谷氨酰胺在预防动物应激反应中的应用
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摘要
谷氨酰胺在机体内可作为小肠代谢的能源物质、免疫细胞的营养物质与抗氧化物质的合成前体,对多种应激导致的生理功能代谢异常有明显的改善与预防效果。所以,谷氨酰胺已在缓解冷应激、热应激、免疫应激及断奶应激等方面得到广泛的应用。现对谷氨酰胺的发现、结构、功能作用及其在畜禽应激和其他领域的应用进行了综述。
Glutamine can be used as the precursor for the synthesis of energy substance of small intestine metabolism,nutrient substance of immunocytes and antioxidants in the organism.Glutamine play the key role in improvement and prevention effects on a variety of stress-induced physiological and metabolic disorders.Therefore,glutamine has been widely used to remit cold stress,heat stress,immunological stress,weanling stress,etc.This article reviewed the discovery,structure,function,effect of glutamine on its application in livestock stress and other fields.
Glutamine can be used as the precursor for the synthesis of energy substance of small intestine metabolism,nutrient substance of immunocytes and antioxidants in the organism.Glutamine play the key role in improvement and prevention effects on a variety of stress-induced physiological and metabolic disorders.Therefore,glutamine has been widely used to remit cold stress,heat stress,immunological stress,weanling stress,etc.This article reviewed the discovery,structure,function,effect of glutamine on its application in livestock stress and other fields.
引文
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[2]王永华.应激对动物的危害及其防制对策[J].养殖技术顾问,2012,40(2):22.
[3]朱光来,王建国,封琦,等.养殖生产中的应激反应及其防治[J].现代农业科技,2012,41(24):275-276.
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[5]SINGH S,ARTHUR S,SUNDARAM U,et al.U-nique regulation of Na-glutamine cotransporter SN2/SNAT5in rabbit intestinal crypt cells during chronic enteritis[J].J Cell Mol Med,2018,22(3):1443-1451.
[6]ZHANG W,ZHANG H Y,ZHANG Q,et al.Glutamine ameliorates lipopolysaccharideinduced cardiac dysfunction by regulating the tolllike receptor 4/mitogenactivated protein kinase/nuclear factorκB signaling pathway[J].Exp Ther Med,2017,14(6):5825-5832.
[7]BERNARD K,LOGSDON N J,BENAVIDES G A,et al.Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation[J].J Biol Chem,2018,293(4):1218-1228.
[8]SCHRANZ A L,MANNING K Y,DEKABAN G A,et al.Reduced brain glutamine in female varsity rugby athletes after concussion and in non-concussed athletes after a season of play[J].Hum Bran Map,2018,39(4):1489-1499.
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[10]RAPOSO B,VAARTJES D,AHLQVIST E,et al.System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis[J].Immunology,2016,146(4):607-617.
[11]LEITE J S,RAIZEL R,HYPOLITO T M,et al.L-glutamine and L-alanine supplementation increase glutamine-glutathione axis and muscle HSP-27in rats trained using aprogressive high-intensity resistance exercise[J].Appl Physiol Nutr Metab,2016,41(8):842-849.
[12]JORDAN I,BALAGUER M,ESTEBAN M E,et al.Glutamine effects on heat shock protein 70and interleukines 6and 10:Randomized trial of glutamine supplementation versus standard parenteral nutrition in critically ill children[J].Clin Nutr,2016,35(1):34-40.
[13]李士泽,李玲,高福久,等.谷氨酰胺和L-肉碱对低温下肉羊抗氧化性能的影响[J].中国畜牧杂志,2012,48(7):43-46.
[14]李士泽,高福久,杨玉英,等.谷氨酰胺和L-肉碱对低温下肉羊瘤胃纤维分解菌的影响[J].动物营养学报,2011,23(3):499-506.
[15]李金敏.谷氨酰胺对慢性冷应激雏鸡肝脏损伤的影响[D].黑龙江哈尔滨:东北农业大学,2009.
[16]纪君波,任慧英,张甜甜,等.谷氨酰胺对夏季水貂生长性能、血清生化指标和抗氧化能力的影响[J].动物营养学报,2017,4(30):1-8.
