新生儿窒息后外周血中性粒细胞与淋巴细胞比值的变化及其临床意义
|
摘要
目的探讨中性粒细胞与淋巴细胞比值(NLR)在新生儿窒息后的变化及临床意义。方法将78例新生儿窒息按阿氏(Apgar)评分分为轻度窒息组(60例)和重度窒息组(18例),同时设正常对照组30例,用全自动血细胞分析仪检测其外周血白细胞分类计数,并计算NLR值。结果相较于正常对照组,窒息组白细胞计数与NLR均升高(P<0.05);重度窒息组NLR高于轻度窒息组(P<0.05);经治疗后重度窒息组NLR呈下降趋势,相较于第1、3及7天差异有统计学意义(P<0.05)。结论 NLR与新生儿窒息的发生发展有关,检测NLR对新生儿窒息的早期诊断和窒息程度判断及预后具有重要意义。
Objective To explore the changes and clinical significances of blood neutrophil-to-lymphocyte ratio(NLR) in neonatal asphyxia. Methods According to Apgar score, 78 cases of neonatal asphyxia were divided into mild asphyxia group(60 cases) and severe asphyxia group(18 cases), while 30 normal newborn infants were enrolled as control group in this study. The peripheral blood leukocyte sorting and counting were measured by automatic blood cell analyzer, and the NLR values were counted. Results Compared with the control group, the white blood cell count and NLR values in asphyxia group were significantly increased(P <0.05). NLR values in severe asphyxia group were significantly higher than those in mild asphyxia group(P <0.05). NLR values declined gradually after treatment in severe asphyxia group. Compared with the first day,the 3rd day and the 7th day had significant differences(P < 0.05). Conclusions NLR value is related to the development of neonatal asphyxia, and the detection of NLR value has great significance in the early diag-nosis of neonatal asphyxia and the degree of asphyxia and prognosis.
Objective To explore the changes and clinical significances of blood neutrophil-to-lymphocyte ratio(NLR) in neonatal asphyxia. Methods According to Apgar score, 78 cases of neonatal asphyxia were divided into mild asphyxia group(60 cases) and severe asphyxia group(18 cases), while 30 normal newborn infants were enrolled as control group in this study. The peripheral blood leukocyte sorting and counting were measured by automatic blood cell analyzer, and the NLR values were counted. Results Compared with the control group, the white blood cell count and NLR values in asphyxia group were significantly increased(P <0.05). NLR values in severe asphyxia group were significantly higher than those in mild asphyxia group(P <0.05). NLR values declined gradually after treatment in severe asphyxia group. Compared with the first day,the 3rd day and the 7th day had significant differences(P < 0.05). Conclusions NLR value is related to the development of neonatal asphyxia, and the detection of NLR value has great significance in the early diag-nosis of neonatal asphyxia and the degree of asphyxia and prognosis.
引文
[1]韩玉昆,杨于嘉,邵肖梅,等.新生儿缺氧缺血性脑病[M].第2版.北京:人民卫生出版社,2010:149-159.
[2]殷俏,郭淑芹,张云良,等.视黄醇结合蛋白4、中性粒细胞淋巴细胞比值与2型糖尿病视网膜病变的关系[J].中国现代医学杂志,2016,26(6):54-58.
[3]季纯珍.新生儿窒息的病因与病理生理[J].吉林医学,1987(6):1-2.
[4]叶鸿瑁.继续深入开展我国的新生儿窒息复苏工作,降低新生儿窒息的病死率和伤残率[J].中华围产医学杂志,2011,14(3):129-131.
[5]彭小明,高喜容,孙正香,等.新生儿缺氧缺血性脑病血清超敏C反应蛋白的变化及临床意义[J].中国优生与遗传杂志,2008,16(6):88.
[6]董文斌,冉隆瑞,冯志强.白细胞在新生儿大鼠窒息后脑损伤中的作用[J].中国全科医学,2002,5(5):360-361.
[7]蔡俊伟.窒息新生儿血液中内皮素、白细胞与血小板参数的动态变化及其临床意义[J].中国妇幼保健,2011,26(25):3901-3903.
[8]DUFFY B K,GURM H S,RAJAGOPAL V,et al.Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention[J].American Journal of Cardiology,2006,97(7):993-996.
[9]HALAZUN K J,ALDOORI A,MALIK H Z,et al.Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases[J].European Journal of Surgical Oncology,2008,34(1):55-60.
[10]AZAB B,JAGLALL N,ATALLAH J P,et al.Neutrophil-lymphocyte ratio as a predictor of adverse outcomes of acute pancreatitis[J].Pancreatology,2011,11(4):445-452.
[11]GOMEZ D,MORRIS-STIFF G,TOOGOOD G J,et al.Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma[J].Journal of Surgical Oncology,2009,16(3):614-622.
[12]常正义,马迎教,潘云,等.新生儿窒息血常规结果分析及其临床意义[J].广西医学,2014,36(9):1240-1242.
[13]王利珍,袭学芹,尹立岩,等.新生儿缺氧缺血性脑病患儿血栓前状态的研究[J].中国现代医学杂志,2014,24(14):72-75.
[14]赵秋剑,柳小红.窒息新生儿血液中白细胞计数与血小板参数的动态变化研究[J].临床和实验医学杂志,2006,5(9):1386-1387.
[2]殷俏,郭淑芹,张云良,等.视黄醇结合蛋白4、中性粒细胞淋巴细胞比值与2型糖尿病视网膜病变的关系[J].中国现代医学杂志,2016,26(6):54-58.
[3]季纯珍.新生儿窒息的病因与病理生理[J].吉林医学,1987(6):1-2.
[4]叶鸿瑁.继续深入开展我国的新生儿窒息复苏工作,降低新生儿窒息的病死率和伤残率[J].中华围产医学杂志,2011,14(3):129-131.
[5]彭小明,高喜容,孙正香,等.新生儿缺氧缺血性脑病血清超敏C反应蛋白的变化及临床意义[J].中国优生与遗传杂志,2008,16(6):88.
[6]董文斌,冉隆瑞,冯志强.白细胞在新生儿大鼠窒息后脑损伤中的作用[J].中国全科医学,2002,5(5):360-361.
[7]蔡俊伟.窒息新生儿血液中内皮素、白细胞与血小板参数的动态变化及其临床意义[J].中国妇幼保健,2011,26(25):3901-3903.
[8]DUFFY B K,GURM H S,RAJAGOPAL V,et al.Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention[J].American Journal of Cardiology,2006,97(7):993-996.
[9]HALAZUN K J,ALDOORI A,MALIK H Z,et al.Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases[J].European Journal of Surgical Oncology,2008,34(1):55-60.
[10]AZAB B,JAGLALL N,ATALLAH J P,et al.Neutrophil-lymphocyte ratio as a predictor of adverse outcomes of acute pancreatitis[J].Pancreatology,2011,11(4):445-452.
[11]GOMEZ D,MORRIS-STIFF G,TOOGOOD G J,et al.Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma[J].Journal of Surgical Oncology,2009,16(3):614-622.
[12]常正义,马迎教,潘云,等.新生儿窒息血常规结果分析及其临床意义[J].广西医学,2014,36(9):1240-1242.
[13]王利珍,袭学芹,尹立岩,等.新生儿缺氧缺血性脑病患儿血栓前状态的研究[J].中国现代医学杂志,2014,24(14):72-75.
[14]赵秋剑,柳小红.窒息新生儿血液中白细胞计数与血小板参数的动态变化研究[J].临床和实验医学杂志,2006,5(9):1386-1387.