调强放疗和三维适形放疗在局部晚期非小细胞肺癌患者中应用价值比较
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摘要
目的比较调强放疗和三维适形放疗在局部晚期非小细胞肺癌患者中应用价值。方法选取经病理学确诊的60例局部晚期非小细胞肺癌作为研究对象,采取随机数字表法分为观察组与对照组,对照组30例患者接受三维适形放疗治疗,观察组30例患者接受调强放疗治疗,比较2组患者临床治疗效果、靶区平均剂量、不均匀性指数、适形指数、患者生存时间及1 a生存率。结果观察组与对照组临床治疗总疾病控制率分别为80. 00%、76. 67%,差异无统计学意义(P> 0. 05); 2组患者靶区平均剂量比较差异无统计学意义(P> 0. 05); 2组患者不均匀性指数及适形指数比较差异均有统计学意义(P <0. 05); 2组患者生存时间、1 a生存率比较差异均无统计学意义(P> 0. 05)。结论调强放疗和三维适形放疗在局部晚期非小细胞肺癌患者中应用价值均较高,治疗效果均良好,而调强放疗可降低患者正常器官照射剂量,安全性更高,值得推广应用。
Objective To compare the value of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy in patients with locally advanced non-small cell lung cancer. Methods Sixty patients wih locally advanced non-small cell lung cancer were divided into two groups. The 30 patients in the control group received the three-dimensional conformal radiation therapy,the 30 patients in the observation group received the intensity modulated radiation therapy. The clinical effect,the mean dose of target,the nonuniformity index,conformal index,the average survival period and the 1-year survival rate were compared between the two groups. Results The total disease control rate of the observation group(80. 00%) was the same as that of the control group(76. 67%,P >0. 05). There was no difference in the mean dose of target between the two groups(P > 0. 05). There were the statistical differences in the inhomogeneity index and conformability index between the two groups(P < 0. 05). There was no difference in the survival period and 1-year survival rate between the two groups(P > 0. 05).Conclusion Intensity-modulated radiation therapy and three-dimensional conformal radiotherapy are effective in the patients with locally advanced non-small cell lung cancer,intensity-modulated radiation therapy can reduce the exposure dose in patients with normal organs,and has the better security.
Objective To compare the value of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy in patients with locally advanced non-small cell lung cancer. Methods Sixty patients wih locally advanced non-small cell lung cancer were divided into two groups. The 30 patients in the control group received the three-dimensional conformal radiation therapy,the 30 patients in the observation group received the intensity modulated radiation therapy. The clinical effect,the mean dose of target,the nonuniformity index,conformal index,the average survival period and the 1-year survival rate were compared between the two groups. Results The total disease control rate of the observation group(80. 00%) was the same as that of the control group(76. 67%,P >0. 05). There was no difference in the mean dose of target between the two groups(P > 0. 05). There were the statistical differences in the inhomogeneity index and conformability index between the two groups(P < 0. 05). There was no difference in the survival period and 1-year survival rate between the two groups(P > 0. 05).Conclusion Intensity-modulated radiation therapy and three-dimensional conformal radiotherapy are effective in the patients with locally advanced non-small cell lung cancer,intensity-modulated radiation therapy can reduce the exposure dose in patients with normal organs,and has the better security.
引文
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[12]王志武,王静怡,胡建,等.肺癌三维适形放疗发生放射性肺损伤早期预测因素分析[J].河北医药,2016,38(6):851-853.
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[14]孙爱华,熊海林,周思维,等.三维适形放疗联合培美曲塞治疗老年晚期非鳞型肺癌的疗效观察[J].中医临床研究,2017,9(36):120-122.
[15]国佳.化疗联合三维适形放疗治疗肺癌局部复发的效果[J].中国保健营养,2017,27(33):137-137.
[16]王波,宋伟男,曹文颖,等.肺癌调强放疗后动态心电图改变及影响因素分析[J].现代生物医学进展,2017,17(16):3144-3147.
[2]潘兴喜,杨文,杨画,等.肺癌骨转移患者放疗前后血清β-CTX和PINP水平变化及其与疗效的关系[J].山东医药,2015,12(8):31-33.
[3]方金梅,王凡.图像引导自适应放疗在肺癌治疗中剂量学研究[J].安徽医科大学学报,2015,09(2):247-249.
[4]闵旭红,宋彪.肺癌患者放疗前后CT灌注成像相关研究[J].中华放射肿瘤学杂志,2016,25(7):694-698.
[5]柳红梅,孙静,邓国栋,等.地塞米松预防肺癌骨转移患者姑息放疗导致疼痛加重的临床研究[J].中国肿瘤临床,2017,44(23):1194-1198.
[6]史卫林,李坚,陆建保,等.苦参素对肺癌A549细胞的放疗增敏作用及其机制[J].山东医药,2015,12(29):33-35.
[7]李波,赵永利,李开艳,等.放疗致肺癌患者发生放射性肺炎的影响因素研究[J].中国全科医学,2015,7(14):1659-1662.
[8]张顺达,邓燕明,冯卫能,等.200例老年肺癌患者临床分析[J].肿瘤基础与临床,2017,30(1):82-83.
[9]聂力,邵腾飞,葛卫红,等.替吉奥单药联合西药调强放疗同步治疗老年晚期非小细胞肺癌的效果[J].中国医药导报,2017,14(17):4-7.
[10]彭雷,戚焕鹏,翟西菊,等.奥氮平辅助治疗肺癌骨转移重度疼痛及相关性焦虑、抑郁的临床观察[J].肿瘤基础与临床,2017,30(1):46-48.
[11]路阳.三维适形放疗联合化疗治疗肺癌局部复发的临床效果评价[J].中国继续医学教育,2015,(16):44-45.
[12]王志武,王静怡,胡建,等.肺癌三维适形放疗发生放射性肺损伤早期预测因素分析[J].河北医药,2016,38(6):851-853.
[13]安安.立体定向放疗与三维适形放疗治疗肺癌脑转移瘤的临床效果分析[J].中国医药指南,2016,14(19):9-10.
[14]孙爱华,熊海林,周思维,等.三维适形放疗联合培美曲塞治疗老年晚期非鳞型肺癌的疗效观察[J].中医临床研究,2017,9(36):120-122.
[15]国佳.化疗联合三维适形放疗治疗肺癌局部复发的效果[J].中国保健营养,2017,27(33):137-137.
[16]王波,宋伟男,曹文颖,等.肺癌调强放疗后动态心电图改变及影响因素分析[J].现代生物医学进展,2017,17(16):3144-3147.