[17]胡洪,张丹,爱友.谷氨酰胺对循环热应激肉鸡(22~28日龄)生长性能和肌肉品质的改善作用[J].畜牧与饲料科学,2017,38(4):17-19,24.
[18]CHIAPPELLI J,SHI Q,WIJTENBURG S A,et al.Glutamatergic response to heat pain stress inschizophrenia[J].Schizophren Bull,2018,44(4):886-895.
[19]段晓燕,高玉鹏,刘宇,等谷氨酰胺对免疫应激蛋鸡应激激素及免疫功能的影响[J].西北农业学报,2014,23(5):32-38.
[20]王可可,陈祥,肖立新,等.谷氨酰胺对肉鸭免疫应激的调节作用[J].黑龙江畜牧兽医,2015,58(7):35-38.
[21]JOHNSON J S,LAY D C.Evaluating the behavior,growth performance,immune parameters,and intestinal morphology of weaned piglets after simulated transport and heat stress when antibiotics are eliminated from the diet or replaced with L-glutamine1[J].JAnim Sci,2017,95(1):91-102.
[22]YI G F,ALLEE G L,KNIGHT C D,et al.Impact of glutamine and oasis hatchling supplement on growth performance,small intestinal morphology,and immune response of broilers vaccinated and challenged with Eimeria Maxima[J].Poult Sci,2005,84(2):283-293.
[23]金三俊,董佳琦,武洪志,等.谷氨酰胺在仔猪断奶应激中的应用[J].黑龙江畜牧兽医,2017,1(2):175-176.
[24]WANG H,ZHANG C,WU G,et al.Glutamine enhances tight junction protein expression and modulates corticotropin-releasing factor signaling in the jejunum of weanling piglets[J].J Nutr,2015,145(1):25-31.
[25]HU Z Y,LI S L,CAO Z J.Short communication:glutamine increases autophagy of liver cells in weaned calves[J].J Dairy Sci,2012,95(12):7336-7339.
[26]毕研亮.谷氨酰胺缓解断奶犊牛断奶应激及其机理研究[D].北京:中国农业大学,2016.
[27]王晶,左小霞,张晔,等.谷氨酰胺临床应用研究进展[J].人民军医,2013,56(4):469-470.
[28]MARSHALL H,CHRISMAS B C,SUCKLING C A,et al.Chronic probiotic supplementation with or without glutamine does not influence the eHsp72response to a multi-day ultra-endurance exercise event[J].Appl Physiol Nutr Metab,2017,42(8):876-883.
[2]王永华.应激对动物的危害及其防制对策[J].养殖技术顾问,2012,40(2):22.
[3]朱光来,王建国,封琦,等.养殖生产中的应激反应及其防治[J].现代农业科技,2012,41(24):275-276.
[4]WINDMUELLER H G,SPAETH A E.Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine[J].J Biol Chem,1978,253(1):69-76.
[5]SINGH S,ARTHUR S,SUNDARAM U,et al.U-nique regulation of Na-glutamine cotransporter SN2/SNAT5in rabbit intestinal crypt cells during chronic enteritis[J].J Cell Mol Med,2018,22(3):1443-1451.
[6]ZHANG W,ZHANG H Y,ZHANG Q,et al.Glutamine ameliorates lipopolysaccharideinduced cardiac dysfunction by regulating the tolllike receptor 4/mitogenactivated protein kinase/nuclear factorκB signaling pathway[J].Exp Ther Med,2017,14(6):5825-5832.
[7]BERNARD K,LOGSDON N J,BENAVIDES G A,et al.Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation[J].J Biol Chem,2018,293(4):1218-1228.
[8]SCHRANZ A L,MANNING K Y,DEKABAN G A,et al.Reduced brain glutamine in female varsity rugby athletes after concussion and in non-concussed athletes after a season of play[J].Hum Bran Map,2018,39(4):1489-1499.
[9]AMORIM A B,BERTO D A,SALEH M A,et al.Dietary glutamine,glutamic acid and nucleotides increase the carbon turnover(δ13C)on the intestinal mucosa of weaned piglets[J].Animal,2017,11(9):1472-1481.
