smears from Advanced non-small cell lung cancer patients[J].Diagn Cytopathol,2015,43(11):941-946.
[11]蒋瑞明,张元海,叶春江,等.纳米银烧伤敷料与磺胺嘧啶银乳膏治疗深Ⅱ度烧伤患者创面感染的研究[J].中华医院感染学杂志,2015,25(22):5228-5230.
[12]陈文峰,王利平.纳米银烧烫伤贴膜联合生肌玉红膏治疗褥疮的效果分析[J].中国现代药物应用,2016,10(5):189-190.
[13]李云青,柏雪.皮生长因子与纳米银烧烫伤贴联合应用治疗深Ⅱ度烧伤创面的疗效观察[J].医学信息,2015,28(45):109-110.
[14]慈海,熊伟.碱性成纤维细胞生长因子联合纳米银敷料促进烧伤残余创面愈合的效果观察[J].山东医药,2017,57(26):78-80.
[15]刘洋,张宜澜,黄亚兰,等.人工真皮联合碱性成纤维细胞生长因子在瘢痕和皮肤深度创面整复中的临床应用[J].中华烧伤杂志,2016,32(4):198-203.
[16]李庆福,王永功,王买全,等.重组牛碱性成纤维细胞生长因子外用凝胶治疗复发性阿弗他口腔溃疡疗效观察[J].中华实用诊断与治疗杂志,2012,26(12):1211-1212.