[10]RAPOSO B,VAARTJES D,AHLQVIST E,et al.System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis[J].Immunology,2016,146(4):607-617.
[11]LEITE J S,RAIZEL R,HYPOLITO T M,et al.L-glutamine and L-alanine supplementation increase glutamine-glutathione axis and muscle HSP-27in rats trained using aprogressive high-intensity resistance exercise[J].Appl Physiol Nutr Metab,2016,41(8):842-849.
[12]JORDAN I,BALAGUER M,ESTEBAN M E,et al.Glutamine effects on heat shock protein 70and interleukines 6and 10:Randomized trial of glutamine supplementation versus standard parenteral nutrition in critically ill children[J].Clin Nutr,2016,35(1):34-40.
[13]李士泽,李玲,高福久,等.谷氨酰胺和L-肉碱对低温下肉羊抗氧化性能的影响[J].中国畜牧杂志,2012,48(7):43-46.
[14]李士泽,高福久,杨玉英,等.谷氨酰胺和L-肉碱对低温下肉羊瘤胃纤维分解菌的影响[J].动物营养学报,2011,23(3):499-506.
[15]李金敏.谷氨酰胺对慢性冷应激雏鸡肝脏损伤的影响[D].黑龙江哈尔滨:东北农业大学,2009.
[16]纪君波,任慧英,张甜甜,等.谷氨酰胺对夏季水貂生长性能、血清生化指标和抗氧化能力的影响[J].动物营养学报,2017,4(30):1-8.
[17]胡洪,张丹,爱友.谷氨酰胺对循环热应激肉鸡(22~28日龄)生长性能和肌肉品质的改善作用[J].畜牧与饲料科学,2017,38(4):17-19,24.
[18]CHIAPPELLI J,SHI Q,WIJTENBURG S A,et al.Glutamatergic response to heat pain stress inschizophrenia[J].Schizophren Bull,2018,44(4):886-895.
[19]段晓燕,高玉鹏,刘宇,等谷氨酰胺对免疫应激蛋鸡应激激素及免疫功能的影响[J].西北农业学报,2014,23(5):32-38.
[20]王可可,陈祥,肖立新,等.谷氨酰胺对肉鸭免疫应激的调节作用[J].黑龙江畜牧兽医,2015,58(7):35-38.
[21]JOHNSON J S,LAY D C.Evaluating the behavior,growth performance,immune parameters,and intestinal morphology of weaned piglets after simulated transport and heat stress when antibiotics are eliminated from the diet or replaced with L-glutamine1[J].JAnim Sci,2017,95(1):91-102.
[22]YI G F,ALLEE G L,KNIGHT C D,et al.Impact of glutamine and oasis hatchling supplement on growth performance,small intestinal morphology,and immune response of broilers vaccinated and challenged with Eimeria Maxima[J].Poult Sci,2005,84(2):283-293.
[23]金三俊,董佳琦,武洪志,等.谷氨酰胺在仔猪断奶应激中的应用[J].黑龙江畜牧兽医,2017,1(2):175-176.
[24]WANG H,ZHANG C,WU G,et al.Glutamine enhances tight junction protein expression and modulates corticotropin-releasing factor signaling in the jejunum of weanling piglets[J].J Nutr,2015,145(1):25-31.
[25]HU Z Y,LI S L,CAO Z J.Short communication:glutamine increases autophagy of liver cells in weaned calves[J].J Dairy Sci,2012,95(12):7336-7339.
[26]毕研亮.谷氨酰胺缓解断奶犊牛断奶应激及其机理研究[D].北京:中国农业大学,2016.
[27]王晶,左小霞,张晔,等.谷氨酰胺临床应用研究进展[J].人民军医,2013,56(4):469-470.
[28]MARSHALL H,CHRISMAS B C,SUCKLING C A,et al.Chronic probiotic supplementation with or without glutamine does not influence the eHsp72response to a multi-day ultra-endurance exercise event[J].Appl Physiol Nutr Metab,2017,42(8):876-883.